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Volumn 13, Issue 7, 2009, Pages 665-672

Synergistic interaction of gabapentin with tiagabine in the formalin test in mice: An isobolographic analysis

Author keywords

Drug interaction; Formalin test; Gabapentin; Isobolographic analysis; Tiagabine

Indexed keywords

FORMALDEHYDE; GABAPENTIN; TIAGABINE;

EID: 67649227514     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2008.08.002     Document Type: Article
Times cited : (11)

References (69)
  • 1
    • 0027241691 scopus 로고
    • The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate
    • Andersen K.E., Braestrup C., Gronwald F.C., Jorgensen A.S., Nielsen E.B., Sonnewald U., et al. The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate. J Med Chem 36 (1993) 1716-1725
    • (1993) J Med Chem , vol.36 , pp. 1716-1725
    • Andersen, K.E.1    Braestrup, C.2    Gronwald, F.C.3    Jorgensen, A.S.4    Nielsen, E.B.5    Sonnewald, U.6
  • 2
    • 0032477294 scopus 로고    scopus 로고
    • Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    • Backonja M., Beydoun A., Edwards K.R., Schwartz S.L., Fonseca V., Hes M., et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA 280 (1998) 1831-1836
    • (1998) JAMA , vol.280 , pp. 1831-1836
    • Backonja, M.1    Beydoun, A.2    Edwards, K.R.3    Schwartz, S.L.4    Fonseca, V.5    Hes, M.6
  • 3
    • 0024847290 scopus 로고    scopus 로고
    • Berenbaum MC. What is synergy? Pharmacol Rev 1989;41:93-141 [Berenbaum MC. Erratum in: Pharmacol Rev 1989;41:422].
    • Berenbaum MC. What is synergy? Pharmacol Rev 1989;41:93-141 [Berenbaum MC. Erratum in: Pharmacol Rev 1989;41:422].
  • 4
    • 0034967810 scopus 로고    scopus 로고
    • The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain gamma-aminobutyric acid type B receptors negatively coupled to voltage-dependent calcium channels
    • Bertrand S., Ng G.Y., Purisai M.G., Wolfe S.E., Severidt M.W., Nouel D., et al. The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain gamma-aminobutyric acid type B receptors negatively coupled to voltage-dependent calcium channels. J Pharmacol Exp Ther 298 (2001) 15-24
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 15-24
    • Bertrand, S.1    Ng, G.Y.2    Purisai, M.G.3    Wolfe, S.E.4    Severidt, M.W.5    Nouel, D.6
  • 5
    • 84940816667 scopus 로고
    • Une nouvelle méthode simple pour explorer l'action tranquilisante: le test de la cheminée
    • Boissier J.R., Tardy J., and Diverres J.C. Une nouvelle méthode simple pour explorer l'action tranquilisante: le test de la cheminée. Med Exp (Basel) 3 (1960) 81-84
    • (1960) Med Exp (Basel) , vol.3 , pp. 81-84
    • Boissier, J.R.1    Tardy, J.2    Diverres, J.C.3
  • 6
    • 4344695255 scopus 로고    scopus 로고
    • Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group
    • Caraceni A., Zecca E., Bonezzi C., Arcuri E., Yaya Tur R., Maltoni M., et al. Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. J Clin Oncol 22 (2004) 2909-2917
    • (2004) J Clin Oncol , vol.22 , pp. 2909-2917
    • Caraceni, A.1    Zecca, E.2    Bonezzi, C.3    Arcuri, E.4    Yaya Tur, R.5    Maltoni, M.6
  • 7
    • 0031921954 scopus 로고    scopus 로고
    • Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats
    • Chapman V., Suzuki R., Chamarette H.L., Rygh L.J., and Dickenson A.H. Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats. Pain 75 (1998) 261-272
    • (1998) Pain , vol.75 , pp. 261-272
    • Chapman, V.1    Suzuki, R.2    Chamarette, H.L.3    Rygh, L.J.4    Dickenson, A.H.5
  • 8
    • 17044391409 scopus 로고    scopus 로고
    • Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia
    • Chen S.R., and Pan H.L. Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia. Brain Res 1042 (2005) 108-113
    • (2005) Brain Res , vol.1042 , pp. 108-113
    • Chen, S.R.1    Pan, H.L.2
  • 9
    • 0034033882 scopus 로고    scopus 로고
    • Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain
    • Cheng J.K., Pan H.L., and Eisenach J.C. Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain. Anesthesiology 92 (2000) 1126-1131
    • (2000) Anesthesiology , vol.92 , pp. 1126-1131
    • Cheng, J.K.1    Pan, H.L.2    Eisenach, J.C.3
  • 10
    • 37849031855 scopus 로고    scopus 로고
    • Tramadol and several anticonvulsants synergize in attenuating nerve injury-induced allodynia
    • Codd E.E., Martinez R.P., Molino L., Rogers K.E., Stone D.J., and Tallarida R.J. Tramadol and several anticonvulsants synergize in attenuating nerve injury-induced allodynia. Pain 134 (2008) 254-262
    • (2008) Pain , vol.134 , pp. 254-262
    • Codd, E.E.1    Martinez, R.P.2    Molino, L.3    Rogers, K.E.4    Stone, D.J.5    Tallarida, R.J.6
  • 11
    • 0346327414 scopus 로고    scopus 로고
    • Evaluation of interaction between gabapentin and baclofen in the formalin test in mice
    • Czuczwar M., Kis J., Luszczki J., Turski W.A., and Przesmycki K. Evaluation of interaction between gabapentin and baclofen in the formalin test in mice. Pol J Pharmacol 55 (2003) 803-806
    • (2003) Pol J Pharmacol , vol.55 , pp. 803-806
    • Czuczwar, M.1    Kis, J.2    Luszczki, J.3    Turski, W.A.4    Przesmycki, K.5
  • 12
    • 0028917022 scopus 로고
    • Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin
    • Dallel R., Raboisson P., Clavelou P., Saade M., and Woda A. Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin. Pain 61 (1995) 11-16
    • (1995) Pain , vol.61 , pp. 11-16
    • Dallel, R.1    Raboisson, P.2    Clavelou, P.3    Saade, M.4    Woda, A.5
  • 13
    • 0033761218 scopus 로고    scopus 로고
    • Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed
    • Deckers C.L., Czuczwar S.J., Hekster Y.A., Keyser A., Kubova H., Meinardi H., et al. Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed. Epilepsia 41 (2000) 1364-1374
    • (2000) Epilepsia , vol.41 , pp. 1364-1374
    • Deckers, C.L.1    Czuczwar, S.J.2    Hekster, Y.A.3    Keyser, A.4    Kubova, H.5    Meinardi, H.6
  • 14
    • 0033911715 scopus 로고    scopus 로고
    • Gabapentin in the prophylaxis of migraine: a double-blind randomized placebo-controlled study
    • Di Trapani G., Mei D., Marra C., Mazza S., and Capuano A. Gabapentin in the prophylaxis of migraine: a double-blind randomized placebo-controlled study. Clin Ther 151 (2000) 145-148
    • (2000) Clin Ther , vol.151 , pp. 145-148
    • Di Trapani, G.1    Mei, D.2    Marra, C.3    Mazza, S.4    Capuano, A.5
  • 15
    • 11444252737 scopus 로고    scopus 로고
    • Gabapentin normalizes spinal neuronal responses that correlate with behavior in a rat model of cancer-induced bone pain
    • Donovan-Rodriguez T., Dickenson A.H., and Urch C.E. Gabapentin normalizes spinal neuronal responses that correlate with behavior in a rat model of cancer-induced bone pain. Anesthesiology 102 (2005) 132-140
    • (2005) Anesthesiology , vol.102 , pp. 132-140
    • Donovan-Rodriguez, T.1    Dickenson, A.H.2    Urch, C.E.3
  • 16
    • 28044437747 scopus 로고    scopus 로고
    • Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials
    • Elia N., Lysakowski C., and Tramer M.R. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology 103 (2005) 1296-1304
    • (2005) Anesthesiology , vol.103 , pp. 1296-1304
    • Elia, N.1    Lysakowski, C.2    Tramer, M.R.3
  • 17
    • 0030796031 scopus 로고    scopus 로고
    • Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents
    • Field M.J., Oles R.J., Lewis A.S., McCleary S., Hughes J., and Singh L. Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br J Pharmacol 121 (1997) 1513-1522
    • (1997) Br J Pharmacol , vol.121 , pp. 1513-1522
    • Field, M.J.1    Oles, R.J.2    Lewis, A.S.3    McCleary, S.4    Hughes, J.5    Singh, L.6
  • 18
  • 19
    • 27644492388 scopus 로고    scopus 로고
    • Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs
    • Garry E.M., Delaney A., Anderson H.A., Sirinathsinghji E.C., Clapp R.H., Martin W.J., et al. Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs. Pain 18 (2005) 97-111
    • (2005) Pain , vol.18 , pp. 97-111
    • Garry, E.M.1    Delaney, A.2    Anderson, H.A.3    Sirinathsinghji, E.C.4    Clapp, R.H.5    Martin, W.J.6
  • 20
    • 0029975930 scopus 로고    scopus 로고
    • The novel anticonvulsant drug, gabapentin (neurontin), binds to the alpha2delta subunit of a calcium channel
    • Gee N.S., Brown J.P., Dissanayake V.U., Offord J., Thurlow R., and Woodruff G.N. The novel anticonvulsant drug, gabapentin (neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem 271 (1996) 5768-5776
    • (1996) J Biol Chem , vol.271 , pp. 5768-5776
    • Gee, N.S.1    Brown, J.P.2    Dissanayake, V.U.3    Offord, J.4    Thurlow, R.5    Woodruff, G.N.6
  • 21
    • 4243191446 scopus 로고    scopus 로고
    • Isobolographic analysis for combinations of a full and partial agonist: curved isoboles
    • Grabovsky Y., and Tallarida R.J. Isobolographic analysis for combinations of a full and partial agonist: curved isoboles. J Pharmacol Exp Ther 310 (2004) 981-986
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 981-986
    • Grabovsky, Y.1    Tallarida, R.J.2
  • 22
    • 0029036955 scopus 로고
    • The search for synergy: a critical review from a response surface perspective
    • Greco W.R., Bravo G., and Parsons J.C. The search for synergy: a critical review from a response surface perspective. Pharmacol Rev 47 (1995) 331-385
    • (1995) Pharmacol Rev , vol.47 , pp. 331-385
    • Greco, W.R.1    Bravo, G.2    Parsons, J.C.3
  • 23
  • 24
    • 0032978974 scopus 로고    scopus 로고
    • Tiagabine antinociception in rodents depends on GABA(B) receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis
    • Ipponi A., Lamberti C., Medica A., Bartolini A., and Malmberg-Aiello P. Tiagabine antinociception in rodents depends on GABA(B) receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis. Eur J Pharmacol 368 (1999) 205-211
    • (1999) Eur J Pharmacol , vol.368 , pp. 205-211
    • Ipponi, A.1    Lamberti, C.2    Medica, A.3    Bartolini, A.4    Malmberg-Aiello, P.5
  • 25
    • 0034750986 scopus 로고    scopus 로고
    • Multimodal analgesia for postoperative pain control
    • Jin F., and Chung F. Multimodal analgesia for postoperative pain control. J Clin Anesth 13 (2001) 524-539
    • (2001) J Clin Anesth , vol.13 , pp. 524-539
    • Jin, F.1    Chung, F.2
  • 26
    • 33847639380 scopus 로고    scopus 로고
    • Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?
    • Jonker D.M., Voskuyl R.A., and Danhof M. Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?. Epilepsia 48 (2007) 412-434
    • (2007) Epilepsia , vol.48 , pp. 412-434
    • Jonker, D.M.1    Voskuyl, R.A.2    Danhof, M.3
  • 27
    • 27744578119 scopus 로고    scopus 로고
    • Tiagabine may reduce bruxism and associated temporomandibular joint pain
    • Kast R.E. Tiagabine may reduce bruxism and associated temporomandibular joint pain. Anesth Prog 52 (2005) 102-104
    • (2005) Anesth Prog , vol.52 , pp. 102-104
    • Kast, R.E.1
  • 28
    • 0036721084 scopus 로고    scopus 로고
    • Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception
    • Laughlin T.M., Tram K.V., Wilcox G.L., and Birnbaum A.K. Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception. J Pharmacol Exp Ther 302 (2002) 1168-1175
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 1168-1175
    • Laughlin, T.M.1    Tram, K.V.2    Wilcox, G.L.3    Birnbaum, A.K.4
  • 29
    • 84951384024 scopus 로고
    • A simplified method of evaluating dose-effect experiments
    • Litchfield J.T., and Wilcoxon F. A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96 (1949) 99-113
    • (1949) J Pharmacol Exp Ther , vol.96 , pp. 99-113
    • Litchfield, J.T.1    Wilcoxon, F.2
  • 30
    • 0001663843 scopus 로고
    • The problem of synergism and antagonism of combined drugs
    • Loewe S. The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 3 (1953) 285-290
    • (1953) Arzneimittelforschung , vol.3 , pp. 285-290
    • Loewe, S.1
  • 31
    • 54249115824 scopus 로고    scopus 로고
    • Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non parallel dose-response relationship curves
    • 10.1007/s00210-008-0305-8
    • Luszczki J.J. Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non parallel dose-response relationship curves. N-S Arch Pharmacol (2008) 10.1007/s00210-008-0305-8
    • (2008) N-S Arch Pharmacol
    • Luszczki, J.J.1
  • 32
    • 33947193434 scopus 로고    scopus 로고
    • Isobolographic analysis of interaction between drugs with nonparallel dose-response relationship curves: a practical application
    • Luszczki J.J. Isobolographic analysis of interaction between drugs with nonparallel dose-response relationship curves: a practical application. N-S Arch Pharmacol 375 (2007) 105-114
    • (2007) N-S Arch Pharmacol , vol.375 , pp. 105-114
    • Luszczki, J.J.1
  • 33
    • 33947267369 scopus 로고    scopus 로고
    • Biphasic characteristic of interactions between stiripentol and carbamazepine in the mouse maximal electroshock-induced seizure model: a three-dimensional isobolographic analysis
    • Luszczki J.J., and Czuczwar S.J. Biphasic characteristic of interactions between stiripentol and carbamazepine in the mouse maximal electroshock-induced seizure model: a three-dimensional isobolographic analysis. N-S Arch Pharmacol 374 (2006) 51-64
    • (2006) N-S Arch Pharmacol , vol.374 , pp. 51-64
    • Luszczki, J.J.1    Czuczwar, S.J.2
  • 34
    • 2142660737 scopus 로고    scopus 로고
    • Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study
    • Luszczki J.J., and Czuczwar S.J. Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study. N-S Arch Pharmacol 369 (2004) 434-446
    • (2004) N-S Arch Pharmacol , vol.369 , pp. 434-446
    • Luszczki, J.J.1    Czuczwar, S.J.2
  • 35
    • 0042572368 scopus 로고    scopus 로고
    • Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice. An isobolographic analysis
    • Luszczki J.J., Czuczwar M., Kis J., Krysa J., Pasztelan I., Swiader M., et al. Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice. An isobolographic analysis. Epilepsia 44 (2003) 1003-1013
    • (2003) Epilepsia , vol.44 , pp. 1003-1013
    • Luszczki, J.J.1    Czuczwar, M.2    Kis, J.3    Krysa, J.4    Pasztelan, I.5    Swiader, M.6
  • 36
    • 33646703115 scopus 로고    scopus 로고
    • Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model
    • Luszczki J.J., Ratnaraj N., Patsalos P.N., and Czuczwar S.J. Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model. N-S Arch Pharmacol 373 (2006) 169-181
    • (2006) N-S Arch Pharmacol , vol.373 , pp. 169-181
    • Luszczki, J.J.1    Ratnaraj, N.2    Patsalos, P.N.3    Czuczwar, S.J.4
  • 37
    • 0642308238 scopus 로고    scopus 로고
    • Tiagabine synergistically interacts with gabapentin in the electroconvulsive threshold test in mice
    • Luszczki J.J., Swiader M., Parada-Turska J., and Czuczwar S.J. Tiagabine synergistically interacts with gabapentin in the electroconvulsive threshold test in mice. Neuropsychopharmacology 28 (2003) 1817-1830
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1817-1830
    • Luszczki, J.J.1    Swiader, M.2    Parada-Turska, J.3    Czuczwar, S.J.4
  • 38
    • 0029871778 scopus 로고    scopus 로고
    • Formalin induces biphasic activity in C-fibers in the rat
    • McCall W.D., Tanner K.D., and Levine J.D. Formalin induces biphasic activity in C-fibers in the rat. Neurosci Lett 208 (1996) 45-48
    • (1996) Neurosci Lett , vol.208 , pp. 45-48
    • McCall, W.D.1    Tanner, K.D.2    Levine, J.D.3
  • 39
    • 0032797278 scopus 로고    scopus 로고
    • Basic mechanisms of gabitril (tiagabine) and future potential developments
    • Meldrum B.S., and Chapman A.G. Basic mechanisms of gabitril (tiagabine) and future potential developments. Epilepsia 40 Suppl. 9 (1999) S2-S6
    • (1999) Epilepsia , vol.40 , Issue.SUPPL. 9
    • Meldrum, B.S.1    Chapman, A.G.2
  • 40
    • 0031030978 scopus 로고    scopus 로고
    • Reflex sympathetic dystrophy treated with gabapentin
    • Mellick G.A., and Mellick L.B. Reflex sympathetic dystrophy treated with gabapentin. Arch Phys Med Rehabil 78 (1997) 98-105
    • (1997) Arch Phys Med Rehabil , vol.78 , pp. 98-105
    • Mellick, G.A.1    Mellick, L.B.2
  • 41
    • 0035164999 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action
    • Ng G.Y., Bertrand S., Sullivan R., Ethier N., Wang J., Yergey J., et al. Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. Mol Pharmacol 59 (2001) 144-152
    • (2001) Mol Pharmacol , vol.59 , pp. 144-152
    • Ng, G.Y.1    Bertrand, S.2    Sullivan, R.3    Ethier, N.4    Wang, J.5    Yergey, J.6
  • 43
    • 0035736203 scopus 로고    scopus 로고
    • Treatment of painful sensory neuropathy with tiagabine: a pilot study
    • Novak V., Kanard R., Kissel J.T., and Mendell J.R. Treatment of painful sensory neuropathy with tiagabine: a pilot study. Clin Auton Res 11 (2001) 357-361
    • (2001) Clin Auton Res , vol.11 , pp. 357-361
    • Novak, V.1    Kanard, R.2    Kissel, J.T.3    Mendell, J.R.4
  • 45
    • 0033022851 scopus 로고    scopus 로고
    • Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats
    • Pan H.L., Eisenach J.C., and Chen S.R. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacol Exp Ther 288 (1999) 1026-1030
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 1026-1030
    • Pan, H.L.1    Eisenach, J.C.2    Chen, S.R.3
  • 46
    • 0033849424 scopus 로고    scopus 로고
    • Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord
    • Patel M.K., Gonzalez M.I., Bramwell S., Pinnock R.D., and Lee K. Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord. Br J Pharmacol 130 (2000) 1731-1734
    • (2000) Br J Pharmacol , vol.130 , pp. 1731-1734
    • Patel, M.K.1    Gonzalez, M.I.2    Bramwell, S.3    Pinnock, R.D.4    Lee, K.5
  • 47
    • 84989593859 scopus 로고
    • Pharmacological principles as a basis for polytherapy
    • Perucca E. Pharmacological principles as a basis for polytherapy. Acta Neurol Scand Suppl. 162 (1995) 31-34
    • (1995) Acta Neurol Scand , vol.SUPPL. 162 , pp. 31-34
    • Perucca, E.1
  • 48
    • 0025127403 scopus 로고
    • The formalin test in mice. Effect of formalin concentration
    • Rosland J.H., Tjolsen A., Maehle B., and Hole K. The formalin test in mice. Effect of formalin concentration. Pain 42 (1990) 235-242
    • (1990) Pain , vol.42 , pp. 235-242
    • Rosland, J.H.1    Tjolsen, A.2    Maehle, B.3    Hole, K.4
  • 49
    • 0032477305 scopus 로고    scopus 로고
    • Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial
    • Rowbotham M., Harden N., Stacey B., Bernstein P., and Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA 280 (1998) 1837-1842
    • (1998) JAMA , vol.280 , pp. 1837-1842
    • Rowbotham, M.1    Harden, N.2    Stacey, B.3    Bernstein, P.4    Magnus-Miller, L.5
  • 50
    • 18044372830 scopus 로고    scopus 로고
    • Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats
    • Shannon H.E., Eberle E.L., and Peters S.C. Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats. Neuropharmacology 48 (2005) 1012-1020
    • (2005) Neuropharmacology , vol.48 , pp. 1012-1020
    • Shannon, H.E.1    Eberle, E.L.2    Peters, S.C.3
  • 51
    • 0034175744 scopus 로고    scopus 로고
    • Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn
    • Shimoyama M., Shimoyama N., and Hori Y. Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn. Pain 85 (2000) 405-414
    • (2000) Pain , vol.85 , pp. 405-414
    • Shimoyama, M.1    Shimoyama, N.2    Hori, Y.3
  • 52
    • 0029795902 scopus 로고    scopus 로고
    • The antiepileptic agent gabapentin (neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by d-serine
    • Singh L., Field M.J., Ferris P., Hunter J.C., Oles R.J., Williams R.G., et al. The antiepileptic agent gabapentin (neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by d-serine. Psychopharmacology (Berlin) 127 (1996) 1-9
    • (1996) Psychopharmacology (Berlin) , vol.127 , pp. 1-9
    • Singh, L.1    Field, M.J.2    Ferris, P.3    Hunter, J.C.4    Oles, R.J.5    Williams, R.G.6
  • 53
    • 0030862045 scopus 로고    scopus 로고
    • Experience with gabapentin for neuropathic pain in the head and neck: report of ten cases
    • Sist T.C., Filadora V.A., Miner M., and Lema M. Experience with gabapentin for neuropathic pain in the head and neck: report of ten cases. Reg Anesth 22 (1997) 473-478
    • (1997) Reg Anesth , vol.22 , pp. 473-478
    • Sist, T.C.1    Filadora, V.A.2    Miner, M.3    Lema, M.4
  • 54
    • 0842330754 scopus 로고    scopus 로고
    • Tiagabine for treating painful tonic spasms in multiple sclerosis: a pilot study
    • Solaro C., and Tanganelli P. Tiagabine for treating painful tonic spasms in multiple sclerosis: a pilot study. J Neurol Neurosurg Psychiatry 75 (2004) 341
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 341
    • Solaro, C.1    Tanganelli, P.2
  • 55
    • 0036747357 scopus 로고    scopus 로고
    • Seizure freedom with more than one antiepileptic drug
    • Stephen L.J., and Brodie M.J. Seizure freedom with more than one antiepileptic drug. Seizure 11 (2002) 349-351
    • (2002) Seizure , vol.11 , pp. 349-351
    • Stephen, L.J.1    Brodie, M.J.2
  • 56
    • 0028986069 scopus 로고
    • Transport of gabapentin, a gamma-amino acid drug, by system l alpha-amino acid transporters: a comparative study in astrocytes, synaptosomes, and CHO cells
    • Su T.Z., Lunney E., Campbell G., and Oxender D.L. Transport of gabapentin, a gamma-amino acid drug, by system l alpha-amino acid transporters: a comparative study in astrocytes, synaptosomes, and CHO cells. J Neurochem 64 (1995) 2125-2131
    • (1995) J Neurochem , vol.64 , pp. 2125-2131
    • Su, T.Z.1    Lunney, E.2    Campbell, G.3    Oxender, D.L.4
  • 59
    • 0028999957 scopus 로고
    • A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor
    • Suzdak P.D., and Jansen J.A. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia 36 (1995) 612-626
    • (1995) Epilepsia , vol.36 , pp. 612-626
    • Suzdak, P.D.1    Jansen, J.A.2
  • 60
    • 0028285945 scopus 로고
    • The mouse grid-shock analgesia test: pharmacological characterization of latency to vocalization threshold as an index of antinociception
    • Swedberg M.D. The mouse grid-shock analgesia test: pharmacological characterization of latency to vocalization threshold as an index of antinociception. J Pharmacol Exp Ther 269 (1994) 1021-1028
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 1021-1028
    • Swedberg, M.D.1
  • 62
    • 33749007441 scopus 로고    scopus 로고
    • An overview of drug combination analysis with isobolograms
    • Tallarida R.J. An overview of drug combination analysis with isobolograms. J Pharmacol Exp Ther 319 (2006) 1-7
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 1-7
    • Tallarida, R.J.1
  • 63
    • 33845716253 scopus 로고    scopus 로고
    • Interactions between drugs and occupied receptors
    • Tallarida R.J. Interactions between drugs and occupied receptors. Pharmacol Ther 113 (2007) 197-209
    • (2007) Pharmacol Ther , vol.113 , pp. 197-209
    • Tallarida, R.J.1
  • 66
    • 21144438777 scopus 로고    scopus 로고
    • Tiagabine and gabapentin for the management of chronic pain
    • Todorov A.A., Kolchev C.B., and Todorov A.B. Tiagabine and gabapentin for the management of chronic pain. Clin J Pain 21 (2005) 358-361
    • (2005) Clin J Pain , vol.21 , pp. 358-361
    • Todorov, A.A.1    Kolchev, C.B.2    Todorov, A.B.3
  • 67
    • 0033623174 scopus 로고    scopus 로고
    • GABAB receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia
    • Towers S., Princivalle A., Billinton A., Edmunds M., Bettler B., Urban L., et al. GABAB receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia. Eur J Neurosci 12 (2000) 3201-3210
    • (2000) Eur J Neurosci , vol.12 , pp. 3201-3210
    • Towers, S.1    Princivalle, A.2    Billinton, A.3    Edmunds, M.4    Bettler, B.5    Urban, L.6
  • 68
    • 0346886917 scopus 로고    scopus 로고
    • Spinal gabapentin and antinociception: mechanisms of action
    • Yoon M.H., Choi J.I., and Jeong S.W. Spinal gabapentin and antinociception: mechanisms of action. J Korean Med Sci 18 (2003) 255-261
    • (2003) J Korean Med Sci , vol.18 , pp. 255-261
    • Yoon, M.H.1    Choi, J.I.2    Jeong, S.W.3
  • 69
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1


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