-
1
-
-
0002052695
-
Discovery and development of antiretroviral therapeutics for HIV infection
-
Edited by Merigan TC, Bartlet JG, Bolognesi D. Baltimore, MD: Williams & Wilkins
-
Mitsuya H, Erickson J. Discovery and development of antiretroviral therapeutics for HIV infection. In Textbook of AIDS Medicine, 2nd edn. Edited by Merigan TC, Bartlet JG, Bolognesi D. Baltimore, MD: Williams & Wilkins; 1999:751-780.
-
(1999)
Textbook of AIDS Medicine, 2nd Edn.
, pp. 751-780
-
-
Mitsuya, H.1
Erickson, J.2
-
2
-
-
0004674209
-
Outcome and predictors of failure of highly active antiretroviral therapy: One-year follow-up of a cohort of human immunodeficiency virus type 1-infected persons
-
Wit FW, van Leeuwen R, Weverling GJ, Jurriaans S, Nauta K, Steingrover R, et al. Outcome and predictors of failure of highly active antiretroviral therapy: one-year follow-up of a cohort of human immunodeficiency virus type 1-infected persons. J Infect Dis 1999, 179:790-798.
-
(1999)
J Infect Dis
, vol.179
, pp. 790-798
-
-
Wit, F.W.1
Van Leeuwen, R.2
Weverling, G.J.3
Jurriaans, S.4
Nauta, K.5
Steingrover, R.6
-
3
-
-
0033995189
-
Factors associated with clinical and virological failure in patients receiving a triple therapy including a protease inhibitor
-
Grabar S, Pradier C, Le Corfec E, Lancar R, Allavena C, Bentata M, et al. Factors associated with clinical and virological failure in patients receiving a triple therapy including a protease inhibitor. AIDS 2000, 14:141-149.
-
(2000)
AIDS
, vol.14
, pp. 141-149
-
-
Grabar, S.1
Pradier, C.2
Le Corfec, E.3
Lancar, R.4
Allavena, C.5
Bentata, M.6
-
4
-
-
0033576816
-
Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults
-
Staszewski S, Morales-Ramirez J, Tashima KT, Rachlis A, Skiest D, Stanford J, et al. Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. N Engl J Med 1999, 341:1865-1873.
-
(1999)
N Engl J Med
, vol.341
, pp. 1865-1873
-
-
Staszewski, S.1
Morales-Ramirez, J.2
Tashima, K.T.3
Rachlis, A.4
Skiest, D.5
Stanford, J.6
-
5
-
-
0032562985
-
Public health implications of antiretroviral therapy and HIV drug resistance
-
Wainberg MA, Friedland G. Public health implications of antiretroviral therapy and HIV drug resistance. JAMA 1998, 279:1977-1983.
-
(1998)
JAMA
, vol.279
, pp. 1977-1983
-
-
Wainberg, M.A.1
Friedland, G.2
-
6
-
-
0027398296
-
Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: An in vitro comparative study
-
Shirasaka T, Yarchoan R, O'Brien MC, Husson RN, Anderson BD, Kojima E, et al. Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study. Proc Natl Acad Sci USA 1993, 90:562-566.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 562-566
-
-
Shirasaka, T.1
Yarchoan, R.2
O'Brien, M.C.3
Husson, R.N.4
Anderson, B.D.5
Kojima, E.6
-
7
-
-
0028273314
-
Combination therapy with zidovudine and didanosine selects for drug- resistant human immunodeficiency virus type I strains with unique patterns of pol gene mutations
-
Shafer RW, Kozal MJ, Winters MA, Iversen AK, Katzenstein DA, Ragni MV, et al. Combination therapy with zidovudine and didanosine selects for drug- resistant human immunodeficiency virus type I strains with unique patterns of pol gene mutations. J Infect Dis 1994, 169:722-729.
-
(1994)
J Infect Dis
, vol.169
, pp. 722-729
-
-
Shafer, R.W.1
Kozal, M.J.2
Winters, M.A.3
Iversen, A.K.4
Katzenstein, D.A.5
Ragni, M.V.6
-
8
-
-
0032533207
-
A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors
-
Winters MA, Coolley KL, Girard YA, Levee DJ, Hamdan H, Shafer RW, et al. A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors. J Clin Invest 1998, 102:1769-1775.
-
(1998)
J Clin Invest
, vol.102
, pp. 1769-1775
-
-
Winters, M.A.1
Coolley, K.L.2
Girard, Y.A.3
Levee, D.J.4
Hamdan, H.5
Shafer, R.W.6
-
9
-
-
0036149707
-
Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection
-
Brenner BG, Routy JP. Petrella M, Moisi D, Oliveira M, Detorio M, et al. Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection. J Virol 2002, 76:1753-1761.
-
(2002)
J Virol
, vol.76
, pp. 1753-1761
-
-
Brenner, B.G.1
Routy, J.P.2
Petrella, M.3
Moisi, D.4
Oliveira, M.5
Detorio, M.6
-
10
-
-
0028940084
-
Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
-
Shirasaka T, Kavlick MF, Ueno T, Gao WY, Kojima E, Alcaide ML, et al. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc Natl Acad Sci USA 1995, 92:2398-2402.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2398-2402
-
-
Shirasaka, T.1
Kavlick, M.F.2
Ueno, T.3
Gao, W.Y.4
Kojima, E.5
Alcaide, M.L.6
-
11
-
-
19244363136
-
Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain
-
Schmit JC, Cogniaux J, Hermans P, Van Vaeck C, Sprecher S, Van Remoortel B, et al. Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain. J Infect Dis 1996, 174:962-968.
-
(1996)
J Infect Dis
, vol.174
, pp. 962-968
-
-
Schmit, J.C.1
Cogniaux, J.2
Hermans, P.3
Van Vaeck, C.4
Sprecher, S.5
Van Remoortel, B.6
-
12
-
-
0031802175
-
Emergence of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 variants, viral sequence variation, and disease progression in patients receiving antiretroviral chemotherapy
-
Kavlick MF, Wyvill K, Yarchoan R, Mitsuya H. Emergence of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 variants, viral sequence variation, and disease progression in patients receiving antiretroviral chemotherapy. J Infect Dis 1998, 177:1506-1513.
-
(1998)
J Infect Dis
, vol.177
, pp. 1506-1513
-
-
Kavlick, M.F.1
Wyvill, K.2
Yarchoan, R.3
Mitsuya, H.4
-
13
-
-
0030048748
-
Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy
-
Iversen AK, Shafer RW, Wehrly K, Winters MA, Mullins JI, Chesebro B, et al. Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy. J Virol 1996, 70:1086-1090.
-
(1996)
J Virol
, vol.70
, pp. 1086-1090
-
-
Iversen, A.K.1
Shafer, R.W.2
Wehrly, K.3
Winters, M.A.4
Mullins, J.I.5
Chesebro, B.6
-
14
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
-
Huang H, Chopra R, Verdine GL, Harrison SC. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 1998, 282:1669-1675.
-
(1998)
Science
, vol.282
, pp. 1669-1675
-
-
Huang, H.1
Chopra, R.2
Verdine, G.L.3
Harrison, S.C.4
-
15
-
-
0033064963
-
Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an in vitro competitive HIV-1 replication assay
-
Kosalaraksa P, Kavlick MF, Maroun V, Le R, Mitsuya H. Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an in vitro competitive HIV-1 replication assay. J Virol 1999, 73:5356-5363.
-
(1999)
J Virol
, vol.73
, pp. 5356-5363
-
-
Kosalaraksa, P.1
Kavlick, M.F.2
Maroun, V.3
Le, R.4
Mitsuya, H.5
-
16
-
-
0024784519
-
Identification of four conserved motifs among the RNA-dependent polymerase encoding elements
-
Poch O, Sauvaget I, Delarue M, Tordo N. Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO J 1989, 8:3867-3874.
-
(1989)
EMBO J
, vol.8
, pp. 3867-3874
-
-
Poch, O.1
Sauvaget, I.2
Delarue, M.3
Tordo, N.4
-
17
-
-
0031948662
-
Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance
-
Maeda Y, Venzon DJ, Mitsuya H. Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance. J Infect Dis 1998, 177:1207-1213.
-
(1998)
J Infect Dis
, vol.177
, pp. 1207-1213
-
-
Maeda, Y.1
Venzon, D.J.2
Mitsuya, H.3
-
18
-
-
33745158157
-
A simple method of estimating fifty percent endpoints
-
Reed LJ. Muench H. A simple method of estimating fifty percent endpoints. Am J Hyg 1938, 27:493-497.
-
(1938)
Am J Hyg
, vol.27
, pp. 493-497
-
-
Reed, L.J.1
Muench, H.2
-
19
-
-
0031009294
-
In vitro induction of human immunodeficiency virus type I variants resistant to 2′-beta-Fluoro-2′,3′-dideoxyadenosine
-
Tanaka M, Srinivas RV, Ueno T, Kavlick MF, Hui FK, Fridland A, et al. In vitro induction of human immunodeficiency virus type I variants resistant to 2′-beta-Fluoro-2′,3′-dideoxyadenosine. Antimicrob Agents Chemother 1997, 41:1313-1318.
-
(1997)
Antimicrob Agents Chemother
, vol.41
, pp. 1313-1318
-
-
Tanaka, M.1
Srinivas, R.V.2
Ueno, T.3
Kavlick, M.F.4
Hui, F.K.5
Fridland, A.6
-
20
-
-
13044254785
-
JE-2147: A dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1
-
Yoshimura K, Kato R, Yusa K, Kavlick MF, Maroun V, Nguyen A, et al. JE-2147: A dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1. Proc Natl Acad Sci USA 1999, 96:8675-8680.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8675-8680
-
-
Yoshimura, K.1
Kato, R.2
Yusa, K.3
Kavlick, M.F.4
Maroun, V.5
Nguyen, A.6
-
21
-
-
0028784434
-
Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2′,3′-dideoxynucleoside 5′-triphosphates
-
Ueno T, Shirasaka T, Mitsuya H. Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2′,3′-dideoxynucleoside 5′-triphosphates. J Biol Chem 1995, 270;23605-23611.
-
(1995)
J Biol Chem
, vol.270
, pp. 23605-23611
-
-
Ueno, T.1
Shirasaka, T.2
Mitsuya, H.3
-
22
-
-
0344348869
-
Second-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity
-
Olivares I, Sánchez-Merino V, Martínez MA, Domingo E, López-Galíndez C, Menéndez-Arias L. Second-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity. J Virol 1999, 73:6293-6298.
-
(1999)
J Virol
, vol.73
, pp. 6293-6298
-
-
Olivares, I.1
Sánchez-Merino, V.2
Martínez, M.A.3
Domingo, E.4
López-Galíndez, C.5
Menéndez-Arias, L.6
-
23
-
-
0024310253
-
Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
-
Larder BA, Kemp SD. Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 1989, 246:1155-1158.
-
(1989)
Science
, vol.246
, pp. 1155-1158
-
-
Larder, B.A.1
Kemp, S.D.2
-
24
-
-
0026465275
-
Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine
-
Gu Z, Gao Q, Li X, Parniak MA, Wainberg MA. Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine. J Virol 1992, 66:7128-7135.
-
(1992)
J Virol
, vol.66
, pp. 7128-7135
-
-
Gu, Z.1
Gao, Q.2
Li, X.3
Parniak, M.A.4
Wainberg, M.A.5
-
25
-
-
0026565278
-
Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine
-
Kellam P, Boucher CA, Larder BA. Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine. Proc Natl Acad Sci USA 1992, 89:1934-1938.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 1934-1938
-
-
Kellam, P.1
Boucher, C.A.2
Larder, B.A.3
-
26
-
-
0029024089
-
Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC)
-
Schuurman R, Nijhuis M, van Leeuwen R, Schipper P, de Jong D, Collis P, et al. Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC). J Infect Dis 1995, 171:1411-1419.
-
(1995)
J Infect Dis
, vol.171
, pp. 1411-1419
-
-
Schuurman, R.1
Nijhuis, M.2
Van Leeuwen, R.3
Schipper, P.4
De Jong, D.5
Collis, P.6
-
27
-
-
0028341306
-
Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not
-
Boyer PL, Tantillo C, Jacobo-Molina A, Nanni RG, Ding J, Arnold E, et al. Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not. Proc Natl Acad Sci USA 1994, 91:4882-4886.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 4882-4886
-
-
Boyer, P.L.1
Tantillo, C.2
Jacobo-Molina, A.3
Nanni, R.G.4
Ding, J.5
Arnold, E.6
-
28
-
-
0029038744
-
Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase
-
Sarafianos SG, Pandey VN, Kaushik N, Modak MJ. Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase. Biochemistry 1995, 34:7207-7216.
-
(1995)
Biochemistry
, vol.34
, pp. 7207-7216
-
-
Sarafianos, S.G.1
Pandey, V.N.2
Kaushik, N.3
Modak, M.J.4
-
29
-
-
0030664549
-
Role of glutamine-151 of human immunodeficiency virus type-1 reverse transcriptase in RNA-directed DNA synthesis
-
Kaushik N, Harris D, Rege N, Modak MJ, Yadav PN, Pandey VN. Role of glutamine-151 of human immunodeficiency virus type-1 reverse transcriptase in RNA-directed DNA synthesis. Biochemistry 1997, 36:14430-14438.
-
(1997)
Biochemistry
, vol.36
, pp. 14430-14438
-
-
Kaushik, N.1
Harris, D.2
Rege, N.3
Modak, M.J.4
Yadav, P.N.5
Pandey, V.N.6
-
30
-
-
0034696648
-
Role of glutamine 151 of human immunodeficiency virus type-1 reverse transcriptase in substrate selection as assessed by site-directed mutagenesis
-
Kaushik N, Talele TT, Pandey PK, Harris D, Yadav PN, Pandey VN. Role of glutamine 151 of human immunodeficiency virus type-1 reverse transcriptase in substrate selection as assessed by site-directed mutagenesis. Biochemistry 2000, 39:2912-2920.
-
(2000)
Biochemistry
, vol.39
, pp. 2912-2920
-
-
Kaushik, N.1
Talele, T.T.2
Pandey, P.K.3
Harris, D.4
Yadav, P.N.5
Pandey, V.N.6
-
31
-
-
0031046557
-
Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2′,3′-dideoxynucleotide analogs using the single-nucleotide incorporation assay
-
Ueno T, Mitsuya H. Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2′,3′-dideoxynucleotide analogs using the single-nucleotide incorporation assay. Biochemistry 1997, 36:1092-1099.
-
(1997)
Biochemistry
, vol.36
, pp. 1092-1099
-
-
Ueno, T.1
Mitsuya, H.2
-
32
-
-
0033133780
-
Touching the heart of HIV-1 drug resistance: The fingers close down on the dNTP at the polymerase active site
-
Sarafianos SG, Das K, Ding J, Boyer PL, Hughes SH, Arnold E. Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site. Chem Biol 1999, 6:R137-R146.
-
(1999)
Chem Biol
, vol.6
-
-
Sarafianos, S.G.1
Das, K.2
Ding, J.3
Boyer, P.L.4
Hughes, S.H.5
Arnold, E.6
-
33
-
-
0034521513
-
Loss of antiretroviral drug susceptibility at low viral load during early virological failure in treatment-experienced patients
-
Parkina NT, Deeksb SG, Wrina MT, Yapa J, Grantc RM, Leeb KH, et al. Loss of antiretroviral drug susceptibility at low viral load during early virological failure in treatment-experienced patients. AIDS 2000, 14:2877-2887.
-
(2000)
AIDS
, vol.14
, pp. 2877-2887
-
-
Parkina, N.T.1
Deeksb, S.G.2
Wrina, M.T.3
Yapa, J.4
Grantc, R.M.5
Leeb, K.H.6
-
34
-
-
0030768138
-
Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation
-
Sharma PL, Crumpacker CS. Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation. J Virol 1997, 71:8846-8851.
-
(1997)
J Virol
, vol.71
, pp. 8846-8851
-
-
Sharma, P.L.1
Crumpacker, C.S.2
-
35
-
-
0035970694
-
Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype
-
Van Laethem K, Witvrouw M, Pannecouque C, Van Remoortel B, Schmit JC, Esnouf R, et al. Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype. AIDS 2001, 15:553-561.
-
(2001)
AIDS
, vol.15
, pp. 553-561
-
-
Van Laethem, K.1
Witvrouw, M.2
Pannecouque, C.3
Van Remoortel, B.4
Schmit, J.C.5
Esnouf, R.6
-
36
-
-
7844241226
-
Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries
-
Schmit JC, Van Laethem K, Ruiz L, Hermans P, Sprecher S, Sonnerborg A, et al. Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries. AIDS 1998, 12:2007-2015.
-
(1998)
AIDS
, vol.12
, pp. 2007-2015
-
-
Schmit, J.C.1
Van Laethem, K.2
Ruiz, L.3
Hermans, P.4
Sprecher, S.5
Sonnerborg, A.6
-
37
-
-
0033819048
-
Evidence of a role for the Q151L mutation and the viral background in development of multiple dideoxynucleoside-resistant human immunodeficiency virus type 1
-
Garcia-Lerma JG, Gerrish PJ, Wright AC, Qari SH, Heneine W. Evidence of a role for the Q151L mutation and the viral background in development of multiple dideoxynucleoside-resistant human immunodeficiency virus type 1. J Virol 2000, 74:9339-9346.
-
(2000)
J Virol
, vol.74
, pp. 9339-9346
-
-
Garcia-Lerma, J.G.1
Gerrish, P.J.2
Wright, A.C.3
Qari, S.H.4
Heneine, W.5
|