Identification of the α2-δ-1 subunit of voltage-calcium calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 46, 2006, Pages 17537-17542

  Field, Mark J ^a   Cox, Peter J ^a   Stott, Emma ^a   Melrose, Heather ^a,d   Offord, James ^b   Su, Ti Zhi ^b   Bramwell, Steve ^a   Corradini, Laura ^a   England, Steven ^a   Winks, Joanna ^a   Kinloch, Ross A ^a   Hendrich, Jan ^c   Dolphin, Annette C ^c   Webbl, Tony ^a   Williams, Dic ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER INC   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANALGESIC AGENT; GABAPENTIN; MORPHINE; NARCOTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PREGABALIN; PROTEIN SUBUNIT; VOLTAGE GATED CALCIUM CHANNEL; 4 AMINOBUTYRIC ACID; ARGININE; CACNA1B PROTEIN, MOUSE; CALCIUM CHANNEL; CALCIUM CHANNEL N TYPE; DRUG DERIVATIVE; FORMALDEHYDE;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN; CONTROLLED STUDY; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG TARGETING; FEMALE; MALE; MOUSE; MOUSE MUTANT; NERVE COMPRESSION; NEUROPATHIC PAIN; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; SPINAL CORD; TISSUE DISTRIBUTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CERCOPITHECUS; CHANNEL GATING; CHEMISTRY; DRUG EFFECT; GENETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PAIN; PROTEIN BINDING; STENOSIS, OCCLUSION AND OBSTRUCTION; SWINE; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; ARGININE; AUTORADIOGRAPHY; BASE SEQUENCE; CALCIUM CHANNELS; CALCIUM CHANNELS, N-TYPE; CELL LINE; CERCOPITHECUS AETHIOPS; CONSTRICTION, PATHOLOGIC; FEMALE; FORMALDEHYDE; GAMMA-AMINOBUTYRIC ACID; ION CHANNEL GATING; MALE; MICE; MICE, TRANSGENIC; MUTATION; PAIN; PROTEIN BINDING; PROTEIN SUBUNITS; SWINE;

EID: 33751232667     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409066103     Document Type: Article

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