Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall

American Journal of Pathology

Volumn 155, Issue 1, 1999, Pages 293-301

  DiFederico, Elaine ^a   Genbacev, Olga ^a   Fisher, Susan J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL INTERACTION; CELL INVASION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTROPHOBLAST; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; MITOSIS; MYOMETRIUM; PATHOGENESIS; PLACENTA; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032983892     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65123-1     Document Type: Article

References (33)

1. Levine RJ, Hauth JC, Curet LB, Sibai BM, Catalano PM, Morris CD, DerSimonian R, Esterlitz JR, Raymond EG, Bild DE, Clemens JD, Cutler JA: Trial of calcium to prevent preeclampsia. N Engl J Med 1997, 337:69-76
2. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK: Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989, 161:1200-1204
3. Albrecht JL, Tomich PG: The maternal and neonatal outcome of triplet gestations. Am J Obstet Gynecol 1996, 174:1551-1556
4. Chun D, Braga C, Chow C, Lok L: Clinical observations on some aspects of hydatidiform moles. J Obstet Gynaecol Br Commonw 1964, 71:180-184
5. Brosens IA, Robertson WB, Dixon HG: The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu 1972, 1:177-191
6. Gerretsen G, Huisjes HJ, Elema JD: Morphological changes of the spiral arteries in the placental bed in relation to pre-eclampsia and fetal growth retardation. Br J Obstet Gynaecol 1981, 88:876-881
7. Khong TY, De Wolf F, Robertson WB, Brosens I: Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol 1986, 93:1049-1059
8. Zhou Y, Damsky CH, Chiu K, Roberts JM, Fisher SJ: Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts. J Clin Invest 1993, 91:950-960
9. Zhou Y, Fisher SJ, Janatpour M, Genbacev O, Dejana E, Wheelock M, Damsky CH: Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion? J Clin Invest 1997, 99:2139-2151
10. Zhou Y, Damsky CH, Fisher SJ: Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest 1997, 99:2152-2164
11. Genbacev O, Joslin R, Damsky CH, Polliotti BM, Fisher SJ: Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia. J Clin Invest 1996, 97:540-550
12. Genbacev O, Zhou Y, Ludlow JW, Fisher SJ: Regulation of human placental development by oxygen tension. Science 1997, 277:1669-1672
13. Chesley LC: Diagnosis of preeclampsia. Obstet Gynecol 1985, 65: 423-425
14. Damsky CH, Fitzgerald ML, Fisher SJ: Distribution patterns of extra-cellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo. J Clin Invest 1992, 89:210-222
15. Fisher SJ, Cui TY, Zhang L, Hartman L, Grahl K, Zhang GY, Tarpey J, Damsky CH: Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. J Cell Biol 1989, 109:891-902
16. Smith SC, Baker PN, Symonds EM: Placental apoptosis in normal human pregnancy. Am J Obstet Gynecol 1997, 177:57-65
17. Kerr JF, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972, 26:239-257
18. Coles HS, Burne JF, Raff MC: Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development 1993, 118:777-784
19. Redline RW, Patterson P: Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblast. Hum Pathol 1995, 26:594-600
20. Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y: Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 1995, 374:811-813
21. Jacobson MD, Raff MC: Programmed cell death and Bcl-2 protection in very low oxygen. Nature 1995, 374:814-816
22. Lea RG, al-Sharekh N, Tulppala M, Critchley HO: The immunolocalization of bcl-2 at the maternal-fetal interface in healthy and failing pregnancies. Hum Reprod 1997, 12:153-158
23. Ashkenas J, Werb Z: Proteolysis and the biochemistry of life-or-death decisions. J Exp Med 1996, 183:1947-1951
24. Hermiston ML, Gordon JI: In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J Cell Biol 1995, 129:489-506
25. Frisch SM, Ruoslahti E: Integrins and anoikis. Curr Opin Cell Biol 1997, 9:701-706
26. Franceschi C: Cell proliferation, cell death and aging. Aging (Milano) 1989, 1:3-15
27. Meikrantz W, Schlegel R: Apoptosis and the cell cycle. J Cell Biochem 1995, 58:160-174
28. White E: Life, death, and the pursuit of apoptosis: Genes Dev 1996, 10:1-15
29. Kanfer A, Bruch JF, Nguyen G, He CJ, Delarue F, Flahault A, Nessmann C, Uzan S: Increased placental antifibrinolytic potential and fibrin deposits in pregnancy-induced hypertension and preeclampsia. Lab Invest 1996, 74:253-258
30. Casciola-Rosen L, Rosen A. Petri M, Schlissel M: Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc Natl Acad Sci USA 1996, 93:1624-1629
31. Redman CW: Platelets and the beginnings of preeclampsia. N Engl J Med 1990, 323:478-480
32. Welsch S, Branch DW: Antiphospholipid syndrome in pregnancy. Obstetric concerns and treatment. Rheum Dis Clin North Am 1997, 23:71-84
33. Smith SC, Baker PN, Symonds EM: Increased placental apoptosis in intrauterine growth restriction. Am J Obstet Gynecol 1997, 177: 1395-1401