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Volumn 31, Issue 3 I, 2005, Pages 233-242

Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes

Author keywords

Glucagon like peptide 1; Incretin hormones; Insulin; Type 2 diabetes

Indexed keywords

CJC 1131; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GASTROINTESTINAL HORMONE; GLIMEPIRIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; LIRAGLUTIDE; METFORMIN; ORAL ANTIDIABETIC AGENT; P 9301; SITAGLIPTIN; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG; VILDAGLIPTIN;

EID: 21744433419     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1262-3636(07)70190-8     Document Type: Review
Times cited : (163)

References (58)
  • 1
    • 0002025725 scopus 로고
    • On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane
    • Moore B, Edie ES, Abram JH. On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane. Biochem J, 1906, 1, 28-38.
    • (1906) Biochem J , vol.1 , pp. 28-38
    • Moore, B.1    Edie, E.S.2    Abram, J.H.3
  • 2
    • 0001101009 scopus 로고
    • Studies on the physiology of secretin. Further studies on the effect of secretin on the blood sugar
    • Labarre J, Still EU. Studies on the physiology of secretin. Further studies on the effect of secretin on the blood sugar. Am J Physiol, 1930, 91, 649-53.
    • (1930) Am J Physiol , vol.91 , pp. 649-653
    • Labarre, J.1    Still, E.U.2
  • 4
    • 0021864130 scopus 로고
    • New developments in the incretin concept
    • Creutzfeldt W, Ebert R. New developments in the incretin concept. Diabetologia, 1985, 28, 565-73.
    • (1985) Diabetologia , vol.28 , pp. 565-573
    • Creutzfeldt, W.1    Ebert, R.2
  • 5
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide 1 (7-36) amide in normal subjects and patients with diabetes mellitus
    • Gutniak M, Orkosv C, Holst JJ et al. Antidiabetogenic effect of glucagon-like peptide 1 (7-36) amide in normal subjects and patients with diabetes mellitus. N Eng J Med, 1992, 326, 1316-22.
    • (1992) N Eng J Med , vol.326 , pp. 1316-1322
    • Gutniak, M.1    Orkosv, C.2    Holst, J.J.3
  • 6
    • 0026542396 scopus 로고
    • Insulinotropic actions of glucagon-like peptide 1 (7-37) in diabetic and nondiabetic subjects
    • Nathan DM, Schreiber E, Fogel H et al. Insulinotropic actions of glucagon-like peptide 1 (7-37) in diabetic and nondiabetic subjects. Diabetes Care, 1992, 15, 270-6.
    • (1992) Diabetes Care , vol.15 , pp. 270-276
    • Nathan, D.M.1    Schreiber, E.2    Fogel, H.3
  • 7
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1(7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, et al. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1(7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia, 1993, 36, 741-4.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3
  • 8
    • 0037357951 scopus 로고    scopus 로고
    • GLP-1 receptor agonist are growth and differentiation factors for pancreatic islet beta cells
    • Egan JM, Bulotta A, Hui H, Perfetti R. GLP-1 receptor agonist are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metab Res Rev, 2003, 19, 115-23.
    • (2003) Diabetes Metab Res Rev , vol.19 , pp. 115-123
    • Egan, J.M.1    Bulotta, A.2    Hui, H.3    Perfetti, R.4
  • 9
    • 0029043139 scopus 로고
    • Cell and molecular biology of the incretin hormones glucagon-like peptide 1 and glucose dependent insulin releasing polypeptide
    • Fehmann HC, Goke R, Goke B. Cell and molecular biology of the incretin hormones glucagon-like peptide 1 and glucose dependent insulin releasing polypeptide. Endocrine Rev, 1995, 16, 390-410.
    • (1995) Endocrine Rev , vol.16 , pp. 390-410
    • Fehmann, H.C.1    Goke, R.2    Goke, B.3
  • 10
    • 0036158954 scopus 로고    scopus 로고
    • Biological actions and therapeutic potential of the glucagon-like peptides
    • Drucker DJ. Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology, 2002, 122, 531-44.
    • (2002) Gastroenterology , vol.122 , pp. 531-544
    • Drucker, D.J.1
  • 11
    • 0035106978 scopus 로고    scopus 로고
    • Minireview: The glucagon-like peptides
    • Drucker DJ. Minireview: the glucagon-like peptides. Endocrinology, 2001, 142, 521-7.
    • (2001) Endocrinology , vol.142 , pp. 521-527
    • Drucker, D.J.1
  • 12
    • 0033520869 scopus 로고    scopus 로고
    • GIP biology and fat metabolism
    • Yip RGC and Wolfe MM. GIP biology and fat metabolism. Life Sciences, 2000, 66, 91-103.
    • (2000) Life Sciences , vol.66 , pp. 91-103
    • Yip, R.G.C.1    Wolfe, M.M.2
  • 13
    • 0141953908 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 synthetic analogues: New therapeutic agents for use in the treatment of diabetes mellitus
    • Holz GG and Chepurny OG. Glucagon-like peptide-1 synthetic analogues: new therapeutic agents for use in the treatment of diabetes mellitus. Current Med Chem, 2003, 10, 2471-83.
    • (2003) Current Med Chem , vol.10 , pp. 2471-2483
    • Holz, G.G.1    Chepurny, O.G.2
  • 14
  • 15
    • 0018185347 scopus 로고
    • Oral glucose augmentation of insulin secretion: Interactions of gastric inhibitory polypeptide with ambient glucose and insulin levels
    • Andersen DK, Elahi D, Brown JC, Tobin JD, Andres R. Oral glucose augmentation of insulin secretion: interactions of gastric inhibitory polypeptide with ambient glucose and insulin levels. J Clin Invest, 1978, 49, 152-61.
    • (1978) J Clin Invest , vol.49 , pp. 152-161
    • Andersen, D.K.1    Elahi, D.2    Brown, J.C.3    Tobin, J.D.4    Andres, R.5
  • 16
    • 1842855423 scopus 로고    scopus 로고
    • Incretins, insulin secretion and type 2 diabetes mellitus
    • Vilsboll T, Hoist JJ. Incretins, insulin secretion and type 2 diabetes mellitus. Diabetologia, 2004, 47, 357-66.
    • (2004) Diabetologia , vol.47 , pp. 357-366
    • Vilsboll, T.1    Hoist, J.J.2
  • 17
    • 0007866067 scopus 로고    scopus 로고
    • Glucose intolerance caused by a defect in the enteroinsular axis: A study in gastric inhibitory polypeptide receptor knockout mice
    • Myiawaki K, Yamada Y, Yano H, et al. Glucose intolerance caused by a defect in the enteroinsular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci USA, 1999, 96, 14843-7.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14843-14847
    • Myiawaki, K.1    Yamada, Y.2    Yano, H.3
  • 18
    • 0034838323 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signalling
    • Trumper A, Trumper K, Trusheim H, Arnold R, Goke B, Horsch D. Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signalling. Mol Endocrinol, 2001, 15, 1559-70.
    • (2001) Mol Endocrinol , vol.15 , pp. 1559-1570
    • Trumper, A.1    Trumper, K.2    Trusheim, H.3    Arnold, R.4    Goke, B.5    Horsch, D.6
  • 19
    • 0033028297 scopus 로고    scopus 로고
    • Is glucagon-like peptide 1 an incretin hormone?
    • Nauck MA. Is glucagon-like peptide 1 an incretin hormone? Diabetologia, 1999, 42, 373-9.
    • (1999) Diabetologia , vol.42 , pp. 373-379
    • Nauck, M.A.1
  • 20
    • 0029765475 scopus 로고    scopus 로고
    • Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
    • Orskov C, Wettergren A, Holst JJ. Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scand J Gastroenterol, 1996, 31, 665-70.
    • (1996) Scand J Gastroenterol , vol.31 , pp. 665-670
    • Orskov, C.1    Wettergren, A.2    Holst, J.J.3
  • 21
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 (7-36): A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 (7-36): a physiological incretin in man. Lancet, 1987, 2, 1300-4.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 22
    • 0027419106 scopus 로고
    • Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon like peptide-1 (7-36) amide infused at near physiological insulinotropic hormone and glucose concentrations
    • Nauck MA, Bartels E, Orskov C, Ebert R, Creutzfeldt W. Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon like peptide-1 (7-36) amide infused at near physiological insulinotropic hormone and glucose concentrations. J Clin Endocrinol Metab, 1993, 76, 912-7.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 912-917
    • Nauck, M.A.1    Bartels, E.2    Orskov, C.3    Ebert, R.4    Creutzfeldt, W.5
  • 23
    • 0030667056 scopus 로고    scopus 로고
    • Inhibition of gastric emptying by physiological and pharmacological doses of exogenous glucagon-like peptide -1 (GLP-1) outweighs insulinotropic effects in healthy normoglycemic volunteers
    • Nauck MA, Niedereichholtz U, Ettler R, Hoist JJ, Orskov C, Schmeigel WH. Inhibition of gastric emptying by physiological and pharmacological doses of exogenous glucagon-like peptide -1 (GLP-1) outweighs insulinotropic effects in healthy normoglycemic volunteers. Am J Physiol, 1997, 273, E981-E988.
    • (1997) Am J Physiol , vol.273
    • Nauck, M.A.1    Niedereichholtz, U.2    Ettler, R.3    Hoist, J.J.4    Orskov, C.5    Schmeigel, W.H.6
  • 24
    • 0036869408 scopus 로고    scopus 로고
    • Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1
    • Holst JJ. Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1. Diabetes Metab Res Rev, 2002, 18, 430-41.
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 430-441
    • Holst, J.J.1
  • 25
    • 0029954211 scopus 로고    scopus 로고
    • Glucagonostatic actions and reduction of fasting hyperglycaemia by exogenous glucagon-like peptide-1 (7-36) amide in type I diabetic patients
    • Creutzfeldt WO, Kleine N, Willms B, Orskov C, Hoist JJ, Nauck MA. Glucagonostatic actions and reduction of fasting hyperglycaemia by exogenous glucagon-like peptide-1 (7-36) amide in type I diabetic patients. Diabetes Care, 1996, 19, 580-6.
    • (1996) Diabetes Care , vol.19 , pp. 580-586
    • Creutzfeldt, W.O.1    Kleine, N.2    Willms, B.3    Orskov, C.4    Hoist, J.J.5    Nauck, M.A.6
  • 26
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counter regulatory hormone responses, cognitive functions and insulin secretion during hyperinsulinemic stepped hypoglycaemic clamp experiments in healthy volunteers
    • Nauck MA, Heimesaat MM, Behle K, et al. Effects of glucagon-like peptide 1 on counter regulatory hormone responses, cognitive functions and insulin secretion during hyperinsulinemic stepped hypoglycaemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab, 2002, 87, 1239-46.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3
  • 27
    • 0032756657 scopus 로고    scopus 로고
    • Glucagon-like peptide-1(7-36) amide: A central regulator of satiety and interoceptive stress
    • van Dijk G, Thiele TE. Glucagon-like peptide-1(7-36) amide: a central regulator of satiety and interoceptive stress. Neuropeptides, 1999, 33, 406-14.
    • (1999) Neuropeptides , vol.33 , pp. 406-414
    • Van Dijk, G.1    Thiele, T.E.2
  • 28
    • 0037066595 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 as a regulator of food intake and body weight: Therapeutic perspectives
    • Meier JJ, Gallwitz B, Schmidt WE, Nauck MA. Glucagon-like peptide 1 as a regulator of food intake and body weight: therapeutic perspectives. Eur J Pharmacol, 2002, 440, 269-79.
    • (2002) Eur J Pharmacol , vol.440 , pp. 269-279
    • Meier, J.J.1    Gallwitz, B.2    Schmidt, W.E.3    Nauck, M.A.4
  • 29
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intakes in humans
    • Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide 1 promotes satiety and suppresses energy intakes in humans. J Clin Invest, 1998, 101, 515-20.
    • (1998) J Clin Invest , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 30
    • 0033021677 scopus 로고    scopus 로고
    • Energy intake and appetite are suppressed by glucagon-like peptide 1 (GLP-1) in obese men
    • Naslund E, Barkeling B, King N, Gutniak M, et al. Energy intake and appetite are suppressed by glucagon-like peptide 1 (GLP-1) in obese men. Int J Obes Relat Metab Disord, 1999, 23, 304-11.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 304-311
    • Naslund, E.1    Barkeling, B.2    King, N.3    Gutniak, M.4
  • 31
    • 0032966882 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
    • Gutzwiller JP, Drewe J, Goke B, et al. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol, 1999, 276, 1541-4.
    • (1999) Am J Physiol , vol.276 , pp. 1541-1544
    • Gutzwiller, J.P.1    Drewe, J.2    Goke, B.3
  • 32
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycemic control, insulin sensitivity, and β-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study. Lancet, 2002, 359, 824-30.
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 33
    • 0345257136 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and the islet β-cell: Augmenta-tion of cell proliferation and inhibition of apoptosis
    • Drucker DJ. Glucagon-like peptide-1 and the islet β-cell: augmenta-tion of cell proliferation and inhibition of apoptosis. Endocrinology, 2003, 144, 5145-8.
    • (2003) Endocrinology , vol.144 , pp. 5145-5148
    • Drucker, D.J.1
  • 34
    • 0345374580 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
    • Farilla L, Bulotta A, Hirshberg B, et al. Glucagon-like peptide-1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology, 2003, 141, 5149-58.
    • (2003) Endocrinology , vol.141 , pp. 5149-5158
    • Farilla, L.1    Bulotta, A.2    Hirshberg, B.3
  • 35
    • 0034880655 scopus 로고    scopus 로고
    • Determinants of the impaired secretion of glucagon-like peptide 1 in type 2 diabetes
    • Toft-Nielsen MB, Damholt MB, Madsbas S, et al. Determinants of the impaired secretion of glucagon-like peptide 1 in type 2 diabetes. J Clin Endocrinol Metab, 2001, 86, 3717-23.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3717-3723
    • Toft-Nielsen, M.B.1    Damholt, M.B.2    Madsbas, S.3
  • 36
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsboll T, Krarup T, Deacon CF, Madsbad S, et al. Reduced postprandial concentrations of glucagon-like peptide 1 in type 2 diabetic patients. Diabetes, 2001, 50, 609-13.
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsboll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4
  • 37
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 (GLP-1) (7-36) amide but not of synthetic human gastric inhibitory polypeptide (GIP) in patients with type 2 diabetes mellitus
    • Nauck MA, Heisematt MM, Orskov C, et al. Preserved incretin activity of glucagon-like peptide 1 (GLP-1) (7-36) amide but not of synthetic human gastric inhibitory polypeptide (GIP) in patients with type 2 diabetes mellitus. J Clin Invest, 1993, 30, 301-7.
    • (1993) J Clin Invest , vol.30 , pp. 301-307
    • Nauck, M.A.1    Heisematt, M.M.2    Orskov, C.3
  • 38
    • 0030068620 scopus 로고    scopus 로고
    • Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of exogenous glucagon-like peptide-1 (GLP-1-(7-36) amide) in type 2 (noninsulin-dependent) diabetic patients
    • Willms B, Werner J, Holst JJ, Orskov C, Creutzfeldt W, Nauck MA. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1-(7-36) amide) in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab, 1996, 81, 327-32.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 327-332
    • Willms, B.1    Werner, J.2    Holst, J.J.3    Orskov, C.4    Creutzfeldt, W.5    Nauck, M.A.6
  • 39
    • 1042302789 scopus 로고    scopus 로고
    • Prevention or delay of type 2 diabetes
    • American Diabetes Association. Prevention or delay of type 2 diabetes. Diabetes Care, 2004, 27 (suppl 1), S47-S53.
    • (2004) Diabetes Care , vol.27 , Issue.SUPPL. 1
  • 41
    • 0003179974 scopus 로고    scopus 로고
    • Recommandations de bonne pratique. Traitement médicamenteux du diabète de type 2 (Diabète non insulinodépendant)
    • Agence Française de Sécurité Sanitaire des Produits de Santé, AFSSAPS. Recommandations de bonne pratique. Traitement médicamenteux du diabète de type 2 (Diabète non insulinodépendant). Diabetes Metab, 1999, 25 (suppl 6), 1-79.
    • (1999) Diabetes Metab , vol.25 , Issue.SUPPL. 6 , pp. 1-79
  • 42
    • 0028963260 scopus 로고
    • United Kingdom Prospective Diabetes Study 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years
    • United Kingdom Prospective Diabetes Study 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. BMJ, 1995, 310, 83-8.
    • (1995) BMJ , vol.310 , pp. 83-88
  • 43
    • 0347360186 scopus 로고    scopus 로고
    • Pharmacology of exenatide (synthetic exendin-4): A potential therapeutic for improved glycemic control of type 2 diabetes
    • Nielsen LL, Young AA, Parkes DG. Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regulatory Peptides, 2004, 117, 77-88.
    • (2004) Regulatory Peptides , vol.117 , pp. 77-88
    • Nielsen, L.L.1    Young, A.A.2    Parkes, D.G.3
  • 44
    • 0034814047 scopus 로고    scopus 로고
    • Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers
    • Edwards CM, Stanley SA, Davis R, et al. Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers. Am J Physiol Endocrinol Metab, 2001, 281, E155-E161.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Edwards, C.M.1    Stanley, S.A.2    Davis, R.3
  • 45
    • 0038497464 scopus 로고    scopus 로고
    • Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes
    • Kolterman OG, Buse JB, Fineman MS, et al. Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes. J Clin Endocrinol Metab, 2003, 88, 3082-9.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3082-3089
    • Kolterman, O.G.1    Buse, J.B.2    Fineman, M.S.3
  • 46
    • 4344713643 scopus 로고    scopus 로고
    • Effect of intravenous infusion of Exenatide (Synthetic Exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycaemia
    • Degn K, Brock B, Juhl CB, et al. Effect of intravenous infusion of Exenatide (Synthetic Exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycaemia. Diabetes, 2004, 53, 2397-403.
    • (2004) Diabetes , vol.53 , pp. 2397-2403
    • Degn, K.1    Brock, B.2    Juhl, C.B.3
  • 47
    • 0037850667 scopus 로고    scopus 로고
    • Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin in patients with type 2 diabetes
    • Fineman M, Bicsak T, Shen L, et al. Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin in patients with type 2 diabetes. Diabetes Care, 2003, 26, 2370-7.
    • (2003) Diabetes Care , vol.26 , pp. 2370-2377
    • Fineman, M.1    Bicsak, T.2    Shen, L.3
  • 48
    • 3142658598 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • De Fronzo R, Ratner R, Han J, et al. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes [Abstract]. Diabetologia, 2004, 47 (suppl 1), A280.
    • (2004) Diabetologia , vol.47 , Issue.SUPPL. 1
    • De Fronzo, R.1    Ratner, R.2    Han, J.3
  • 49
    • 19444367290 scopus 로고    scopus 로고
    • Effects of Exenatide (Exendin-4) on glycemic control and weight in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall D, Riddle M, Zhuang D, et al. Effects of Exenatide (Exendin-4) on glycemic control and weight in patients with type 2 diabetes treated with metformin and a sulfonylurea [Abstract]. Diabetologia, 2004, 47 (suppl 1), A279.
    • (2004) Diabetologia , vol.47 , Issue.SUPPL. 1
    • Kendall, D.1    Riddle, M.2    Zhuang, D.3
  • 50
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care, 2004, 27, 2628-35.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3
  • 51
    • 0036676385 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, safety and tolerability of a single dose of NN2211, a long acting glucagon-like peptide 1 derivative, in healthy male subjects
    • Elbrond B, Jakobsen G, Larsen S. Pharmacokinetics, pharmacodynamics, safety and tolerability of a single dose of NN2211, a long acting glucagon-like peptide 1 derivative, in healthy male subjects. Diabetes Care, 2002, 25, 1398-404.
    • (2002) Diabetes Care , vol.25 , pp. 1398-1404
    • Elbrond, B.1    Jakobsen, G.2    Larsen, S.3
  • 52
    • 2542451393 scopus 로고    scopus 로고
    • Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long acting glucagon-like peptide 1 analogue liraglutide (NN2211)
    • Madsbad S, Schmitz O, Ranstam J, et al. Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long acting glucagon-like peptide 1 analogue liraglutide (NN2211). Diabetes Care, 2004, 27, 1335-42.
    • (2004) Diabetes Care , vol.27 , pp. 1335-1342
    • Madsbad, S.1    Schmitz, O.2    Ranstam, J.3
  • 53
    • 33845206667 scopus 로고    scopus 로고
    • Liraglutide significantly improves glycemic control and reduces body weight compared with glimepiride as add-on to metformin in type 2 diabetes
    • Nauck MA, Hompesch M, Filipczak, et al. Liraglutide significantly improves glycemic control and reduces body weight compared with glimepiride as add-on to metformin in type 2 diabetes [Abstract]. Diabetes, 2004, 53 (suppl 2), A83.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Nauck, M.A.1    Hompesch, M.2    Filipczak3
  • 54
    • 32644473365 scopus 로고    scopus 로고
    • CJC-1131, a long acting GLP-1 analog for Type 2 diabetes mellitus: Clinical development update
    • Guivarch PH, Dreyfus JF, Mathi S, et al. CJC-1131, a long acting GLP-1 analog for Type 2 diabetes mellitus: clinical development update [Abstract] Diabetologia, 2004, 47 (suppl 1), A282.
    • (2004) Diabetologia , vol.47 , Issue.SUPPL. 1
    • Guivarch, P.H.1    Dreyfus, J.F.2    Mathi, S.3
  • 55
    • 4544344541 scopus 로고    scopus 로고
    • Twelve-week monotherapy with the DPP-4 inhibitor LAF237 improves glycemic control in patients with type 2 diabetes
    • Pratley R, Galbreath E. Twelve-week monotherapy with the DPP-4 inhibitor LAF237 improves glycemic control in patients with type 2 diabetes (Abstract]. Diabetes, 2004, 53 (suppl 2), A83.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Pratley, R.1    Galbreath, E.2
  • 56
    • 9444285818 scopus 로고    scopus 로고
    • Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
    • Ahren B, Gomis R, Standl E, Mills D, Schweizer A. Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care, 2004, 27, 2874-80.
    • (2004) Diabetes Care , vol.27 , pp. 2874-2880
    • Ahren, B.1    Gomis, R.2    Standl, E.3    Mills, D.4    Schweizer, A.5
  • 57
    • 4544302130 scopus 로고    scopus 로고
    • DP-IV inhibitor MK-0431 enhances active GLP-1 and reduces glucose following an OGTT in type 2 diabetes
    • Herman GA, Peng-Liang Z, Dietrich B, et al. the DP-IV inhibitor MK-0431 enhances active GLP-1 and reduces glucose following an OGTT in type 2 diabetes [Abstract]. Diabetes, 2004, 53 (suppl 2), A82.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Herman, G.A.1    Peng-Liang, Z.2    Dietrich, B.3    The, E.A.4
  • 58
    • 14044253388 scopus 로고    scopus 로고
    • The DP IV-inhibitor P93/01 improves glucose tolerance in humans with HbA1c greater than 6.0
    • Heinz J, Glund K, Hoffmann T, et al. The DP IV-inhibitor P93/01 improves glucose tolerance in humans with HbA1c greater than 6.0 [Abstract]. Diabetes, 2004, 53 (suppl 2), A128.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Heinz, J.1    Glund, K.2    Hoffmann, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.