Dose-response relationship analysis of pregabalin doses and their antinociceptive effects in hot-plate test in mice

Pharmacological Reports

Volumn 62, Issue 5, 2010, Pages 942-948

  Łuszczki, Jarogniew J ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

Acute thermal pain; Dose response relationship; Hot plate test; Linear regression analysis; Maximum possible antinociceptive effect; Pregabalin

Indexed keywords

PREGABALIN;

ACUTE THERMAL PAIN; ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOSE CALCULATION; DOSE RESPONSE; DRUG STRUCTURE; HOT PLATE TEST; MALE; MOUSE; NONHUMAN; PAIN;

EID: 79551471849     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(10)70355-8     Document Type: Article

References (41)

1. Abdi S, Lee DH, Chung JM: The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain. Anesth Analg, 1998, 87, 1360-1366.
2. Backonja MM: Use of anticonvulsants for treatment of neuropathic pain. Neurology, 2002, 59, Suppl 2, S14-S17.
3. 2δ ligand pregabalin. J Neurosci, 2009, 29, 4076-4088.
4. Bennett MI, Simpson KH: Gabapentin in the treatment of neuropathic pain. Palliat Med, 2004, 18, 5-11.
5. 2-delta type 1 genetically modified mice. Brain Res, 2006, 1075, 68-80.
6. Christensen D, Gautron M, Guilbaud G, Kayser V: Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain. Pain, 2001, 93, 147-153.
7. 3H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin. J Pharmacol Exp Ther, 2000, 295, 1086-1093.
8. +-evoked glutamate release from rat neocortical and hippocampal slices by gabapentin. Neurosci Lett, 2000, 280, 107-110.
9. 2δ ligands: novel modulators of neurotransmission. Trends Pharmacol Sci, 2007, 28, 75-82. Erratum in: Trends Pharmacol Sci, 2007, 28, 151.
10. Eddy NB, Leimbach D: Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. J Pharmacol Exp Ther, 1953, 107, 385-393.
11. Ettinger AB, Argoff CE: Use of antiepileptic drugs for nonepileptic conditions: psychiatric disorders and chronic pain. Neurotherapeutics, 2007, 4, 75-83.
12. Feng MR, Turluck D, Burleigh J, Lister R, Fan C, Middlebrook A, Taylor C, Su T: Brain microdialysis and PK/PD correlation of pregabalin in rats. Eur J Drug Metab Pharmacokinet, 2001, 26, 123-128.
13. 2-δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci USA, 2006, 103, 17537-17542.
14. Field MJ, Holloman EF, McCleary S, Hughes J, Singh L: Evaluation of gabapentin and S-(+)-3-isobutylgaba in a rat model of postoperative pain. J Pharmacol Exp Ther, 1997, 282, 1242-1246.
15. Field MJ, McCleary S, Hughes J, Singh L: Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat. Pain, 1999, 80, 391-398.
16. 2+ influx by gabapentin and pregabalin in the human neocortex. Neuropharmacology, 2002, 42, 229-236.
17. 2δ subunit of a calcium channel. J Biol Chem, 1996, 271, 5768-5776.
18. Hunter JC, Gogas KR, Hedley LR, Jacobson LO, Kassotakis L, Thompson J, Fontana DJ: The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. Eur J Pharmacol, 1997, 324, 153-160.
19. B receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis. Eur J Pharmacol, 1999, 368, 205-211.
20. Jun JH, Yaksh TL: The effect of intrathecal gabapentin and 3-isobutyl γ-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. Anesth Analg, 1998, 86, 348-354.
21. Laughlin TM, Tram KV, Wilcox GL, Birnbaum AK: Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception. J Pharmacol Exp Ther, 2002, 302, 1168-1175.
22. Leniger T, Isbruch K, von den Driesch S, Diener HC, Hufnagel A: Seizure-associated headache in epilepsy. Epilepsia, 2001, 42, 1176-1179.
23. 1 subunit mediates spinal hyperexcitability in pain modulation. Pain, 2006, 125, 20-34.
24. 2δ calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. J Neurosci, 2001, 21, 1868-1875.
25. Łuszczki JJ: Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. Adv Med Sci, 2010, 55, 43-52.
26. Łuszczki JJ, Czuczwar SJ: Dose-response relationship analysis of vigabatrin doses and their antinociceptive effects in the hot-plate test in mice. Pharmacol Rep, 2008, 60, 409-414.
27. Łuszczki JJ, Kołacz A, Czuczwar M, Przesmycki K, Czuczwar SJ: Synergistic interaction of gabapentin with tiagabine in the formalin test in mice: an isobolographic analysis. Eur J Pain, 2009, 13, 665-672.
28. Łuszczki JJ, Kołacz A, Wojda E, Czuczwar M, Przesmycki K, Czuczwar SJ: Synergistic interaction of gabapentin with tiagabine in the hot-plate test in mice: an isobolographic analysis. Pharmacol Rep, 2009, 61, 459-467.
29. Motulsky HJ, Christopoulos A: Fitting models to biological data using linear and nonlinear regression. A practical guide to curve fitting. GraphPad Software Inc., San Diego CA, 2003.
30. Nair DR, Najm I, Bulacio J, Luders H: Painful auras in focal epilepsy. Neurology, 2001, 57, 700-702.
31. Partridge BJ, Chaplan SR, Sakamoto E, Yaksh TL: Characterization of the effects of gabapentin and 3-isobutyl-γ-aminobutyric acid on substance P-induced thermal hyperalgesia. Anesthesiology, 1998, 88, 196-205.
32. Schmauss C, Yaksh TL: In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat. J Pharmacol Exp Ther, 1984, 228, 1-12.
33. Shannon HE, Eberle EL, Peters SC: Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats. Neuropharmacology, 2005, 48, 1012-1020.
34. Su TZ, Feng MR, Weber ML: Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells. J Pharmacol Exp Ther, 2005, 313, 1406-1415.
35. Takeuchi Y, Takasu K, Ono H, Tanabe M: Pregabalin, S-(+)-3-isobutylgaba, activates the descending noradrenergic system to alleviate neuropathic pain in the mouse partial sciatic nerve ligation model. Neuropharmacology, 2007, 53, 842-853.
36. 2-δ] ligands. Pain, 2009, 142, 13-16.
37. Taylor CP, Gee NS, Su TZ, Kocsis JD, Welty DF, Brown JP, Dooley DJ et al.: A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res, 1998, 29, 233-249.
38. Taylor CP, Vartanian MG, Yuen PW, Bigge C, Suman-Chauhan N, Hill DR: Potent and stereospecific anticon-vulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin. Epilepsy Res, 1993, 14, 11-15.
39. Todorov AA, Kolchev CB, Todorov AB: Tiagabine and gabapentin for the management of chronic pain. Clin J Pain, 2005, 21, 358-361.
40. Tremont-Lukats IW, Megeff C, Backonja MM: Anticon-vulsants for neuropathic pain syndromes: mechanisms of action and place in therapy. Drugs, 2000, 60, 1029-1052.
41. Wallin J, Cui JG, Yakhnitsa V, Schechtmann G, Meyerson BA, Linderoth B: Gabapentin and pregabalin suppress tactile allodynia and potentiate spinal cord stimulation in a model of neuropathy. Eur J Pain, 2002, 6, 261-272.