Statins enhance peroxisome proliferator-activated receptor γ coactivator-1α activity to regulate energy metabolism

Journal of Molecular Medicine

Volumn 88, Issue 3, 2010, Pages 309-317

  Wang, Wenxian ^a   Wong, Chi Wai ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

Author keywords

oxidation; Glycolysis; PGC 1 ; Statins

Indexed keywords

ACYL COENZYME A OXIDASE; CARNITINE PALMITOYLTRANSFERASE I; CARNITINE PALMITOYLTRANSFERASE IA; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; PYRUVATE DEHYDROGENASE KINASE 4; UNCLASSIFIED DRUG; XUEZHIKANG;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENERGY METABOLISM; ENZYME ACTIVITY; GENE EXPRESSION; GENE REPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOLIPEMIA; METABOLIC REGULATION; PROTEIN EXPRESSION;

ANIMALS; CELLS, CULTURED; ENERGY METABOLISM; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; PPAR ALPHA; PPAR GAMMA; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION;

EID: 77951252664     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0561-1     Document Type: Article

References (36)

1. GA Francis E Fayard F Picard J Auwerx 2003 Nuclear receptors and the control of metabolism Annu Rev Physiol 65 261 311 10.1146/annurev.physiol.65. 092101.142528 1:CAS:528:DC%2BD3sXjt1Glt7Y%3D 12518001 (Pubitemid 38249155)
2. V Giguere 1999 Orphan nuclear receptors: from gene to function Endocr Rev 20 689 725 10.1210/er.20.5.689 1:CAS:528:DyaK1MXmvFalsLs%3D 10529899 (Pubitemid 30654814)
3. DH van Raalte M Li PH Pritchard KM Wasan 2004 Peroxisome proliferator-activated receptor (PPAR)-α: a pharmacological target with a promising future Pharm Res 21 1531 1538 10.1023/B:PHAM.0000041444.06122.8d 15497675 (Pubitemid 41184380)
4. BN Finck DP Kelly 2006 PGC-1 coactivators: inducible regulators of energy metabolism in health and disease J Clin Invest 116 615 622 10.1172/JCI27794 1:CAS:528:DC%2BD28XitlGkt7s%3D 16511594 (Pubitemid 43326866)
5. JJ Lehman PM Barger A Kovacs JE Saffitz DM Medeiros DP Kelly 2000 Peroxisome proliferator-activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis J Clin Invest 106 847 856 10.1172/JCI10268 1:CAS:528:DC%2BD3cXntVyiu7g%3D 11018072
6. VK Mootha C Handschin D Arlow X Xie J St. Pierre S Sihag W Yang D Altshuler P Puigserver N Patterson PJ Willy IG Schulman RA Heyman ES Lander BM Spiegelman 2004 Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle Proc Natl Acad Sci U S A 101 6570 6575 10.1073/pnas.0401401101 1:CAS:528: DC%2BD2cXjvVyiuro%3D 15100410 (Pubitemid 38586015)
7. RB Vega JM Huss DP Kelly 2000 The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes Mol Cell Biol 20 1868 1876 10.1128/MCB.20.5.1868-1876.2000 1:CAS:528:DC%2BD3cXhtF2ntb8%3D 10669761 (Pubitemid 30100203)
8. JC Yoon P Puigserver G Chen J Donovan Z Wu J Rhee G Adelmant J Stafford CR Kahn DK Granner CB Newgard BM Spiegelman 2001 Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 Nature 413 131 138 10.1038/35093050 1:CAS:528:DC%2BD3MXntVOrtLs%3D 11557972 (Pubitemid 32867868)
9. P Puigserver J Rhee J Lin Z Wu JC Yoon C Zhang S Krauss VK Mootha BB Lowell BM Spiegelman 2001 Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPAR? coactivator-1 Mol Cell 8 971 982 10.1016/S1097-2765(01)00390-2 1:CAS:528:DC%2BD3MXovFOit78%3D 11741533 (Pubitemid 34031800)
10. X Li B Monks Q Ge MJ Birnbaum 2007 Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator Nature 447 1012 1016 10.1038/nature05861 1:CAS:528:DC%2BD2sXms1yqu7c%3D 17554339 (Pubitemid 46975750)
11. B Horard JM Vanacker 2003 Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand J Mol Endocrinol 31 349 357 10.1677/jme.0.0310349 1:CAS:528:DC%2BD2cXjsVCrtw%3D%3D 14664699 (Pubitemid 38054510)
12. V Giguere 2008 Transcriptional control of energy homeostasis by the estrogen-related receptors Endocr Rev 29 677 696 10.1210/er.2008-0017 10.1210/er.2008-0017 1:CAS:528:DC%2BD1cXhtlWrurzI 18664618
13. VK Mootha CM Lindgren K-F Eriksson A Subramanian S Sihag J Lehar P Puigserver E Carlsson M Ridderstrale E Laurila N Houstis MJ Daly N Patterson JP Mesirov TR Golub P Tamayo B Spiegelman ES Lander JN Hirschhorn D Altshuler LC Groop 2003 PGC-1[alpha]-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes Nat Genet 34 267 273 10.1038/ng1180 1:CAS:528:DC%2BD3sXkvFSrs7o%3D 12808457 (Pubitemid 36792858)
14. ME Patti AJ Butte S Crunkhorn K Cusi R Berria S Kashyap Y Miyazaki I Kohane M Costello R Saccone EJ Landaker AB Goldfine E Mun R DeFronzo J Finlayson CR Kahn LJ Mandarino 2003 Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1 Proc Natl Acad Sci U S A 100 8466 8471 10.1073/pnas.1032913100 1:CAS:528:DC%2BD3sXlsFGntbs%3D 12832613 (Pubitemid 36842568)
15. VK Mootha C Handschin D Arlow X Xie J St. Pierre S Sihag W Yang D Altshuler P Puigserver N Patterson PJ Willy IG Schulman RA Heyman ES Lander BM Spiegelman 2004 Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle Proc Natl Acad Sci U S A 101 6570 6575 10.1073/pnas.0401401101 1:CAS:528: DC%2BD2cXjvVyiuro%3D 15100410 (Pubitemid 38586015)
16. C Handschin 2009 The biology of PGC-1α and its therapeutic potential Trends Pharmacol Sci 30 322 329 10.1016/j.tips.2009.03.006 1:CAS:528:DC%2BD1MXntVKmsbo%3D 19446346
17. D Heber I Yip JM Ashley DA Elashoff RM Elashoff VLW Go 1999 Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement Am J Clin Nutr 69 231 236 1:CAS:528:DyaK1MXovVKitQ%3D%3D 9989685 (Pubitemid 29065544)
18. SP Zhao L Liu YC Cheng MH Shishehbor MH Liu DQ Peng YL Li 2004 Xuezhikang, an extract of cholestin, protects endothelial function through antiinflammatory and lipid-lowering mechanisms in patients with coronary heart disease Circulation 110 915 920 10.1161/01.CIR.0000139985.81163.CE 15313947 (Pubitemid 39128616)
19. JC Chang MC Wu IM Liu JT Cheng 2006 Plasma glucose-lowering action of Hon-Chi in streptozotocin-induced diabetic rats Horm Metab Res 38 76 81 10.1055/s-2006-925116 1:CAS:528:DC%2BD28XisFKqsbc%3D 16523406
20. J Ma Y Li Q Ye J Li Y Hua D Ju D Zhang R Cooper M Chang 2000 Constituents of red yeast rice, a traditional Chinese food and medicine J Agric Food Chem 48 5220 5225 10.1021/jf000338c 1:CAS:528:DC%2BD3cXnt1SlsLo%3D 11087463
21. JK Liao U Laufs 2005 Pleiotropic effects of statins Annu Rev Pharmacol Toxicol 45 89 118 10.1146/annurev.pharmtox.45.120403.095748 1:CAS:528: DC%2BD2MXisVWjtrY%3D 15822172 (Pubitemid 40261799)
22. HN Ginsberg 1998 Effects of statins on triglyceride metabolism Am J Cardiol 81 32B 35B 10.1016/S0002-9149(98)00035-6 1:CAS:528:DyaK1cXktVKqsL0%3D 9526811 (Pubitemid 28113943)
23. G Martin H Duez C Blanquart V Berezowski P Poulain JC Fruchart J Najib-Fruchart C Glineur B Staels 2001 Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I J Clin Invest 107 1423 1432 10.1172/JCI10852 1:CAS:528:DC%2BD3MXktFynt7k%3D 11390424 (Pubitemid 32522036)
24. HN Ginsberg 2006 Review: efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia J Clin Endocrinol Metab 91 383 392 10.1210/jc.2005-2084 1:CAS:528:DC%2BD28XhsFKnt7s%3D 16291700 (Pubitemid 43236897)
25. J Wang F Fang Z Huang Y Wang C Wong 2009 Kaempferol is an estrogen-related receptor [alpha] and [gamma] inverse agonist FEBS Lett 583 643 647 10.1016/j.febslet.2009.01.030 1:CAS:528:DC%2BD1MXitFSmu7w%3D 19171140
26. PO Seglen 1976 Preparation of isolated rat liver cells Methods Cell Biol 13 29 83 10.1016/S0091-679X(08)61797-5 1:CAS:528:DyaE28XkslCgtbY%3D 177845
27. W Xu T Koeck AR Lara D Neumann FP DiFilippo M Koo AJ Janocha FA Masri AC Arroliga C Jennings RA Dweik RM Tuder DJ Stuehr SC Erzurum 2007 Alterations of cellular bioenergetics in pulmonary artery endothelial cells Proc Natl Acad Sci 104 1342 1347 10.1073/pnas.0605080104 1:CAS:528:DC%2BD2sXht12hs7o%3D 17227868 (Pubitemid 46184006)
28. L Abu-Elheiga W Oh P Kordari SJ Wakil 2003 Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets Proc Natl Acad Sci USA 100 10207 10212 10.1073/pnas.1733877100 1:CAS:528:DC%2BD3sXntFygtbs%3D 12920182 (Pubitemid 37071857)
29. S Boudina S Sena BT O'Neill P Tathireddy ME Young ED Abel 2005 Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity Circulation 112 2686 2695 10.1161/ CIRCULATIONAHA.105.554360 16246967 (Pubitemid 41532606)
30. P Rodriguez-Viciana PH Warne R Dhand B Vanhaesebroeck I Gout MJ Fry MD Waterfield J Downward 1994 Phosphatidylinositol-3-OH kinase direct target of Ras Nature 370 527 532 10.1038/370527a0 1:CAS:528:DyaK2cXmsV2hs7w%3D 8052307 (Pubitemid 24264918)
31. SM Hyatt EL Lockamy RA Stein DP McDonnell AB Miller LA Orband-Miller TM Willson WJ Zuercher 2007 On the intractability of estrogen-related receptor α as a target for activation by small molecules J Med Chem 50 6722 6724 10.1021/jm7012387 1:CAS:528:DC%2BD2sXhtlynu7jL 18052088 (Pubitemid 350309110)
32. P Puigserver Z Wu CW Park R Graves M Wright BM Spiegelman 1998 A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis Cell 92 829 839 10.1016/S0092-8674(00)81410-5 1:CAS:528:DyaK1cXit1Klsb8%3D 9529258 (Pubitemid 28155321)
33. Y Zhang K Ma P Sadana F Chowdhury S Gaillard F Wang DP McDonnell TG Unterman MB Elam EA Park 2006 Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression J Biol Chem 281 39897 39906 10.1074/jbc.M608657200 1:CAS:528:DC%2BD28XhtlCrtrfN 17079227 (Pubitemid 46041793)
34. JM Huss IP Torra B Staels V Giguere DP Kelly 2004 Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle Mol Cell Biol 24 9079 9091 10.1128/MCB.24.20.9079-9091.2004 1:CAS:528:DC%2BD2cXotl2mur8%3D 15456881 (Pubitemid 39313912)
35. BL Olson MB Hock S Ekholm-Reed JA Wohlschlegel KK Dev A Kralli SI Reed 2008 SCFCdc4 acts antagonistically to the PGC-1α transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis Genes Dev 22 252 264 10.1101/gad.1624208 1:CAS:528:DC%2BD1cXhtFOrs70%3D 18198341
36. M Sano S Tokudome N Shimizu N Yoshikawa C Ogawa K Shirakawa J Endo T Katayama S Yuasa M Ieda S Makino F Hattori H Tanaka K Fukuda 2007 Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferator-activated receptor gamma coactivator 1α J Biol Chem 282 25970 25980 10.1074/jbc.M703634200 1:CAS:528: DC%2BD2sXpsFWktrw%3D 17620342 (Pubitemid 47372787)