Active site binding modes of curcumin in HIV-1 protease and integrase

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 14, 2005, Pages 3364-3368

  Vajragupta, Opa ^a   Boonchoong, Preecha ^b   Morris, Garrett M ^c   Olson, Arthur J ^c  

^a MAHIDOL UNIVERSITY   (Thailand)

^b Department of Mathematics   (Thailand)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

5 CITEP; Curcumin; Docking; HIV integrase; HIV protease; HIV 1

Indexed keywords

AMINO ACID; ASPARAGINE; ASPARTIC ACID; CURCUMIN; GLUTAMIC ACID; GLYCINE; HISTIDINE; HYDROXYL GROUP; INTEGRASE; LYSINE; MAGNESIUM ION; PROTEINASE; SERINE; THREONINE; VIRUS ENZYME;

AMINO ACID ANALYSIS; ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; HUMAN IMMUNODEFICIENCY VIRUS 1; METAL BINDING; MOLECULAR INTERACTION; PHARMACOLOGICAL BLOCKING; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TERMINAL SEQUENCE;

BINDING SITES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CURCUMIN; DRUG DESIGN; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 20644442241     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.032     Document Type: Article

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