Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain

Biochemical Journal

Volumn 407, Issue 2, 2007, Pages 199-205

  Middelhaufe, Sabine ^a   Garzia, Livia ^b   Ohndorf, Uta Maria ^a   Kachholz, Barbara ^a   Zollo, Massimo ^b,c   Steegborn, Clemens ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b Centro di Ingegneria Genetica e Biotecnologie Avanzate   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Dimerization; Metastasis; Non metastatic protein 23 (NM23 H1); Phosphodiesterase (PDE); Protein protein interaction; Prune

Indexed keywords

NON-METASTATIC PROTEIN 23 (NM23-H1); PHOSPHODIESTERASE (PDE); PROTEIN-PROTEIN INTERACTION; PRUNE;

CATALYSIS; DIMERIZATION; MAMMALS; OLIGOMERS; TUMORS;

PROTEINS;

ASPARTIC ACID; CYCLIC AMP; H PRUNE PROTEIN; HISTIDINE; NUCLEOSIDE DIPHOSPHATE KINASE A; PHOSPHODIESTERASE; PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANALYTIC METHOD; ARTICLE; BREAST CANCER; CANCER MODEL; CARBOXY TERMINAL SEQUENCE; CHEMICAL STRUCTURE; DIMERIZATION; METASTASIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BREAST NEOPLASMS; CARRIER PROTEINS; DIMERIZATION; HUMANS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; PEPTIDE MAPPING; PHOSPHORIC DIESTER HYDROLASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 35048883354     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070408     Document Type: Article

References (25)

1. Florenes, V. A., Aamdal, S., Myklebost, O., Maelandsmo, G. M., Bruland, O. S. and Fodstad, O. (1992) Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression. Cancer Res. 52, 6088-6091
2. Fan, Z., Beresford, P. J., Oh, D. Y., Zhang, D. and Lieberman, J. (2003) Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 112, 659-672
3. Steeg, P. S. (2003) Metastasis suppressors alter the signal transduction of cancer cells. Nat. Rev. Cancer 3, 55-63
4. Radinsky, R., Weisberg, H. Z., Staroselsky, A. N. and Fidler, I. J. (1992) Expression level of the nm23 gene in clonal populations of metastatic murine and human neoplasms. Cancer Res. 52, 5808-5814
5. Hartsough, M. T. and Steeg, P. S. (2000) Nm23/nucleoside diphosphate kinase in human cancers. J. Bioenerg. Biomembr. 32, 301-308
6. Niitsu, N., Okabe-Kado, J., Okamoto, M., Takagi, T., Yoshida, T., Aoki, S., Hirano, M. and Honma, Y. (2001) Serum nm23-H1 protein as a prognostic factor in aggressive non-Hodgkin lymphoma. Blood 97, 1202-1210
7. D'Angelo, A., Garzia, L., Andre, A., Carotenuto, P., Aglio, V., Guardiola, O., Arrigoni, G., Cossu, A., Palmieri, G., Aravind, L. and Zollo, M. (2004) Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis. Cancer Cell 5, 137-149
8. Timmons, L. and Shearn, A. (1996) Germline transformation using a prune cDNA rescues prune/killer of prune lethality and the prune eye color phenotype in Drasophila. Genetics 144, 1589-1600
9. Forus, A., D'Angelo, A., Henriksen, J., Merla, G., Maelandsmo, G. M., Florenes, V. A., Olivieri, S., Bjerkehagen, B., Meza-Zepeda, L. A., del Vecchio Blanco, F. et al. (2001) Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity. Oncogene 20, 6881-6890
10. Reymond, A., Volorio, S., Merla, G., Al-Maghtheh, M., Zuffardi, O., Bulfone, A., Ballabio, A. and Zollo, M. (1999) Evidence for interaction between human PRUNE and nm23-H1 NDPKinase. Oncogene 18, 7244-7252
11. Kobayashi, T., Hino, S., Oue, N., Asahara, T., Zollo, M., Yasui, W. and Kikuchi, A. (2006) Glycogen synthase kinase 3 and h-Prune regulate cell migration by modulating focal adhesions. Mol. Cell Biol. 26, 898-911
12. Aravind, L. and Koonin, E. V. (1998) A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease. Trends Biochem. Sci. 23, 17-19
13. Yamagata, A., Kakuta, Y., Masui, R. and Fukuyama, K. (2002) The crystal structure of exonuclease RecJ bound to Mn2+ ion suggests how its characteristic motifs are involved in exonuclease activity. Proc. Natl. Acad. Sci. U.S.A. 99, 5908-5912
14. Ahn, S., Milner, A. J., Futterer, K., Konopka, M., Ilias, M., Young, T. W. and White, S. A. (2001) The "open" and "closed" structures of the type-C inorganic pyrophosphatases from Bacillus subtilis and Streptococcus gordonii. J. Mol. Biol. 313, 797-811
15. Lupas, A., Van Dyke, M. and Stock, J. (1991) Predicting coiled coils from protein sequences. Science 252, 1162-1164
16. Cuff, J. A., Clamp, M. E., Siddiqui, A. S., Finlay, M. and Barton, G. J. (1998) JPred: a consensus secondary structure prediction server. Bioinformatics 14, 892-893
17. Burkhard, P., Kammerer, R. A., Steinmetz, M. O., Bourenkov, G. P. and Aebi, U. (2000) The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges. Structure 8, 223-230
18. Fabrichniy, I. P., Lehtio, L., Tammenkoski, M., Zyryanov, A. B., Oksanen, E., Baykov, A. A., Lahti, R. and Goldman, A. (2007) A trimetal site and substrate distortion in a family II inorganic pyrophosphatase. J. Biol. Chem. 282, 1422-1431
19. D'Angelo, A. and Zollo, M. (2004) Unraveling genes and pathways influenced by H-Prune PDE overexpression: a model to study cellular motility. Cell Cycle 3, 758-761
20. Schaper, W. (2005) Dipyridamole, an underestimated vascular protective drug. Cardiovasc. Drugs Ther. 19, 357-363
21. Kamenetsky, M., Middelhaufe, S., Bank, E. M., Levin, L. R., Buck, J. and Steegborn, C. (2006) Molecular details of cAMP generation in mammalian cells: a tale of two systems. J. Mol. Biol. 362, 623-639
22. Henrissat, B. (1991) A classification of glycosyl hydrolases based on amino acid sequence similarities. Biochem. J. 280, 309-316
23. Ma, D., McCorkle, J. R. and Kaetzel, D. M. (2004) The metastasis suppressor NM23-H1 possesses 3′-5′ exonuclease activity. J. Biol. Chem. 279, 18073-18084
24. Meima, M. E., Biondi, R. M. and Schaap, P. (2002) Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants. Mol. Biol. Cell 13, 3870-3877
25. Rose, A. and Meier, I. (2004) Scaffolds, levers, rods and springs: diverse cellular functions of long coiled-coil proteins. Cell. Mol. Life Sci. 61, 1996-2009