Gabapentin and pregabalin suppress tactile allodynia and potentiate spinal cord stimulation in a model of neuropathy

European Journal of Pain

Volumn 6, Issue 4, 2002, Pages 261-272

  Wallin, Johan ^a   Cui, Jian Guo ^a   Yakhnitsa, Vadim ^a   Schechtmann, Gastón ^a   Meyerson, Björn A ^a   Linderoth, Bengt ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Gabapentin; Neuropathy; Pain; Pregabalin; Rat; Spinal cord stimulation

Indexed keywords

GABAPENTIN; PREGABALIN;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; MALE; NEUROMODULATION; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; SPINAL CORD STIMULATION; TACTILE STIMULATION;

EID: 0036397519     PISSN: 10903801     EISSN: None     Source Type: Journal    
DOI: 10.1053/eujp.2002.0329     Document Type: Article

References (48)

1. Abdi S, Lee DH, Chung JM. The anti-allodynic effects of amitriptyline, gabapentin, and lidocain in a rat model of neuropathic pain. Anesth Analg 1998; 87: 1360-1366.
2. Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M, LaMoreaux L, Garofalo E. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. J Am Med Assoc 1998; 280: 1831-1836.
3. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat produces disorders of pain sensation like: those seen in man. Pain 1988; 33: 87-107.
4. Carlton SM, Zhou S. Attenuation of formalin-induced nociceptive behaviors following local peripheral injection of gabapentin. Pain 1998; 76: 201-207.
5. Castro-Lopes JM, Tavares I, Coimbra A. GABA decreases in the spinal cord dorsal horn after peripheral neurectomy. Brain Res 1993; 620: 287-291.
6. Chapman V, Suzuki R, Chamarette HL, Rygh LJ, Dickenson AH. Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats. Pain 1998; 75: 261-272.
7. Committee for Research and Ethical Issues of the IASP. Ethical standards for investigation of experimental pain in animals. Pain 1983; 16: 109-110.
8. Cui JG, Linderoth B, Meyerson BA. Effects of spinal cord stimulation on touch-evoked allodynia involve GABAergic mechanisms. An experimental study in the mononeuropathic rat. Pain 1996; 66: 287-295.
9. Cui JG, O'Connor WT, Ungerstedt U, Linderoth B, Meyerson BA. Spinal cord stimulation attenuates augmented dorsal horn release of excitatory amino acids in mononeuropathy via a GABAergic mechanism. Pain 1997a; 73: 87-95.
10. Cui JG, Linderoth B, Meyerson BA. Incidence of mononeuropathy in rats is influenced by pre-emptive alteration of spinal excitability. Eur J Pain 1997b; 1: 53-59.
11. Cui JG, Meyerson BA, Sollevi A, Linderoth B. Effect of spinal cord stimulation on tactile hypersensitivity in mononeuropathic rats is potentiated by simultaneous GABA(B) and adenosine receptor activation. Neurosci Lett 1998; 247: 183-186.
12. Field MJ, Oles RJ, Lewis AS, McCleary S, Hughes J, Singh L. Gabapentin (Neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br J Pharmacol 1997; 121: 1513-1522.
13. Field MJ, Bramwell S, Hughes J, Singh L. Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones? Pain 1999a; 83: 303-311.
14. Field MJ, McCleary S, Hughes J, Singh L. Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat. Pain 1999b; 80: 391-398.
15. Gazelius B, Cui JG, Svensson M, Meyerson B, Linderoth B. Photochemically induced ischaemic lesion of the rat sciatic nerve. A novel method providing high incidence of mononeuropathy. Neuroreport 1996; 7: 2619-2623.
16. 2δ subunit of a calcium channel. J Biol Chem 1996; 271: 5768-5776.
17. G̈tz E, Feuerstein TJ, Meyer DK. Effects of gabapentin on release of gamma-aminobutyric acid from slices of rat neostriatum. Drug Res 1993; 43: 636-638.
18. Hamilton SL, Hawkes MJ, Brush K, Cook R, Chang RJ, Smilowitz HM. Subunit composition of the purified dihydropyridine binding protein from skeletal muscle. Biochemistry 1989; 28: 7820-7828.
19. Hunter JC, Gogas KR, Hedley LR, Jacobson LO, Kassotakis L, Thompson J, Fontana DJ. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. Eur J Pharmacol 1997; 324: 153-160.
20. Jun JH, Yaksh TL. The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. Anesth Analg 1998; 86: 348-354.
21. Kayser V, Christensen D. Antinociceptive effect of systemic gabapentin in mononeuropathic rats, depends on stimulus characteristics and level of test integration. Pain 2000; 88: 53-60.
22. Linderoth B, Foreman RD. Physiology of spinal cord stimulation: review and update. Neuromodulation 1999; 2: 150-164.
23. Linderoth B, Fedorcsak I, Meyerson BA. Peripheral vasodilatation after spinal cord stimulation: animal studies of putative effector mechanisms. Neurosurgery 1991; 28: 187-195.
24. Linderoth B, Stiller CO, Gunasekera L, O'Connor WT, Franck J, Gazelius B, Brodin E. Release of neurotransmitters in the CNS by spinal cord stimulation: survey of present state of knowledge and recent experimental studies. Stereotact Funct Neurosurg 1993; 61: 157-170.
25. Loscher W, Honack D, Taylor CP. Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. Neurosci Lett 1991; 128: 150-154.
26. Mellick GA, Mellick LB. Reflex sympathetic dystrophy treated with gabapentin. Arch Phys Med Rehabil 1997; 78: 98-105.
27. Meyerson BA, Linderoth B. Mechanisms of spinal cord stimulation in neuropathic pain. Neurol Res 2000a; 22: 285-292.
28. Meyerson BA, Linderoth B. Spinal cord stimulation. In: Loeser JD, editor. Bonica's Management of Pain. Philadelphia, PA: Lippincott Williams & Wilkins, 2000b: 1857-1876.
29. Meyerson BA, Ren B, Herregodts P, Linderoth B. Spinal cord stimulation in animal models of mononeuropathy: effects on the withdrawal response and the flexor reflex. Pain 1995; 61: 229-243.
30. Meyerson BA, Cui JG, Yakhnitsa V, Sollevi A, Segerdahl M, Stiller CO, O'Connor WT, Linderoth B. Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy. Stereotact Funct Neurosurg 1997; 68: 129-140.
31. Nicholson B. Gabapentin use in neuropathic pain syndromes. Acta Neurol Scand 2000; 101: 359-371.
32. Novelli GP, Trovati F. Gabapentin and neuropathic pain. Pain Clinic 1998; 11: 5-32.
33. Pan HL, Eisenach JC, Chen SR. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacol Exp Ther 1999; 288: 1026-1030.
34. Partridge BJ, Chaplan SR, Sakamoto E, Yaksh TL. Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia. Anesthesiology 1998; 88: 196-205.
35. Pertovaara A, Kontinen VK, Kalso EA. Chronic spinal nerve ligation induces changes in response characteristics of nociceptive spinal dorsal horn neurons and in their descending regulation originating in the periaqueductal gray in the rat. Exp Neurol 1997; 147: 428-436.
36. Petroff OAC, Rothman DL, Behar KL, Lamoureux D, Mattson RH. The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Ann Neurol 1996; 39: 95-99.
37. Ramsay RE. Clinical efficacy and safety of gabapentin. Neurology 1994; 44: S23-S30.
38. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. J Am Med Assoc 1998; 280: 1837-1842.
39. Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 1990; 43: 205-218.
40. Shimoyama M, Shimoyama N, Hori Y. Gabapentin affects glutaminergic excitatory neurotransmission in the rat dorsal horn. Pain 2000; 85: 405-414.
41. Simpson BA. Spinal cord stimulation. Pain Rev 1994; 1: 199-230.
42. Sotgiu ML, Lacerenza M, Marchettini P. Effect of systemic lidocaine on dorsal horn neuron hyperactivity following chronic peripheral nerve injury in rats. Somatosens Mot Res 1992; 9: 227-233.
43. Stiller CO, Cui JG, O'Connor WT, Brodin E, Meyerson BA, Linderoth B. Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats. Neurosurgery 1996; 39: 367-374.
44. Takahashi T, Momiyama A. Different types of calcium channels mediate central synaptic transmission. Nature 1993; 366: 156-158.
45. Taylor CP, Gee NS, Su TZ, Kocsis JD, Welty DF, Brown JP, Dooley DJ, Boden P, Singh L. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 1998; 29: 233-249.
46. 2+ channel function and drug action. Trends Pharmacol Sci 1995; 16: 43-49.
47. Xiao W-H, Bennett GJ. Gabapentin relieves abnormal pains in a rat model of painful peripheral neuropathy. Soc Neurosci Abstr 1995; 21: 897.
48. Yakhnitsa V, Linderoth B, Meyerson BA. Spinal cord stimulation attenuates dorsal horn neuronal hyperexcitability in a rat model of mononeuropathy. Pain 1999; 79: 223-233.