Advances in non-peptide glucagon receptor antagonists

Current Pharmaceutical Design

Volumn 5, Issue 9, 1999, Pages 683-691

  Madsen, P ^a   Brand, C L ^a   Holst, J J ^b   Knudsen, L B ^a  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; GLUCAGON ANTIBODY; GLUCAGON RECEPTOR; HYDRAZONE DERIVATIVE; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; PYRROLO[1,2 A]QUINOLINE DERIVATIVE; QUINOLINE DERIVATIVE; QUINOXALINE DERIVATIVE; RECEPTOR BLOCKING AGENT;

ARTICLE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BLOCKING;

ANIMALS; ANTIBODIES; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; HYPOGLYCEMIC AGENTS; PEPTIDES; RECEPTORS, GLUCAGON;

EID: 0032758393     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. DeFronzo, R.A.; Bonadonna, R.C.; Ferrannini, E. Diabetes Care, 1992, 15, 318-368.
2. Unger, R.H.; Orci, L. Lancet, 1975, 1, 14-16.
3. Dobbs, R.E.; Sakurai, H.; Sasaki, H.; Faloona, G.; Valverde, I.; Baetens, D.; Orci, L.; Unger, R.H. Science 1975, 187, 544-547.
4. Gerich, J.E.; Lorenzi, M.; Bier, D.M.; Schneider, V.; Tsalikian, E.; Karam, J.H.; Forsham, P.H. N.Engl.J.Med., 1975, 292, 985-989.
5. Brand, C.L.; Rolin, B.; Jørgensen, P.N.; Svendsen, I.; Kristensen, J.S.; Holst, J.J. Diabetologia, 1994, 37, 985-993.
6. Brand, C.L.; Jørgensen, P.N.; Knigge, U.; Warberg, J.; Svendsen, I.; Kristensen, J.S.; Holst, J.J. Am.J.Physiol., 1995, 32, E469-E477.
7. Brand, C.L.; Jørgensen, P.N.; Svendsen, I.; Holst, J.J. Diabetes, 1996, 45, 1076-1083.
8. Jelinek, L.J.; Lok, S.; Rosenberg, G.B.; Smith, R.A.; Grant, F.J.; Biggs, S.; Bensch, S.; Kuijper, J.L.; Sheppard, P.O.; Sprecher, C.A.; O'Hara, P.J.; Foster, D.; Walker, K.M.; Chen, L.H.; McKernan, P.A.; Kindsvogel, W. Science, 1993, 259, 1614-1616.
9. Kindsvogel, W.; Jelinek, L.J.; Grant, F.J.; Kuijper, J.L.; Foster, D.C.; Lok, S.; O'Hara, P.J.; US5770445.
10. Hansen, L.H.; Gromada, J.; Bouchelouche, P.; Whitmore, T.; Jelinek, L.; Kindsvogel, W.; Nishimura, E. Am. J. Physiol. - Cell Physiol., 1998, 43, C1552.
11. Hansen, L.H.; Abrahamsen, N.; Hager, J.; Jelinek, L.; Kindsvogel, W.; Froguel, P.; Nishimura, E. Diabetes, 1996, 45, 725-730.
12. Hjort, S.A.; Ørskov, C.; Schwartz, T.W. Molecular Endocrinology, 1998, 12, 78-86.
13. Chicchi, G.; Graziano, M.; Koch, G.; Vicario, P.; Cascieri, M. Diabetes, 1997, 46 (Suppl. 1), 1096.
14. Chicchi, G.; Graziano, M.; Koch, G.; Hey, P.; Sullivan, K.; Vicario, P.; Cascieri, M. J.Biol.Chem., 1997, 272, 7765-7769.
15. Buggy, J.J.; Livingston, J.N.; Rabin, D.U.; Yoo-Warren, H. J.Biol.Chem., 1995, 270, 7474-7478.
16. Hjort, S.A.; Schwartz, T.W. Acta Physiol.Scand., 1996, 157, 343-345.
17. Unson, C.G.; Cypress, A.M.; Goldschmidt, P.K.; Carruthers, C.J.L.; Merrifield, R.B.; Sakmar, T.P. J.Biol.Chem., 1995, 270, 27720-27727.
18. Cascieri, M.A.; Koch, G.E.; Ber, E.; Sadowski, S.J.; Louizides, D.; de Laszlo, S.E.; Hacker, C.; Hagmann, W.K.; MacCoss, M.; Chicchi, G.G.; Vicario, P.P. J.Biol.Chem., 1999, 274, 8694-8697.
19. Faraci, W.S.; Collins, J.L.; Dambek, P.J.; Goldstein, S.W. Bioorg.Med.Chem.Lett., 1992, 2, 915-918.
20. Rault, S.; Guillon, J.; Dallemagne, P.; Pfeiffer, B.; Renard, P.; Manechez, D.; Kervran, A. Eur.J.Med.Chem., 1998, 33 (1998), 293-308.
21. Madsen, P.; Knudsen, L.B.; Wiberg, F.C.: Carr, R.D. J. Med. Chem., 1998, 41, 5150-5157.
22. de Laszlo, S.; Hacker, C.; Li, B.; Kim, D.; MacCoss, M.; Mantlo, N.; Pivnichny, J.V.; Koch, G.E.; Cascieri, M.A.; Hagmann, W.K. XVth EFMC International Symosium on Medicinal Chemistry, Sept. 6-10 1998, Edingburgh, Scotland.
23. de Laszlo, S.; Hacker, C.; Li, B.; Kim, D.; MacCoss, M.; Mantlo, N.; Pivnichny, J.V.; Koch, G.E.; Cascieri, M.A.; Hagmann, W.K.; Colwell, L. Bioorg. Med. Chem. Lett., 1999, 9, 641-646.
24. Kim, D.; Leung, K.-P.; MacCoss, M.; Koch, G.E.; Cascieri, M.A.; Mantlo, N.; Hagmann, W.K. 217th ACS National Meeting, Anaheim, CA, March 21-24, 1999.
25. th ACS National Meeting, Boston, Ma, Aug. 23-27, 1998.
26. Schmidt, G.; Angerbauer, R.; Brandes, R.; Muller-Gliemann, M.; Bischoff, H.; Schmidt, D.; Wohlfeil, S.; Schoen, W.R.; Ladouceur, G.; Cook, J.H.; Lease, T.G.; Wolanin, D.J. WO9804528.
27. Ling, A.; Gregor, V.; Gonzalez, J.; Hong, Y.; Kiel, D.; Kuki, A.; Shi, S.; Naerum, L.; Madsen, P.; Sams, C.K.; Lau, J.; Plewe, M.B.; Feng, J.; Teng, M.; Johnson, M.D.; Teston, K.A.; Sidelmann, U.G.; Knudsen, L.B. WO9901423.