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Volumn 31, Issue 1, 2011, Pages 15-32

Emerging Role of Relaxin in the Maternal Adaptations to Normal Pregnancy: Implications for Preeclampsia

Author keywords

Angiogenic growth factors; Artery; Decidualization; Endothelin; Matrix metalloproteinases; Nitric oxide; Placenta; Renal circulation; Trophoblast

Indexed keywords

ANGIOGENIC FACTOR; BIG ENDOTHELIN 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN B RECEPTOR; GELATINASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLACENTAL GROWTH FACTOR; PROTEIN KINASE B; RELAXIN; VASCULOTROPIN;

EID: 78751699508     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2010.10.003     Document Type: Article
Times cited : (105)

References (131)
  • 1
    • 0000563125 scopus 로고
    • Relaxin
    • Raven Press, New York, E. Knobil, J.D. Neill, G.S. Greenwald, C.L. Markert, D.W. Pfaff (Eds.)
    • Sherwood O.D. Relaxin. The physiology of reproduction 1994, 861-1008. Raven Press, New York. E. Knobil, J.D. Neill, G.S. Greenwald, C.L. Markert, D.W. Pfaff (Eds.).
    • (1994) The physiology of reproduction , pp. 861-1008
    • Sherwood, O.D.1
  • 4
    • 0003412980 scopus 로고
    • Experimental relaxation of the public ligament of the guinea pig
    • Hisaw F.L. Experimental relaxation of the public ligament of the guinea pig. Proc Exp Biol Med 1926, 23:661-663.
    • (1926) Proc Exp Biol Med , vol.23 , pp. 661-663
    • Hisaw, F.L.1
  • 6
    • 84981822993 scopus 로고
    • The effect of relaxin on the endometrium of monkeys. Histological and histochemical studies
    • Dallenbach-Hellweg G., Dawson A.B., Hisaw F.L. The effect of relaxin on the endometrium of monkeys. Histological and histochemical studies. Am J Anat 1966, 119:61-78.
    • (1966) Am J Anat , vol.119 , pp. 61-78
    • Dallenbach-Hellweg, G.1    Dawson, A.B.2    Hisaw, F.L.3
  • 7
    • 0014114657 scopus 로고
    • Effects of relaxin on the endothelium of endometrial blood vessels in monkeys (Macaca mulatta)
    • Hisaw F.L., Hisaw F.L., Dawson A.B. Effects of relaxin on the endothelium of endometrial blood vessels in monkeys (Macaca mulatta). Endocrinology 1967, 81:375-385.
    • (1967) Endocrinology , vol.81 , pp. 375-385
    • Hisaw, F.L.1    Hisaw, F.L.2    Dawson, A.B.3
  • 8
    • 3242794260 scopus 로고    scopus 로고
    • The emerging role of relaxin in renal and cardiovascular function
    • Conrad K.P., Novak J. The emerging role of relaxin in renal and cardiovascular function. Am J Physiol Regul Integr Comp Physiol 2004, 287:R250-R261.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287
    • Conrad, K.P.1    Novak, J.2
  • 10
    • 0021829026 scopus 로고
    • Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats
    • St-Louis J., Massicotte G. Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats. Life Sci 1985, 37:1351-1357.
    • (1985) Life Sci , vol.37 , pp. 1351-1357
    • St-Louis, J.1    Massicotte, G.2
  • 11
    • 0024550486 scopus 로고
    • Blunted responses to vasoconstrictors in mesenteric vasculature but not in portal vein of spontaneously hypertensive rats treated with relaxin
    • Massicotte G., Parent A., St-Louis J. Blunted responses to vasoconstrictors in mesenteric vasculature but not in portal vein of spontaneously hypertensive rats treated with relaxin. Proc Soc Exp Biol Med 1989, 190:254-259.
    • (1989) Proc Soc Exp Biol Med , vol.190 , pp. 254-259
    • Massicotte, G.1    Parent, A.2    St-Louis, J.3
  • 12
    • 0024423961 scopus 로고
    • Lack of evidence of a vasodepressor role for relaxin in spontaneously hypertensive and normotensive pregnant rats
    • Ahokas R.A., Sabai B.M., Anderson G.D. Lack of evidence of a vasodepressor role for relaxin in spontaneously hypertensive and normotensive pregnant rats. Am J Obstet Gynecol 1989, 161:618-622.
    • (1989) Am J Obstet Gynecol , vol.161 , pp. 618-622
    • Ahokas, R.A.1    Sabai, B.M.2    Anderson, G.D.3
  • 13
    • 0029126464 scopus 로고
    • Relaxin-induced increased coronary flow through stimulation of nitric oxide production
    • Bani-Sacchi T., Bigazzi M., Bani D., Mannaioni P.F., Masini E. Relaxin-induced increased coronary flow through stimulation of nitric oxide production. Br J Pharmacol 1995, 116:1589-1594.
    • (1995) Br J Pharmacol , vol.116 , pp. 1589-1594
    • Bani-Sacchi, T.1    Bigazzi, M.2    Bani, D.3    Mannaioni, P.F.4    Masini, E.5
  • 14
    • 84974602933 scopus 로고    scopus 로고
    • Renal physiology and pathophysiology in pregnancy
    • Lippincott Williams & Wilkins, Philadelphia, R.W. Schrier (Ed.)
    • Jeyabalan A., Conrad K.P. Renal physiology and pathophysiology in pregnancy. Renal and electrolyte disorders 2010, 462-518. Lippincott Williams & Wilkins, Philadelphia. R.W. Schrier (Ed.).
    • (2010) Renal and electrolyte disorders , pp. 462-518
    • Jeyabalan, A.1    Conrad, K.P.2
  • 15
    • 0027051067 scopus 로고
    • Systemic hemodynamics and oxygen transport during pregnancy in chronically instrumented, conscious rats
    • Gilson G.J., Mosher M.D., Conrad K.P. Systemic hemodynamics and oxygen transport during pregnancy in chronically instrumented, conscious rats. Am J Physiol 1992, 263:H1911-H1918.
    • (1992) Am J Physiol , vol.263
    • Gilson, G.J.1    Mosher, M.D.2    Conrad, K.P.3
  • 16
    • 0029933870 scopus 로고    scopus 로고
    • Hemodynamic changes in early pregnancy in chronically instrumented, conscious rats
    • Slangen B.F., Out I.C., Verkeste C.M., Peeters L.L. Hemodynamic changes in early pregnancy in chronically instrumented, conscious rats. Am J Physiol 1996, 270:H1779-H1784.
    • (1996) Am J Physiol , vol.270
    • Slangen, B.F.1    Out, I.C.2    Verkeste, C.M.3    Peeters, L.L.4
  • 18
    • 84961002731 scopus 로고
    • Hemodynamics at rest and during exercise in normal pregnancy as studied by cardiac catheterization
    • Bader N.W., Bader M.E., Rose D.J., Braunwald E. Hemodynamics at rest and during exercise in normal pregnancy as studied by cardiac catheterization. J Clin Invest 1955, 34:1524-1536.
    • (1955) J Clin Invest , vol.34 , pp. 1524-1536
    • Bader, N.W.1    Bader, M.E.2    Rose, D.J.3    Braunwald, E.4
  • 19
    • 16944362287 scopus 로고    scopus 로고
    • Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy
    • Chapman A.B., Zamudio S., Woodmansee W., Merouani A., Osorio F., Johnson A., et al. Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy. Am J Physiol 1997, 273:F777-F782.
    • (1997) Am J Physiol , vol.273
    • Chapman, A.B.1    Zamudio, S.2    Woodmansee, W.3    Merouani, A.4    Osorio, F.5    Johnson, A.6
  • 20
    • 0030985938 scopus 로고    scopus 로고
    • Serial assessment of the cardiovascular system in normal pregnancy. Role of arterial compliance and pulsatile arterial load
    • Poppas A., Shroff S.G., Korcarz C.E., Hibbard J.U., Berger D.S., Lindheimer M.D., et al. Serial assessment of the cardiovascular system in normal pregnancy. Role of arterial compliance and pulsatile arterial load. Circulation 1997, 95:2407-2415.
    • (1997) Circulation , vol.95 , pp. 2407-2415
    • Poppas, A.1    Shroff, S.G.2    Korcarz, C.E.3    Hibbard, J.U.4    Berger, D.S.5    Lindheimer, M.D.6
  • 21
    • 67049100070 scopus 로고    scopus 로고
    • Influence of the menstrual cycle, pregnancy, and preeclampsia on arterial stiffness
    • Robb A.O., Mills N.L., Din J.N., Smith I.B., Paterson F., Newby D.E., et al. Influence of the menstrual cycle, pregnancy, and preeclampsia on arterial stiffness. Hypertension 2009, 53:952-958.
    • (2009) Hypertension , vol.53 , pp. 952-958
    • Robb, A.O.1    Mills, N.L.2    Din, J.N.3    Smith, I.B.4    Paterson, F.5    Newby, D.E.6
  • 22
    • 33751243624 scopus 로고    scopus 로고
    • Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats
    • Debrah D.O., Novak J., Matthews J.E., Ramirez R.J., Shroff S.G., Conrad K.P. Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats. Endocrinology 2006, 147:5126-5131.
    • (2006) Endocrinology , vol.147 , pp. 5126-5131
    • Debrah, D.O.1    Novak, J.2    Matthews, J.E.3    Ramirez, R.J.4    Shroff, S.G.5    Conrad, K.P.6
  • 23
    • 3042685353 scopus 로고    scopus 로고
    • Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats
    • Conrad K.P., Debrah D.O., Novak J., Danielson L.A., Shroff S.G. Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats. Endocrinology 2004, 145:3289-3296.
    • (2004) Endocrinology , vol.145 , pp. 3289-3296
    • Conrad, K.P.1    Debrah, D.O.2    Novak, J.3    Danielson, L.A.4    Shroff, S.G.5
  • 24
    • 84882507059 scopus 로고    scopus 로고
    • The kidney in normal pregnancy and preeclampsia
    • Elsevier (Academic Press), San Diego, M. Lindheimer, J.M. Roberts, F.G. Cunningham (Eds.)
    • Conrad K.P., Gaber L.W., Lindheimer M. The kidney in normal pregnancy and preeclampsia. Chesley's hypertensive disorders in pregnancy 2009, 297-334. Elsevier (Academic Press), San Diego. M. Lindheimer, J.M. Roberts, F.G. Cunningham (Eds.).
    • (2009) Chesley's hypertensive disorders in pregnancy , pp. 297-334
    • Conrad, K.P.1    Gaber, L.W.2    Lindheimer, M.3
  • 25
    • 5344261050 scopus 로고    scopus 로고
    • Mechanisms of renal vasodilation and hyperfiltration during pregnancy
    • Conrad K.P. Mechanisms of renal vasodilation and hyperfiltration during pregnancy. J Soc Gynecol Invest 2004, 11:438-448.
    • (2004) J Soc Gynecol Invest , vol.11 , pp. 438-448
    • Conrad, K.P.1
  • 26
    • 0021182995 scopus 로고
    • Renal hemodynamics during pregnancy in chronically catheterized, conscious rats
    • Conrad K.P. Renal hemodynamics during pregnancy in chronically catheterized, conscious rats. Kidney Int 1984, 26:24-29.
    • (1984) Kidney Int , vol.26 , pp. 24-29
    • Conrad, K.P.1
  • 27
    • 14144250653 scopus 로고    scopus 로고
    • Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response
    • Debrah D.O., Conrad K.P., Danielson L.A., Shroff S.G. Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response. J Appl Physiol 2005, 98:1013-1020.
    • (2005) J Appl Physiol , vol.98 , pp. 1013-1020
    • Debrah, D.O.1    Conrad, K.P.2    Danielson, L.A.3    Shroff, S.G.4
  • 28
    • 31944449600 scopus 로고    scopus 로고
    • Relaxin increases cardiac output and reduces systemic arterial load in hypertensive rats
    • Debrah D.O., Conrad K.P., Jeyabalan A., Danielson L.A., Shroff S.G. Relaxin increases cardiac output and reduces systemic arterial load in hypertensive rats. Hypertension 2005, 46:745-750.
    • (2005) Hypertension , vol.46 , pp. 745-750
    • Debrah, D.O.1    Conrad, K.P.2    Jeyabalan, A.3    Danielson, L.A.4    Shroff, S.G.5
  • 29
    • 62649155715 scopus 로고    scopus 로고
    • Intravenous recombinant human relaxin in compensated heart failure: a safety, tolerability, and pharmacodynamic trial
    • Dschietzig T., Teichman S., Unemori E., Wood S., Boehmer J., Richter C., et al. Intravenous recombinant human relaxin in compensated heart failure: a safety, tolerability, and pharmacodynamic trial. J Card Fail 2009, 15:182-190.
    • (2009) J Card Fail , vol.15 , pp. 182-190
    • Dschietzig, T.1    Teichman, S.2    Unemori, E.3    Wood, S.4    Boehmer, J.5    Richter, C.6
  • 32
    • 0033557269 scopus 로고    scopus 로고
    • Relaxin is a potent renal vasodilator in conscious rats
    • Danielson L.A., Sherwood O.D., Conrad K.P. Relaxin is a potent renal vasodilator in conscious rats. J Clin Invest 1999, 103:525-533.
    • (1999) J Clin Invest , vol.103 , pp. 525-533
    • Danielson, L.A.1    Sherwood, O.D.2    Conrad, K.P.3
  • 33
    • 0033680477 scopus 로고    scopus 로고
    • Impact of gender and endothelin on renal vasodilation and hyperfiltration induced by relaxin in conscious rats
    • Danielson L.A., Kercher L.J., Conrad K.P. Impact of gender and endothelin on renal vasodilation and hyperfiltration induced by relaxin in conscious rats. Am J Physiol Regul Integr Comp Physiol 2000, 279:R1298-R1304.
    • (2000) Am J Physiol Regul Integr Comp Physiol , vol.279
    • Danielson, L.A.1    Kercher, L.J.2    Conrad, K.P.3
  • 34
    • 0022606865 scopus 로고
    • Evidence against the hypothesis that prostaglandins are the vasodepressor agents of pregnancy. Serial studies in chronically instrumented, conscious rats
    • Conrad K.P., Colpoys M.C. Evidence against the hypothesis that prostaglandins are the vasodepressor agents of pregnancy. Serial studies in chronically instrumented, conscious rats. J Clin Invest 1986, 77:236-245.
    • (1986) J Clin Invest , vol.77 , pp. 236-245
    • Conrad, K.P.1    Colpoys, M.C.2
  • 35
    • 0029115365 scopus 로고
    • Acute blockade of nitric oxide synthase inhibits renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats
    • Danielson L.A., Conrad K.P. Acute blockade of nitric oxide synthase inhibits renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats. J Clin Invest 1995, 96:482-490.
    • (1995) J Clin Invest , vol.96 , pp. 482-490
    • Danielson, L.A.1    Conrad, K.P.2
  • 37
    • 11144303405 scopus 로고    scopus 로고
    • Relaxin-induced changes in renal sodium excretion in the anesthetized male rat
    • Bogzil A.H., Eardley R., Ashton N. Relaxin-induced changes in renal sodium excretion in the anesthetized male rat. Am J Physiol 2005, 288:R322-R328.
    • (2005) Am J Physiol , vol.288
    • Bogzil, A.H.1    Eardley, R.2    Ashton, N.3
  • 39
    • 0035016563 scopus 로고    scopus 로고
    • Endothelin and nitric oxide mediate reduced myogenic reactivity of small renal arteries from pregnant rats
    • Gandley R.E., Conrad K.P., McLaughlin M.K. Endothelin and nitric oxide mediate reduced myogenic reactivity of small renal arteries from pregnant rats. Am J Physiol Regul Integr Comp Physiol 2001, 280:R1-R7.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.280
    • Gandley, R.E.1    Conrad, K.P.2    McLaughlin, M.K.3
  • 40
    • 0141455506 scopus 로고    scopus 로고
    • Time course and dose response of relaxin-mediated renal vasodilation, hyperfiltration, and changes in plasma osmolality in conscious rats
    • Danielson L.A., Conrad K.P. Time course and dose response of relaxin-mediated renal vasodilation, hyperfiltration, and changes in plasma osmolality in conscious rats. J Appl Physiol 2003, 95:1509-1514.
    • (2003) J Appl Physiol , vol.95 , pp. 1509-1514
    • Danielson, L.A.1    Conrad, K.P.2
  • 41
    • 33750731616 scopus 로고    scopus 로고
    • Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers
    • Smith M.C., Danielson L.A., Conrad K.P., Davison J.M. Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. J Am Soc Nephrol 2006, 17:3192-3197.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3192-3197
    • Smith, M.C.1    Danielson, L.A.2    Conrad, K.P.3    Davison, J.M.4
  • 43
    • 65249109216 scopus 로고    scopus 로고
    • Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial
    • Khanna D., Clements P.J., Furst D.E., Korn J.H., Ellman M., Rothfield N., et al. Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2009, 60:1102-1111.
    • (2009) Arthritis Rheum , vol.60 , pp. 1102-1111
    • Khanna, D.1    Clements, P.J.2    Furst, D.E.3    Korn, J.H.4    Ellman, M.5    Rothfield, N.6
  • 46
    • 0023243279 scopus 로고
    • Possible mechanisms for changes in renal hemodynamics during pregnancy: studies from animal models
    • Conrad K. Possible mechanisms for changes in renal hemodynamics during pregnancy: studies from animal models. Am J Kidney Dis 1987, 9:253-259.
    • (1987) Am J Kidney Dis , vol.9 , pp. 253-259
    • Conrad, K.1
  • 47
    • 0024437328 scopus 로고
    • Plasma level, urinary excretion, and metabolic production of cGMP during gestation in rats
    • Conrad K.P., Vernier K.A. Plasma level, urinary excretion, and metabolic production of cGMP during gestation in rats. Am J Physiol 1989, 257:R847-R853.
    • (1989) Am J Physiol , vol.257
    • Conrad, K.P.1    Vernier, K.A.2
  • 48
    • 0032782853 scopus 로고    scopus 로고
    • Plasma and 24-h NO(x) and cGMP during normal pregnancy and preeclampsia in women on a reduced NO(x) diet
    • Conrad K.P., Kerchner L.J., Mosher M.D. Plasma and 24-h NO(x) and cGMP during normal pregnancy and preeclampsia in women on a reduced NO(x) diet. Am J Physiol 1999, 277:F48-F57.
    • (1999) Am J Physiol , vol.277
    • Conrad, K.P.1    Kerchner, L.J.2    Mosher, M.D.3
  • 49
    • 0017345120 scopus 로고
    • Urinary excretion of cyclic 3', 5' -adenosine monophosphate and cyclic 3', 5' -guanosine monophosphate during and after pregnancy
    • Kopp L., Paradiz G., Tucci J. Urinary excretion of cyclic 3', 5' -adenosine monophosphate and cyclic 3', 5' -guanosine monophosphate during and after pregnancy. J Clin Endocrinol Metab 1977, 44:590-594.
    • (1977) J Clin Endocrinol Metab , vol.44 , pp. 590-594
    • Kopp, L.1    Paradiz, G.2    Tucci, J.3
  • 50
    • 0028901593 scopus 로고
    • Atrial natriuretic peptide and hemodynamics changes during normal human pregnancy
    • Sala C., Campise M., Ambroso G., Motta T., Zanchetti A., Morganti A. Atrial natriuretic peptide and hemodynamics changes during normal human pregnancy. Hypertension 1995, 25:631-636.
    • (1995) Hypertension , vol.25 , pp. 631-636
    • Sala, C.1    Campise, M.2    Ambroso, G.3    Motta, T.4    Zanchetti, A.5    Morganti, A.6
  • 51
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • Palmer R.M., Ferrige A.G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987, 327:524-526.
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.M.1    Ferrige, A.G.2    Moncada, S.3
  • 52
  • 53
    • 0030927193 scopus 로고    scopus 로고
    • The effect of chronic nitric oxide synthesis inhibition on blood pressure and angiotensin II responsiveness in the pregnant rat
    • Lubarsky S.L., Ahokas R.A., Friedman S.A., Sibai B.M. The effect of chronic nitric oxide synthesis inhibition on blood pressure and angiotensin II responsiveness in the pregnant rat. Am J Obstet Gynecol 1997, 176:1069-1076.
    • (1997) Am J Obstet Gynecol , vol.176 , pp. 1069-1076
    • Lubarsky, S.L.1    Ahokas, R.A.2    Friedman, S.A.3    Sibai, B.M.4
  • 54
    • 0029832390 scopus 로고    scopus 로고
    • Impact of nitric oxide deficiency on blood pressure and glomerular hemodynamic adaptations to pregnancy in the rat
    • Deng A., Engels K., Baylis C. Impact of nitric oxide deficiency on blood pressure and glomerular hemodynamic adaptations to pregnancy in the rat. Kidney Int 1996, 50:1132-1138.
    • (1996) Kidney Int , vol.50 , pp. 1132-1138
    • Deng, A.1    Engels, K.2    Baylis, C.3
  • 56
    • 0029789972 scopus 로고    scopus 로고
    • Importance of nitric oxide in control of systemic and renal hemodynamics during normal pregnancy: studies in the rat implications for preeclampsia
    • Baylis C., Suto T., Conrad K. Importance of nitric oxide in control of systemic and renal hemodynamics during normal pregnancy: studies in the rat implications for preeclampsia. Hypertens Pregnancy 1996, 15:147-169.
    • (1996) Hypertens Pregnancy , vol.15 , pp. 147-169
    • Baylis, C.1    Suto, T.2    Conrad, K.3
  • 59
    • 0035006959 scopus 로고    scopus 로고
    • Chronic NOS inhibition reverses systemic vasodilation and glomerular hyperfiltration in pregnancy
    • Cadnapaphornchai M.A., Ohara M., Morris K.G., Knotek M., Rogachev B., Ladtkow T., et al. Chronic NOS inhibition reverses systemic vasodilation and glomerular hyperfiltration in pregnancy. Am J Physiol 2001, 280:F592-F598.
    • (2001) Am J Physiol , vol.280
    • Cadnapaphornchai, M.A.1    Ohara, M.2    Morris, K.G.3    Knotek, M.4    Rogachev, B.5    Ladtkow, T.6
  • 60
    • 0026539655 scopus 로고
    • Adverse interactions between pregnancy and a new model of systemic hypertension produced by chronic blockade of endothelial derived relaxing factor (EDRF) in the rat
    • Baylis C., Engels K. Adverse interactions between pregnancy and a new model of systemic hypertension produced by chronic blockade of endothelial derived relaxing factor (EDRF) in the rat. Clin Exp Hypertens Pregnancy 1992, B11:117-129.
    • (1992) Clin Exp Hypertens Pregnancy , vol.B11 , pp. 117-129
    • Baylis, C.1    Engels, K.2
  • 61
    • 0029810210 scopus 로고    scopus 로고
    • Prostaglandins maintain renal vasodilation and hyperfiltration during chronic nitric oxide synthase blockade in conscious pregnant rats
    • Danielson L.A., Conrad K.P. Prostaglandins maintain renal vasodilation and hyperfiltration during chronic nitric oxide synthase blockade in conscious pregnant rats. Circ Res 1996, 79:1161-1166.
    • (1996) Circ Res , vol.79 , pp. 1161-1166
    • Danielson, L.A.1    Conrad, K.P.2
  • 63
    • 0032878745 scopus 로고    scopus 로고
    • Nitric oxide activity in the peripheral vasculature during normotensive and preeclamptic pregnancy
    • Anumba D.O., Robson S.C., Boys R.J., Ford G.A. Nitric oxide activity in the peripheral vasculature during normotensive and preeclamptic pregnancy. Am J Physiol 1999, 277:H848-H854.
    • (1999) Am J Physiol , vol.277
    • Anumba, D.O.1    Robson, S.C.2    Boys, R.J.3    Ford, G.A.4
  • 66
    • 0033043767 scopus 로고    scopus 로고
    • Endothelin mediates renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats
    • Conrad K.P., Gandley R.E., Ogawa T., Nakanishi S., Danielson L.A. Endothelin mediates renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats. Am J Physiol 1999, 276:F767-F776.
    • (1999) Am J Physiol , vol.276
    • Conrad, K.P.1    Gandley, R.E.2    Ogawa, T.3    Nakanishi, S.4    Danielson, L.A.5
  • 67
    • 0037428061 scopus 로고    scopus 로고
    • Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB
    • Dschietzig T., Bartsch C., Richter C., Laule M., Baumann G., Stangl K. Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB. Circ Res 2003, 92:32-40.
    • (2003) Circ Res , vol.92 , pp. 32-40
    • Dschietzig, T.1    Bartsch, C.2    Richter, C.3    Laule, M.4    Baumann, G.5    Stangl, K.6
  • 68
    • 18844369874 scopus 로고    scopus 로고
    • Evidence against the hypothesis that endothelial endothelin B receptor expression is regulated by relaxin and pregnancy
    • Kerchner L.J., Novak J., Hanley-Yanez K., Doty K.D., Danielson L.A., Conrad K.P. Evidence against the hypothesis that endothelial endothelin B receptor expression is regulated by relaxin and pregnancy. Endocrinology 2005, 146:2791-2797.
    • (2005) Endocrinology , vol.146 , pp. 2791-2797
    • Kerchner, L.J.1    Novak, J.2    Hanley-Yanez, K.3    Doty, K.D.4    Danielson, L.A.5    Conrad, K.P.6
  • 69
    • 0032719798 scopus 로고    scopus 로고
    • Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor
    • Fernandez-Patron C., Radomski M.W., Davidge S.T. Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. Circ Res 1999, 85:906-911.
    • (1999) Circ Res , vol.85 , pp. 906-911
    • Fernandez-Patron, C.1    Radomski, M.W.2    Davidge, S.T.3
  • 70
    • 0346120209 scopus 로고    scopus 로고
    • Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries
    • Jeyabalan A., Novak J., Danielson L.A., Kerchner L.J., Opett S.L., Conrad K.P. Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries. Circ Res 2003, 93:1249-1257.
    • (2003) Circ Res , vol.93 , pp. 1249-1257
    • Jeyabalan, A.1    Novak, J.2    Danielson, L.A.3    Kerchner, L.J.4    Opett, S.L.5    Conrad, K.P.6
  • 71
    • 33845909264 scopus 로고    scopus 로고
    • Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin
    • Jeyabalan A., Novak J., Doty K.D., Matthews J., Fisher M.C., Kerchner L.J., et al. Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin. Endocrinology 2007, 148:189-197.
    • (2007) Endocrinology , vol.148 , pp. 189-197
    • Jeyabalan, A.1    Novak, J.2    Doty, K.D.3    Matthews, J.4    Fisher, M.C.5    Kerchner, L.J.6
  • 72
    • 33744946031 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats
    • Jeyabalan A., Kerchner L.J., Fisher M.C., McGuane J.T., Doty K.D., Conrad K.P. Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats. J Appl Physiol 2006, 100:1955-1963.
    • (2006) J Appl Physiol , vol.100 , pp. 1955-1963
    • Jeyabalan, A.1    Kerchner, L.J.2    Fisher, M.C.3    McGuane, J.T.4    Doty, K.D.5    Conrad, K.P.6
  • 75
    • 2642549766 scopus 로고    scopus 로고
    • Aortic adaptation to pregnancy: elevated expression of matrix metalloproteinases-2 and -3 in rat gestation
    • Kelly B.A., Bond B.C., Poston L. Aortic adaptation to pregnancy: elevated expression of matrix metalloproteinases-2 and -3 in rat gestation. Mol Hum Reprod 2004, 10:331-337.
    • (2004) Mol Hum Reprod , vol.10 , pp. 331-337
    • Kelly, B.A.1    Bond, B.C.2    Poston, L.3
  • 76
    • 33646359679 scopus 로고    scopus 로고
    • Relaxin improves renal function and histology in aging Munich Wistar rats
    • Danielson L.A., Welford A., Harris A. Relaxin improves renal function and histology in aging Munich Wistar rats. J Am Soc Nephrol 2006, 17:1325-1333.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1325-1333
    • Danielson, L.A.1    Welford, A.2    Harris, A.3
  • 77
    • 44849106400 scopus 로고    scopus 로고
    • Mechanisms leading to increased vasodilator responses to calcitonin-gene-related peptide in mesenteric resistance arteries of early pregnant rats
    • van Eijndhoven H.W., Janssen G.M., Aardenburg R., Spaanderman M.E., Peeters L.L., De Mey J.G. Mechanisms leading to increased vasodilator responses to calcitonin-gene-related peptide in mesenteric resistance arteries of early pregnant rats. J Vasc Res 2008, 45:350-356.
    • (2008) J Vasc Res , vol.45 , pp. 350-356
    • van Eijndhoven, H.W.1    Janssen, G.M.2    Aardenburg, R.3    Spaanderman, M.E.4    Peeters, L.L.5    De Mey, J.G.6
  • 78
    • 77953811636 scopus 로고    scopus 로고
    • Small renal arteries isolated from ETB receptor deficient rats fail to exhibit the normal maternal adaptation to pregnancy [abstract]
    • Novak J., Conrad K.P. Small renal arteries isolated from ETB receptor deficient rats fail to exhibit the normal maternal adaptation to pregnancy [abstract]. FASEB J 2004, 18:32.
    • (2004) FASEB J , vol.18 , pp. 32
    • Novak, J.1    Conrad, K.P.2
  • 79
    • 77953807551 scopus 로고    scopus 로고
    • Changes in arterial function by chronic relaxin infusion are mediated by the leucine rich repeat G coupled Lgr7 receptor [abstract]
    • Debrah J.E., Agoulnik A., Conrad K.P. Changes in arterial function by chronic relaxin infusion are mediated by the leucine rich repeat G coupled Lgr7 receptor [abstract]. Reprod Sci 2008, 15. Suppl:217A.
    • (2008) Reprod Sci , vol.15 , Issue.SUPPL.
    • Debrah, J.E.1    Agoulnik, A.2    Conrad, K.P.3
  • 80
    • 64549148901 scopus 로고    scopus 로고
    • Vascular endothelial and placental growth factors: new players in the slow relaxin vasodilatory pathway
    • Debrah J.E., McGuane J.T., Novak J., Rubin J.P., Conrad K.P. Vascular endothelial and placental growth factors: new players in the slow relaxin vasodilatory pathway. Ann N Y Acad Sci 2009, 1160:304-312.
    • (2009) Ann N Y Acad Sci , vol.1160 , pp. 304-312
    • Debrah, J.E.1    McGuane, J.T.2    Novak, J.3    Rubin, J.P.4    Conrad, K.P.5
  • 81
    • 77953806775 scopus 로고    scopus 로고
    • Relaxin-induced renal vasodilation and hyperfiltration are mediated by vascular endothelial growth factor receptor(s) in chronically-instrumented, conscious rats [abstract]
    • Danielson L.A., McGuane J.T., Debrah J.E., Conrad K.P. Relaxin-induced renal vasodilation and hyperfiltration are mediated by vascular endothelial growth factor receptor(s) in chronically-instrumented, conscious rats [abstract]. Reprod Sci 2010, 11:357.
    • (2010) Reprod Sci , vol.11 , pp. 357
    • Danielson, L.A.1    McGuane, J.T.2    Debrah, J.E.3    Conrad, K.P.4
  • 82
    • 0037118672 scopus 로고    scopus 로고
    • Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart
    • Fisher C., MacLean M., Morecroft I., Seed A., Johnston F., Hillier C., et al. Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart? Circulation 2002, 106:292-295.
    • (2002) Circulation , vol.106 , pp. 292-295
    • Fisher, C.1    MacLean, M.2    Morecroft, I.3    Seed, A.4    Johnston, F.5    Hillier, C.6
  • 84
    • 0036854088 scopus 로고    scopus 로고
    • The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: a review of the literature
    • Brosens J.J., Pijnenborg R., Brosens I.A. The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: a review of the literature. Am J Obstet Gynecol 2002, 187:1416-1423.
    • (2002) Am J Obstet Gynecol , vol.187 , pp. 1416-1423
    • Brosens, J.J.1    Pijnenborg, R.2    Brosens, I.A.3
  • 85
    • 67349192531 scopus 로고    scopus 로고
    • Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
    • Burton G.J., Woods A.W., Jauniaux E., Kingdom J.C. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta 2009, 30:473-482.
    • (2009) Placenta , vol.30 , pp. 473-482
    • Burton, G.J.1    Woods, A.W.2    Jauniaux, E.3    Kingdom, J.C.4
  • 86
    • 33749444631 scopus 로고    scopus 로고
    • Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation
    • Red-Horse K., Rivera J., Schanz A., Zhou Y., Winn V., Kapidzic M., et al. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest 2006, 116:2643-2652.
    • (2006) J Clin Invest , vol.116 , pp. 2643-2652
    • Red-Horse, K.1    Rivera, J.2    Schanz, A.3    Zhou, Y.4    Winn, V.5    Kapidzic, M.6
  • 87
    • 67449127563 scopus 로고    scopus 로고
    • Trophoblast-mediated spiral artery remodelling: a role for apoptosis
    • Whitley G.S., Cartwright J.E. Trophoblast-mediated spiral artery remodelling: a role for apoptosis. J Anat 2009, 215:21-26.
    • (2009) J Anat , vol.215 , pp. 21-26
    • Whitley, G.S.1    Cartwright, J.E.2
  • 88
    • 76749103340 scopus 로고    scopus 로고
    • Review: trophoblast-vascular cell interactions in early pregnancy: how to remodel a vessel
    • Harris L.K. Review: trophoblast-vascular cell interactions in early pregnancy: how to remodel a vessel. Placenta 2010, 31. Suppl:S93-8.
    • (2010) Placenta , vol.31 , Issue.SUPPL.
    • Harris, L.K.1
  • 89
    • 0032983892 scopus 로고    scopus 로고
    • Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall
    • DiFederico E., Genbacev O., Fisher S.J. Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am J Pathol 1999, 155:293-301.
    • (1999) Am J Pathol , vol.155 , pp. 293-301
    • DiFederico, E.1    Genbacev, O.2    Fisher, S.J.3
  • 90
    • 78751689086 scopus 로고    scopus 로고
    • The placenta in normal pregnancy and preeclampsia
    • Academic Press, San Diego, M.D. Lindheimer, J.M. Roberts, F.G. Cunningham (Eds.)
    • Fisher S.J., McMaster M., Roberts J.M. The placenta in normal pregnancy and preeclampsia. Chesley's hypertensive disorders in pregnancy 2009, 73-86. Academic Press, San Diego. M.D. Lindheimer, J.M. Roberts, F.G. Cunningham (Eds.).
    • (2009) Chesley's hypertensive disorders in pregnancy , pp. 73-86
    • Fisher, S.J.1    McMaster, M.2    Roberts, J.M.3
  • 91
    • 77950350575 scopus 로고    scopus 로고
    • Critical growth factors and signalling pathways controlling human trophoblast invasion
    • Knofler M. Critical growth factors and signalling pathways controlling human trophoblast invasion. Int J Dev Biol 2010, 54:269-280.
    • (2010) Int J Dev Biol , vol.54 , pp. 269-280
    • Knofler, M.1
  • 92
    • 0030828484 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast
    • Shore V.H., Wang T.H., Wang C.L., Torry R.J., Caudle M.R., Torry D.S. Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast. Placenta 1997, 18:657-665.
    • (1997) Placenta , vol.18 , pp. 657-665
    • Shore, V.H.1    Wang, T.H.2    Wang, C.L.3    Torry, R.J.4    Caudle, M.R.5    Torry, D.S.6
  • 93
    • 0027615758 scopus 로고
    • Human cytotrophoblast invasion
    • Fisher S.J., Damsky C.H. Human cytotrophoblast invasion. Semin Cell Biol 1993, 4:183-188.
    • (1993) Semin Cell Biol , vol.4 , pp. 183-188
    • Fisher, S.J.1    Damsky, C.H.2
  • 94
    • 46149098917 scopus 로고    scopus 로고
    • Effects of recombinant H2 relaxin on the expression of matrix metalloproteinases and tissue inhibitor metalloproteinase in cultured early placental extravillous trophoblasts
    • Maruo N., Nakabayashi K., Wakahashi S., Yata A., Maruo T. Effects of recombinant H2 relaxin on the expression of matrix metalloproteinases and tissue inhibitor metalloproteinase in cultured early placental extravillous trophoblasts. Endocrine 2007, 32:303-310.
    • (2007) Endocrine , vol.32 , pp. 303-310
    • Maruo, N.1    Nakabayashi, K.2    Wakahashi, S.3    Yata, A.4    Maruo, T.5
  • 95
    • 0032989856 scopus 로고    scopus 로고
    • Co-operation between endothelin and nitric oxide in promoting endothelial cell migration and angiogenesis
    • Goligorsky M.S., Budzikowski A.S., Tsukahara H., Noiri E. Co-operation between endothelin and nitric oxide in promoting endothelial cell migration and angiogenesis. Clin Exp Pharmacol Physiol 1999, 26:269-271.
    • (1999) Clin Exp Pharmacol Physiol , vol.26 , pp. 269-271
    • Goligorsky, M.S.1    Budzikowski, A.S.2    Tsukahara, H.3    Noiri, E.4
  • 96
    • 0033965463 scopus 로고    scopus 로고
    • Expression of endothelial nitric oxide synthase by extravillous trophoblast cells in the human placenta
    • Martin D., Conrad K.P. Expression of endothelial nitric oxide synthase by extravillous trophoblast cells in the human placenta. Placenta 2000, 21:23-31.
    • (2000) Placenta , vol.21 , pp. 23-31
    • Martin, D.1    Conrad, K.P.2
  • 97
    • 0030253620 scopus 로고    scopus 로고
    • Endothelin-1 stimulates the proliferation and invasion of first trimester trophoblastic cells in vitro-a possible role in the etiology of pre-eclampsia
    • Cervar M., Puerstner P., Kainer F., Desoye G. Endothelin-1 stimulates the proliferation and invasion of first trimester trophoblastic cells in vitro-a possible role in the etiology of pre-eclampsia? J Investig Med 1996, 44:447-453.
    • (1996) J Investig Med , vol.44 , pp. 447-453
    • Cervar, M.1    Puerstner, P.2    Kainer, F.3    Desoye, G.4
  • 98
    • 0037471183 scopus 로고    scopus 로고
    • Endothelin-1 promotes migration and induces elevation of [Ca2+]i and phosphorylation of MAP kinase of a human extravillous trophoblast cell line
    • Chakraborty C., Barbin Y.P., Chakrabarti S., Chidiac P., Dixon S.J., Lala P.K. Endothelin-1 promotes migration and induces elevation of [Ca2+]i and phosphorylation of MAP kinase of a human extravillous trophoblast cell line. Mol Cell Endocrinol 2003, 201:63-73.
    • (2003) Mol Cell Endocrinol , vol.201 , pp. 63-73
    • Chakraborty, C.1    Barbin, Y.P.2    Chakrabarti, S.3    Chidiac, P.4    Dixon, S.J.5    Lala, P.K.6
  • 99
    • 35848947442 scopus 로고    scopus 로고
    • Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives
    • Gellersen B., Brosens I.A., Brosens J.J. Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives. Semin Reprod Med 2007, 25:445-453.
    • (2007) Semin Reprod Med , vol.25 , pp. 445-453
    • Gellersen, B.1    Brosens, I.A.2    Brosens, J.J.3
  • 100
    • 57749175087 scopus 로고    scopus 로고
    • Altered global gene expression in first trimester placentas of women destined to develop preeclampsia
    • Founds S.A., Conley Y.P., Lyons-Weiler J.F., Jeyabalan A., Hogge W.A., Conrad K.P. Altered global gene expression in first trimester placentas of women destined to develop preeclampsia. Placenta 2009, 30:15-24.
    • (2009) Placenta , vol.30 , pp. 15-24
    • Founds, S.A.1    Conley, Y.P.2    Lyons-Weiler, J.F.3    Jeyabalan, A.4    Hogge, W.A.5    Conrad, K.P.6
  • 102
    • 4344623297 scopus 로고    scopus 로고
    • Biology of primate relaxin: a paracrine signal in early pregnancy
    • Hayes E.S. Biology of primate relaxin: a paracrine signal in early pregnancy? Reprod Biol Endocrinol 2004, 2:36.
    • (2004) Reprod Biol Endocrinol , vol.2 , pp. 36
    • Hayes, E.S.1
  • 103
  • 104
    • 0033037935 scopus 로고    scopus 로고
    • Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women
    • Unemori E.N., Erikson M.E., Rocco S.E., Sutherland K.M., Parsell D.A., Mak J., et al. Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women. Hum Reprod 1999, 14:800-806.
    • (1999) Hum Reprod , vol.14 , pp. 800-806
    • Unemori, E.N.1    Erikson, M.E.2    Rocco, S.E.3    Sutherland, K.M.4    Parsell, D.A.5    Mak, J.6
  • 105
    • 84866257928 scopus 로고    scopus 로고
    • Low relaxin concentrations in the first trimester are associated with increased risk of developing preeclampsia [abstract]
    • Jeyabalan A., Stewart D.R., McGonigal S.C., Powers R.W., Conrad K.P. Low relaxin concentrations in the first trimester are associated with increased risk of developing preeclampsia [abstract]. Reproductive Sci 2009, 16:101A.
    • (2009) Reproductive Sci , vol.16
    • Jeyabalan, A.1    Stewart, D.R.2    McGonigal, S.C.3    Powers, R.W.4    Conrad, K.P.5
  • 106
    • 54349088696 scopus 로고    scopus 로고
    • The association of in vitro fertilization and perinatal morbidity
    • Kalra S.K., Molinaro T.A. The association of in vitro fertilization and perinatal morbidity. Semin Reprod Med 2008, 26:423-435.
    • (2008) Semin Reprod Med , vol.26 , pp. 423-435
    • Kalra, S.K.1    Molinaro, T.A.2
  • 107
    • 0001076663 scopus 로고
    • The relation between hydatid moles, relative ischemia of the gravid uterus, and the placental origin of eclampsia
    • Page E.W. The relation between hydatid moles, relative ischemia of the gravid uterus, and the placental origin of eclampsia. Am J Obstet Gynecol 1939, 37:291-293.
    • (1939) Am J Obstet Gynecol , vol.37 , pp. 291-293
    • Page, E.W.1
  • 108
    • 34547640468 scopus 로고    scopus 로고
    • Placental HIF-1 alpha, HIF-2 alpha, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction
    • Rajakumar A., Jeyabalan A., Markovic N., Ness R., Gilmour C., Conrad K.P. Placental HIF-1 alpha, HIF-2 alpha, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction. Am J Physiol 2007, 293:R766-R774.
    • (2007) Am J Physiol , vol.293
    • Rajakumar, A.1    Jeyabalan, A.2    Markovic, N.3    Ness, R.4    Gilmour, C.5    Conrad, K.P.6
  • 109
    • 60249103032 scopus 로고    scopus 로고
    • Placental stress and pre-eclampsia: a revised view
    • Redman C.W., Sargent I.L. Placental stress and pre-eclampsia: a revised view. Placenta 2009, 30. Suppl A:S38-42.
    • (2009) Placenta , vol.30 , Issue.SUPPL. A
    • Redman, C.W.1    Sargent, I.L.2
  • 110
    • 0035143802 scopus 로고    scopus 로고
    • Selective overexpression of the hypoxia-inducible transcription factor, HIF-2alpha, in placentas from women with preeclampsia (erratum: Biol Reprod. 2001;64:1019-20)
    • Rajakumar A., Whitelock K.A., Weissfeld L.A., Daftary A.R., Markovic N., Conrad K.P. Selective overexpression of the hypoxia-inducible transcription factor, HIF-2alpha, in placentas from women with preeclampsia (erratum: Biol Reprod. 2001;64:1019-20). Biol Reprod 2001, 64:499-506.
    • (2001) Biol Reprod , vol.64 , pp. 499-506
    • Rajakumar, A.1    Whitelock, K.A.2    Weissfeld, L.A.3    Daftary, A.R.4    Markovic, N.5    Conrad, K.P.6
  • 111
    • 34548698845 scopus 로고    scopus 로고
    • Microparticles and immunomodulation in pregnancy and pre-eclampsia
    • Redman C.W., Sargent I.L. Microparticles and immunomodulation in pregnancy and pre-eclampsia. J Reprod Immunol 2007, 76:61-67.
    • (2007) J Reprod Immunol , vol.76 , pp. 61-67
    • Redman, C.W.1    Sargent, I.L.2
  • 112
    • 20444409135 scopus 로고    scopus 로고
    • Latest advances in understanding preeclampsia
    • Redman C.W., Sargent I.L. Latest advances in understanding preeclampsia. Science 2005, 308:1592-1594.
    • (2005) Science , vol.308 , pp. 1592-1594
    • Redman, C.W.1    Sargent, I.L.2
  • 113
    • 38749094859 scopus 로고    scopus 로고
    • Relaxin physiology in the female reproductive tract during pregnancy
    • Parry L.J., Vodstrcil L.A. Relaxin physiology in the female reproductive tract during pregnancy. Adv Exp Med Biol 2007, 612:34-48.
    • (2007) Adv Exp Med Biol , vol.612 , pp. 34-48
    • Parry, L.J.1    Vodstrcil, L.A.2
  • 114
    • 0027933063 scopus 로고
    • The role of relaxin in the development of the uteroplacental circulation in early pregnancy
    • Jauniaux E., Johnson M.R., Jurkovic D., Ramsay B., Campbell S., Meuris S. The role of relaxin in the development of the uteroplacental circulation in early pregnancy. Obstet Gynecol 1994, 84:338-342.
    • (1994) Obstet Gynecol , vol.84 , pp. 338-342
    • Jauniaux, E.1    Johnson, M.R.2    Jurkovic, D.3    Ramsay, B.4    Campbell, S.5    Meuris, S.6
  • 115
    • 72049124006 scopus 로고    scopus 로고
    • Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester
    • Anumba D.O., El Gelany S., Elliott S.L., Li T.C. Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester. Eur J Obstet Gynecol Reprod Biol 2009, 147:41-45.
    • (2009) Eur J Obstet Gynecol Reprod Biol , vol.147 , pp. 41-45
    • Anumba, D.O.1    El Gelany, S.2    Elliott, S.L.3    Li, T.C.4
  • 116
    • 42449109125 scopus 로고    scopus 로고
    • Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina
    • Yao L., Agoulnik A.I., Cooke P.S., Meling D.D., Sherwood O.D. Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina. Endocrinology 2008, 149:2072-2079.
    • (2008) Endocrinology , vol.149 , pp. 2072-2079
    • Yao, L.1    Agoulnik, A.I.2    Cooke, P.S.3    Meling, D.D.4    Sherwood, O.D.5
  • 117
    • 0032983892 scopus 로고    scopus 로고
    • Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall
    • DiFederico E., Genbacev O., Fisher S.J. Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am J Pathol 1999, 155:293-301.
    • (1999) Am J Pathol , vol.155 , pp. 293-301
    • DiFederico, E.1    Genbacev, O.2    Fisher, S.J.3
  • 118
    • 36049029573 scopus 로고    scopus 로고
    • Emerging concepts in preeclampsia investigation
    • Gammill H.S., Roberts J.M. Emerging concepts in preeclampsia investigation. Front Biosci 2007, 12:2403-2411.
    • (2007) Front Biosci , vol.12 , pp. 2403-2411
    • Gammill, H.S.1    Roberts, J.M.2
  • 119
    • 0037373006 scopus 로고    scopus 로고
    • Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    • Maynard S.E., Min J.Y., Merchan J., Lim K.H., Li J., Mondal S., et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003, 111:649-658.
    • (2003) J Clin Invest , vol.111 , pp. 649-658
    • Maynard, S.E.1    Min, J.Y.2    Merchan, J.3    Lim, K.H.4    Li, J.5    Mondal, S.6
  • 120
    • 0032924922 scopus 로고    scopus 로고
    • Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor
    • Wallukat G., Homuth V., Fischer T., Lindschau C., Horstkamp B., Jupner A., et al. Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. J Clin Invest 1999, 103:945-952.
    • (1999) J Clin Invest , vol.103 , pp. 945-952
    • Wallukat, G.1    Homuth, V.2    Fischer, T.3    Lindschau, C.4    Horstkamp, B.5    Jupner, A.6
  • 121
    • 21444452423 scopus 로고    scopus 로고
    • Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women
    • Rajakumar A., Michael H.M., Rajakumar P.A., Shibata E., Hubel C.A., Karumanchi S.A., et al. Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. Placenta 2005, 26:563-573.
    • (2005) Placenta , vol.26 , pp. 563-573
    • Rajakumar, A.1    Michael, H.M.2    Rajakumar, P.A.3    Shibata, E.4    Hubel, C.A.5    Karumanchi, S.A.6
  • 122
  • 123
    • 4644281668 scopus 로고    scopus 로고
    • Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae
    • Rajakumar A., Brandon H.M., Daftary A., Ness R., Conrad K.P. Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta 2004, 25:763-769.
    • (2004) Placenta , vol.25 , pp. 763-769
    • Rajakumar, A.1    Brandon, H.M.2    Daftary, A.3    Ness, R.4    Conrad, K.P.5
  • 125
    • 22244491319 scopus 로고    scopus 로고
    • Maternal serum soluble fms-like tyrosine kinase 1 concentrations are not increased in early pregnancy and decrease more slowly postpartum in women who develop preeclampsia
    • Powers R.W., Roberts J.M., Cooper K.M., Gallaher M.J., Frank M.P., Harger G.F., et al. Maternal serum soluble fms-like tyrosine kinase 1 concentrations are not increased in early pregnancy and decrease more slowly postpartum in women who develop preeclampsia. Am J Obstet Gynecol 2005, 193:185-191.
    • (2005) Am J Obstet Gynecol , vol.193 , pp. 185-191
    • Powers, R.W.1    Roberts, J.M.2    Cooper, K.M.3    Gallaher, M.J.4    Frank, M.P.5    Harger, G.F.6
  • 127
    • 33845933437 scopus 로고    scopus 로고
    • Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules
    • Scott D.J., Layfield S., Yan Y., Sudo S., Hsueh A.J., Tregear G.W., et al. Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. J Biol Chem 2006, 281:34942-34954.
    • (2006) J Biol Chem , vol.281 , pp. 34942-34954
    • Scott, D.J.1    Layfield, S.2    Yan, Y.3    Sudo, S.4    Hsueh, A.J.5    Tregear, G.W.6
  • 128
    • 64549117814 scopus 로고    scopus 로고
    • Mechanisms of relaxin receptor (LGR7/RXFP1) expression and function
    • Kern A., Bryant-Greenwood G.D. Mechanisms of relaxin receptor (LGR7/RXFP1) expression and function. Ann N Y Acad Sci 2009, 1160:60-66.
    • (2009) Ann N Y Acad Sci , vol.1160 , pp. 60-66
    • Kern, A.1    Bryant-Greenwood, G.D.2
  • 129
    • 0036199988 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase: location, location, location
    • Shaul P.W. Regulation of endothelial nitric oxide synthase: location, location, location. Annu Rev Physiol 2002, 64:749-774.
    • (2002) Annu Rev Physiol , vol.64 , pp. 749-774
    • Shaul, P.W.1


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