Noradrenergic neurons in the rat solitary nucleus participate in the esophageal-gastric relaxation reflex

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 285, Issue 2 54-2, 2003, Pages

  Rogers, R C ^a   Travagli, R A ^b   Hermann, G E ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Brain stem; C Fos; Vagus

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; PRAZOSIN; PROPRANOLOL; PROTEIN C FOS; TYROSINE 3 MONOOXYGENASE; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; BREATHING; CATECHOLAMINE NERVE CELL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ESOPHAGEAL GASTRIC RELAXATION REFLEX; IMMUNOHISTOCHEMISTRY; MALE; MECHANORECEPTOR; MICROINJECTION; NEUROCHEMISTRY; NITRERGIC NERVE; NONHUMAN; NORADRENERGIC NERVE; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; REFLEX; SENSORY NERVE; SOLITARY TRACT NUCLEUS; STOMACH DISTENSION; SWALLOWING; VAGUS NERVE; VOMITING;

EID: 0041808015     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00155.2003     Document Type: Article

References (37)

1. Altschuler SM, Bao XM, Bieger D, Hopkins DA, and Miselis RR. Viscerotopic representation of the upper alimentary tract in the rat: sensory ganglia and nuclei of the solitary and spinal trigeminal tracts. J Comp Neurol 283: 248-268, 1989.
2. 2-adrenoceptors inhibit excitatory synaptic transmission in rat brain stem. Am J Physiol Gastrointest Liver Physiol 272: G654-G661, 1997.
3. Bieger D. The brainstem esophagomotor network pattern generator: a rodent model. Dysphagia 8: 203-208, 1993.
4. Bieger D and Hopkins DA. Viscerotopic representation of the upper alimentary tract in the medulla oblongata in the rat: the nucleus ambiguus. J Comp Neurol 262: 546-562, 1987.
5. Blessing WW. Eating and metabolism. In: The Lower Brainstem and Bodily Homeostasis. Oxford, UK: Oxford Univ. Press, 1997, p. 323-372.
6. Broussard DL and Altschuler SM. Central integration of swallow and airway-protective reflexes. Am J Med 108, Suppl 4a: 62S-67S, 2000.
7. Browning KN and Travagli RA. Characterization of the in vitro effects of 5-hydroxytryptamine (5-HT) on identified neurones of the rat dorsal motor nucleus of the vagus (DMV). Br J Pharmacol 128: 1307-1315, 1999.
8. Buelke-Sam J, Holson JF, Bazare JJ, and Young JF. Comparative stability of physiological parameters during sustained anesthesia in rats. Lab Anim Sci 28: 157-162, 1978.
9. Canon WB and Leib CW. The receptive relaxation of the stomach. Am J Physiol 29: 267-273, 1911.
10. Cunningham ET Jr and Sawchenko PE. A circumscribed projection from the nucleus of the solitary tract to the nucleus ambiguus in the rat: anatomical evidence for somatostatin-28-immunoreactive interneurons subserving reflex control of esophageal motility. J Neurosci 9: 1668-1682, 1989.
11. Emch GS, Hermann GE, and Rogers RC. TNF-α activates solitary nucleus neurons responsive to gastric distension. Am J Physiol Gastrointest Liver Physiol 279: G582-G586, 2000.
12. Emch GS, Hermann GE, and Rogers RC. TNF-α-induced c-Fos generation in the nucleus of the solitary tract is blocked by NBQX and MK-801. Am J Physiol Regul Integr Comp Physiol 281: R1394-R1400, 2001.
13. Fryscak T, Zenker W, and Kantner D. Afferent and efferent innervation of the rat esophagus. A tracing study with horseradish peroxidase and nuclear yellow. Anat Embryol (Berl) 170: 63-70, 1984.
14. Fukuda A, Minami T, Nabekura J, and Oomura Y. The effects of noradrenaline on neurones in the rat dorsal motor nucleus of the vagus, in vitro. J Physiol 393: 213-231, 1987.
15. Goyal RK, Padmanabhan R, and Sang Q. Neural circuits in swallowing and abdominal vagal afferent-mediated lower esophageal sphincter relaxation. Am J Med 111, Suppl 8A: 95S-105S, 2001.
16. Hayakawa T, Zheng JQ, and Yajima Y. Direct synaptic projections to esophageal motoneurons in the nucleus ambiguus from the nucleus of the solitary tract of the rat. J Comp Neurol 381: 18-30, 1997.
17. Hermann G and Rogers RC. Tumor necrosis factor-alpha in the dorsal vagal complex suppresses gastric motility. Neuroimmunomodulation 2: 74-81, 1995.
18. Hermann GE, Emch GS, Tovar CA, and Rogers RC. c-Fos generation in the dorsal vagal complex after systemic endotoxin is not dependent on the vagus nerve. Am J Physiol Regul Integr Comp Physiol 280: R289-R299, 2001.
19. Jean A. Control of the central swallowing program by inputs from the peripheral receptors. A review. J Auton Nerv Syst 10: 225-233, 1984.
20. Kalia M, Fuxe K, and Goldstein M. Rat medulla oblongata. III. Adrenergic (C1 and C2) neurons, nerve fibers and presumptive terminal processes. J Comp Neurol 233: 333-349, 1985.
21. Krowicki ZK, Sharkey KA, Serron SC, Nathan NA, and Hornby PJ. Distribution of nitric oxide synthase in rat dorsal vagal complex and effects of microinjection of nitric oxide compounds upon gastric motor function. J Comp Neurol 377: 49-69, 1997.
22. Loomis CW, Yao D, and Bieger D. Characterization of an esophagocardiovascular reflex in the rat. Am J Physiol Regul Integr Comp Physiol 272: R1783-R1791, 1997.
23. Lu WY and Bieger D. Vagovagal reflex motility patterns of the rat esophagus. Am J Physiol Regul Integr Comp Physiol 274: R1425-R1435, 1998.
24. McCann MJ, Hermann GE, and Rogers RC. Thyrotropin-releasing hormone: effects on identified neurons of the dorsal vagal complex. J Auton Nerv Syst 26: 107-112, 1989.
25. Miolan JP and Roman C. The role of oesophageal and intestinal receptors in the control of gastric motility. J Auton Nerv Syst 10: 235-241, 1984.
26. Partosoedarso ER and Blackshaw LA. Vagal efferent fibre responses to gastric and oesophageal mechanical and chemical stimuli in the ferret. J Auton Nerv Syst 66: 169-178, 1997.
27. Paton JF, Li YW, and Kasparov S. Reflex response and convergence of pharyngoesophageal and peripheral chemoreceptors in the nucleus of the solitary tract. Neuroscience 93: 143-154, 1999.
28. Rinaman L, Verbalis JG, Stricker EM, and Hoffman GE. Distribution and neurochemical phenotypes of caudal medullary neurons activated to express cFos following peripheral administration of cholecystokinin. J Comp Neurol 338: 475-490, 1993.
29. Rogers RC and Hermann GE. Oxytocin, oxytocin antagonist, TRH, and hypothalamic paraventricular nucleus stimulation effects on gastric motility. Peptides 8: 505-513, 1987.
30. Rogers RC, Hermann GE, and Travagli RA. Brainstem pathways responsible for oesophageal control of gastric motility and tone in the rat. J Physiol 514: 369-383, 1999.
31. Rogers RC, McTigue DM, and Hermann GE. Vagal control of digestion: modulation by central neural and peripheral endocrine factors. Neurosci Biobehav Rev 20: 57-66, 1996.
32. Schemann MGD. Electrophysiological identification of vagally innervated enteric neurons in guinea pig stomach. Am J Physiol Gastrointest Liver Physiol 263: G709-G718, 1992.
33. Sengupta JN, Kauvar D, and Goyal RK. Characteristics of vagal esophageal tension-sensitive afferent fibers in the opossum. J Neurophysiol 61: 1001-1010, 1989.
34. Takahashi T and Owyang C. Characterization of vagal pathways mediating gastric accommodation reflex in rats. J Physiol 504: 479-488, 1997.
35. Travagli RA and Rogers RC. Receptors and transmission in the brain-gut axis: potential for novel therapies. V. Fast and slow extrinsic modulation of dorsal vagal complex circuits. Am J Physiol Gastrointest Liver Physiol 281: G595-G601, 2001.
36. Wiedner EB, Bao X, and Altschuler SM. Localization of nitric oxide synthase in the brain stem neural circuit controlling esophageal peristalsis in rats. Gastroenterology 108: 367-375, 1995.
37. Willing AE and Berthoud HR. Gastric distension-induced c-fos expression in catecholaminergic neurons of rat dorsal vagal complex. Am J Physiol Regul Integr Comp Physiol 272: R59-R67, 1997.