Free radical scavengers and antioxidants from lemongrass (Cymbopogon citratus (DC.) Stapf.)

Journal of Agricultural and Food Chemistry

Volumn 53, Issue 7, 2005, Pages 2511-2517

  Cheel, José ^a   Theoduloz, Cristina ^a   Rodríguez, Jaime ^a   Schmeda Hirschmann, Guillermo ^a  

^a UNIVERSIDAD DE TALCA   (Chile)

Author keywords

Antioxidants; Cymbopogon citratus; Flavonoid C glycosides; Free radical scavengers

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTIOXIDANT; CAFFEIC ACID; CHLOROGENIC ACID; CYMBOPOGON CITRATUS EXTRACT; ISOORIENTIN; ISOORIENTIN 2'' O RHAMNOSIDE; ISOSCOPARIN; METHANOL; METHANOL DERIVATIVE; ORIENTIN; SCAVENGER; SUPEROXIDE; SWERTIAJAPONIN; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ARTICLE; CYMBOPOGON CITRATUS; DRUG ACTIVITY; DRUG ISOLATION; ERYTHROCYTE; LIPID PEROXIDATION; SPECTROSCOPY;

ANTIOXIDANTS; CYMBOPOGON; ENZYME INHIBITORS; ERYTHROCYTES; FLAVONOIDS; FREE RADICAL SCAVENGERS; HUMANS; LIPID PEROXIDATION; LIPIDS; METHANOL; PICRATES; PLANT EXTRACTS; SUPEROXIDES; XANTHINE OXIDASE;

CYMBOPOGON CITRATUS; LETHRINIDAE;

EID: 16344368074     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf0479766     Document Type: Article

References (30)

1. Carlini, E. A.; Contar, J.; Silva-Filho, A.; Da Silveira-Filho, N.; Frochtengarten, M.; Bueno, O. Pharmacology of lemongrass (Cymbopogon citratus Stapf). I. Effects of teas prepared from the leaves on laboratory animals. J. Ethnopharmacol. 1986, 17, 37-64.
2. Middleton, E., Jr.; Kandaswami, C.; Theoharides, J. C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 2000, 52, 673-751.
3. Oh, T. Y.; Lee, J. S.; Ahn, B. O.; Cho, H.; Kim, W. B.; Kim, Y. B.; Surh, Y. J.; Cho S. W.; Hahm, K. B. Oxidative damages are critical in pathogenesis of reflux esophagitis: Implication of antioxidants in its treatment. Free Radical Biol. Med. 2001, 30, 905-915.
4. Oh, T. Y.; Lee, J. S.; Ahn, B. O.; Cho, H.; Kim, W. B.; Kim, Y. B.; Surh, Y. J.; Cho, S. W.; Lee, K. M.; Hahm, K. B. Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats. Gut 2001, 49, 364-371.
5. Taub, R. Hepatoprotection via the IL-6/Stat3. J. Clin. Invest. 2003, 112, 978-980.
6. Kato, T.; Morita, Y. C-Glycosylflavones with acetyl substitution from Rumex acetosa L. Chem. Pharm. Bull. 1990, 38, 2277-2280.
7. De Matouschek, B. V.; Stahl-Biskup, E. Phytochemische Untersuchung der nichtflüchtigen Inhaltsstoffe von Cymbopogon citratus (DC.) Stapf (Poaceae). Pharm. Helv. Acta 1991, 66, 242-245.
8. Lin, Y. L.; Kuo, Y. H.; Shiao, M. S.; Chen, C. C.; Ou, J. C. Flavonoid glycosides from Terminalia catappa L. J. Chin. Chem. Soc.-Taip. 2000, 47, 253-256.
9. Wu, F. E.; Koike, K.; Nikaido, T.; Ishii, K.; Ohmoto, T.; Ikeda, K. Terpenoids and flavonoids from Arenaria kansuensis. Chem. Pharm. Bull. 1990, 38, 2281-2282.
10. Maatooq, G. T.; El-Sharkawy, S. H.; Afifi, M. S.; Rosazza, J. P. N. C-p-Hydroxybenzoylglycoflavones from Citrullus colocynthis. Phytochemistry 1997, 44, 187-190.
11. Nawwar, M. A. M.; El Sissi, H. I.; Baracat, H. H. The flavonoids of Phragmites australis flowers. Phytochemistry 1980, 19, 1854-1856.
12. Cheng, G.; Bai, Y.; Zhao, Y.; Tao, J.; Liu, Y.; Tu, G.; Ma, L.; Liaoc, N.; Xu, X. Flavonoids from Ziziphus jujuba Mill var. spinosa. Tetrahedron 2000, 56, 8915-8920.
13. Wang, H.; Nair, M. G.; Strasburg, G. M.; Booren, A. M.; Gray, J. I. Antioxidant polyphenols from tart cherries (Prunus cerasus). J. Agric. Food Chem. 1999, 47, 840-844.
14. Sánchez-Rabaneda, F.; Jáuregui, O.; Casals, I. C.; Lacueva, A.; Izquierdo-Pulido, M.; Lamuela-Raventós, R. M. Liquid chromatographic/electrospray ionization tandem mass spectometric study of the phenolic composition of cocoa (Thebroma cacao). J. Mass Spectrom. 2003, 38, 35-42.
15. Schmeda-Hirschman, G.; Rodríguez, J. A.; Theoduloz, C.; Astudillo, L.; Feresin, G. E.; Tapia, A. Free radical scavengers and antioxidants from Peumus boldus Mol. (Boldo). Free Radical Res. 2003, 37, 447-452.
16. Rodríguez, J. A.; Haun, M. Cytotoxicity of irans-dehydrocrotonin from Croton cajucara (Euphorbiaceae) on V79 cells and rat hepatocytes. Planta Med. 1999, 65, 522-526.
17. Harborne, J. B.; Williams, C. A. Flavonoid patterns in leaves of the Gramineae. Biochem. Syst. Ecol. 1976, 4, 267-280.
18. Budzianowski, J.; Pakulski, G.; Robak, J. Studies on antioxidative activity of some C-glycosylflavones. Pol. J. Pharmacol. Pharm. 1991, 43, 395-401.
19. Huguet, A. I.; Manez, S.; Alcaraz, M. J. Superoxide scavenging properties of flavonoids in a nonenzymic system. Z. Naturforsch. C 1990, 45, 19-24.
20. Mun'im, A.; Negishi, O.; Ozawa, T. Antioxidative compounds from Crotalaria sessiliflora. Biosci. Biotechnol. Biochem. 2003, 67, 410-414.
21. Mora, A.; Paya, M.; Rios, J. L.; Alcaraz, M. J. Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of nonenzymic lipid peroxidation. Biochem. Pharmacol. 1990, 40, 793-797.
22. Vrinda, B.; Uma Devi, P. Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin. Mutat. Res. 2000, 498, 39-46.
23. Ko, F. N.; Chu, C. C.; Lin, C. N.; Chang, C. C.; Teng, C. M. Isoorientin-6″-O-glucoside, a water-soluble antioxidant isolated from Gentiana arisanensis. Biochim. Biophys. Acta 1998, 1389, 81-90.
24. Hoffmann-Bohm, K.; Lotter, H.; Seligmann, O.; Wagner, H. Antihepatotoxic C-glycosylflavones from the leaves of Allophyllus edulis var. edulis and gracilis. Planta Med. 1992, 58, 544-548.
25. Orhan, D. D.; Aslan, M.; Aktay, G.; Ergun, E.; Yesilada, E.; Ergun, F. Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle. Life Sci. 2003, 72, 2273-2283.
26. Leite, J. R.; Seabra, M. de L. V.; Maluf, E.; Assolant, K.; Suchecki, D.; Tufik, S.; Klepacz, S.; Calil, H. M.; Carlini, E. A. Pharmacology of lemongrass (Cymbopogon citratus Stapf). III. Assessment of eventual toxic, hypnotic, and anxiolytic effects on humans. J. Ethnopharmacol. 1986, 17, 15-83.
27. Carbajal, D.; Casaco, A.; Arruzazabala, L.; Gonzales, R.; Tolon, Z. Pharmacological study of Cymbopogon citratus leaves. J. Ethnopharmacol. 1989, 25, 103-107.
28. Vinitketkumnuen, U.; Puatanachokchai, R.; Kongtawelert, P.; Lertprasertsuke, N.; Matsushima, T. Antimutagenicity of lemon grass (Cymbopogon citratus Stapf) to various known mutagens in salmonella mutation assay. Mutat. Res. 1994, 341, 71-75.
29. Puatanachokchai, R.; Kishida, H.; Denda, A.; Murata, N.; Konishi, Y.; Vinitketkumnuen, U.; Nakae, D. Inhibitory effects of lemon grass (Cymbopogon citratus, Stapf) extract on the early phase of hepatocarcinogenesis after initiation with diethyl-nitrosamine in male Fischer 344 rats. Cancer Lett. 2002, 183, 9-15.
30. Andrade-Cetto, A.; Wiedenfeld, H. Hypoglycaemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J. Ethnopharmacol. 2001, 78, 145-149.