Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 3, 2011, Pages 1256-1263

  Bodiwala, Hardik S ^a   Sabde, Sudeep ^b   Gupta, Pawan ^a   Mukherjee, Ruchira ^b   Kumar, Rajender ^a   Garg, Prabha ^a   Bhutani, Kamlesh Kumar ^a   Mitra, Debashis ^b   Singh, Inder Pal ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Anti HIV; Caffeoyl anilide; CCR5 inhibitor; Integrase inhibitor; Portmanteau inhibitor

Indexed keywords

3 (4 AMINOPHENYL) 1 (3,4 DIHYDROXYPHENYL)PROP 2 EN 1 ONE; ANILIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; AZATHIOPRINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; GREEN FLUORESCENT PROTEIN; INTEGRASE; INTEGRASE INHIBITOR; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL) PHENYL) FURAN 2 CARBOXAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) 1 ADAMANTYLAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) 2 (THIOPHEN 2 YL)ACETAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) 2 FLUORO 4 (TRIFLUOROMETHYL)BENZAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) 2 NAPHTHAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) 2,4 DIFLUOROBENZAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) 3 METHYLBUTANAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) 3,4 DIFLUOROBENZAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) 3,5 DIFLUOROBENZAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) 4 METHOXYBENZAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) ACETAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) BENZAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) ISOBUTYRAMIDE; N (4 (3 (3,4 DIHYDROXYPHENYL)ACRYLOYL)PHENYL) THIOPHENE 2 CARBOXAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

ACETANILIDES; ANILIDES; ANTI-HIV AGENTS; CAFFEIC ACIDS; DRUG DESIGN; HIV INTEGRASE INHIBITORS; HIV-1; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79551489157     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.12.031     Document Type: Article

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