Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina

Endocrinology

Volumn 149, Issue 5, 2008, Pages 2072-2079

  Yao, LiJuan ^a   Agoulnik, Alexander I ^c   Cooke, Paul S ^b   Meling, Daryl D ^b   Sherwood, O David ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYURIDINE; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA NUCLEOTIDYLEXOTRANSFERASE; ESTRADIOL; PROGESTERONE; RELAXIN; SILICON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; EPITHELIUM CELL; FEMALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; STROMA CELL; TISSUE GRAFT; UTERINE CERVIX; VAGINA;

ALGORITHMS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CELL LINEAGE; CELL PROLIFERATION; CERVIX UTERI; EPITHELIAL CELLS; FEMALE; GREEN FLUORESCENT PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, G-PROTEIN-COUPLED; RELAXIN; STROMAL CELLS; VAGINA;

EID: 42449109125     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1176     Document Type: Article

References (46)

1. Sherwood OD 2004 Relaxin's physiological roles and other diverse actions. Endocr Rev 25:205-234
2. Hwang J-J, Sherwood OD 1988 Monoclonal antibodies specific for rat relaxin. III. Passive immunization with monoclonal antibodies throughout the second half of pregnancy reduces cervical growth and extensibility in intact rats. Endocrinology 123:2486-2490
3. Hwang J-J, Shanks RD, Sherwood OD 1989 Monoclonal antibodies specific for rat relaxin. IV. Passive immunization with monoclonal antibodies during the antepartum period reduces cervical growth and extensibility, disrupts birth, and reduces pup survival in intact rats. Endocrinology 125:260-266
4. Zhao S, Kuenzi MJ, Sherwood OD 1996 Monoclonal antibodies specific for rat relaxin. IX. Evidence that endogenous relaxin promotes growth of the vagina during the second half of pregnancy in rats. Endocrinology 137:425-430
5. Zhao S, Sherwood OD 1998 Monoclonal antibodies specific for rat relaxin. X. Endogenous relaxin induces changes in the histological characteristics of the rat vagina during the second half of pregnancy. Endocrinology 139:4726-4734
6. Zhao L, Samuel CS, Tregear GW, Beck F, Wintour EM 2000 Collagen studies in late pregnant relaxin null mice. Biol Reprod 63:697-703
7. Burger LL, Sherwood OD 1995 Evidence that cellular proliferation contributes to relaxin-induced growth of both the vagina and the cervix in the pregnant rat. Endocrinology 136:4820-4826
8. Burger LL, Sherwood OD 1998 Relaxin increases the accumulation of new epithelial and stromal cells in the rat cervix during the second half of pregnancy. Endocrinology 139:3984-3995
9. Zhao S, Fields PA, Sherwood OD 2001 Evidence that relaxin inhibits apoptosis in the cervix and the vagina during the second half of pregnancy in the rat. Endocrinology 142:2221-2229
10. Lee H-Y, Zhao S, Fields PA, Sherwood OD 2005 The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy. Endocrinology 146:511-518
11. Lee H-Y, Sherwood OD 2005 The effects of blocking the actions of estrogen and progesterone on the rates of proliferation and apoptosis of cervical epithelial and stromal cells during the second half of pregnancy in rats. Biol Reprod 73:790-797
12. Kuenzi MJ, Sherwood OD 1995 Immunohistochemical localization of specific relaxin-binding cells in the cervix, mammary glands, and nipples of pregnant rats. Endocrinology 136:1367-1373
13. Min G, Sherwood OD 1996 Identification of specific relaxin-binding cells in the cervix, mammary glands, nipples, small intestine, and skin of pregnant pigs. Biol Reprod 55:1243-1252
14. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJW 2002 Activation of orphan receptors by the hormone relaxin. Science 295:671-674
15. Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ 2006 International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol Rev 58:7-31
16. Parry LJ, McGuane JT, Gehring HM, Kostic IGT, Siebel AL 2005 Mechanisms of relaxin action in the reproductive tract. Ann NY Acad Sci 1041:91-103
17. Krajnc-Franken MA, van Disseldorp JM, Koenders JE, Mosselman S, van Duin M, Gossen JA 2004 Impaired nipple development and parturition in LGR7 knockout mice. Mol Cell Biol 24:687-696
18. Cooke PS, Buchanan DL, Young P, Setiawan T, Brody J, Korach KS, Taylor J, Lubahn DB, Cunha GR 1997 Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium. Proc Natl Acad Sci USA 94:6535-6540
19. Buchanan DL, Kurita T, Taylor JA, Lubahn DB, Cunha GR, Cooke PS 1998 Role of stromal and epithelial estrogen receptors in vaginal epithelial proliferation, stratification and cornification. Endocrinology 139:4345-4352
20. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O 1993 Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 90:11162-11166
21. Kamat AA, Feng S, Bogatcheva NV, Truong A, Bishop CE, Agoulnik AI 2004 Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. Endocrinology 145:4712-4720
22. Cohen PE, Milligan SR 1993 Silastic implants for delivery of oestradiol to mice. J Reprod Fertil 99:219-223
23. Milligan SR, Cohen PE 1994 Silastic implants for delivering physiological concentrations of progesterone to mice. Reprod Fertil Dev 6:235-239
24. Milligan SR, Finn CA 1997 Minimal progesterone support required for the maintenance of pregnancy in mice. Hum Reprod 12:602-607
25. Smith ER, Damassa DA, Davidson JM 1977 Hormone administration: peripheral and intracranial implants. In: Myers RD, ed. Methods in psychobiology. Vol 3. New York: Academic Press; 259-279
26. Sherwood OD, O'Byrne EM 1974 Purification and characterization of porcine relaxin. Arch Biochem Biophys 160:185-196
27. Bigsby RM, Cooke PS, Cunha GR 1986 A simple efficient method for separating murine uterine epithelial and mesenchymal cells. Am J Physiol 251:E630-E636
28. Sheehan DC, Hrapchak BB 1980 Fixation. In: Theory and practice of histotechnology. 2nd ed. Columbus, OH: Battelle Press; 40-58
29. Cunha GR, Lung B, Kato K 1977 Role of the epithelial-stromal interaction during the development and expression of ovary-independent vaginal hyperplasia. Dev Biol 56:52-67
30. Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y 1997 'Green mice' as a source of ubiquitous green cells. FEBS Lett 407:313-319
31. Schutte B, Reynders MMJ, Bosman FT, Blijham GH 1987 Effect of tissue fixation on anti-bromodeoxyuridine immunochemistry. J Histochem Cytochem 35:1343-1345
32. Gavrieli Y, Sherman Y, Ben-Sasson SA 1992 Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501
33. Denton CP, Zheng B, Evans LA, Shi-wen X, Ong VH, Fisher I, Lazaridis K, Abraham DJ, Black CM, de Crombrugghe B 2003 Fibroblast specific expression of a kinase-deficient type II transforming growth factor β (TGFβ) receptor leads to paradoxical activation of TGFβ signaling pathways with fibrosis in transgenic mice. J Biol Chem 278:25109-25119
34. Feng S, Bogatcheva NV, Kamat AA, Truong A, Agoulnik AI 2006 Endocrine effects of relaxin overexpression in mice. Endocrinology 147:407-414
35. Cunha GR, Cooke PS, Kurita T 2004 Role of stromal-epithelial interactions in hormonal responses. Arch Histol Cytol 67:417-434
36. Buchanan DL, Setiawan T, Lubahn DB, Taylor JA, Kurita T, Cunha GR, Cooke PS 1999 Tissue compartment-specific estrogen receptor α participation in the mouse uterine epithelial secretory response. Endocrinology 140:484-491
37. Kurita T, Wang Y-Z, Donjacour AA, Zhao C, Lydon JP, O'Malley BP, Isaacs JT, Dahiya R, Cunha GR 2001 Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system. Cell Death Differ 8:192-200
38. Kurita T, Young P, Brody JR, Lydon JP, O'Malley BW, Cunha GR 1998 Stromal progesterone receptors mediate the inhibitory effects of progesterone on estrogen-induced uterine epithelial cell deoxynucleic acid synthesis. Endocrinology 139:4708-4713
39. Dürnbereger H, Kratochwil K 1980 Specificity of tissue interaction and origin of mesenchymal cells of the androgen response of the embryonic mammary gland. Cell 19:465-471
40. Tsuji M, Shima H, Yonemura CY, Brody J, Donahue PK, Cunha GR 1992 Effect of human recombinant mullerian inhibiting substance on isolated epithelial and mesenchymal cells during mullerian duct regression in the rat. Endocrinology 131:1481-1488
41. Cullen BM, Harkness RD 1960 The effect of hormones on the physical properties and collagen content of the rat's uterine cervix. J Physiol 152:419-436
42. Kroc RL, Steinetz BG, Beach VL 1959 The effects of estrogens, progestagens, and relaxin in pregnant and nonpregnant laboratory rodents. Ann NY Acad Sci 75:942-980
43. Sherwood OD 1994 Relaxin. In: Knobil E, Neill JD, eds. The physiology of reproduction. 2nd ed. New York: Raven Press; 861-1009
44. Yamashita S, Korach KS 1989 A modified immunohistochemical procedure for the detection of estrogen receptor in mouse tissues. Histochemistry 90:325-330
45. Yamashita S, Newbold RR, McLachlan JA, Korach KS 1989 Developmental pattern of estrogen receptor expression in female mouse genital tracts. Endocrinology 125:2888-2896
46. Celli G, Darwiche N, De Luca LM 1996 Estrogen induces retinoid receptor expression in mouse cervical epithelia. Exp Cell Res 226:273-282