Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated raw 264.7 cells: Differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production

Journal of Immunology

Volumn 161, Issue 12, 1998, Pages 6947-6954

  Salh, B ^a   Wagey, R ^a   Marotta, A ^a   Tao, J S ^a   Pelech, S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECT; EFFECTOR CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNE RESPONSE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CARRIER PROTEINS; CELL LINE; CHROMONES; ENZYME ACTIVATION; ENZYME INHIBITORS; IMMUNOPHILINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MORPHOLINES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 0032534586     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Morrison, D. C., and J. L. Ryan. 1979. Bacterial endotoxins and host immune responses. Adv. Immunol. 28:293.
2. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051.
3. Kielian, T. L., and F. Blecha. 1995. CD14 and other recognition molecules for lipopolysaccharide. Immunopharmacology 29:187.
4. lyn. J. Biol. Chem. 268:20725.
5. Meng, F., and C. A. Lowell. 1997. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J. Exp. Med. 185:1661.
6. Vanhaesebroeck, B., S. J. Leevers, G. Panayatou, and M. D. Waterfield. 1997. Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem. Sci. 22:267.
7. Toker, A., and L. C. Cantley. 1997. Signaling through the lipid products of phosphoinositide-3-OH kinase. Nature 387:673.
8. lyn and phosphatidylinositol 3-kinase in human monocytes. J. Immunol. 156:1157.
9. Herrera-Velit, P., K. L. Knutson, and N. E. Reiner. 1997. Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-ζ in bacterial lipopolysaccharide-treated human monocytes. J. Biol. Chem. 272:16445.
10. Reif, K., B. M. T. Burgering, and D. A. Cantrell. 1997. Phosphatidylinositol 3-kinase links the interleukin 2 receptor to protein kinase B and p70 S6 kinase. J. Biol. Chem. 272:14426.
11. Crawley, J. B., L. M. Williams, T. Mander, F. M. Brennan, and B. M. J. Foxwell. 1996. Interleukin 10 stimulation of phosphatidylinositol 3-kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine. J. Biol. Chem. 271:16357.
12. Wright, K., S. G. Ward, G. Kolios, and J. Westwick. 1997. Activation of phosphatidylinositol 3-kinase by interleukin-13. J. Biol. Chem. 272:12626.
13. Gold, M. R., V. Duronio, S. P. Saxena, J. W. Schrader, and R. Aebersold. 1994. Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. J. Biol. Chem. 269:5403.
14. Coffer, P. J., N. Geijsen, L. M'Rabet, R. C. Schweizer, T. Maikoe, J. A. M. Raaijmakers, J.-W. J. Lammers, and L. Koenderman. 1997. Comparison of the roles of the mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function. Biochem. J. 329:121.
15. Reif, K., S. Lucas, and D. A. Cantrell. 1997. A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function. Curr. Biol. 7:285.
16. Burgering, B. M., and P. J. Coffer. 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599.
17. Franke, T. F., S. Yang, T. O. Chan, K. Datta, A. Kazlauskas, D. K. Morrison, D. R. Kaplan, and P. N. Tsichlis. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727.
18. Alessi, D. R., M. Andjelkovic, B. Cauldwell, P. Cron, N. Morrice, P. Cohen, and B. A. Hemmings. 1996. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15:6541.
19. Wijkander, J., L. S. Holst, T. Rahn, S. Rejso, I. Castan, V. Manganiello, P. Belfrage, and E. Degerman. 1997. Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. J. Biol. Chem. 272:21520.
20. Andjelkovic M., D. R. Alessi, R. Meier, A. Fernandez, N. J. C. Lamb, M. Frech, P. Cron, P. Cohen, J. M. Lucocq, and B. A. Hemmings. 1997. Role of translocation in the activation and function of protein kinase B. J. Biol. Chem. 272: 31515.
21. Alessi, D. R., S. R. James, C.P. Downes, A. B. Holmes, P. R. J. Gaffney, C. B. Reese, and P. Cohen. 1997. Characterisation of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr. Biol. 7:261.
22. Hemmings, B. A. 1997. Akt signaling:linking membrane events to life and death decisions. Science 275:628.
23. Dudek, H., S. R. Datta, T. F. Franke, M. J. Birnbaum, R. Yao, G. M. Cooper, R. A. Segal, D. R. Kaplan, and M. E. Greenberg. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661.
24. Chou, M., and J. Blenis. 1995. The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signaling. Curr. Opin. Cell Biol. 7:806.
25. Brown, E. J., P. A. Beal, C. T. Keith, J. Chen, T. B. Shin, and S. L. Schreiber. 1995. Control of p70 S6 kinase by kinase activity of FRAP in vivo. Nature 377:441.
26. Brunn, G. J., J. Williams, C. Sabers, G. Wiederrecht, J. C. Lawrence, and R. T. Abraham. 1996. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and Ly294002. EMBO J. 15:5256.
27. Brunn, G. J., C. C. Hudson, A. Sekulic, J. M. Williams, H. Hosoi, P. J. Houghton, J. C. Lawrence, and R. T. Abraham. 1997. Phosphorylation of the translational repressor PHAS-1 by the mammalian target of rapamycin. Science 277:99.
28. Brunn, G. J., P. Fadden, T. A. J. Haystead, and J. C. Lawrence. 1997. The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. J. Biol. Chem. 272:32547.
29. Alessi, D. R., M. T. Kowzlowski, Q.-P. Weng, N. Morrice, and J. Avruch. 1997. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr. Biol. 8:69.
30. Proud, C. 1996. P70 S6 kinase:an enigma with variations. Trends Biochem. Sci. 21:181.
31. De Groot, R. P., L. M. Ballou, and P. Sassone-Corsi. 1994. Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternate route to mitogen-induced gene expression. Cell 79:81.
32. Sanghera, J. S., S. L. Weinstein, M. Ahluwalia, J. Girn, and S. L. Pelech. 1996. Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages. J. Immunol. 156:4457.
33. Swantek, J. L., M. H. Cobb, and T. D. Geppert. 1997. Jun N-terminal kinase/ stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor (TNF-α) translation: glucocorticoids inhibit TNF-α translation by blocking JNK/SAPK. Mol. Cell. Biol. 17:6274.
34. Da Silva, J., B. Pierrat, J.-L. Mary, and W. Lesslauer. 1997. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. J. Biol. Chem. 272:28373.
35. Bhat, N. R., P. Zhang, J. C. Lee, and E. L. Hogan. 1998. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18:1633.
36. Yano, H., S. Nakanishi, K. Kimura, N. Hanai, Y. Saitoh, Y. Fukui, Y. Nonomura, and Y. Matsuda. 1993. Inhibition of histamine secretion by Wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem. 268:25846.
37. Altmeyer, A., and F. J. Dumont. 1993. Rapamycin inhibits IL-1-mediated interferon-γ production in the YAC-1 T cell lymphoma. Cytokine 5:133.
38. Dong, Z., X. Qui, K. Xie, and I. J. Fidler. 1993. Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages. J. Immunol. 151:2717.
39. Pan, J., K. L. Burgher, A. M. Szcepanik, and G. E. Ringheim. 1996. Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation. Biochem. J. 314:889.
40. Messmer, U. K., and B. Brune. 1995. Nitric oxide-induced apoptosis: p53-dependent and p53-independent signaling pathways. Biochem. J. 319:299.
41. Lundberg, J. O. N., J. M. Lundberg, K. Alving, and E. Weitzberg. 1997. Nitric oxide and inflammation: the answer is blowing in the wind. Nat. Med. 3:30.
42. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
43. Tudan, C., J. K. Jackson, L. Charlton, S. Pelech, B. Salh, and H. Burt. 1998. Activation of S6 kinase in human neutrophils by calcium pyrophosphate dihydrate crystals: protein kinase C-dependent and phosphatidylinositol-3-kinase-independent pathways. Biochem. J. 331:531.
44. Picking, W. D., T. Hackstadt, and D. Paretsky. 1989. Endotoxicosis induced by Coxiella burnetti lipopolysaccharide stimulates a ribosomal protein S6 kinase: some properties of the partially purified enzyme. Infect. Immun. 57:3683.
45. Stephens, L. R., A. Eguinoa, H. Erdjument-Bromage, M. Lui, F. Cooke, J. Coadwell, A. S. Smrcka, M. Thelan, K. Cadwallader, P. Tempst, and P. T. Hawkins. 1997. The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89:105.
46. Konishi, H., H. Matsuzaki, M. Tanaka, Y. Ono, C. Tokunaga, S. Kuroda, and U. Kikkawa. 1996. Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 93:7639.
47. Sable, C. L., N. Filippa, B. Hemmings, and E. Van Obberghen. 1997. cAMP stimulates protein kinase B in a wortmannin-insensitive manner. FEBS Lett. 409: 253.
48. Weinstein, S. L., M. R. Gold, and A. L. DeFranco. 1991. Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc. Natl. Acad. Sci. USA 88:4148.
49. Beaty, C. D., T. L. Franklin, Y. Uehara, and C. B. Wilson. 1994. Lipopolysaccharide-induced cytokine production in human monocytes: role of tyrosine phosphorylation in transmembrane signal transduction. Eur. J. Immunol. 24:1278.
50. Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, J. R. Heys, S. W. Landvalter, et al. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739.
51. Wang, X., and C. Proud. 1997. p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase. Biochem. Biophys. Res. Commun. 238:207.
52. Scott, P. H., C. M. Belham, J. al-Hafidh, E. R. Chilvers, A. J. Peacock, G. W. Gould, and R. Plevin. 1996. A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth muscle cells. Biochem. J. 318:965.
53. Inukai, K., M. Funaki, T. Ogihara, H. Katagiri, A. Kanda, M. Anai, Y. Fukushima, T. Hosaka, M. Suzuki, B.-C. Shin, et al. 1997. P85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase, p50α, p55α, and p85α, with different PI 3-kinase activity elevating responses to insulin. J. Biol. Chem. 272:7873.
54. Yang, M., W. Wu, and C. J. Mirocha. 1996. Wortmannin inhibits the production of reactive oxygen and nitrogen intermediates and the killing of the Saccharomyces cerevisiae by isolated chicken macrophages. Immunopharmacol. Immunotoxicol. 18:597.
55. 3. J. Biol. Chem. 269:32358.
56. Severn, A., M. J. Wakelam, and F. Y. Liew. 1992. The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages. Biochem. Biophys. Res. Commun. 188:997.
57. Fujihara, M., N. Connolly, N. Ito, and T. Suzuki. 1994. Properties of protein kinase C isoforms (βII, ε, and ζ) in a macrophage cell line (J774) and their roles in LPS-induced nitric oxide production. J. Immunol. 152:1898.
58. Paul, A., K. Doherty, and R. Plevin. 1997. Differential regulation by protein kinase C isoforms of nitric oxide synthase induction in RAW 264.7 macrophages and rat aortic smooth muscle cells. Br. J. Pharmacol. 120:940.
59. Diaz-Guerra, M. J., O. G. Bodelon, M. Velasco, R. Whelan, P. J. Parker, and L. Bosca. 1996. Up-regulation of protein kinase C-ε promotes the expression of cytokine-inducible nitric oxide synthase in Raw 264.7 cells. J. Biol. Chem. 271: 32028.
60. von Manteuffel, S. R., P. B. Dennis, N. Pullen, A.-C. Gingras, N. Sonenberg, and G. Thomas. 1997. The insulin-induced signaling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70 S6 kinase. Mol. Cell. Biol. 17:5426.
61. Thomas, G., and M. N. Hall. 1997. Tor signaling and control of cell growth. Curr. Opin. Cell Biol. 9:782.