Phosphatidylinositol 3-kinase affects mitochondrial function in part through inducing peroxisome proliferator-activated receptor γ coactivator-1β expression

British Journal of Pharmacology

Volumn 162, Issue 4, 2011, Pages 1000-1008

  Gao, Minghui ^a   Wang, Junjian ^b   Wang, Wenxian ^c   Liu, Jinsong ^a   Wong, Chi Wai ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

mitochondrial function; PGC 1 ; PI3K; ROS

Indexed keywords

2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTIOXIDANT; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GROWTH INHIBITION; HOMEOSTASIS; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ANTIOXIDANTS; CARRIER PROTEINS; CELL LINE, TUMOR; ENZYME INHIBITORS; G1 PHASE; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HEAT-SHOCK PROTEINS; HUMANS; ION CHANNELS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NUCLEAR RESPIRATORY FACTOR 1; PHOSPHATIDYLINOSITOL 3-KINASE; PROMOTER REGIONS, GENETIC; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; RNA, SMALL INTERFERING; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS;

EID: 79251499726     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01105.x     Document Type: Article

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