CD40, but Not CD40L, Is Required for the Optimal Priming of T Cells and Control of Aerosol M. tuberculosis Infection

Immunity

Volumn 19, Issue 6, 2003, Pages 823-835

  Lazarevic, Vanja ^a   Myers, Amy J ^a   Scanga, Charles A ^b   Flynn, JoAnne L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; GAMMA INTERFERON; HEAT SHOCK PROTEIN 70; INTERLEUKIN 12; LIGAND; RECOMBINANT PROTEIN;

AEROSOL; AIRBORNE INFECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE COURSE; EXPERIMENTAL INFECTION; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; INFECTION CONTROL; INFECTION RESISTANCE; KNOCKOUT MOUSE; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; STRAIN DIFFERENCE; T LYMPHOCYTE; TUBERCULOSIS; WILD TYPE;

EID: 0346849665     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(03)00324-8     Document Type: Article

References (32)

1. Bluestone J.A. New perspectives of CD28-B7-mediated T cell costimulation. Immunity. 2:1995;555-559.
2. Bodnar K.A., Serbina N.V., Flynn J.L. Fate of Mycobacterium tuberculosis within murine dendritic cells. Infect. Immun. 69:2001;800-809.
3. Borrow P., Tishon A., Lee S., Xu J., Grewal I.S., Oldstone M.B., Flavell R.A. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response. J. Exp. Med. 183:1996;2129-2142.
4. Campbell K.A., Ovendale P.J., Kennedy M.K., Fanslow W.C., Reed S.G., Maliszewski C.R. CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity. 4:1996;283-289.
5. Campos-Neto A., Ovendale P., Bement T., Koppi T.A., Fanslow W.C., Rossi M.A., Alderson M.R. CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis. J. Immunol. 160:1998;2037-2041.
6. Caruso A.M., Serbina N., Klein E., Triebold K., Bloom B.R., Flynn J.L. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis. J. Immunol. 162:1999;5407-5416.
7. Cella M., Scheidegger D., Palmer-Lehmann K., Lane P., Lanzavecchia A., Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity. T-T help via APC activation J. Exp. Med. 184:1996;747-752.
8. Chalupny N.J., Peach R., Hollenbaugh D., Ledbetter J.A., Farr A.G., Aruffo A. T-cell activation molecule 4-1BB binds to extracellular matrix proteins. Proc. Natl. Acad. Sci. USA. 89:1992;10360-10364.
9. Chan J., Xing Y., Magliozzo R.S., Bloom B.R. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J. Exp. Med. 175:1992;1111-1122.
10. Chaussabel D., Jacobs F., de Jonge J., de Veerman M., Carlier Y., Thielemans K., Goldman M., Vray B. CD40 ligation prevents Trypanosoma cruzi infection through interleukin-12 upregulation. Infect. Immun. 67:1999;1929-1934.
11. Giulietti A., Overbergh L., Valckx D., Decallonne B., Bouillon R., Mathieu C. An overview of real-time quantitative PCR. applications to quantify cytokine gene expression Methods. 25:2001;386-401.
12. Gonzalez-Juarrero M., Orme I.M. Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis. Infect. Immun. 69:2001;1127-1133.
13. Grewal I.S., Foellmer H.G., Grewal K.D., Xu J., Hardardottir F., Baron J.L., Janeway C.A. Jr., Flavell R.A. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science. 273:1996;1864-1867.
14. Grewal I.S., Borrow P., Pamer E.G., Oldstone M.B., Flavell R.A. The CD40-CD154 system in anti-infective host defense. Curr. Opin. Immunol. 9:1997;491-497.
15. Henderson R.A., Watkins S.C., Flynn J.L. Activation of human dendritic cells following infection with Mycobacterium tuberculosis. J. Immunol. 159:1997;635-643.
16. Kamanaka M., Yu P., Yasui T., Yoshida K., Kawabe T., Horii T., Kishimoto T., Kikutani H. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity. 4:1996;275-281.
17. Kundig T.M., Shahinian A., Kawai K., Mittrucker H.W., Sebzda E., Bachmann M.F., Mak T.W., Ohashi P.S. Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity. 5:1996;41-52.
18. Liu W., Saint D.A. A new quantitative method of real time reverse transcription polymerase chain reaction assay based on simulation of polymerase chain reaction kinetics. Anal. Biochem. 302:2002;52-59.
19. Mackey M.F., Barth R.J. Jr., Noelle R.J. The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells. J. Leukoc. Biol. 63:1998;418-428.
20. MacMicking J.D., North R.J., LaCourse R., Mudgett J.S., Shah S.K., Nathan C.F. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Natl. Acad. Sci. USA. 94:1997;5243-5248.
21. Mogues T., Goodrich M.E., Ryan L., LaCourse R., North R.J. The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice. J. Exp. Med. 193:2001;271-280.
22. Ridge J.P., Di Rosa F., Matzinger P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature. 393:1998;474-478.
23. Saunders B., Frank A., Orme I., Cooper A. CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis. Cell. Immunol. 216:2002;65-72.
24. Scanga C.A., Mohan V.P., Yu K., Joseph H., Tanaka K., Chan J., Flynn J.L. Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2. J. Exp. Med. 192:2000;347-358.
25. Serbina N.V., Liu C.C., Scanga C.A., Flynn J.L. CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages. J. Immunol. 165:2000;353-363.
26. Serbina N.V., Lazarevic V., Flynn J.L. CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection. J. Immunol. 167:2001;6991-7000.
27. Soong L., Xu J.C., Grewal I.S., Kima P., Sun J., Longley B.J. Jr., Ruddle N.H., McMahon-Pratt D., Flavell R.A. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity. 4:1996;263-273.
28. Thomsen A.R., Nansen A., Christensen J.P., Andreasen S.O., Marker O. CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus. J. Immunol. 161:1998;4583-4590.
29. Van Kooten C., Banchereau J. CD40-CD40 ligand. a multifunctional receptor-ligand pair Adv. Immunol. 61:1996;1-77.
30. Wang Y., Kelly C.G., Karttunen J.T., Whittall T., Lehner P.J., Duncan L., MacAry P., Younson J.S., Singh M., Oehlmann W.et al. CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines. Immunity. 15:2001;971-983.
31. Wang Y., Kelly C.G., Singh M., McGowan E.G., Carrara A.S., Bergmeier L.A., Lehner T. Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells, and adjuvant function by the peptide binding fragment of heat shock protein 70. J. Immunol. 169:2002;2422-2429.
32. Whitmire J.K., Slifka M.K., Grewal I.S., Flavell R.A., Ahmed R. CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection. J. Virol. 70:1996;8375-8381.