Brain microdialysis and PK/PD correlation of pregabalin in rats

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 1-2, 2001, Pages 123-128

  Feng, M R ^a   Turluck, D ^a   Burleigh, J ^a   Lister, R ^a   Fan, C ^a   Middlebrook, A ^a   Taylor, C ^a   Su, T ^a  

^a PFIZER INC   (United States)

Author keywords

Brain; CLin; CLout; Microdialysis; PK PD link model; Pregabalin

Indexed keywords

4 AMINOBUTYRIC ACID; PREGABALIN;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANXIETY; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CORRELATION FUNCTION; DRUG BRAIN LEVEL; DRUG PENETRATION; EXTRACELLULAR FLUID; HYSTERESIS; MICRODIALYSIS; NONHUMAN; RAT;

EID: 0034878887     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190385     Document Type: Article

References (8)

1. Transport of Gabapentin, ag-amino acid drug, by system L a-amino acid transporters: A comparative study in astrocytes, synaptosomes, and CHO cells
2. The simultaneous estimation of influx and efflux blood-brain barrier permeability of gabapentin using a microdialysis-pharmacokinetic approach
3. Microdialysis calibration using retrodialysis and zero-net influx: Application to a study of the distribution of zidovudine in rabbit CSF and thalamus
4. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptide and plasma proteins
5. Gabapentin anticonvulsant action in rats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate
6. Simultaneous modeling of pharmacokinetics and pharmacodynamic: Application to d-tubocurarine
7. A general conceptual model for non-steady state pharmacokinetic/pharmacodynamic data
8. Disposition of gabapentin (Neurotin) in mice, rats, dogs, and monkeys