Regulation of tyrosine hydroxylase levels and activity and Fos expression during opioid withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups innervating the PVN

European Journal of Neuroscience

Volumn 17, Issue 1, 2003, Pages 103-112

  Benavides, Marta ^a   Laorden, M Luisa ^a   García Borrón, J Carlos ^b   Milanés, M Victoria ^a  

^a Equip of Cell/M P U S of M   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

Author keywords

Fos; Morphine withdrawal; NTS A2; Tyrosine hydroxylase (TH); VLM A1; Western blot

Indexed keywords

MORPHINE; NALOXONE; PROTEIN FOS; TYROSINE 3 MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INNERVATION; MALE; MEDULLA OBLONGATA; NONHUMAN; NORADRENERGIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; WITHDRAWAL SYNDROME;

ANIMALS; BLOTTING, WESTERN; IMMUNOHISTOCHEMISTRY; MALE; MEDULLA OBLONGATA; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NARCOTICS; NEURONS; NOREPINEPHRINE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE WITHDRAWAL SYNDROME; TYROSINE 3-MONOOXYGENASE;

EID: 0037232515     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02434.x     Document Type: Article

References (44)

1. Berhow, M.T., Russel, D.S., Terwilliger, R.Z., Beitner-Johnson, D., Self, D.W., Lindsay, R.M. & Nestler, E.J. (1995) Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. Neuroscience, 68, 969-979.
2. Blendy, J.A. & Maldonado, R. (1998) Genetic analysis of drug addiction: the role of cAMP response element binding protein. J. Mol. Med., 76, 104-110.
3. Boundy, V.A., Gold, S.J., Messer, C.J., Chen, J., Son, J.H., Joh, T.H. & Nestler, E.J. (1998) Regulation of tyrosine hydroxylase promoter activity by chronic morphine in TH9.0-lacZ transgenic mice. J. Neurosci., 18, 9989-9995.
4. Brown, C.H., Murphy, N.P., Munro, G., Ludwig, M., Bull., P.M., Leng, G. & Russell, J.A. (1998) Interruption of central noradrenergic pathways and morphine withdrawal excitation of oxytocin neurones in the rat. J. Physiol., 507, 831-842.
5. Cunningham, E.T. & Sawchenko, P.E. (1988) Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J. Comp. Neurol., 274, 60-76.
6. Curran, E., Akil, H. & Watson, S. (1996) Psychomotor stimulant- and opiate-induced c-fos mRNA expression patterns in the rat forebrain: comparisons between acute drug treatment and a drug challenge in sensitised animals. Neurochem. Res., 21, 1425-1435.
7. De Vries, T.J., Tjon Tien Ril, G.H.K., van der Laan, J.W., Mulder, A.H. & Schoffelmeer, A.N.M. (1993) Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering mu-opioid receptor sensitivity. Life Sci., 52, 1685-1693.
8. Everitt, B.J., Meister, B. & Hökfelt, T. (1992) The organization of monoaminergic neurons in the hypothalamus in relation to neuroendocrine integration. In Nemeroff, C.B. (Ed), Neuroendocrinology, CRC Press, Boca Raton, pp. 87-127.
9. Fuertes, G., Laorden, M.L. & Milanés, M.V. (2000) Noradrenergic and dopaminergic activity in the hypothalamic paraventricular nucleus after naloxone-induced morphine withdrawal. Neuroendocrinology, 71, 60-67.
10. Gizang, E. & Ziff, E.B. (1994) Fos family members successively occupy the tyrosine hydroxylase gene AP-1 site after nerve growth factor or epidermal growth factor stimulation and can repress transcription. Mol. Endocrinol., 8, 249-262.
11. Guitart, X., Hayward, M., Nisenbaum, L.K., Beitner-Johnson, D., Haykock, J.W. & Nestler, E.J. (1990) Identification of MARPP-58, a morphine- and cAMP-regulated phosphoproteins of 58 kDa, as tyrosine hydroxylase: evidence for regulation of its expression by chronic morphine in the rat locus coeruleus. J. Neurosci., 10, 2649-2659.
12. Hughes, P. & Dragunow, M. (1995) Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol. Rev., 47, 133-178.
13. Imaki, T., Shibasaki, T., Hotta, M. & Demura, H. (1992) Early induction of c-fos precedes increased expression of corticotropin-releasing factor mRNA in the paraventricular nucleus after immobilization stress. Endocrinology, 131, 240-246.
14. Itoi, K., Helmreich, D.L., Lopez-Figueroa, M. & Watson, S.J. (1999) Differential regulation of corticotropin-releasing hormone and vasopressin gene transcription in the hypothalamus by norepinephrine. J. Neurosci., 19, 5464-5472.
15. Itoi, K., Seasholtz, A.F. & Watson, S.J. (1998) Cellular and extracellular regulatory mechanisms of hypothalamic corticotropin-releasing hormone neurons. Endocrine J., 45, 13-33.
16. Jara, J.R., Solano, F. & Lozano, J.A. (1988) Assays for mammalian tyrosinase: a comparative study. Pigment Cell Res., 1, 332-339.
17. Kovács, K. (1998) c-Fos as a transcription factor: a stressful (re) view from a functional map. Neurochem. Int., 33, 287-297.
18. Kumer, S.C. & Vrana, K.E. (1996) Intricate regulation of tyrosine hydroxylase activity and gene expression. J. Neurochem., 67, 443-462.
19. Laorden, M.L., Castells, M.T., Martínez, M.D., Martínez, P.J. & Milanés, M.V. (2000a) Activation of c-fos expression in hypothalamic nuclei by mu- and kappa-receptor agonists. Correlation with catecholaminergic activity in the hypothalamic paraventricular nucleus. Endocrinology, 141, 1366-1376.
20. Laorden, M.L., Castells, M.T. & Milanés, M.V. (2002) Effects of morphine and morphine withdrawal on brainstem neurons innervating hypothalamic nuclei that control the pituitary-adrenocortical axis in rats. Br. J. Pharmacol., 136, 67-75.
21. 2-adrenoceptors. J. Pharmacol. Exp. Ther., 293, 578-584.
22. Laorden, M.L. & Milanés, M.V. (2000) Effects of U-50,488H and U-50,488H withdrawal on catecholaminergic neurons of the rat hypothalamus. Life Sci., 66, 803-815.
23. Lee, S., Rivier, C. & Torres, G. (1994) Induction of c-fos and CRF mRNA by MA-801 in the parvocellular paraventricular nucleus of the rat hypothalamus. Mol. Brain Res., 24, 192-198.
24. Lew, J.Y., Garcia-Espana, A., Lee, K.Y., Carr, K.D., Goldstein, M., Haykock, J.W. & Meller, E. (1998) Increased site-specific phosphorylation of tyrosine hydroxylase accompanies stimulation of enzymatic activity induced by cessation of dopamine neuronal activity. Mol. Pharmacol., 55, 202-209.
25. Liposits, Z., Sherman, D., Phelix, C. & Paull, W.K. (1986) A combined light and electron microscopic immunocytochemical method for simultaneous localization of multiple tissue antigens; tyrosine hydroxylase immunoreactive innervation of corticotropin releasing factor synthesizing neurons in the paraventricular nucleus of the rat. Histochemistry, 85, 95-106.
26. Maldonado, R. (1997) Participation of noradrenergic pathways in the expression of opiate withdrawal: biochemical and pharmacological evidence. Neurosci. Biobehav. Rev., 1, 91-104.
27. Martínez, J.A., Vargas, M.L., Fuente, T., del Río-García, J. & Milanés, M.V. (1990) Plasma β-endorphin and cortisol levels in morphine-tolerant rats and in naloxone-induced withdrawal. Eur. J. Pharmacol., 182, 117-123.
28. Milanés, M.V., Laorden, M.L., Chapleur-Chateau, M. & Burlet, A. (1998) Alterations in corticotropin-releasing factor and vasopressin content in rat brain during morphine withdrawal. Correlation with hypothalamic noradrenergic activity and pituitary-adrenal response. J. Pharmacol. Exp. Ther., 285, 700-706.
29. Morgan, J.I. & Curran, T. (1991) Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and. Jun. Ann. Rev. Neurosci., 14, 421-451.
30. Murphy, N.P., Onaka, T., Brown, C.H. & Leng, G. (1997) The role of afferent inputs to supraoptic nucleus oxytocin neurons during naloxone-precipitated morphine withdrawal in the rat. Neuroscience, 80, 567-577.
31. Nestler, E.J. (1992) Molecular mechanism of drug addiction. J. Neurosci., 12, 2439-2450.
32. Nestler, E.J. & Aghajanian, G.K. (1997) Molecular and cellular basis of addiction. Science, 278, 58-63.
33. Nye, H.E. & Nestler, E.J. (1996) Induction of chronic fos-related antigens in rat brain by chronic morphine administration. Mol. Pharmacol., 49, 636-645.
34. Palkovits, M. (1973) Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Res., 59, 449-450.
35. Palkovits, M. & Brownstein, M.J. (1988) Maps and Guide to Microdissection of the Rat Brain. Elsevier, New York.
36. Paxinos, G. & Watson, C. (1998) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
37. Pechnick, R.N. (1993) Effects of opioids on the hypothalamo-pituitary-adrenal axis. Ann. Rev. Pharmacol. Toxicol., 32, 353-382.
38. Plotsky, P.M., Cunningham, E.T. & Widmaier, E.P. (1989) Catecholaminergic modulation of corticotropin-releasing factor and adrenocorticotropin secretion. Endocrine Rev., 10, 437-458.
39. Sawchenko, P.E. & Swanson, L.W. (1982) The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat. Brain Res. Rev., 4, 275-325.
40. Stachowiak, M.K., Rigual, R.J., Lee, P.H.K., Viveros, O.H. & Hong, J.S. (1988) Regulation of tyrosine hydroxylase and phenyl-ethanolamine N-methyltrans-ferase mRNA levels in the sympathoadrenal system by the pituitary-adrenocortical axis. Mol. Brain Res., 3, 275-286.
41. Torres, G. & Horowitz, J.M. (1996) Individual and combined effects of ethanol and cocaine on intracellular signals and gene expression. Prog. Neuro-Psychopharmacol. Biol. Psychiat., 20, 561-596.
42. Vargas, M.L., Martínez-Piñero, M.G. & Milanés, M.V. (1997) Neurochemical activity of noradrenergic neurons and pituitary-adrenal response after naloxone-induced withdrawal: the role of calcium channels. Naunyn-Schmiedeberg's Arch. Pharmacol., 355, 501-506.
43. Wiechelman, K.J., Braun, R.D. & Fitzpatrick, J.D. (1988) Investigation of the bicinchoninic acid protein assay: identification of the groups responsible for colour formation. Anals Biochem., 175, 231-237.
44. Williams, J.T., Christie, M.J. & Manzoni, O. (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol. Rev., 81, 299-343.