Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 147, Issue 1, 2009, Pages 41-45

  Anumba, Dilly O C ^a   El Gelany, Saad ^a   Elliott, Sarah L ^a   Li, Tin C ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Doppler; Implantation; Pregnancy; Recurrent miscarriage; Relaxin

Indexed keywords

RELAXIN;

ADULT; ARTICLE; CONTROLLED STUDY; DOPPLER FLOWMETRY; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; PREGNANT WOMAN; PRIORITY JOURNAL; RECURRENT DISEASE; SPONTANEOUS ABORTION; UMBILICAL CORD BLOOD;

EID: 72049124006     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2009.07.008     Document Type: Article

References (27)

1. Mtiraoui N., Borgi L., Gris J.C., Almawi W.Y., and Mahjoub T. Factor V Leiden, prothrombin G20210A and antibodies against phospholipids in recurrent spontaneous abortion. J Thromb Haemost 2 (2004) 1482-1484
2. Emmer P.M., Steegers E.A., Kerstens H.M., et al. Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies. Hum Reprod 17 (2002) 1072-1080
3. Palomba S., Falbo A., Orio Jr. F., Russo T., Tolino A., and Zullo F. Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome. Fertil Steril 85 1511 (2006) e3-e5
4. Craig L.B., Ke R.W., and Kutteh W.H. Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss. Fertil Steril 78 (2002) 487-490
5. Jivraj S., Anstie B., Cheong Y.C., Fairlie F.M., Laird S.M., and Li T.C. Obstetric and neonatal outcome in women with a history of recurrent miscarriage: a cohort study. Hum Reprod 16 (2001) 102-106
6. Nicolaides K.H., Bindra R., Turan O.M., et al. A novel approach to first-trimester screening for early pre-eclampsia combining serum PP-13 and Doppler ultrasound. Ultrasound Obstet Gynecol 27 (2006) 13-17
7. Prakash A., Laird S., Tuckerman E., Li T.C., and Ledger W.L. Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage. Fertil Steril 83 (2005) 1758-1763
8. Salim R., Miel J., Savvas M., Lee C., and Jurkovic D. A comparative study of glycodelin concentrations in uterine flushings in women with subseptate uteri, history of unexplained recurrent miscarriage and healthy controls. Eur J Obstet Gynecol Reprod Biol 133 (2007) 76-80
9. Carp H., Dardik R., Lubetsky A., et al. Prevalence of circulating procoagulant microparticles in women with recurrent miscarriage: a case-controlled study. Hum Reprod 19 (2004) 191-195
10. Laird S.M., Quinton N.D., Anstie B., Li T.C., and Blakemore A.I. Leptin and leptin-binding activity in women with recurrent miscarriage: correlation with pregnancy outcome. Hum Reprod 16 (2001) 2008-2013
11. Johnson M.R., Jauniaux E., Jurkovic D., Sannino P., Campbell S., and Nicolaides K.H. Relaxin concentrations in exoembryonic fluids during the first trimester. Hum Reprod 9 (1994) 1561-1562
12. Piccinni M.P., Maggi E., and Romagnani S. Role of hormone-controlled T-cell cytokines in the maintenance of pregnancy. Biochem Soc Trans 28 (2000) 212-215
13. Bogic L.V., Yamamoto S.Y., Millar L.K., and Bryant-Greenwood G.D. Developmental regulation of the human relaxin genes in the decidua and placenta: overexpression in the preterm premature rupture of the fetal membranes. Biol Reprod 57 (1997) 908-920
14. Parry L.J., and Vodstrcil L.A. Relaxin physiology in the female reproductive tract during pregnancy. Adv Exp Med Biol 612 (2007) 34-48
15. Petersen L.K., Vogel I., Agger A.O., Westergard J., Nils M., and Uldbjerg N. Variations in serum relaxin (hRLX-2) concentrations during human pregnancy. Acta Obstet Gynecol Scand 74 (1995) 251-256
16. Hollis B., Mavrides E., Campbell S., Tekay A., and Thilaganathan B. Reproducibility and repeatability of transabdominal uterine artery Doppler velocimetry between 10 and 14 weeks of gestation. Ultrasound Obstet Gynecol 18 6 (2001) 593-597
17. Seki K., Uesato T., Tabei T., and Kato K. Serum relaxin and steroid hormones in spontaneous abortions. Acta Obstet Gynecol Scand 67 6 (1988) 483-486
18. Gardosi J., Mongelli M., Wilcox M., and Chang A. An adjustable fetal weight standard. Ultrasound Obstet Gynecol 6 (1995) 168-174
19. Jauniaux E., Johnson M.R., Jurkovic D., Ramsay B., Campbell S., and Meuris S. The role of relaxin in the development of the uteroplacental circulation in early pregnancy. Obstet Gynecol 84 (1994) 338-342
20. Maynard S.E., Min J.Y., Merchan J., et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111 (2003) 649-658
21. Unemori E.N., Erikson M.E., Rocco S.E., et al. Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women. Hum Reprod 14 (1999) 800-806
22. Johnson M.R., Abdalla H., Allman A.C., Wren M.E., Kirkland A., and Lightman S.L. Relaxin levels in ovum donation pregnancies. Fertil Steril 56 (1991) 59-61
23. Bogic L.V., Mandel M., and Bryant-Greenwood G.D. Relaxin gene expression in human reproductive tissues by in situ hybridization. J Clin Endocrinol Metab 80 (1995) 130-137
24. Goldsmith L.T., Weiss G., and Steinetz B.G. Relaxin and its role in pregnancy. Endocrinol Metab Clin North Am 24 (1995) 171-186
25. MacLennan A.H., Grant P., and Borthwick A.C. Relaxin and relaxin c-peptide levels in human reproductive tissues. Reprod Fertil Dev 3 5 (1991) 577-583
26. Sakbun V., Ali S.M., Greenwood F.C., and Bryant-Greenwood G.D. Human relaxin in the amnion, chorion, decidua parietalis, basal plate, and placental trophoblast by immunocytochemistry and northern analysis. J Clin Endocrinol Metab 70 (1990) 508-514
27. Yki-Jarvinen H., Wahlstrom T., and Seppala M. Immunohistochemical demonstration of relaxin in the genital tract of pregnant and nonpregnant women. J Clin Endocrinol Metab 57 3 (1983) 451-454