Cymbopogon citratus as source of new and safe anti-inflammatory drugs: Bio-guided assay using lipopolysaccharide-stimulated macrophages

Journal of Ethnopharmacology

Volumn 133, Issue 2, 2011, Pages 818-827

  Francisco, Vera ^a,b   Figueirinha, Artur ^a,c   Neves, Bruno Miguel ^a,b   García Rodríguez, Carmen ^d   Lopes, Maria Celeste ^a,b   Cruz, Maria Teresa ^a,b   Batista, Maria Teresa ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c POLYTECHNIC INSTITUTE OF VISEU   (Portugal)

^d UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Cymbopogon citratus; Inflammation; Mitogen activated protein kinases; Nitric oxide; Nuclear factor B; Poaceae Gramineae; Polyphenol

Indexed keywords

CYCLOOXYGENASE 2; CYMBOPOGON CITRATUS EXTRACT; FLAVONOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITRITE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYPHENOL; PROSTAGLANDIN E2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE 1; TANNIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; ENZYME ACTIVATION; GENE EXPRESSION; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PLANT LEAF; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL ASSAY; CELL LINE; CYCLOOXYGENASE 2; CYMBOPOGON; DINOPROSTONE; ETHNOPHARMACOLOGY; FLAVONOIDS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MEDICINE, TRADITIONAL; MICE; MODELS, BIOLOGICAL; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOLS; PLANT LEAVES; PLANT PREPARATIONS; PORTUGAL; SIGNAL TRANSDUCTION;

CYMBOPOGON CITRATUS; MURINAE; POACEAE;

EID: 78651410773     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.11.018     Document Type: Article

References (41)

1. D. Carbajal, A. Casaco, L. Arruzazabala, R. Gonzalez, and Z. Tolon Pharmacological study of Cymbopogon citratus leaves Journal of Ethnopharmacology 25 1989 103 107
2. A.B. Carter, K.L. Knudtson, M.M. Monick, and G.W. Hunninghake The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP) The Journal of Biological Chemistry 274 1999 30858 30863
3. J. Cheel, C. Theoduloz, J. Rodriguez, and G. Schmeda-Hirschmann Free radical scavengers and antioxidants from Lemongrass (Cymbopogon citratus (DC.) Stapf.) Journal of Agricultural and Food Chemistry 53 2005 2511 2517
4. C. Chen, Y.H. Chen, and W.W. Lin Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages Immunology 97 1999 124 129
5. C.C. Chen, and J.K. Wang p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages Molecular Pharmacology 55 1999 481 488
6. Z. Cheng, C. Lin, T. Hwang, and C. Teng Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages Biochemical Pharmacology 61 2001 939 946
7. H.J. Choi, J.S. Eun, Y.R. Park, D.K. Kim, R. Li, W.S. Moon, J.M. Park, H.S. Kim, N.P. Cho, S.D. Cho, and Y. Soh Ikarisoside A inhibits inducible nitric oxide synthase in lipopolysaccharide-stimulated RAW 264.7 cells via p38 kinase and nuclear factor-kappaB signaling pathways European Journal of Pharmacology 601 2008 171 178
8. J.B. Crawley, L.M. Williams, T. Mander, F.M. Brennan, and B.M. Foxwell Interleukin-10 stimulation of phosphatidylinositol 3-kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine The Journal of Biological Chemistry 271 1996 16357 16362
9. R.J. Davis MAPKs: new JNK expands the group Trends in Biochemical Sciences 19 1994 470 473
10. A. Figueirinha, A. Paranhos, J.J. Pérez-Alonso, C. Santos-Buelga, and M.T. Batista Cymbopogon citratus leaves: characterisation of flavonoids by HPLC-PDA-ESI/MS/MS and an approach to their potential as a source of bioactive polyphenols Food Chemistry 110 2008 718 728
11. A. Figueirinha, M.T. Cruz, V. Francisco, M.C. Lopes, and M.T. Batista Anti-inflammatory activity of Cymbopogon citratus leaf infusion in lipopolysaccharide-stimulated dendritic cells: contribution of the polyphenols Journal of Medicinal Food 13 2010 681 690
12. D.A. Geller, and T.R. Billiar Molecular biology of nitric oxide synthases Cancer Metastasis Reviews 17 1998 7 23
13. M.R. Gold, V. Duronio, S.P. Saxena, J.W. Schrader, and R. Aebersold Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins The Journal of Biological Chemistry 269 1994 5403 5412
14. J. Gonzalez-Gallego, S. Sanchez-Campos, and M.J. Tunon Anti-inflammatory properties of dietary flavonoids Nutricion Hospitalaria 22 2007 287 293
15. L.C. Green, D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, and S.R. Tannenbaum Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Analytical Biochemistry 126 1982 131 138
16. T.J. Guzik, R. Korbut, and T. Adamek-Guzik Nitric oxide and superoxide in inflammation and immune regulation Journal of Physiology and Pharmacology 54 2003 469 487
17. J. Han, J.D. Lee, L. Bibbs, and R.J. Ulevitch A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells Science 265 1994 808 811
18. S. Harirforoosh, and F. Jamali Renal adverse effects of nonsteroidal anti-inflammatory drugs Expert Opinion on Drug Safety 8 2009 669 681
19. J.D. Hunter, and M. Doddi Sepsis and the heart British Journal of Anaesthesia 104 2010 3 11
20. H.J. Lee, H.S. Jeong, D.J. Kim, Y.H. Noh, D.Y. Yuk, and J.T. Hong Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-kappa B activation in RAW264.7 cells Archives of Pharmacal Research 31 2008 342 349
21. H.J. Lee, H.J. Lim, Y. Lee da, H. Jung, M.R. Kim, D.C. Moon, K.I. Kim, M.S. Lee, and J.H. Ryu Carabrol suppresses LPS-induced nitric oxide synthase expression by inactivation of p38 and JNK via inhibition of I-kappaBalpha degradation in RAW 264.7 cells Biochemical and Biophysical Research Communications 391 2010 1400 1404
22. B.B. Lorenzetti, G.E. Souza, S.J. Sarti, D. Santos Filho, and S.H. Ferreira Myrcene mimics the peripheral analgesic activity of lemongrass tea Journal of Ethnopharmacology 34 1991 43 48
23. M. Mori, and T. Gotoh Regulation of nitric oxide production by arginine metabolic enzymes Biochemical and Biophysical Research Communications 275 2000 715 719
24. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 65 1983 55 63
25. H. Nakano, M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1 Proceedings of the National Academy of Sciences of the United States of America 95 1998 3537 3542
26. R.R.B. Negrelle, and E.C. Gomes Cymbopogon citratus (DC.) Stapf: chemical composition and biological activities Revista Brasileira de Plantas Medicinais 9 2007 80 92
27. D.J. Newman, and G.M. Cragg Natural products as sources of new drugs over the last 25 years Journal of Natural Products 70 2007 461 477
28. R. Orrego, E. Leiva, and J. Cheel Inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus (Lemongrass) on human low density lipoprotein oxidation Molecules 14 2009 3906 3913
29. M.H. Pan, S.Y. Lin-Shiau, and J.K. Lin Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages Biochemical Pharmacology 60 2000 1665 1676
30. H.J. Park, H.J. Lee, M.S. Choi, D.J. Son, H.S. Song, M.J. Song, J.M. Lee, S.B. Han, Y. Kim, and J.T. Hong JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin Journal of Inflammation (London, England) 5 2008 7
31. C. Porta, P. Larghi, M. Rimoldi, M.G. Totaro, P. Allavena, A. Mantovani, and A. Sica Cellular and molecular pathways linking inflammation and cancer Immunobiology 214 2009 761 777
32. K.M. Rao MAP kinase activation in macrophages Journal of Leukocyte Biology 69 2001 3 10
33. J.M. Ritter, I. Harding, and J.B. Warren Precaution, cyclooxygenase inhibition, and cardiovascular risk Trends in Pharmacological Sciences 30 2009 503 508
34. B. Salh, R. Wagey, A. Marotta, J.S. Tao, and S. Pelech Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production Journal of Immunology 161 1998 6947 6954
35. C. Santangelo, R. Vari, B. Scazzocchio, R. Di Benedetto, C. Filesi, and R. Masella Polyphenols, intracellular signalling and inflammation Annalli delĺIstituto Superiore di Sanita 43 2007 394 405
36. M.I. Schmidt, and B.B. Duncan Diabesity: an inflammatory metabolic condition Clinical Chemistry and Laboratory Medicine 41 2003 1120 1130
37. C. Thiemermann Nitric oxide and septic shock General Pharmacology 29 1997 159 166
38. C. Tsatsanis, A. Androulidaki, M. Venihaki, and A.N. Margioris Signalling networks regulating cyclooxygenase-2 The International Journal of Biochemistry & Cell Biology 38 2006 1654 1661
39. N.P. Whitney, T.M. Eidem, H. Peng, Y. Huang, and J.C. Zheng Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders Journal of Neurochemistry 108 2009 1343 1359
40. R. Zamora, Y. Vodovotz, and T.R. Billiar Inducible nitric oxide synthase and inflammatory diseases Molecular Medicine 6 2000 347 373
41. H.Y. Zhou, E.M. Shin, L.Y. Guo, U.J. Youn, K. Bae, S.S. Kang, L.B. Zou, and Y.S. Kim Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivation European Journal of Pharmacology 586 2008 340 349