O-48: TNFa and insulin sensitivity in humans: Effects in vivo of antibody blockade in obese NIDDM patients and in vitro upon human cultured myotubes

Experimental and Clinical Endocrinology and Diabetes

Volumn 104, Issue , 1996, Pages 59-60

  Hurel, Stevn ^a   Ofei, Francis ^a   Wells, Ann ^a   Newkirk, José ^a   Sopwith, Mark ^a   Turnbull, Douglas ^a   Taylor, Roy ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0342618563     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0029-1211539     Document Type: Article

References (4)

1. Ohno Y, Aoki N, Nishimura A: In vitro production of interleukin-l, interleukin-6, and tumor necrosis factor-α in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 77: 1072–1077, 1993.
2. Hotamisligil GS, Shargill NS, Spiegelmann BM: Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259: 87–91, 1993
3. Hofmann C, Lorenz K, Braithwaite SS, Colca JR. Palazuk BJ, Hotamisligil GS, Spiegelman BM: Altered gene expression for tumor necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance. Endocrínology 134: 264–270, 1994
4. Hotamisligil GS, Budavari A, Murray D, Spiegelman BM: Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes: central role of tumor necrosis factor-α. J Clin Invert 94: 1543–1549, 1994