Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NFκB activation in macrophages

Biochemical Pharmacology

Volumn 60, Issue 11, 2000, Pages 1665-1676

  Pan, Min Hsiung ^a   Lin Shiau, Shoei Yn ^a   Lin, Jen Kun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Curcumin; IKK; Inducible NO synthase (iNOS); Macrophages; NF B; RAW 264.7 monocytes

Indexed keywords

CURCUMIN; DRUG METABOLITE; HEXAHYDROCURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; OCTAHYDROCURCUMIN; TETRAHYDROCURCUMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ELECTROPHORETIC MOBILITY; ENZYME INHIBITION; IMMUNOBLOTTING; MACROPHAGE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; CELLS, CULTURED; CURCUMIN; DOWN-REGULATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROGENATION; I-KAPPA B KINASE; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER;

EID: 0034578521     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00489-5     Document Type: Article

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