Hindbrain noradrenergic A2 neurons: Diverse roles in autonomic, endocrine, cognitive, and behavioral functions

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 300, Issue 2, 2011, Pages

  Rinaman, Linda ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Catecholaminergic; Dorsal vagal complex; Nucleus of the solitary tract; Stress; Visceral

Indexed keywords

AUTONOMIC NERVOUS SYSTEM FUNCTION; BEHAVIOR; BEHAVIORAL STRESS; BRAIN REGION; BRAIN STEM; COGNITION; DRUG DEPENDENCE; EMOTIONAL DISORDER; ENDOCRINE FUNCTION; FOOD INTAKE; HUMAN; HYPOTHALAMUS; LEARNING; LIMBIC CORTEX; NONHUMAN; NORADRENERGIC A2 NERVE; NORADRENERGIC NERVE; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; REVIEW; RHOMBENCEPHALON; VAGUS NERVE DORSAL NUCLEUS;

ANIMALS; AUTONOMIC NERVOUS SYSTEM; BEHAVIOR, ANIMAL; COGNITION; NEUROENDOCRINE CELLS; NEURONS; NOREPINEPHRINE; RHOMBENCEPHALON; RODENTIA;

EID: 79551566749     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00556.2010     Document Type: Review

References (295)

1. Abelson JL, Cameron OG. Adrenergic dysfunction in anxiety disorders. In: Adrenergic Dysfunction and Psychobiology, edited by Cameron OG. Washington, DC: American Psychiatric Press, 1994.
2. Ahlskog JE, Hoebel BG. Overeating and obesity from damage to a noradrenergic system in the brain. Science 182: 166-169, 1973.
3. Al-Damluji S. Adrenergic mechanisms in the control of corticotropin secretion. J Endocrinol 119: 5-14, 1988.
4. Alonso G, Szafarczyk A, Balmefrezol M, Assenmacher I. Immunocytochemical evidence of stimulatory control by the ventral noradrenergic bundle of parvicellular neurons of the paraventricular nucleus secreting corticotropin-releasing hormone and vasopressin in rats. Brain Res 397: 297-307, 1986.
5. Altschuler SM, Bao X, Bieger D, Hopkins DA, Miselis RR. Viscerotopic representation of the upper alimentary tract in the rat: sensory ganglia and nuclei of the solitary and spinal trigeminal tracts. J Comp Neurol 283: 248-268, 1989.
6. Appleyard SM, Marks D, Kobayashi K, Okano H, Low MJ, Andresen MC. Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus. J Neurosci 27: 13292-13302, 2007. (Pubitemid 350220485)
7. Arbab MA, Delgado T, Wiklund L, Svendgaard NA. Brain stem terminations of the trigeminal and upper spinal ganglia innervation of the cerebrovascular system: WGA-HRP transganglionic study. J Cereb Blood Flow Metab 8: 54-63, 1988. (Pubitemid 18045944)
8. Armstrong DM, Ross CA, Pickel VP, Joh TH, Reis DJ. Distribution of dopamine, noadrenaline and adrenaline-containing cell bodies in the rat medulla oblongata: demonstration by immunocytochemical localization of catecholamine biosynthetic enzymes. J Comp Neurol 211: 173-187, 1982.
9. Asakura M, Nagashima H, Fujii S, Sasuga Y, Misonoh A, Hasegawa H, Osada K. Influences of chronic stress on central nervous systems. Jpn J Psychopharmacol 20: 97-105, 2000.
10. Asan E, Yilmazer-Hanke DM, Eliava M, Hantsch M, Lesch KP, Schmitt A. The corticotropin-releasing factor (CRF)-system and monoaminergic afferents in the central amygdala: investigations in different mouse strains and comparison with the rat. Neuroscience 131: 953-967, 2005.
11. Aston-Jones G, Delfs JM, Druhan J, Zhu Y. The bed nucleus of the stria terminalis: a target site for noradrenergic actions in opiate withdrawal. Ann NY Acad Sci 877: 486-498, 1999.
12. Aston-Jones G, Harris GC. Brain substrates for increased drug seeing during protracted withdrawal. Neuropsychopharmacology 47, Suppl 1: 167-179, 2004.
13. Babic T, de Oliveira CV, Ciriello J. Collateral axonal projections from rostral ventromedial medullary nitric oxide synthase containing neurons to brainstem autonomic sites. Brain Res 1211: 2008.
14. Bailey TW, Hermes SM, Andresen MC, Aicher AA. Cranial visceral afferent pathways through the nucleus of the solitary tract to caudal ventrolateral medulla or paraventricular hypothalamus: target-specific synaptic reliability and convergence patterns. J Neurosci 26: 11893-11902, 2006.
15. Balcita-Pedicino JJ, Rinaman L. Noradrenergic axon terminals contact gastric pre-autonomic neurons in the paraventricular nucleus of the hypothalamus in rats. J Comp Neurol 501: 608-618, 2007. (Pubitemid 46622498)
16. Banihashemi L, Rinaman L. Noradrenergic inputs to the bed nucleus of the stria teminalis and paraventricular nucleus of the hypothalamus underlie hypothalamic-pituitary-adrenal axis but not hypophagic or conditioned avoidance responses to systemic yohimbine. J Neurosci 26: 11442-11453, 2006. (Pubitemid 44772175)
17. Barrera G, Hernandez A, Poulin JF, Laforest S, Drolet G, Morilak DA. Galanin-mediated anxiolytic effect in rat central amygdala is not a result of corelease from noradrenergic terminals. Synapse 59: 27-40, 2006. (Pubitemid 41706152)
18. Benavides M, Laorden ML, García-Borrón JC, Milanés MV. Regulation of tyrosine hydroxylase levels and activity and Fos expression during opioid withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups innervating the PVN. Eur J Neurosci 17: 103-112, 2003. (Pubitemid 36098880)
19. Berntson GG, Sarter M, Cacioppo JT. Ascending visceral regulation of cortical affective information processing. Eur J Neurosci 18: 2103-2109, 2003.
20. Bienkowski MS, Rinaman L. Noradrenergic inputs to the paraventricular hypothalamus contribute to hypothalamic-pituitary-adrenal axis and central Fos activation in rats after acute systemic endotoxin exposure. Neuroscience 156: 1093-1102, 2008.
21. Blessing WW. The Lower Brainstem and Bodily Homeostasis. New York: Oxford University Press, 1997.
22. Bojo L, Cassuto J, Nellgard P. Pain-induced inhibition of gastric motility is mediated by adrenergic and vagal non-adrenergic reflexes in the rat. Acta Physiol Scand 146: 377-383, 1992.
23. Bonnet MS, Pecchi E, Trouslard J, Jean A, Dallaporta M, Troadec JD. Central nesfatin-1-expressing neurons are sensitive to peripheral inflammatory stimulus. J Neuroinflammation 6: 27, 2009.
24. Brown ZJ, Tribe E, D'souza NA, Erb S. Interaction between noradrenaline and corticotrophin-releasing factor in the reinstatement of cocaine seeking in the rat. Psychopharmacologia 203: 121-130, 2009.
25. Brownstein MJ, Palkovits M. Catecholamines, serotonin, acetylcholine, and γ-aminobutyric acid in the rat brain: biochemical studies. In: Handbook of Chemical Neuroanatomy, edited by Bjorklund A and Hokfelt T. Amsterdam: Elsevier, 1984, p. 23-54.
26. Brunton PJ, McKay AJ, Ochedalski T, Piastowska A, Rebas E, Lachowicz A, Russell JA. Central opioid inhibition of neuroendocrine stress responses in pregnancy in the rat is induced by the neurosteroid allopregnanolone. J Neurosci 29: 6449-6460, 2009.
27. Brunton PJ, Russell JA. Attenuated hypothalamo-pituitary-adrenal axis responses to immune challenge during pregnancy: the neurosteroid-opioid connection. J Physiol 586: 369-375, 2008.
28. Brunton PJ, Russell JA. Keeping oxytocin neurons under control during stress in pregnancy. Prog Brain Res 170: 365-377, 2008.
29. Buller K, Xu Y, Dayas C, Day T. Dorsal and ventral medullary catecholamine cell groups contribute differentially to systemic interleukin-1β-induced hypothalamic pituitary adrenal axis responses. Neuroendocrinology 73: 129-138, 2001.
30. Buller KM, Dayas CV, Day TA. Descending pathways from the paraventricular nucleus contribute to the recruitment of brainstem nuclei following a systemic immune challenge. Neuroscience 118: 189-203, 2003.
31. Cahill L, Babinsky R, Markowitsch HJ, McGaugh JL. The amygdala and emotional memory. Nature 377: 295-296, 1995.
32. Cahill L, McGaugh JL. Amygdaloid complex lesions differentially affect retention of tasks using appetitive and aversive reinforcement. Behav Neurosci 104: 532-543, 1990.
33. Cahill L, McGaugh JL. Mechanisms of emotional arousal and lasting declarative memory. Trends Neurosci 21: 294-299, 1998.
34. Cahill L, McGaugh JL. A novel demonstration of enhanced memory associated with emotional arousal. Conscious Cogn 4: 410-421, 1995.
35. Cahill L, Prins B, Weber M, McGaugh JL. β-Adrenergic activation and memory for emotional events. Nature 371: 702-704, 1994. (Pubitemid 2146911)
36. Caillé S, Espejo EF, Reneric JP, Cador M, Koob GF, Stinus L. Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal. J Pharmacol Exp 290: 881-892, 1999.
37. Callahan JB, Rinaman L. The postnatal emergence of dehydration anorexia in rats is temporally associated with the emergence of dehydration-induced inhibition of gastric emptying. Physiol Behav 64: 683-687, 1998.
38. Carvalho AF, Mackie K, Van Bockstaele EJ. Cannabinoid modulation of limbic forebrain noradrenergic circuitry. Eur J Neurosci 31: 286-301, 2010.
39. Carvalho AF, Reyes ARS, Sterling RC, Unterwald E, Van Bockstaele EJ. Contribution of limbic norepinephrine to cannabinoid-induced aversion. Psychopharmacology (Berl) 211: 479-491, 2010.
40. Ceccatelli S, Seroogyb KB, Millhornc DE, Tereniusd L. Presence of a dynorphin-like peptide in a restricted subpopulation of catecholaminergic neurons in rat nucleus tractus solitarii. Brain Res 589: 225-230, 1992.
41. Cecchi M, Khoshbouei H, Javors M, Morilak DA. Modulatory effects of norepinephrine in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress. Neuroscience 112: 13-21, 2002. (Pubitemid 34603494)
42. Cecchi M, Khoshbouei H, Morilak DA. Modulatory effects of norepinephrine, acting on α1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress. Neuropharmacology 43: 1139-1147, 2002. (Pubitemid 36009367)
43. Chan RK, Sawchenko PE. Spatially and temporally differentiated patterns of c-fos expression in brainstem catecholaminergic cell groups induced by cardiovascular challenges in the rat. J Comp Neurol 348: 433-460, 1994.
44. Chan RKW, Peto CA, Sawchenko PE. A1 catecholamine cell group: fine structure and synaptic input from the nucleus of the solitary tract. J Comp Neurol 351: 62-80, 1995.
45. Chan RKW, Sawchenko PE. Organization and transmitter specificity of medullary neurons activated by sustained hypertension: implications for understanding baroreceptor reflex circuitry. J Neurosci 18: 371-387, 1998.
46. Chang HT. Noradrenergic innervation of the substantia innominata: a light and electron microscopic analysis of dopamine β-hydroxylase immunoreactive elements in the rat. Exp Neurol 104: 101-112, 1989.
47. Chapman IM, Kapoor R, Willoughby JO. Endogenous catecholamines modulate growth hormone release in the conscious rat during hypoglycaemia but not in the basal state. J Neuroendocrinol 5: 145-150, 1993.
48. Charney DS, Grillon C, Bremner JD. The neurobiological basis of anxiety and fear: circuits, mechanisms, and neurochemical interactions (part I). Neuroscientist 4: 35-44, 1998. (Pubitemid 28303604)
49. Charney DS, Grillon CCG, Bremner JD. The neurobiological basis of anxiety and fear: circuits, mechanisms, and neurochemical interactions (part II). Neuroscientist 4: 122-132, 1998. (Pubitemid 28160568)
50. Charney DS, Grillon CCG, Bremner JD. The neurobiological basis of anxiety and fear: circuits, mechanisms, and neurochemical interactions (part III). Neuroscientist 4: 122-132, 1998.
51. Charney DS, Heninger GR, Redmond J DE. Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine. Life Sci 33: 19-29, 1983.
52. Chen CT, Dun SL, Dun NJ, Chang JK. Prolactin-releasing peptide-immunoreactivity in A1 and A2 noradrenergic neurons of the rat medulla. Brain Res 822: 276-279, 1999. (Pubitemid 29222856)
53. Cryan JF, Page ME, Lucki I. Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test. Eur J Pharmacol 436: 197-205, 2002.
54. Cunningham ET Jr, Miselis RR, Sawchenko PE. The relationship of efferent projections from the area postema to vagal motor and brain stem catecholamine-containing cell groups: an axonal transport and immunohistochemical study in the rat. Neuroscience 58: 635-648, 1994.
55. Cunningham ET Jr, Sawchenko PE. Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J Comp Neurol 274: 60-76, 1988.
56. Curran-Rauhut MA, Petersen SL. Oestradiol-dependent and -independent modulation of tyrosine hydroxylase mRNA levels in subpopulations of A1 and A2 neurones with oestrogen receptor (ER)α and ERβ gene expression. J Neuroendocrinol 15: 296-303, 2003.
57. Daftary SS, Boudaba C, Szabo K, Tasker JG. Noradrenergic excitation of magnocellular neurons in the rat hypothalamic paraventricular nucleus via intranuclear glutamatergic circuits. J Neurosci 18: 10619-10628, 1998.
58. Daftary SS, Boudaba C, Tasker JG. Noradrenergic regulation of parvocellular neurons in the rat hypothalamic paraventricular nucleus. Neuroscience 96: 743-751, 2000.
59. Dahlström A, Fuxe K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand 62, Suppl 232: 3-55, 1964.
60. Damasio A. The Feeling of What Happens: Body and Emotion in the Making of Consciousness. New York: Harcourt Brace, 1999.
61. Das M, Vihlen CS, Legradi G. Hypothalamic and brainstem sources of pituitary adenylate cyclase-activating polypeptide nerve fibers innervating the hypothalamic paraventricular nucleus in the rat. J Comp Neurol 500: 761-776, 2007.
62. Date Y, Shimbara T, Koda S, Toshinai K, Ida T, Murakami N, Miyazato M, Kokame K, Ishizuka Ishida Y, Kageyama H, Shioda S, Kangawa K, Nakazato M. Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus. Cell Metab 4: 323-331, 2006.
63. Davis M. Are different parts of the extended amygdala involved in fear versus anxiety? Biol Psychiatry 44: 1239-1247, 1998.
64. Davis M, Rainnie D, Cassell M. Neurotransmission in the rat amygdala related to fear and anxiety. Trends Neurosci 17: 208-214, 1994.
65. Day T, Ferguson AV, Renaud L. Noradrenergic afferents facilitate the activity of tuberoinfundibular neurons of the hypothalamic paraventricular nucleus. Neuroendocrinology 41: 17-22, 1985. (Pubitemid 15022915)
66. Dayas CV, Buller KM, Crane JW, Xu Y, Day TA. Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups. Eur J Neurosci 14: 1143-1152, 2001. (Pubitemid 35463758)
67. Dayas CV, Buller KM, Day TA. Hypothalamic paraventricular nucleus neurons regulate medullary catecholamine cell responses to restraint stress. J Comp Neurol 478: 22-34, 2004.
68. Dayas CV, Day TA. Opposing roles for medial and central amygdala in the initiation of noradrenergic cell responses to a psychological stressor. Eur J Neurosci 15: 1712-1718, 2001.
69. Delfs JM, Zhu Y, Druhan JP, Aston-Jones G. Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion. Nature 403: 430-434, 2000.
70. Delfs JM, Zhu Y, Druhan JP, Aston-Jones GS. Origin of noradrenergic afferents to the shell subregion of the nucleus accumbens: anterograde and retrograde tract-tracing studies in the rat. Brain Res 806: 127-140, 1998.
71. de Sousa Buck H, Caous CA, Lindsey CJ. Projections of the paratrigeminal nucleus to the ambiguus, rostroventrolateral and lateral reticular nuclei, and the solitary tract. Auton Neurosci 87: 187-200, 2001.
72. Dinan TG, Barry S, Ahkion S, Chua A, Keeling PW. Assessment of central noradrenergic functioning in irritable bowel syndrome using a neuroendocrine challenge test. J Psychosom Res 43: 575-580, 1990.
73. Dong HW, Petrovich GD, Swanson LW. Topography of projections from amygdala to bed nuclei of the stria terminalis. Brain Res Rev 38: 192-246, 2001.
74. Dong HW, Petrovich GD, Watts AG, Swanson LW. Basic organization of projections from the oval and fusiform nuclei of the bed nuclei of the stria terminalis in adult rat brain. J Comp Neurol 436: 430-455, 2001.
75. Dong HW, Swanson LW. Organization of axonal projections from the anterolateral area of the bed nucleus of the stria terminalis. J Comp Neurol 468: 277-298, 2004.
76. Douglas AJ. Central noradrenergic mechanisms underlying acute stress responses of the hypothalamo-pituitary-adrenal axis: adaptations through pregnancy and lactation. Stress 8: 5-18, 2005.
77. Duale H, Waki H, Howorth P, Kasparov S, Teschemacher AG, Paton JFR. Restraining influence of A2 neurons in chronic control of arterial pressure in spontaneously hypertensive rats. Cardiovasc Res 76: 184-193, 2007.
78. A inhibition of bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area. J Neurosci 24: 8198-8204, 2004.
79. Dunn AJ, Swiergiel AH, Palamarchouk V. Brain circuits involved in corticotropin-releasing factor-norepinephrine interactions during stress. Ann NY Acad Sci 1018: 25-34, 2004.
80. Ellacott KLJ, Lawrence CB, Rothwell NJ, Luckman SM. PRL-releasing peptide interacts with leptin to reduce food intake and body weight. Endocrinology 143: 368-374, 2002.
81. Emanuel AJ, Ritter S. Hindbrain catecholamine neurons modulate the growth hormone but not the feeding response to ghrelin. Neuroendocrinology 151: 3237-3246, 2010.
82. Ericson H, Blomqvist A, Köhler C. Brainstem afferents to the tuberomammillary nucleus in the rat brain with special reference to monoaminergic innervation. J Comp Neurol 281: 169-192, 1989.
83. Everitt BJ, Hökfelt T. The coexistence of neuropeptide-Y with other peptides and amines in the central nervous system. In: Neuropeptide Y, edited by Mutt V, Fuxe K, Hökfelt T, and Lundberg JM. New York: Raven, 1989, p. 61-71.
84. Fekete C, Wittman G, Liposits Z, Lechan RM. Origin of cocaine- and amphetamine-regulated transcript (CART)-immunoreactive innervation of the hypothalamic paraventricular nucleus. J Comp Neurol 469: 340-350, 2004.
85. Ferry B, Roozendaal B, McGaugh JL. Role of norepinephrine in mediating stress hormone regulation of long-term memory storage: a critical involvement of the amygdala. Biol Psychiatry 46: 1140-1152, 1999.
86. Flak JN, Ostrander MM, Tasker JG, Herman JP. Chronic stress-induced neurotransmitter plasticity in the PVN. J Comp Neurol 517: 156-165, 2009.
87. Flanagan LM, Verbalis JG, Stricker EM. Effects of anorexigenic treatments on gastric motility in rats. Am J Physiol Regul Integr Comp Physiol 256: R955-R961, 1989.
88. Forray MI, Gysling K. Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary- adrenal axis. Brain Res Rev 47: 145-160, 2004.
89. Forray MI, Gysling K, Andres ME, Bustos G, Araneda S. Medullary noradrenergic neurons projecting to the bed nucleus of the stria terminalis express mRNA for the NMDA-NR1 receptor. Brain Res Bull 52: 163-169, 2000.
90. Fraley GS, Ritter S. Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Endocrinology 144: 75-83, 2003.
91. Fuentealba JA, Forray MI, Gysling K. Chronic morphine treatment and withdrawal increase extracellular levels of norepinephrine in the rat bed nucleus of the stria terminalis. J Neurochem 75: 741-748, 2000.
92. Fuertes G, Laorden ML, Milanés MV. Noradrenergic and dopaminergic activity in the hypothalamic paraventricular nucleus after naloxone-induced morphine withdrawal. Neuroendocrinology 71: 60-67, 2000. (Pubitemid 30045336)
93. Füzesi T, Wittmann G, Lechan RM, Liposits Z, Fekete C. Noradrenergic innervation of hypophysiotropic thyrotropin-releasing hormone synthesizing neurons in rats. Brain Res 1294: 38-44, 2009.
94. Gabbott PL, Warner T, Busby SJ. Catecholaminergic neurons in medullary nuclei are among the post-synaptic targets of descending projections from infralimbic area 25 of the rat medial prefrontal cortex. Neuroscience 144: 623-635, 2007.
95. Gaillet S, Alonso G, LeBorgne R, Barbanel G, Malaval F, Assenmacher I, Szafarczyk A. Effects of discrete lesions in the ventral noradrenergic ascending bundle on the corticotropic stress response depend on the site of the lesion and on the plasma levels of adrenal steroids. Neuroendocrinology 58: 408-419, 1993.
96. Gaykema RP, Park SM, McKibbin CR, Goehler LE. Lipopolysaccharide suppresses activation of the tuberomammillary histaminergic system concomitant with behavior: a novel target of immune-sensory pathways. Neuroscience 152: 273-287, 2008.
97. Gaykema RPA, Chen CC, Goehler LE. Organization of immuneresponsive medullary projections to the bed nucleus of the stria terminalis, central amygdala, and paraventricular nucleus of the hypothalamus: evidence for parallel viscerosensory pathways in the rat brain. Brain Res 1130: 130-145, 2007.
98. Gaykema RPA, Daniels TE, Shapiro NJ, Thacker GC, Park SM, Goehler LE. Immune challenge and satiety-related activation of both distinct and overlapping neuronal populations in the brainstem indicate parallel pathways for viscerosensory signaling. Brain Res 1294: 61-79, 2009.
99. Geerling JC, Kawata M, Loewy AD. Aldosterone-sensitive neurons in the rat central nervous system. J Comp Neurol 494: 515-527, 2006.
100. Geerling JC, Shin JW, Chimenti PC, Loewy AD. Paraventricular hypothalamic nucleus: axonal projections to the brainstem. J Comp Neurol 518: 1460-1499, 2010.
101. Härfstrand A, Fuxe K, Cintra A, Agnati LF, Zini I, Wikström AC, Okret S, Yu ZY, Goldstein M, Steinbusch H, Verhofstad A, Gustafsson JA. Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain. Proc Natl Acad Sci USA 83: 9779-9783, 1986.
102. Harris GC, Aston-Jones G. Activation in extended amygdala corresponds to altered hedonic processing during protracted morphine withdrawal. Behav Brain Res 176: 251-258, 2007.
103. Harro J, Oreland L, Vasar E, Bradwejn J. Impaired exploratory behavior after DSP-4 treatment in rats: implications for the increased anxiety after noradrenergic denervation. Eur Neuropsychopharmacol 5: 447-455, 1995.
104. Herbert H, Moga MM, Saper CB. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J Comp Neurol 293: 540-580, 1990.
105. Herbert H, Saper CB. Cholecystokinin-, galanin-, and corticotropin- releasing factor-like immunoreactive projections from the nucleus of the solitary tract to the parabrachial nucleus in the rat. J Comp Neurol 293: 581-598, 1990.
106. Herman JP, Cullinan WE. Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci 20: 78-84, 1997.
107. Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC, Cullinan WE. Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol 24: 151-180, 2003.
108. Herman JP, Ostrander MM, Mueller NK, Figueiredo H. Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Prog Neuro-Psychopharm Biol Psych 29: 1201-1213, 2005.
109. Herman MA, Niedringhaus M, Alayan A, Verbalis JG, Sahibzada N, Gillis RA. Characterization of noradrenergic transmission at the dorsal motor nucleus of the vagus involved in reflex control of fundus tone. Am J Physiol Regul Integr Comp Physiol 294: R720-R729, 2008.
110. Hermann GE, Nasse JS, Rogers RC. α-1 Adrenergic input to solitary nucleus neurones: calcium oscillations, excitation and gastric reflex control. J Physiol 562: 553-568, 2005.
111. Hermes SM, Mitchell JL, Aicher SA. Most neurons in the nucleus tractus solitarii do not send collateral projections to multiple autonomic targets in the rat brain. Exp Neurol 198: 539-551, 2006.
112. Hollis JH, Lightman SL, Lowry CA. Integration of systematic and visceral sensory information by medullary catecholaminergic systems during peripheral inflammation. Ann NY Acad Sci 1018: 71-75, 2004.
113. Horie S, Shioda S, Nakai Y. Catecholaminergic innervation of oxytocin neurons in the paraventricular nucleus of the rat hypothalamus as revealed by double-labeling immunoelectron microscopy. Acta Anat (Basel) 147: 184-192, 1993.
114. Itoi K, Sugimoto N. The brainstem noradrenergic systems in stress, anxiety and depression. J Neuroendocrinol 22: 355-361, 2010.
115. Jelsing J, Galzin AM, Guillot E, Pruniaux MP, Larsen PJ, Vrang N. Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2. Brain Res Bull 78: 202-210, 2009.
116. Jia HG, Rao ZR, Shi JW. Evidence of g-aminobutyric acidergic control over the catecholaminergic projection from the medulla oblongata to the central nucleus of the amygdala. J Comp Neurol 381: 262-281, 1997.
117. Jin GR, Rao ZR, Shi JW. Visceral noxious stimulation induced expression of Fos protein in medullary catecholaminergic neurons projecting to nucleus accumbens in the rat: a study with triple labelig method of HRP tracing combined with Fos and TH immunohistochemistry. Brain Res 648: 196-202, 1985.
118. Kachidian P, Pickel VM. Localization of tyrosine hydroxylase in neuronal targets and efferents of the area postrema in the nucleus tractus solitarii of the rat. J Comp Neurol 329: 337-353, 1993.
119. Kalia M, Sullivan JM. Brainstem projections of sensory and motor components of the vagus nerve in the rat. J Comp Neurol 211: 248-265, 1982.
120. Kasparov S, Teschemacher AG. Altered central catecholaminergic transmission and cardiovascular disease. Exp Physiol 93: 725-740, 2008.
121. Kawai Y, Takagi H, Yanai K, Tohyama M. Adrenergic projection from the caudal part of the nucleus of the tractus solitarius to the parabrachial nucleus in the rat: immunocytochemical study combined with a retrograde tracing method. Brain Res 459: 369-372, 1988.
122. Kawaia Y, Takagi H, Tohyama M. Co-localization of neurotensin- and cholecystokinin-like immunoreactivities in catecholamine neurons in the rat dorsomedial medulla. Neuroscience 24: 227-236, 1988.
123. Kawano H, Masuko S. Neurons in the caudal ventrolateral medulla projecting to the paraventricular hypothalamic nucleus receive synaptic inputs from the nucleus of the solitary tract: a light and electron microscopic double-labeling study in the rat. Neurosci Lett 218: 33-36, 1996.
124. Kerfoot EC, Chattillion EA, Williams CL. Functional interactions between the nucleus tractus solitarius (NTS) and nucleus accumbens shell in modulating memory for arousing experiences. Neurobiol Learn Mem 89: 47-60, 2008.
125. Khoshbouei H, Cecchi M, Dove S, Javors M, Morilak DA. Behavioral reactivity to stress: amplification of stress-induced noradrenergic activation elicits a galanin-mediated anxiolytic effect in central amygdala. Pharmacol Biochem 71: 407-417, 2002.
126. Kirouac GJ, Ciriello J. Medullary inputs to nucleus accumbens neurons. Am J Physiol Regul Integr Comp Physiol 273: R2080-R2088, 1997.
127. Kitazawa S, Shioda S, Nakai Y. Catecholaminergic innervation of neurons containing corticotropin-releasing factor in the paraventricular nucleus of the rat hypothalamus. Acta Anat (Basel) 129: 337-343, 1987.
128. Koob GF. Corticotropin-releasing factor, norepinephrine, and stress. Biol Psychiatry 46: 1167-1180, 1999.
129. Kreek MJ, Koob GF. Drug dependence: stress and dysregulation of brain reward pathways. Drug Alcohol Depend 51: 23-47, 1998.
130. Krukoff TL, Harris KH, Jhamandas JH. Efferent projections from the parabrachial nucleus demonstrated with the anterograde tracer Phaseolus vulgaris leucoagglutinin. Brain Res Bull 30: 163-172, 1993.
131. 2-adrenoceptors. J Pharmacol Exp 293: 578-584, 2000.
132. Laorden ML, Núñez C, Almela P, Milanés MV. Morphine withdrawal-induced c-fos expression in the hypothalamic paraventricular nucleus is dependent on the activation of catecholaminergic neurones. J Neurochem 83: 132-140, 2002.
133. Larsen PJ, Tang-Christensen M, Holst JJ, Orskov C. Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in rat hypothalamus and brainstem. Neuroscience 77: 257-270, 1997.
134. Lawrence CB, Celsi F, Brennand J, Luckman SM. Alternative role for prolactin-releasing peptide in the regulation of food intake. Nature 3: 645-646, 2000.
135. Leri F, Flores J, Rodaros D, Stewart J. Blockade of stress-induced but not cocaine-induced reinstatement by infusion of noradrenergic antagonists into the bed nucleus of the stria terminalis or the central nucleus of the amygdala. J Neurosci 22: 5713-5718, 2002.
136. Levin MC, Sawchenko PE, Howe PRC, Bloom SR, Polak JM. Organization of galanin-immunoreactive inputs to the paraventricular nucleus with special reference to their relationship to catecholaminergic afferents. J Comp Neurol 261: 562-582, 1987.
137. Li HY, Ericsson A, Sawchenko PE. Distinct mechanisms underlie activation of hypothalamic neurosecretory neurons and their medullary catecholaminergic afferents in categorically different stress paradigms. Proc Natl Acad Sci USA 93: 2359-2364, 1996.
138. Li HY, Sawchenko PE. Hypothalamic effector neurons and extended circuitries activated in "neurogenic" stress: a comparison of footshock effects exerted acutely, chronically, and in animals with controlled glucocorticoid levels. J Comp Neurol 393: 244-266, 1998.
139. Liposits Z, Phelix C, Paull WK. Adrenergic innervation of corticotropin releasing factor (CRF)-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. Histochemistry 84: 201-205, 1986.
140. Liubashina O, Jolkkonen E, Pitkanen A. Projections from the central nucleus of the amygdala to the gastric related area of the dorsal vagal complex: a Phaseolus vulgaris-leucoagglutinin study in rat. Neurosci Lett 291: 85-88, 2000.
141. Loewy AD. Central autonomic pathways. In: Central Regulation of Autonomic Functions, edited by Loewy AD and Spyer KM. New York: Oxford University Press, 1990, p. 88-103.
142. Lorden J, Oltmans GA, Margules DL. Central noradrenergic neurons: differential effects on body weight of electrolytic and 6-hydroxydopamine lesions in rats. J Comp Physiol Psychol 90: 144-155, 1976.
143. Lundy RF Jr, Norgren R. Gustatory system. In: The Rat Nervous System (3rd ed.), edited by Paxinos G. San Diego, CA: Elsevier Academic, 2004, p. 890-921.
144. Lynn RB, Kreider MS, Miselis RR. Thyrotropin-releasing hormoneimmunoreactive projections to the dorsal motor nucleus and the nucleus of the solitary tract of the rat. J Comp Neurol 311: 271-288, 1991.
145. Maldonado R. Participation of noradrenergic pathways in the expression of opiate withdrawal: biochemical and pharmacological evidence. Neurosci Biobehav Rev 21: 91-104, 1997.
146. Martinez-Peña-y-Valenzuela I, Rogers RC, Hermann GE, Travagli RA. Norepinephrine effects on identified neurons of the rat dorsal motor nucleus of the vagus. Am J Physiol Gastrointest Liver Physiol 286: G333-G339, 2004.
147. Maruyama M, Matsumoto H, Fujiwara K, Noguchi J, Kitada C, Fujino M, Inoue K. Prolactin-releasing peptide as a novel stress mediator in the central nervous system. Endocrinology 142: 2032-2038, 2001.
148. Mason ST, Fibiger HC. Current concepts. I. Anxiety: the locus coeruleus disconnection. Life Sci 25: 2141-2147, 1979.
149. Mayer EA, Saper CB (Editors). The Biological Basis for Mind Body Interactions. Amsterdam: Elsevier, 2000.
150. Mehendale S, Xie JT, Aung HH, Guan XF, Yuan CS. Nucleus accumbens receives gastric vagal inputs. Acta Pharmacol Sin 25: 271-275, 2004.
151. Mejías-Aponte CA, Drouin C, Astron-Jones G. Adrenergic and noradrenergic innervation of the midbrain ventral tegmental area and retrorubal field: prominent inputs from medullary homeostatic centers. J Neurosci 29: 3613-3626, 2009.
152. Menétrey D, Basbaum AI. Spinal and trigeminal projections to the nucleus of the solitary tract: a possible substrate for somatovisceral and viscerovisceral reflex activation. J Comp Neurol 255: 439-450, 1987.
153. Menétrey D, dePommery J. Origins of spinal ascending pathways that reach central areas involved in visceroception and visceronociception in the rat. Eur J Neurosci 3: 249-259, 1991.
154. 2A-adrenoceptor expression by chronic stress in neurons of the brain stem. Brain Res 880: 147-158, 2000.
155. Michaloudi HC, Majdoubi ME, Poulain DA, Papadopoulos GC, Theodosis DT.
156. Milan MJ, Millan MH, Herz A. The role of the ventral noradrenergic bundle in relation to endorphins in the control of core temperature, open-field and ingestive behaviour in the rat. Brain Res 263: 283-294, 1983.
157. Millhorn DE, Seroogy K, Hökfelt T, Schmued LC, Terenius L, Buchan A, Brown JC. Neurons of the ventral medulla oblongata that contain both somatostatin and enkephalin immunoreactivities project to nucleus tractus solitarii and spinal cord. Brain Res 424: 99-108, 1987.
158. Milner TA, Joh TH, Pickel VM. Tyrosine hydroxylase in the rat parabrachial region: ultrastructural localization and extrinsic sources of immunoreactivity. J Neurosci 6: 2585-2603, 1986.
159. Miranda MI, Ferreira G, Ramirez-Lugo L, Bermúdez-Rattoni F. Glutamatergic activity in the amygdala signals visceral input during taste memory formation. Proc Natl Acad Sci USA 99: 11417-11422, 2002.
160. Miyahara S, Oomura Y. Inhibitory action of the ventral noradrenergic bundle on the lateral hypothalamic neurons through α-noradrenergic mechanisms in the rat. Brain Res 234: 459-463, 1982.
161. Miyashita T, Williams CL. Enhancement of noradrenergic neurotransmission in the nucleus of the solitary tract modulates memory storage processes. Brain Res 987: 164-175, 2003.
162. Miyashita T, Williams CL. Glutamatergic transmission in the nucleus of the solitary tract modulates memory through influences on amygdala noradrenergic systems. Behav Neurosci 116: 13-21, 2002.
163. Moore RY, Card JP. Noradrenaline-containing neuron systems. In: Handbook of Chemical Neuroanatomy, edited by Björklund A and Ḧokfelt T. Amsterdam: Elsevier, 1984, p. 123-156.
164. Morilak DA, Barrera G, Echevarria DJ, Garcia AS, Hernandez A, Ma S, Petre CO. Role of brain norepinephrine in the behavioral response to stress. Prog Neuro-Psychopharm Biol Psych 29: 1214-1224, 2005.
165. Mounier F, Bluet-Pajot MT, Durand D, Kordon C, Epelbaum J. α1-Noradrenergic inhibition of growth hormone secretion is mediated through the paraventricular hypothalamic nucleus in male rats. Neuroendocrinology 59: 29-34, 1994.
166. Mtui EP, Anwar M, Reis DJ, Ruggiero DA. Medullary visceral reflex circuits: local afferents to nucleus tractus solitarii synthesize catecholamines and project to thoracic spinal cord. J Comp Neurol 351: 5-26, 1995.
167. Myers EA, Banihashemi L, Rinaman L. The anxiogenic drug yohimbine activates central viscerosensory circuits in rats. J Comp Neurol 492: 426-441, 2005.
168. Myers EA, Rinaman L. Trimethylthiazoline supports conditioned flavor avoidance and activates viscerosensory, hypothalamic, and limbic circuits in rats. Am J Physiol Regul Integr Comp Physiol 288: R1716-R1726, 2005.
169. Myers EA, Rinaman L. Viscerosensory activation of noradrenergic inputs to the amygdala in rats. Physiol Behav 77: 723-729, 2002.
170. Myers RD, McCaleb ML. Feeding: satiety signals from intestine trigger brain's noradrenergic mechanisms. Science 209: 1035-1037, 1980.
171. Navarro-Zaragoza J, Núñez C, Laorden ML, Milanés MV. Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal. Mol Pharmacol 77: 864-873, 2010.
172. Núñez C, Földes A, Pérez-Flores D, García-Borrón JC, Laorden ML, Kovács KJ, Milanés MV. Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawal. Endocrinology 150: 3118-3127, 2009.
173. Núñez C, Martín F, AAF, Laorden ML, Kovács KJ, Milanés MV. Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. J Neurochem 114: 475-487, 2010.
174. Oh-IS, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, Eguchi H, Yamamoto M, Imaki T, Hashimoto K, Tsuchiya T, Monden T, Horiguchi K, Yamada M, Mori M. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature (London) 443: 709-712, 2006.
175. Olschowka JA, Molliver ME, Grzanna R, Rice FL, Coyle JJ. Ultrastructural demonstration of noradrenergic synapses in the rat central neuron system by dopamine-β-hydroxylase immunocytochemistry. J Histochem Cytochem 29: 271-289, 1981.
176. Olson VG, Heusner CL, Bland RJ, During MJ, Weinshenker D, Palmiter RD. Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward. Science 311: 1017-1020, 2006.
177. Onaka T. Neural pathways controlling central and peripheral oxytocin release during stress. J Neuroendocrinol 16: 308-312, 2004.
178. Onaka T, Palmer JR, Yagi K. A selective role of brainstem noradrenergic neurons in oxytocin release from the neurohypophysis following noxious stimuli in the rat. Neurosci Res 25: 67-75, 1996.
179. Onaka T, Yagi K. Role of noradrenergic projections to the bed nucleus of the stria terminalis in neuroendocrine and behavioral responses to fear-related stimuli in rats. Brain Res 788: 287-293, 1998.
180. Otake K, Reis DJ, Ruggiero DA. Afferents to the midline thalamus issue collaterals to the nucleus tractus solitarii: an anatomical basis for thalamic and visceral reflex integration. J Neurosci 14: 5694-5707, 1994.
181. Pacak K, Palkovits M, Kopin IJ, Goldstein DS. Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity: in vivo microdialysis studies. Front Neuroendocrinol 16: 89-150, 1995.
182. Panula P, Pirvola U, Auvinen S, Airaksinen MS. Histamine-immunoreactive nerve fibers in the rat brain. Neuroscience 28: 585-610, 1989. (Pubitemid 19081018)
183. Pardon MC, Ma S, Morilak DA. Chronic cold stress sensitizes brain noradrenergic reactivity and noradrenergic facilitation of the HPA stress response in Wistar Kyoto rats. Brain Res 971: 55-65, 2003.
184. Pearson RJ, Gatti PJ, Sahibzada N, Massari VJ, Gillis RA. Ultrastructural evidence for selective noradrenergic innervation of CNS vagal projections to the fundus of the rat. Auton Neurosci 136: 31-42, 2007.
185. Petrov T, Krukoff TL, Jhamandas JH. Branching projections of catecholaminergic brainstem neurons to the paraventricular hypothalamic nucleus and the central nucleus of the amygdala in the rat. Brain Res 609: 81-92, 1993.
186. Phelix CF, Liposits Z, Paull WK. Catecholamine-CRF synaptic interaction in a septal bed nucleus: afferents of neurons in the bed nucleus of the stria terminalis. Brain Res Bull 33: 109-119, 1994.
187. Phelix CF, Liposits Z, Paull WK. Monoamine innervation of bed nucleus of stria terminalis: an electron microscopic investigation. Brain Res Bull 28: 949-965, 1992.
188. Phelix CF, Paull WK. Demonstration of distinct corticotropin releasing factor-containing neuron populations in the bed nucleus of the stria terminalis. A light and electron microscopic immunocytochemical study in the rat. Histochemistry 94: 345-364, 1990.
189. Pickel VM, Bockstaele EJv Chan J, Cestari DM. Amygdala efferents form inhibitory-type synapses with a subpopulation of catecholaminergic neurons in the rat nucleus tractus solitarius. J Comp Neurol 362: 510-523, 1995.
190. Pickel VM, Nirenberg MJ, Milneer TA. Ultrastructural view of central catecholamine transmission: immunocytochemical localization of synthesizing enzymes, transporters and receptors. J Neurocytol 25: 843-856, 1996.
191. Plotsky P. Facilitation of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation after activation of catecholaminergic pathways or central norepinephrine injection. Endocrinology 121: 924-930, 1987.
192. Plotsky PM, Cunningham ET Jr, Widmaier EP. Catecholaminergic modulation of corticotropin-releasing factor and adrenocorticotropin secretion. Endocr Rev 10: 437-458, 1989.
193. Price JL. Free will versus survival: brain systems that underlie intrinsic constraints on behavior. J Comp Neurol 493: 132-139, 2005.
194. Prinz JJ. Gut Reactions: A Perceptual Theory of Emotion. New York Oxford University Press, 2004.
195. Raby WN, Renaud LP. Dorsomedial medulla stimulation activates rat supraoptic oxytocin and vasopressin neurones through different pathways. J Physiol 417: 279-294, 1989.
196. Raby WN, Renaud LP. Nucleus tractus solitarius innervation of supraoptic nucleus: anatomical and electrophysiological studies in the rat suggest differential innervation of oxytocin and vasopressin neurons. Prog Brain Res 81: 319-327, 1989.
197. Reyes BAS, Bockstaele EJV. Divergent projections of catecholaminergic neurons in the nucleus of the solitary tract to limbic forebrain and medullary autonomic brain regions. Brain Res 1117: 69-79, 2006.
198. Reyes BAS, Tsukamura H, I'Anson H, Amelita M, Estacio C, Hirunagi K, Maeda KI. Temporal expression of estrogen receptor-α in the hypothalamus and medulla oblongata during fasting: a role of noradrenergic neurons. J Endocrinol 190: 593-600, 2006.
199. Ricardo JA, Koh ET. Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat. Brain Res 153: 1-26, 1978.
200. Riche D, Pommery JD, Menetrey D. Neuropeptides and catecholamines in efferent projections of the nuclei of the solitary tract in the rat. J Comp Neurol 293: 399-424, 1990.
201. Rinaman L. Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure. Brain Res 1350: 18-34, 2010.
202. Rinaman L. Hindbrain contributions to anorexia. Am J Physiol Regul Integr Comp Physiol 287: R1035-R1036, 2004.
203. Rinaman L. Hindbrain noradrenergic lesions attenuate anorexia and alter central cFos expression in rats after gastric viscerosensory stimulation. J Neurosci 23: 10084-10092, 2003.
204. Rinaman L. Oxytocinergic inputs to the nucleus of the solitary tract and dorsal motor nucleus of the vagus in neonatal rats. J Comp Neurol 399: 101-109, 1998.
205. Rinaman L. Postnatal development of hypothalamic inputs to the dorsal vagal complex in rats. Physiol Behav 79: 65-70, 2003.
206. Rinaman L. Visceral sensory inputs to the endocrine hypothalamus. Front Neuroendocrinol 28: 50-60, 2007.
207. Rinaman L, Baker EA, Hoffman GE, Stricker EM, Verbalis JG. Medullary c-Fos activation in rats after ingestion of a satiating meal. Am J Physiol Regul Integr Comp Physiol 275: R262-R268, 1998.
208. Rinaman L, Card JP, Schwaber JS, Miselis RR. Ultrastructural demonstration of a gastric monosynaptic vagal circuit in the nucleus of the solitary tract in rat. J Neurosci 9: 1985-1996, 1989.
209. Rinaman L, Dzmura V. Experimental dissociation of neural circuits underlying conditioned avoidance and hypophagic responses to lithium chloride. Am J Physiol Regul Integr Comp Physiol 293: R1495-R1503, 2007.
210. Rinaman L, Hoffman GE, Dohanics J, Le WW, Stricker EM, Verbalis JG. Cholecystokinin activates catecholaminergic neurons in the caudal medulla that innervate the paraventricular nucleus of the hypothalamus in rats. J Comp Neurol 360: 246-256, 1995.
211. Rinaman L, Schwartz GJ. Anterograde transneuronal viral tracing of central viscerosensory pathways in rats. J Neurosci 24: 2782-2786, 2004.
212. Rinaman L, Stricker EM, Hoffman GE, Verbalis JG. Central c-fos expression in neonatal and adult rats after subcutaneous injection of hypertonic saline. Neuroscience 79: 1165-1175, 1997. (Pubitemid 27293766)
213. Rinaman L, Verbalis JG, Stricker EM, Hoffman GE. Distribution and neurochemical phenotypes of caudal medullary neurons activated to express cFos following peripheral administration of cholecystokinin. J Comp Neurol 338: 475-490, 1993. (Pubitemid 23356853)
214. Ritter S, Bugarith K, Dinh TT. Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation. J Comp Neurol 432: 197-216, 2001. (Pubitemid 32187012)
215. Ritter S, Watts AG, Dinh TT, Sanchez-Watts G, Pedrow C. Immunotoxin lesion of hypothalamically projecting norepinephrine and epinephrine neurons differentially affects circadian and stressor-stimulated corticosterone secretion. Endocrinology 144: 1357-1367, 2003. (Pubitemid 36428478)
216. Ritter S, Wise D, Stein L. Neurochemical regulation of feeding in the rat: facilitation by α-noradrenergic, but not dopaminergic, receptor stimulants. J Comp Physiol Psychol 88: 778-784, 1975.
217. Rivier CL, Plotsky PM. Mediation by corticotropin-releasing factor of adenohypophysial hormone secretion. Annu Rev Physiol 48: 475-494, 1986. (Pubitemid 16047629)
218. Rogers RC, Travagli RA, Hermann GE. Noradrenergic neurons in the rat solitary nucleus participate in the esophageal-gastric relaxation reflex. Am J Physiol Regul Integr Comp Physiol 285: R479-R489, 2003.
219. Roozendaal B, Williams CL, McGaugh JL. Glucocorticoid receptor activation in the rat nucleus of the solitary tract facilitates memory consolidation: involvement of the basolateral amygdala. Eur J Neurosci 11: 1317-1323, 1999. (Pubitemid 29142191)
220. Rosin DL, Chang DA, Guyenet PG. Afferent and efferent connections of the rat retrotrapezoid nucleus. J Comp Neurol 499: 64-89, 2006.
221. 2a-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat. Neuroscience 56: 139-155, 1993.
222. Saha S, Batten TFC, Henderson Z. A GABAergic projection from the central nucleus of the amygdala to the nucleus of the solitary tract: a combined anterograde tracing and electron microscopic immunohistochemical study. Neuroscience 99: 613-626, 2000.
223. Sahuque LL, Kullberg EF, Mcgeehan AJ, Kinder JR, Hicks MP, Blanton MG, Janak PH, Olive MF. Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypes. Psychopharmacology (Berl) 186: 122-132, 2006.
224. Sartor DM, Verberne AJM. The sympathoinhibitory effects of systemic cholecystokinin are dependent on neurons in the caudal ventrolateral medulla in the rat. Am J Physiol Regul Integr Comp Physiol 291: R1390-R1398, 2006.
225. Sawchenko PE. Central connections of the sensory and motor nuclei of the vagus nerve. J Auton Nerv Syst 9: 13-26, 1983.
226. Sawchenko PE, Arias C, Bittencourt JC. Inhibin B, somatostatin, and enkephalin immunoreactivities coexist in caudal medullary neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 291: 269-280, 1990.
227. Sawchenko PE, Benoit R, Brown MR. Somatostatin 28-immunoreactive inputs to the paraventricular and supraoptic nuclei: principal origin from non-aminergic neurons in the nucleus of the solitary tract. J Chem Neuroanat 1: 81-94, 1988.
228. Sawchenko PE, Brown ER, Chan RKW, Ericsson A, Li HY, Roland BL, Kovacs KJ. The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress. Prog Brain Res 107: 201-222, 1996.
229. Sawchenko PE, Li HY, Ericsson A. Circuits and mechanisms governing hypothalamic responses to stress: a tale of two paradigms. In: Prog Brain Res, edited by Mayer EA and Saper CB. Amsterdam: Elsevier Science, 2000, p. 61-78.
230. Sawchenko PE, Swanson LW. Central noradrenergic pathways for the integration of hypothalamic neuroendocrine and autonomic responses. Science 214: 685-687, 1981.
231. Sawchenko PE, Swanson LW. The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat. J Comp Neurol 218: 121-144, 1983.
232. Sawchenko PE, Swanson LW. The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat. Brain Res Rev 4: 275-325, 1982.
233. Sawchenko PE, Swanson LW, Grzanna R, Howe PRC, Bloom SR, Polak JM. Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 241: 138-153, 1985.
234. Schiltz JC, Sawchenko PE. Specificity and generality of the involvement of catecholaminergic afferents in hypothalamic responses to immune insults. J Comp Neurol 502: 455-467, 2007.
235. Serova LI, Harris HA, Maharjan S, Sabban EL. Modulation of responses to stress by estradiol benzoate and selective estrogen receptor agonists. J Endocrinol 205: 253-262, 2010.
236. Shaham Y, Erb S, Stewart J. Stress-induced relapse to heroin and cocaine seeking in rats: a review. Brain Res Rev 33: 13-33, 2000.
237. Shaham Y, Highfield D, Delfs J, Leung S, Stewart J. Clonidine blocks stress-induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons. Eur J Neurosci 12: 292-302, 2000.
238. Shapiro RE, Miselis RR. The central neural connections of the area postrema of the rat. J Comp Neurol 234: 344-364, 1985.
239. Shapiro RE, Miselis RR. The central organization of the vagus nerve innervating the stomach of the rat. J Comp Neurol 238: 473-488, 1985.
240. Shioda S, Nakai Y. Medullary synaptic inputs to thyrotropin-releasing hormone (TRH)-containing neurons in the hypothalamus: an ultrastructural study combining WGA-HRP anterograde tracing with TRH immunocytochemistry. Brain Res 625: 9-15, 1993.
241. Siever L, Insel T, Uhde T. Noradrenergic challenges in the affective disorders. J Clin Psychopharmacol 1: 193-206, 1981.
242. Siever LJ, Uhde TW, Silberman EK, Jimerson DC, Aloi JA, Post RM, Murphy DL. The growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls. Psychiatr Res 6: 171-183, 1982.
243. Simonian SX, Delaleu B, Caraty A, Herbison AE. Estrogen receptor expression in brainstem noradrenergic neurons of the sheep. Neuroendocrinology 67: 392-402, 1998.
244. Smith RJ, Aston-Jones G. Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence. Brain Struct Funct 213: 43-61, 2008.
245. Sofroniew MV, Schrell U. Evidence for a direct projection from oxytocin and vasopressin neurons in the hypothalamic paraventricular nucleus to the medulla oblongata: immunohistochemical visualization of both the horseradish peroxidase transported and the peptide produced by the same neurons. Neurosci Lett 22: 211-217, 1981.
246. Spyer KM. The central nervous organization of reflex circulatory control. In: Central Regulation of Autonomic Functions, edited by Loewy AD and Spyer KM. New York: Oxford University Press, 1990, p. 168-188.
247. Stone EA, Quartermain D, Lin Y, Lehmann ML. Central α1-adrenergic system in behavioral activity and depression. Biochem Pharmacol 73: 1063-1075, 2007.
248. Stornetta RL, Sevigny CP, Guyenet PG. Vesicular glutamate transporter DNPI/VGLUT2 mRNA is present in C1 and several other groups of brainstem catecholaminergic neurons. J Comp Neurol 444: 191-206, 2002.
249. Swanson LW, Petrovich GD. What is the amygdala? Trends Neurosci 21: 323-331, 1998.
250. Szafarczyk A, Alonso G, Ixart G, Malaval F, Assenmacher I. Diurnal-stimulated and stress-induced ACTH release in rats is mediated by ventral noradrenergic bundle. Am J Physiol Endocrinol Metab 249: E219-E226, 1985.
251. Taché Y, Garrick T, Raybould H. Central nervous system action of peptides to influence gastrointestinal motor function. Gastroenterology 98: 517-528, 1990.
252. Terenzi MG, Ingram CD. A combined immunocytochemical and retrograde tracing study of noradrenergic connections between the caudal medulla and bed nucleus of the stria terminalis. Brain Res 672: 289-297, 1995.
253. Ter Horst GJ, Boer PD, Luiten PGM, Willigen JDV. Ascending projections from the solitary tract nucleus to the hypothalamus. A Phaseolus vulgaris lectin tracing study in the rat. Neuroscience 31: 785-797, 1989.
254. Ter Horst GJ, Streefland C. Ascending projections of the solitary tract nucleus. In: Nucleus of the Solitary Tract, edited by Barraco IRA. Boca Raton, FL: CRC, 1994, p. 93-103.
255. Thayer JF, Lane RD. A model of neurovisceral integration in emotional regulation and dysregulation. J Affect Disord 61: 201-216, 2000.
256. Thor KB, Helke CJ. Serotonin and substance P colocalization in medullary projections to the nucleus tractus solitarius: dual-colour immunohistochemistry combined with retrograde tracing. J Chem Neuroanat 2: 139-148, 1989.
257. Toufexis DJ, Thrivikraman KV, Plotsky PM, Morilak DA, Huang N, Walker CD. Reduced noradrenergic tone to the hypothalamic paraventricular nucleus contributes to the stress hyporesponsiveness of lactation. J Neuroendocrinol 10: 417-427, 1998.
258. Toufexis DJ, Walker CD. Noradrenergic facilitation of the adrenocorticotropin response to stress is absent during lactation in the rat. Brain Res 737: 71-77, 1996.
259. Travagli RA, Hermann GE, Browning KN, Rogers RC. Brainstem circuits regulating gastric function. Annu Rev Physiol 68: 279-305, 2006.
260. Tucker DC, Saper CB, Ruggiero DA, Reis DJ. Organization of central adrenergic pathways: I. Relationships of ventrolateral medullary projections to the hypothalamus and spinal cord. J Comp Neurol 259: 591-603, 1987.
261. Uchida K, Kobayashi D, Das G, Onaka T, Inoue K, Itoi K. Participation of the prolactin-releasing peptide-containing neurones in caudal medulla in conveying haemorrhagic stress-induced signals to the paraventricular nucleus of the hypothalamus. J Neuroendocrinol 22: 33-42, 2010.
262. Uchoa ET, Sabino HA, Ruginsk SG, Antunes-Rodrigues J, Elias LL. Hypophagia induced by glucocorticoid deficiency is associated with an increased activation of satiety-related responses. J Appl Physiol 106: 596-604, 2009.
263. Ueta Y, Kannan H, Higuchi T, Negoro H, Yamashita H. CCK-8 excites oxytocin-secreting neurons in the paraventricular nucleus in rats-possible involvement of noradrenergic pathway. Brain Res Bull 32: 453-459, 1993.
264. Van Bockstaele EJ, Bajic D, Proudfit H, Valentino RJ. Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus. Physiol Behav 73: 273-283, 2001.
265. Van Bockstaele EJ, Peoples J, Telegan P. Efferent projections of the nucleus of the solitary tract to peri-locus coeruleus dendrites in rat brain: evidence for a monosynaptic pathway. J Comp Neurol 412: 410-428, 1999.
266. Van der Kooy D, Koda LK, McGinty JF, Gerfen CR, Bloom FE. The organization of projections from the cortex, amygdala, and hypothalamus to the nucleus of the solitary tract in rat. J Comp Neurol 1984: 1-24, 1984.
267. Verbalis JG, Hoffman GE, Sherman TG. Use of immediate early genes as markers of oxytocin and vasopressin neuronal activation. Curr Opin Endocrinol Diab 2: 157-168, 1995.
268. Verbalis JG, McHale CM, Gardiner TW, Stricker EM. Oxytocin and vasopressin secretion in response to stimuli producing learned taste aversions in rats. Behav Neurosci 100: 466-475, 1986.
269. Verbalis JG, Stricker EM, Robinson AG, Hoffman GE. Cholecystokinin activates cFos expression in hypothalamic oxytocin and corticotropin-releasing hormone neurons. J Neuroendocrinol 3: 205-213, 1991.
270. Walker DL, Davis M. Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear. J Neurosci 17: 9375-9383, 1997.
271. Walker DL, Toufexis DJ, Davis M. Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. Eur J Pharmacol 463: 199-216, 2003.
272. Wang ZJ, Rao ZR, Shi JW. Tyrosein hydroxylase-, neurotensin-, or cholecystokinin-containing neurons in the nucleus tractus solitarii send projection fibers to the nucleus accumbens in the rat. Brain Res 578: 347-350, 1992.
273. Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M. Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawalinduced conditioned place aversion in rats. Psychopharmacology (Berl) 170: 80-88, 2003.
274. Watts AG. The impact of physiological stimuli on the expression of corticotropin-releasing hormone (CRH) and other neuropeptide genes. Front Neuroendocrinol 17: 281-326, 1996.
275. Watts AG. Neuropeptides and the integration of motor responses to dehydration. Annu Rev Neurosci 24: 357-384, 2001.
276. Weidenfeld J, Itzik A, Feldman S. Effects of glucocorticoids on the adrenocortical axis responses to electrical stimulation of the amygdala and the ventral noradrenergic bundle. Brain Res 754: 187-194, 1997.
277. Wellman PJ. Norepinephrine and the control of food intake. Nutrition 16: 837-842, 2000.
278. Wellman PJ, Davies BT. Suppression of feeding induced by phenylephrine microinjections within the paraventricular hypothalamus in rats. Appetite 17: 121-128, 1991.
279. Williams CL, McGaugh JL. Reversible lesions of the nucleus of the solitary tract attenuate the memory-modulating effects of posttraining epinephrine. Behav Neurosci 107: 955-962, 1993.
280. Williams CL, Men D, Clayton EC. The effects of noradrenergic activation of the nucleus tractus solitarius on memory and potentiating norepinephrine release in the amygdala. Behav Neurosci 114: 1131-1144, 2000.
281. Williams CL, Men D, Clayton EC, Gold PE. Norepinephrine release in the amygdala after systemic injection of epinephrine or escapable footshock: contribution of the nucleus of the solitary tract. Behav Neurosci 112: 1414-1422, 1998.
282. Willoughby JO, Chapman IM, Kapoor R. Local hypothalamic adrenoceptor activation in rat: α1 inhibits and α2 stimulates growth hormone secretion. Neuroendocrinology 57: 687-692, 1993.
283. Wittman G. Regulation of hypophysiotropic corticotrophin-releasing hormone- and thyrotrophin-releasing hormone-synthesising neurones by brainstem catecholaminergic neurones. J Neuroendocrinol 20: 952-960, 2008.
284. Yamada T, Mochiduki A, Sugimoto Y, Suzuki Y, Itoi K, Inoue K. Prolactin-releasing peptide regulates the cardiovascular system via corticotrophin-releasing hormone. J Neuroendocrinol 21: 586-593, 2009.
285. Yamano M, Bai F, Tohyam M, Shiotani Y. Ultrastructural evidence of direct synaptic contact of catecholamine terminals with oxytocin-containing neurons in the parvocellular portion of the rat hypothalamic paraventricular nucleus. Brain Res 336: 176-179, 1985.
286. Yamashita H, Kannan H, Ueta Y. Involvement of caudal ventrolateral medulla neurons in mediating visceroreceptive information to the hypothalamic paraventricular nucleus. Prog Brain Res 81: 293-302, 1989.
287. Yang L, Scott KA, Hyun J, Tamashiro KL, Tray N, Moran TH, Bi S. Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance. J Neurosci 29: 179-190, 2009.
288. Yang SN, Bunnemann B, Cintra A, Fuxe K. Localization of neuropeptide Y Y1 receptor-like immunoreactivity in catecholaminergic neurons of the rat medulla oblongata. Neuroscience 73: 519-530, 1996.
289. Young EA, Abelson JL, Cameron OG. Interaction of brain noradrenergic system and the hypothalamic-pituitary-adrenal (HPA) axis in man. Psychoneuroendocrinology 30: 807-814, 2005.
290. Yu G, Sharp B. Nicotine self-administration diminishes stress-induced norepinephrine secretion but augments adrenergic-responsiveness in the hypothalamic paraventricular nucles and enhances adrenocorticotropic hormone and corticosterone release. J Neurochem 112: 1327-1237, 2010.
291. Zagon A, Rocha I, Ishizuka K, Spyer KM. Vagal modulation of responses elicited by stimulation of the aortic depressor nerve in neurons of the rostral ventrolateral medulla oblongata in the rat. Neuroscience 92: 889-899, 1999.
292. Zhang JF, Zheng F. The role of paraventricular nucleus of hypothalamus in stress-ulcer formation in rats. Brain Res 761: 203-209, 1997.
293. Zhao R, Chen H, Sharp BM. Nicotine-induced norepinephrine release in hypothalamic paraventricular nucleus and amygdala is mediated by N-methyl-D-aspartate receptors and nitric oxide in the nucleus tractus solitarius. J Pharmacol Exp 320: 837-844, 2007.
294. Zheng H, Patterson LM, Berthoud HR. Orexin-A projections to the caudal medulla and orexin-induced c-fos expression, food intake, and autonomic function. J Comp Neurol 485: 127-142, 2005.
295. Zheng H, Patterson LM, Rhodes CJ, Louis GW, Skibicka KP, Grill HJ, Myers MG Jr, Berthoud HR. A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol 298: R720-R728, 2010.