Restoration of skeletal muscle leptin response does not precede the exercise-induced recovery of insulin-stimulated glucose uptake in high-fat-fed rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 300, Issue 2, 2011, Pages

  Ritchie, Ian R W ^a   Gulli, Roberto A ^a   Stefanyk, Leslie E ^a   Harasim, Ewa ^b   Chabowski, Adrian ^b   Dyck, David J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Ceramide; Insulin resistance; Leptin resistance; Soleus

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENYLATE KINASE; CERAMIDE; FATTY ACID; GLUCOSE; INSULIN; LEPTIN; PALMITIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EXERCISE; FATTY ACID METABOLISM; FEMALE; GLUCOSE TRANSPORT; LIPID DIET; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; SOLEUS MUSCLE;

ACETYL-COA CARBOXYLASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD GLUCOSE; CERAMIDES; DIETARY FATS; DIGLYCERIDES; FATTY ACIDS; FEMALE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; INSULIN RESISTANCE; LEPTIN; MUSCLE FIBERS, SLOW-TWITCH; MUSCLE, SKELETAL; OXIDATION-REDUCTION; PALMITIC ACID; PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEPTIN; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRIGLYCERIDES;

EID: 79551563331     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00602.2010     Document Type: Article

References (33)

1. Bjorbak C, Lavery HJ, Bates SH, Olson RK, Davis SM, Flier JS, Myers MG. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 275: 40649-40657, 2000.
2. Bruce CR, Thrush AB, Mertz VA, Bezaire V, Chabowski A, Heigenhauser GJF, Dyck DJ. Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. Am J Physiol Endocrinol Metab 291: E99-E107, 2006.
3. Chavez JA, Knotts TA, Wang L, Summers SA, Florant GL, Li G, Dobrowsky RT. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem 278: 10297-10303, 2003.
4. Colombo C, Cutson JJ, Yamauchi T, Vinson C, Kadowaki T, Gavrilova O, Reitman ML. Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy. Diabetes 51: 2727-2733, 2002.
5. Dunn SL, Bjornholm M, Bates SH, Chen ZB, Seifert M, Myers M. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol 19: 925-938, 2005.
6. Hasty AH, Osuga J, Namatame I, Yahagi N, Perrey S, Iizuka Y, Tamura Y, Amemiya-Kudo M, Yoshikawa T, Okazaki H, Ohashi K, Harada K, Gotoda T, Nagai R, Ishibashi S, Shimano H, Takahashi A, Matsuzaka T, Sone H, Yamada N. Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 276: 37402-37408, 2001.
7. Janovská A, Hatzinikolas G, Staikopoulos V, McInerney J, Mano M, Wittert GA. AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity. Mol Cell Endocrinol 284: 1-10, 2008.
8. Kobayashi K, Forte TM, Taniguchi S, Ishida BY, Oka K, Chan L. The db/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of Western diet feeding. Metab Clin Exp 49: 22-31, 2000.
9. Lebrun P, Cognard E, Bellon-Paul R, Gontard P, Filloux C, Jehl-Pietri C, Grimaldi P, Samson M, Pénicaud L, Ruberte J, Ferre T, Pujol A, Bosch F, Van Obberghen E. Constitutive expression of suppressor of cytokine signalling-3 in skeletal muscle leads to reduced mobility and overweight in mice. Diabetologia 52: 2201-2212, 2009.
10. Lessard SJ, Rivas DA, Chen Z, Bonen A, Febbraio MA, Reeder DW, Kemp BE, Yaspelkis BB, Hawley JA. Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Diabetes 56: 1856-1864, 2007.
11. Mullen KL, Pritchard J, Ritchie I, Snook LA, Chabowski A, Bonen A, Wright D, Dyck DJ. Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats. Am J Physiol Regul Integr Comp Physiol 296: R243-R251, 2009.
12. Mullen KL, Smith AC, Junkin KA, Dyck DJ. Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed rats. Am J Physiol Endocrinol Metab 293: E83-E90, 2007.
13. Muoio DM, Dohm GL, Tapscott EB, Coleman RA. Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. Am J Physiol Endocrinol Metab 276: E913-E921, 1999.
14. Muoio DM, Dohn GL, Fiedorek FT, Jr, Tapscott EB, Coleman RA. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46: 1360-1364, 1997.
15. Sennello JA, Fayad R, Pini M, Gove ME, Fantuzzi G. Transplantation of wild-type white adipose tissue normalizes metabolic, immune and inflammatory alterations in leptin-deficient ob/ob mice. Cytokine 36: 261-266, 2006.
16. Smith AC, Mullen KL, Junkin KA, Nickerson J, Chabowski A, Bonen A, Dyck DJ. Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia. Am J Physiol Endocrinol Metab 293: E172-E181, 2007.
17. Steinberg GR, McAinch AJ, Chen MB, O'Brien PE, Dixon JB, Cameron-Smith D, Kemp BE. The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. J Clin Endocrinol Metab 91: 3592-3597, 2006.
18. Steinberg GR, Parolin ML, Heigenhauser GJ, Dyck DJ. Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. Am J Physiol Endocrinol Metab 283: E187-E192, 2002.
19. Steinberg GR, Smith AC, Wormald S, Malenfant P, Collier C, Dyck DJ. Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle. Am J Physiol Endocrinol Metab 286: E57-E63, 2004.
20. Steinberg G, Dyck D. Development of leptin resistance in rat soleus muscle in response to high-fat diets. Am J Physiol Endocrinol Metab 279: E1374-E1382, 2000.
21. Steinberg GR, Bonen A, Dyck DJ. Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats. Am J Physiol Endocrinol Metab 282: E593-E601, 2002.
22. Steinberg GR, Dyck DJ, Calles-Escandon J, Tandon NN, Luiken JJFP, Glatz JFC, Bonen A. Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscle. J Biol Chem 277: 8854-8860, 2002.
23. Steinberg GR, Parolin ML, Heigenhauser GJF, Dyck DJ. Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. Am J Physiol Endocrinol Metab 283: E187-E193, 2002.
24. Steinberg GR, Rush JWE, Dyck DJ. AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. Am J Physiol Endocrinol Metab 284: E648-E655, 2003.
25. Stratford S, Hoehn KL, Liu F, Summers SA. Regulation of insulin action by ceramide. Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J Biol Chem 279: 36608-36615, 2004.
26. Thrush AB, Brindley DN, Chabowski A, Heigenhauser GJ, Dyck DJ. Skeletal muscle lipogenic protein expression is not different between lean and obese humans; a potential factor in ceramide accumulation. J Clin Endocrinol Metab 94: 5053-5061, 2009.
27. Todd MK, Yaspelkis BB, Turcotte LP. Short-term leptin treatment increases fatty acids uptake and oxidation in muscle of high fat-fed rats. Metab Clin Exp 54: 1218-1224, 2005.
28. Ussher JR, Koves TR, Cadete VJJ, Zhang L, Jaswal JS, Swyrd SJ, Lopaschuk DG, Proctor SD, Keung W, Muoio DM, Lopaschuk GD. Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. Diabetes 59: 2453-2464, 2010.
29. Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami K, Ohnishi Y, Naitoh T, Yamamura K, Ueyama Y, Froguel P, Kimura S, Nagai R, Kadowaki T. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 278: 2461-2468, 2003.
30. Yaspelkis IIIBB, Ansari L, Ramey EL, Holland GJ, Loy SF. Chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport. Metab Clin Exp 48: 671-676, 1999.
31. Yaspelkis IIIBB, Singh MK, Krisan AD, Collins DE, Kwong CC, Bernard JR, Crain AM. Chronic leptin treatment enhances insulin-stimulated glucose disposal in skeletal muscle of high-fat fed rodents. Life Sci 74: 1801-1816, 2004.
32. Yaspelkis BB, Kvasha IA, Figueroa TY. High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKKα/β phosphorylation and decreases PI-3 kinase activity in muscle. Am J Physiol Regul Integr Comp Physiol 296: R1709-R1716, 2009.
33. Zhang J, Farley A, Nicholson S, Willson T, Zugaro L, Simpson R, Moritz R, Cary D, Richardson R, Hausmann G, Kile B, Kent S, Alexander W, Metcalf D, Hilton D, Nicola N, Baca M. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci USA 96: 2071-2076, 1999.