Roles of the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in receptor-mediated apoptosis of WEHI 231 B lymphoma cells

Journal of Experimental Medicine

Volumn 187, Issue 10, 1998, Pages 1671-1679

  Wu, Min ^a   Bellas, Robert E ^a   Shen, Jian ^a   Sonenshein, Gail E ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; CD40 ligand; p21(WAF1 CIP1); p53 tumor suppressor; WEHI 231 B lymphocytes

Indexed keywords

CD40 ANTIGEN; IMMUNOGLOBULIN M; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DEATH; IMMUNOLOGICAL TOLERANCE; LYMPHOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION;

APOPTOSIS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; GENE EXPRESSION REGULATION; GENES, P53; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOGLOBULIN M; LYMPHOMA, B-CELL; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032543214     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.10.1671     Document Type: Article

References (52)

1. Boyd, A.W, and J.W. Schrader. 1981. The regulation of growth and differentiation of a murine B-cell lymphoma. II. The inhibition of WEHI 231 by anti-immunoglobulin antibodies. J. Immunol. 126:2466-2469.
2. Monroe, J.G., and V.L. Seyfert. 1988. Studies of surface immunoglobulin-dependent B cell activation. Immunol. Res. 7:136-151.
3. Ralph, P. 1979. Functional subsets of murine and human B lymphocyte cell lines. Immunol. Rev. 48:107-121.
4. McCormack, J.E., V.H. Pepe, R.B. Kent, M. Dean, A. Marshak-Rothstein, and G.E. Sonenshein. 1984. Specific regulation of c-myc oncogene expression in a murine B-cell lymphoma. Proc. Natl. Acad. Sci. USA. 811:5546-5550.
5. Benhamou, L.E., P.-A. Cazenave, and F. Sarthou. 1990. Anti-immunoglobulins induce death by apoptosis in WEHI 231 B lymphoma cells. Eur. J. Immunol. 20:1405-1407.
6. Hasbold, J., and G.G. Klaus. 1990. Anti-immunoglobulin antibodies induce apoptosis in immature B cell lymphomas. Eur. J. Immunol. 20:1685-1690.
7. Warner, G.L., J.W. Ludlow, D.O. Nelson, A. Gaur, and D. Scott. 1992. Anti-immunoglobulin treatment of B cell lymphomas induces active transforming growth factor beta but pRB hypophosphorylation is transforming growth factor beta independent. Cell Growth Differ. 3:175-181.
8. Maheswaran, S., J.E. McCormack, and G.E. Sonenshein. 1993. Changes in phosphorylation of myc oncogene and RB antioncogene protein products during growth arrest of the murine lymphoma WEHI 231 cell line. Oncogene. 6:1965-1971.
9. Lee, H., M. Arsura, M. Wu, M. Duyao, A.J. Buckler, and G.E. Sonenshein. 1995. Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cells WEHI 231 line. J. Exp. Med. 181:1169-1177.
10. Wu, M., H. Lee, R.E. Bellas, L.S. Schauer, M. Arsura, D. Katz, M.J. FitzGerald, T.L. Rothstein, D.H. Sherr, and G.E. Sonenshein. 1996. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO (Eur. Mol. Biol. Organ.) J. 15:4682-4690.
11. Wu, M., M. Arsura, R.E. Bellas, M.J. FitzGerald, H. Lee, S.L. Schauer, D.H. Sherr, and G.E. Sonenshein. 1996. Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells. Mol. Cell. Biol. 16:5015-5025.
12. Sonenshein, G.E. 1997. Down-modulation of c-Myc expression induces apoptosis of B lymphocyte models of tolerance via clonal deletion. J. Immunol. 178:1994-1997.
13. Lane, D.P., and L.V. Crawford. 1979. T antigen is bound to a host protein in SV40 transformed cells. Nature. 278:261-263.
14. Linzer, D.P., and A.J. Levine. 1979. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell. 17:43-52.
15. Vogelstein, B., and K.W. Kinzler. 1992. p53 function and dysfunction. Cell. 70:523-526.
16. Harris, C.C., and M. Hollstein. 1993. Medical progress: clinical implications of the p53 tumor-suppressor gene. N. Engl. J. Med. 329:1318-1327.
17. Carson, D.A., and A. Lois. 1995. Cancer progression and p53. Lancet. 346:1009-1011.
18. Meikrantz, W., and R. Schlegel. 1995. Apoptosis and cell cycle. J. Cell. Biochem. 58:160-174.
19. Clarke, A.R., C.A. Purdie, D.J. Harrison, R.G. Morris, C.C. Bird, M.L. Hooper, and A.H. Wyllie. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:849-852.
20. Clarke, A.R., S. Gledhill, M.L. Hooper, C.C. Bird, and A.H. Wyllie. 1994. p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene. 9:1767-1773.
21. Hermeking, H., and D. Eick. 1994. Mediation of c-Myc induced apoptosis of by p53. Science. 265:2091-2093.
22. Shick, L., J.A. Carman, J.K. Choi, K. Somasundaram, M. Burrell, D.E. Hill, Y.X. Zeng, Y. Wang, K.G. Wiman, K. Salhany, et al. 1997. Decreased immunoglobulin deposition in tumor and increased immature B cells in p53-null mice. Cell Growth Differ. 8:121-131.
23. 1 cyclin-dependent kinase. Cell. 75:805-816.
24. Xiong, Y., H. Zhang, and D. Beach. 1993. Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev. 7:1572-1583.
25. Zhang, H., Y. Xiong, and D. Beach. 1993. Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complex. Mol. Cell. Biol. 4:897-906.
26. Waga, S., G.J. Hannon, D. Beach, and B. Stillman. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature. 369:574-578.
27. 1 cyclin-dependent kinases. Genes Dev. 9:1149-1163.
28. El-Deiry, W.S., T. Tokino, V.E. Velculesu, D.B. Levy, R. Parsons, J.M. Trent, D. Lin, W.E. Mercer, K.W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:817-825.
29. 1 arrest. Cell. 76:1013-1023.
30. WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines. Oncogene. 11:1899-1905.
31. Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells. Cell Growth Differ. 7:1599-1607.
32. Chresta, C.M., J.R. Masters, and J.A. Hickman. 1996. Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax: Bcl-2 ratio. Cancer Res. 56:1834-1841.
33. Schauer, S.L., Z. Wang, G.E. Sonenshein, and T.L. Rothstein. 1996. Maintenance of NF-κB/Rel and c-myc expression during CD4 ligand rescue of WEHI 231 cells from receptor-mediated apoptosis through modulation of IκB proteins. J. Immunol. 157:81-86.
34. Smith, C.A., G.T. Williams, R. Kingston, E.J. Jenkinson, and J.J. Owen. 1989. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature. 337:181-184.
35. Finlay, C.A., P.W. Hinds, T.H. Tan, D. Eliyahu, M. Oren, and A.J. Levine. 1988. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol. Cell. Biol. 8:531-539.
36. Michalovitz, D., O. Halevy, and M. Oren. 1990. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell. 62:671-680.
37. Martinez, J., I. Georgoff, J. Martinez, and A.J. Levine. 1991. Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev. 5:151-159.
38. Hann, S.R., M. Dixit, R.C. Sears, and L. Sealy. 1994. The alternatively initiated c-Myc proteins differentially regulate transcription through a non-canonical DNA-binding site. Genes Dev. 8:2441-2452.
39. Feinberg, A.P., and U. Vogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6-13.
40. Arsura, M., M. Wu, and G.E. Sonenshein. 1996. TGF-β1 inhibits NF-κB/Rel activity inducing apoptosis of B cells: transcriptional activation of IκBα. Immunity. 5:31-40.
41. Tsubata, T., J. Wu, and T. Honjo. 1993. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40. Nature. 364:645-648.
42. 1 growth arrest of murine B cell lymphomas. Mol. Biol. Cell. 7:553-564.
43. Newcomb, E.W. 1995. p53 gene mutations in lymphoid diseases and their possible relevance to drug resistance. Leuk. Lymphoma. 17:211-221.
44. Ichikawa, A., T. Hotta, and H. Saito. 1993. Mutations of the p53 gene in B-cell lymphoma. Leuk. Lymphoma. 11:21-25.
45. Lens, D., P.J. De Schouwer, R.A. Hamoudi, M. Abdul-Rauf, N. Farahat, E. Matutes, T. Crook, M.J. Dyer, and D. Catovsky. 1997. p53 abnormalities in B-cell prolymphocytic leukemia. Blood. 89:2015-2023.
46. Norvell, A., L. Mandik, and J.G. Monroe. 1995. Engagement of the antigen receptor on immature murine B lymphocytes results in death by apoptosis. J. Immunol. 154:4403-4413.
47. Shaulsky, G., A. Goldfinger, A. Peled, and V. Rotter. 1991. Involvement of wild type p53 in pre-B-cells differentiation in vitro. Proc. Natl. Acad. Sci. USA. 88:8982-8986.
48. Aloni-Grinstein, R., I. Zan-Bar, I. Alboum, N. Goldfinger, and V. Rotter. 1993. Wild-type p53 functions as a control protein in the differentiation pathway of the B cell-lineage. Oncogene. 8:3297-3305.
49. Wu, M., W. Yang, R.E. Bellas, M. Arsura, L.S. Schauer, D. Katz, M.J. FitzGerald, H.Y. Lee, and G.E. Sonenshein. 1997. c-Myc promotes survival of WEHI 231 B lymphoma cells from apoptosis. Curr. Top. Microbiol. Immunol. 224:91-101.
50. Reisman, D., N.B. Elkind, B. Roy, J. Beamon, and V. Rotter. 1993. c-myc transactivates the p53 promoter through a required downstream CACGTG motif. Cell Growth Differ. 4:57-65.
51. Roy, B., J. Beamon, E. Balint, and D. Reisman. 1994. Transactivation of the human p53 tumor suppressor gene by c-Myc/ Max contributes to elevated mutant p53 expression in some tumors. Mol. Cell. Biol. 14:7805-7815.
52. Moberg, K.H., W.A. Tyndall, and D.J. Hall. 1992. Wild-type murine p53 represses transcription from the murine c-myc promoter in a human glial cell line. J. Cell. Biochem. 49:208-215.