메뉴 건너뛰기




Volumn 46, Issue 2-3, 2011, Pages 174-177

Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets

Author keywords

Aging; Calorie restriction; Cyclic nucleotide; Drug development; Mitochondria; P66Shc; Phosphodiesterase; Reactive oxygen species; Sirtuin

Indexed keywords

CYCLIC AMP; PROTEIN INHIBITOR; PROTEIN P66; REACTIVE OXYGEN METABOLITE; SIRTUIN; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; SIRTUIN 6; SIRTUIN 7; SIRTUIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 78751704777     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2010.08.024     Document Type: Article
Times cited : (27)

References (30)
  • 2
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban R.S., Nemoto S., Finkel T. Mitochondria, oxidants, and aging. Cell 2005, 120:483-495.
    • (2005) Cell , vol.120 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 3
    • 34447265905 scopus 로고    scopus 로고
    • Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling
    • Conti M., Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu. Rev. Biochem. 2007, 76:481-511.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 481-511
    • Conti, M.1    Beavo, J.2
  • 4
    • 77953940108 scopus 로고    scopus 로고
    • Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc
    • Gertz M., Fischer F., Leipelt M., Wolters D., Steegborn C. Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc. Aging 2009, 1:254-265.
    • (2009) Aging , vol.1 , pp. 254-265
    • Gertz, M.1    Fischer, F.2    Leipelt, M.3    Wolters, D.4    Steegborn, C.5
  • 5
    • 44449151542 scopus 로고    scopus 로고
    • Activation of the lifespan regulator p66Shc through reversible disulfide bond formation
    • Gertz M., Fischer F., Wolters D., Steegborn C. Activation of the lifespan regulator p66Shc through reversible disulfide bond formation. Proc. Natl Acad. Sci. USA 2008, 105:5705-5709.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 5705-5709
    • Gertz, M.1    Fischer, F.2    Wolters, D.3    Steegborn, C.4
  • 6
    • 77953285831 scopus 로고    scopus 로고
    • Function and regulation of the mitochondrial Sirtuin isoform Sirt5 in Mammalia
    • Gertz M., Steegborn C. Function and regulation of the mitochondrial Sirtuin isoform Sirt5 in Mammalia. Biochim. Biophys. Acta 2010, 1804:1658-1665.
    • (2010) Biochim. Biophys. Acta , vol.1804 , pp. 1658-1665
    • Gertz, M.1    Steegborn, C.2
  • 7
    • 77957086876 scopus 로고    scopus 로고
    • The lifespan-regulator p66Shc in mitochondria - redox enzyme or redox sensor?
    • doi:10.1089/ars.2010.3147
    • Gertz M., Steegborn C. The lifespan-regulator p66Shc in mitochondria - redox enzyme or redox sensor?. Antioxid. Redox Signal. 2010, doi:10.1089/ars.2010.3147.
    • (2010) Antioxid. Redox Signal.
    • Gertz, M.1    Steegborn, C.2
  • 8
    • 13944253348 scopus 로고    scopus 로고
    • Calorie restriction-the SIR2 connection
    • Guarente L., Picard F. Calorie restriction-the SIR2 connection. Cell 2005, 120:473-482.
    • (2005) Cell , vol.120 , pp. 473-482
    • Guarente, L.1    Picard, F.2
  • 9
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
    • Haigis M.C., Guarente L.P. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006, 20:2913-2921.
    • (2006) Genes Dev. , vol.20 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 12
    • 21144437565 scopus 로고    scopus 로고
    • Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development
    • Jeon Y.H., Heo Y.S., Kim C.M., Hyun Y.L., Lee T.G., Ro S., Cho J.M. Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development. Cell. Mol. Life Sci. 2005, 62:1198-1220.
    • (2005) Cell. Mol. Life Sci. , vol.62 , pp. 1198-1220
    • Jeon, Y.H.1    Heo, Y.S.2    Kim, C.M.3    Hyun, Y.L.4    Lee, T.G.5    Ro, S.6    Cho, J.M.7
  • 14
    • 53249121556 scopus 로고    scopus 로고
    • Sirtuins-novel therapeutic targets to treat age-associated diseases
    • Lavu S., Boss O., Elliott P.J., Lambert P.D. Sirtuins-novel therapeutic targets to treat age-associated diseases. Nat. Rev. Drug Discov. 2008, 7:841-853.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 841-853
    • Lavu, S.1    Boss, O.2    Elliott, P.J.3    Lambert, P.D.4
  • 15
    • 39049184073 scopus 로고    scopus 로고
    • Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene
    • Mahlknecht U., Ho A.D., Voelter-Mahlknecht S. Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene. Int. J. Oncol. 2006, 28:447-456.
    • (2006) Int. J. Oncol. , vol.28 , pp. 447-456
    • Mahlknecht, U.1    Ho, A.D.2    Voelter-Mahlknecht, S.3
  • 16
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: insights into their biological function
    • Michan S., Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem. J. 2007, 404:1-13.
    • (2007) Biochem. J. , vol.404 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 17
    • 35048883354 scopus 로고    scopus 로고
    • Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain
    • Middelhaufe S., Garzia L., Ohndorf U.M., Kachholz B., Zollo M., Steegborn C. Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain. Biochem. J. 2007, 407:199-205.
    • (2007) Biochem. J. , vol.407 , pp. 199-205
    • Middelhaufe, S.1    Garzia, L.2    Ohndorf, U.M.3    Kachholz, B.4    Zollo, M.5    Steegborn, C.6
  • 19
    • 65249087389 scopus 로고    scopus 로고
    • SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
    • Nakagawa T., Lomb D.J., Haigis M.C., Guarente L. SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 2009, 137:560-570.
    • (2009) Cell , vol.137 , pp. 560-570
    • Nakagawa, T.1    Lomb, D.J.2    Haigis, M.C.3    Guarente, L.4
  • 20
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto S., Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 2002, 295:2450-2452.
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 21
    • 77149179080 scopus 로고    scopus 로고
    • Cell biology. Rise of the rival
    • Norvell A., McMahon S.B. Cell biology. Rise of the rival. Science 2010, 327:964-965.
    • (2010) Science , vol.327 , pp. 964-965
    • Norvell, A.1    McMahon, S.B.2
  • 25
    • 13944258164 scopus 로고    scopus 로고
    • Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition
    • Sauve A.A., Moir R.D., Schramm V.L., Willis I.M. Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Mol. Cell 2005, 17:595-601.
    • (2005) Mol. Cell , vol.17 , pp. 595-601
    • Sauve, A.A.1    Moir, R.D.2    Schramm, V.L.3    Willis, I.M.4
  • 27
    • 11444256177 scopus 로고    scopus 로고
    • Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment
    • Steegborn C., Litvin T.N., Levin L.R., Buck J., Wu H. Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat. Struct. Mol. Biol. 2005, 12:32-37.
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 32-37
    • Steegborn, C.1    Litvin, T.N.2    Levin, L.R.3    Buck, J.4    Wu, H.5
  • 28
    • 50649122731 scopus 로고    scopus 로고
    • Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells
    • Veeramani S., Yuan T.C., Lin F.F., Lin M.F. Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells. Oncogene 2008, 27:5057-5068.
    • (2008) Oncogene , vol.27 , pp. 5057-5068
    • Veeramani, S.1    Yuan, T.C.2    Lin, F.F.3    Lin, M.F.4
  • 29
    • 68149099553 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial disease as modeled in the mouse
    • Wallace D.C., Fan W. The pathophysiology of mitochondrial disease as modeled in the mouse. Genes Dev. 2009, 23:1714-1736.
    • (2009) Genes Dev. , vol.23 , pp. 1714-1736
    • Wallace, D.C.1    Fan, W.2
  • 30
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: molecular mechanisms of action
    • Xu W.S., Parmigiani R.B., Marks P.A. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 2007, 26:5541-5552.
    • (2007) Oncogene , vol.26 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.