Epigenetic modulation of host: New insights into immune evasion by viruses

Journal of Biosciences

Volumn 35, Issue 4, 2010, Pages 647-663

  Adhya, Dwaipayan ^a   Basu, Anirban ^a  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

Author keywords

Epigenetic modulation; HDAC inhibitors; histone deacetylases; immune evasion; methyl binding domains

Indexed keywords

ANTIVIRUS AGENT; BUTYRIC ACID; DEPSIPEPTIDE; ENTINOSTAT; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LATENT MEMBRANE PROTEIN 1; MICRORNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P300; SINGLE STRANDED RNA; SIRTUIN; TETRAPEPTIDE; TRAPOXIN; TRICHOSTATIN A; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT;

GENE EXPRESSION; GENOME; HOST; IMMUNE RESPONSE; IMMUNE SYSTEM; PATHOGEN; VIRUS;

ACETYLATION; APOPTOSIS; BOVINE LEUKEMIA VIRUS; CD4+ T LYMPHOCYTE; CELL DIVISION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CPG ISLAND; DEACETYLATION; DENGUE VIRUS; DNA METHYLATION; EPIGENETICS; EPSTEIN BARR VIRUS; GENE EXPRESSION REGULATION; GENE SILENCING; HEPATITIS B VIRUS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HISTONE MODIFICATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE EVASION; IMMUNOMODULATION; IMMUNOREGULATION; MOLECULAR MIMICRY; NONHUMAN; NUCLEOSOME; PROMOTER REGION; REVIEW; SIMIAN VIRUS 40; VARICELLA ZOSTER VIRUS; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS LATENCY; VIRUS PATHOGENESIS; VIRUS SURVIVAL; WART VIRUS;

ACETYLATION; ANTIVIRAL AGENTS; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; HISTONE ACETYLTRANSFERASES; HISTONES; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; MOLECULAR MIMICRY; VIRUS DISEASES; VIRUS LATENCY; VIRUS PHYSIOLOGICAL PROCESSES; VIRUSES;

EID: 78651290340     PISSN: 02505991     EISSN: 02505991     Source Type: Journal    
DOI: 10.1007/s12038-010-0072-9     Document Type: Review

References (127)

1. E. Agbottah L. Deng L. Dannenberg A. Pumfery F. Kashanchi 2006 Effect of SWI/SNF chromatin remodeling complex on HIV-1 Tat activated transcription Retrovirology 3 1 19 10.1186/1742-4690-3-48 1:CAS:528:DC%2BD28XhtVGlt7bJ (Pubitemid 44472637)
2. S. Ait-Si-Ali S. Ramirez F. X. Barre F. Dkhissi L. Magnaghi-Jaulin J. A. Girault P. Robin M. Knibiehler, et al. 1998 Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A Nature (London) 396 184 186 1:CAS:528:DyaK1cXnslarurg%3D 10.1038/24190 (Pubitemid 28523622)
3. A. Alcami U. H. Koszinowski 2000 Viral mechanisms of immune evasion Trends Microbiol. 8 410 418 1:STN:280:DC%2BD3cvptlektg%3D%3D 10989308 10.1016/S0966-842X(00)01830-8
4. S. H. Ali J. A. Decaprio 2001 Cellular transformation by SV40 large T antigen: interaction with host proteins Semin. Cancer Biol. 11 15 23 1:CAS:528:DC%2BD3MXhslSntLc%3D 11243895 10.1006/scbi.2000.0342 (Pubitemid 32222747)
5. N. Archin D. Margolis 2006 Attacking latent HIV provirus: from mechanism to therapeutic strategies Curr. Opin. HIV AIDS 1 134 140 19372797
6. M. Avantaggiati A. Graessmann Y. Nakatani B. Howard A. S. Levine 1996 The SV40 large T antigen and adenovirus E1A oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300 EMBO J. 15 2236 2248 1:CAS:528:DyaK28XjtFyjt78%3D 8641289
7. E. Ballestar A. P. Wolffe 2001 Methyl-CpG-binding proteins Targeting specific gene repression Eur. J. Biochem. 268 1 6 1:CAS:528: DC%2BD3MXktVKqsw%3D%3D 11121095 10.1046/j.1432-1327.2001.01869.x (Pubitemid 32052241)
8. U. Baron S. Floess G. Wieczorek 2007 DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells Eur. J. Immunol. 37 2378 2389 1:CAS:528:DC%2BD2sXhtFahs7bE 17694575 10.1002/eji.200737594 (Pubitemid 47423608)
9. S3 activates and functionally overlaps protein kinase A to block apoptosis Proc. Natl. Acad. Sci. USA 101 9411 9416 1:CAS:528: DC%2BD2cXltlKjsL0%3D 15192152 10.1073/pnas.0403160101 (Pubitemid 38812888)
10. J. Benn R. Schneider 1994 Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade Proc. Natl. Acad. Sci. USA 91 10350 10354 1:CAS:528:DyaK2cXmslOrt7k%3D 7937954 10.1073/pnas.91.22.10350 (Pubitemid 24328994)
11. A. Bird 1996 The relationship of DNA methylation to cancer Cancer Surv. 28 87 101 1:CAS:528:DyaK2sXit1antb4%3D 8977030
12. T. Block A. Mehta C. Fimmel R. Jordan 2003 Molecular viral oncology of hepatocellular carcinoma Oncogene. 22 5093 5107 1:CAS:528:DC%2BD3sXmtFahu74%3D 12910247 10.1038/sj.onc.1206557 (Pubitemid 37059591)
13. J. E. Bolden M. J. Peart R. W. Johnstone 2006 Anticancer activities of histone deacetylase inhibitors Nat. Rev. Drug Discov. 5 769 784 1:CAS:528:DC%2BD28XptVCltrY%3D 16955068 10.1038/nrd2133 (Pubitemid 44348499)
14. I. Bosch K. Xhaja L. Estevez G. Raines H. Melichar R. Warke M. Fournier Ennis, et al. 2002 Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge J. Virol. 76 5588 1:CAS:528:DC%2BD38XjslGntbc%3D 11991987 10.1128/JVI.76.11.5588-5597.2002 (Pubitemid 34517909)
15. M. J. Bottomley P. Lo Surdo P. Di Giovine A. Cirillo R. Scarpelli F. Ferrigno P. Jones P. Neddermann, et al. 2008 Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain J. Biol. Chem. 283 26694 2704 1:CAS:528:DC%2BD1cXhtFejtr3O 18614528 10.1074/jbc.M803514200
16. A. Brehm S. Nielsen E. Miska D. McCance 1999 The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth EMBO J. 18 2449 2458 1:CAS:528:DyaK1MXjtlKhs7s%3D 10228159 10.1093/emboj/18.9.2449 (Pubitemid 29213278)
17. D. Chakravarti V. Ogryzko H. Y. Kao A. Nash H. Chen Y. Nakatani R. M. Evans 1999 A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity Cell 96 393 403 1:CAS:528:DyaK1MXht1eqs7s%3D 10025405 10.1016/S0092-8674(00)80552-8 (Pubitemid 29077593)
18. H. W. Chen C. H. Pan H. W. Huan M. Y. Liau J. R. Chiang M. H. Tao 2001 Suppression of immune response and protective immunity to a Japanese encephalitis virus DNA vaccine by coadministration of an IL-12-expressing plasmid J. Immunol. 166 7419 426 1:CAS:528:DC%2BD3MXksVOmsro%3D 11390494
19. E. Choy K. Siu K. Kok R. Lung C. Tsang K. To D. Kwong S. Tsao D. Jin 2008 An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival J. Exp. Med. 205 2551 2560 1:CAS:528:DC%2BD1cXhtlWntL7O 18838543 10.1084/jem.20072581
20. D. Cobrinik S. F. Dowdy P. W. Hinds S. Mittnacht R. A. Weinberg 1992 The retinoblastoma protein and the regulation of cell cycling Trends Biochem. Sci. 17 312 315 1:CAS:528:DyaK38Xls1yisb0%3D 1412705 10.1016/0968-0004(92)90443-D
21. J. Dahl H. I. Chen M. George T. L. Benjamin 2007 Polyomavirus small T antigen controls viral chromatin modifications through effects on kinetics of virus growth and cell cycle progression J. Virol. 81 10064 10071 1:CAS:528:DC%2BD2sXhtVehtL7J 17626093 10.1128/JVI.00821-07 (Pubitemid 350067710)
22. R. J. Danaher R. J. Jacob M. R. Steiner W. R. Allen J. M. Hill C. S. Miller 2005 Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latencyassociated transcript-independent manner in neuronal cells J. Neurovirol. 11 306 317 1:CAS:528:DC%2BD2MXmt1GkurY%3D 16036811 10.1080/13550280590952817 (Pubitemid 41122419)
23. A. J. de Ruijter A. H. van Gennip H. N. Caron S. Kemp A. B. van Kuilenburg 2003 Histone deacetylases (HDACs): characterization of the classical HDAC family Biochem. J. 370 737 749 12429021 10.1042/BJ20021321 (Pubitemid 36399066)
24. J. A. Decaprio J. W. Ludlow J. Figge J. Y. Shew C. M. Huang W. H. Lee E. Marsilio E. Paucha D. M. Livingston 1988 SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene Cell 54 275 283 1:CAS:528:DyaL1cXls1Kqs7Y%3D 2839300 10.1016/0092-8674(88)90559-4
25. V. Duong C. Bret L. Altucci A. Mai C. Duraffourd J. Loubersac P. Harmand S. Bonnet, et al. 2008 Specific activity of class II histone deacetylases in human breast cancer cells Mol. Cancer Res. 6 1908 1919 1:CAS:528: DC%2BD1cXhsV2iu7bI 19074835 10.1158/1541-7786.MCR-08-0299
26. K. Dutta M. K. Mishra A. Nazmi K. L. Kumawat A. Basu 2010 Minocycline differentially modulates macrophage mediated peripheral immune response following Japanese encephalitis virus infection Immunobiology 215 884 893 1:CAS:528:DC%2BC3cXht1CgtbnE 20153075 10.1016/j.imbio.2009.12.003
27. N. Dyson P. Howley K. Munger E. Harlow 1989 The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product Science 243 934 937 1:CAS:528:DyaL1MXhslWjs7k%3D 2537532 10.1126/science.2537532
28. R. Eckner J. W. Ludlow N. L. Lill E. Oldread Z. Arany N. Modjtahedi J. A. Decaprio D. M. Livingston, et al. 1996 Association of p300 and CBP with simian virus 40 large T antigen Mol. Cell. Biol. 16 3454 3464 1:CAS:528: DyaK28XjvVWnt7o%3D 8668161
29. L. C. Edelstein S. Micheva-Viteva B. D. Phelan J. P. Dougherty 2009 Short communication: activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphoma AIDS Res. Hum. Retroviruses 25 883 887 1:CAS:528:DC%2BD1MXhtFars7jM 19689202 10.1089/aid.2008.0294
30. T. Ego Y. Ariumi K. Shimotohno 2002 The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression Oncogene 21 7241 7246 1:CAS:528:DC%2BD38XnsFylu78%3D 12370815 10.1038/sj.onc.1205701 (Pubitemid 35305612)
31. H. Everett G. McFadden 1999 Apoptosis: an innate immune response to virus infection Trends Microbiol. 7 160 165 1:STN:280:DyaK1M3jsFymsQ%3D%3D 10217831 10.1016/S0966-842X(99)01487-0 (Pubitemid 29229902)
32. H. Farrell N. Davis-Poynter 1998 From sabotage to camouflage: viral evasion of cytotoxic T lymphocyte and natural killer cell-mediated immunity Semin. Cell Dev. Biol. 9 369 378 1:STN:280:DyaK1czms1ertA%3D%3D 9705659 10.1006/scdb.1998.0246 (Pubitemid 128350235)
33. P. J. Farrell 1998 Signal transduction from the Epstein-Barr virus LMP-1 transforming protein Trends Microbiol. 6 175 178 1:STN:280:DyaK1c3ns1CktQ%3D%3D 9614338 10.1016/S0966-842X(98)01262-1 (Pubitemid 28259582)
34. R. D. Fusunyan J. J. Quinn M. Fujimoto R. P. MacDermott I. R. Sanderson 1999 Butyrate switches the pattern of chemokine secretion by intestinal epithelial cells through histone acetylation Mol. Med. 5 631 640 1:CAS:528:DyaK1MXnvFaltLk%3D 10551904
35. M. Gazzar B. Yoza X. Chen J. Hu G. Hawkins C. McCall 2008 G9a and HP1 couple histone and DNA methylation to TNFα transcription silencing during endotoxin tolerance J. Biol. Chem. 283 32198 18809684 10.1074/jbc.M803446200 1:CAS:528:DC%2BD1cXhtlOjtL7I
36. S. Goodbourn L. Didcock R. E. Randall 2000 Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures J. Gen. Virol. 81 2341 2364 1:CAS:528:DC%2BD3cXnt12iu7o%3D 10993923
37. H. Gu Y. Liang G. Mandel B. Roizman 2005 Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells Proc. Natl. Acad. Sci. USA 102 7571 7576 1:CAS:528:DC%2BD2MXkslOntbs%3D 15897453 10.1073/pnas.0502658102 (Pubitemid 40741012)
38. H. Gu B. Roizman 2007 Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex Proc. Natl. Acad. Sci. USA 104 17134 17139 1:CAS:528:DC%2BD2sXht1Kit7%2FL 17939992 10.1073/pnas.0707266104 (Pubitemid 350211004)
39. H. Gu B. Roizman 2009 Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1 J. Virol. 83 4376 4385 1:CAS:528:DC%2BD1MXlt1Kqu70%3D 19193804 10.1128/JVI.02515-08
40. Y. Gwack H. Byun S. Hwang C. Lim J. Choe 2001 CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50 J. Virol. 75 1909 1917 1:CAS:528:DC%2BD3MXhtVSns7c%3D 11160690 10.1128/JVI.75.4.1909-1917.2001 (Pubitemid 32110181)
41. Y. Hamamori V. Sartorelli V. Ogryzko P. L. Puri H. Y. Wu J. Y. Wang Y. Nakatani L. Kedes 1999 Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A Cell 96 405 413 1:CAS:528:DyaK1MXht1eqs7g%3D 10025406 10.1016/S0092-8674(00)80553-X (Pubitemid 29077594)
42. I. Haviv M. Shamay G. Doitsh 1998 Hepatitis B virus pX targets TFIIB in transcription coactivation Mol Cell Biol. 18 1562 1569 1:CAS:528: DyaK1cXhtlehsrc%3D 9488473
43. F. Herrera S. Triezenberg 2004 VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection J. Virol. 78 9689 1:CAS:528:DC%2BD2cXnvVaku7s%3D 15331701 10.1128/JVI.78.18.9689-9696.2004 (Pubitemid 39187086)
44. W. Hobbs N. A. DeLuca 1999 Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0 J. Virol. 73 8245 8255 1:CAS:528:DyaK1MXlvFyrt7k%3D 10482575
45. J. Huang J. Kent B. Placek K. Whelan C. Hollow P. Zeng N. Fraser S. Berger 2006 Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1 J. Virol. 80 5740 1:CAS:528: DC%2BD28XlsFWnur4%3D 16731913 10.1128/JVI.00169-06 (Pubitemid 43849152)
46. Y. H. Huang H. Y. Lei H. S. Liu Y. S. Lin C. C. Liu T. M. Yeh 2000 Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production Am. J. Trop. Med. Hyg. 63 71 75 1:STN:280:DC%2BD3M3mslGhtg%3D%3D 11357999
47. K. Huh X. Zhou H. Hayakawa J. Cho 2007 Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor J. Virol. 81 9737 9747 1:CAS:528:DC%2BD2sXhtVeht7nI 17609271 10.1128/JVI.00881-07 (Pubitemid 350067678)
48. M. Husain K. Harrod 2009 Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells FEBS lett. 583 2517 2520 1:CAS:528:DC%2BD1MXptlahu70%3D 19596000 10.1016/j.febslet.2009.07.005
49. K. Imai H. Togami T. Okamoto 2010 Involvement of histone H3 Lysine 9 (H3K9) methyl transferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294 J. Biol. Chem. 285 16538 16545 1:CAS:528: DC%2BC3cXmtlygs7g%3D 20335163 10.1074/jbc.M110.103531
50. T. Jenuwein 2006 The epigenetic magic of histone lysine methylation FEBS J. 273 3121 3135 1:CAS:528:DC%2BD28Xot1Cqu7s%3D 16857008 10.1111/j.1742-4658. 2006.05343.x (Pubitemid 43990918)
51. T. Jenuwein C. D. Allis 2001 Translating the histone code Science 293 1074 1080 1:CAS:528:DC%2BD3MXmtVWltro%3D 11498575 10.1126/science.1063127 (Pubitemid 32758077)
52. C. Jopling S. Schutz P. Sarnow 2008 Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome Cell Host Microbe. 4 77 85 1:CAS:528:DC%2BD1cXptF2mu7s%3D 18621012 10.1016/j.chom.2008.05.013 (Pubitemid 351944051)
53. M. Juffrie G. M. van Der Meer C. E. Hack K. Haasnoot Sutaryo A. J. Veerman L. G. Thijs 2000 Inflammatory mediators in dengue virus infection in children: interleukin-8 and its relationship to neutrophil degranulation Infect. Immun. 68 702 707 1:CAS:528:DC%2BD3cXotFOltw%3D%3D 10639436 10.1128/IAI.68.2.702-707.2000 (Pubitemid 30056526)
54. Q. H. Karlsson C. Schelcher E. Verrall C. Petosa A. J. Sinclair 2008 The reversal of epigenetic silencing of the EBV genome is regulated by viral bZIP protein Biochem. Soc. Trans. 36 637 639 1:CAS:528:DC%2BD1cXoslCltL4%3D 18631132 10.1042/BST0360637
55. S. E. Kauder A. Bosque A. Lindqvist V. Planelles E. Verdin 2009 Epigenetic regulation of HIV-1 latency by cytosine methylation PLoS Pathog. 5 e1000495 19557157 10.1371/journal.ppat.1000495 1:CAS:528:DC%2BD1MXotVSkurc%3D
56. J. Kent P. Zeng D. Atanasiu J. Gardner N. Fraser S. Berger 2004 During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription J. Virol. 78 10178 10186 1:CAS:528:DC%2BD2cXnvVartro%3D 15331750 10.1128/JVI.78.18.10178-10186.2004 (Pubitemid 39187135)
57. Y. Kim J. Jung S. Lee K. Jang 2010 Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16INK4a expression via DNA methylation Cancer Lett. 288 226 235 1:CAS:528:DC%2BC3cXhtlSju7w%3D 19656618 10.1016/j.canlet.2009.07.007
58. S. Kutluay J. Doroghazi M. Roemer S. Triezenberg 2008 Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity Virology 373 239 247 1:CAS:528:DC%2BD1cXjs1Wjurw%3D 18191976 10.1016/j.virol.2007.11.028
59. M. Lachner R. O'sullivan T. Jenuwein 2003 An epigenetic road map for histone lysine methylation J. Cell Sci. 116 2117 2124 1:CAS:528: DC%2BD3sXkslCltLg%3D 12730288 10.1242/jcs.00493 (Pubitemid 36722358)
60. A. Lalani J. Barrett G. McFadden 2000 Modulating chemokines: more lessons from viruses Immunol. Today 21 100 106 1:CAS:528:DC%2BD3cXpsFGrtg%3D%3D 10652469 10.1016/S0167-5699(99)01556-X (Pubitemid 30069624)
61. D. Lee C. Teyssier B. Strahl M. Stallcup 2005 Role of protein methylation in regulation of transcription Endocr. Rev. 26 147 170 1:CAS:528: DC%2BD2MXjslGjsbc%3D 15479858 10.1210/er.2004-0008
62. J. Lee H. Kwun J. Jung K. Choi D. Min K. Jang 2005 Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1 Oncogene 24 6617 6625 1:CAS:528:DC%2BD2MXhtVOjsrzE 16007161 10.1038/sj.onc.1208827 (Pubitemid 41486792)
63. I. Lemasson N. Polakowski P. Laybourn J. Nyborg 2006 Taxdependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1 J. Biol. Chem. 281 13075 13082 1:CAS:528: DC%2BD28Xkt1ymsrg%3D 16547351 10.1074/jbc.M512193200 (Pubitemid 43855217)
64. A. Levine 1990 The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses Virology 177 419 426 1:CAS:528:DyaK3cXltFSqurk%3D 2142553 10.1016/0042-6822(90)90505-L (Pubitemid 20235161)
65. S. Li S. Floess A. Hamann S. Gaudieri A. Lucas M. Hellard S. Roberts G. Paukovic M. Plebanski, et al. 2009 Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection PLoS Pathog. 5 e1000707 20041222 10.1371/journal.ppat.1000707 1:CAS:528:DC%2BC3cXhtlCmtQ%3D%3D
66. S. Li S. Labrecque M. C. Gauzzi A. R. Cuddihy A. H. Wong S. Pellegrini G. J. Matlashewski A. E. Koromilas 1999 The human papilloma virus ( HPV) -18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha Oncogene 18 5727 5737 1:CAS:528:DyaK1MXnt1Klu70%3D 10523853 10.1038/sj.onc.1202960 (Pubitemid 29507426)
67. Z. Lin M. Bazzaro M. Wang K. C. Chan S. Peng R. B. Roden 2009 Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment Clin. Cancer Res. 15 570 577 1:CAS:528:DC%2BD1MXlvFertA%3D%3D 19147762 10.1158/1078-0432.CCR-08-1813
68. X. Liu Q. Xu W. Chen H. Cao R. Zheng G. Li 2009 Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA Oncol. Rep. 21 941 947 1:CAS:528:DC%2BD1MXmsVaqtLw%3D 19287992 10.3892/or-00000394
69. H. Lu C. Pise-Masison R. Linton H. Park R. Schiltz V. Sartorelli J. Brady 2004 Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat J. Virol. 78 6735 6743 1:CAS:528:DC%2BD2cXltFOju7s%3D 15194748 10.1128/JVI.78.13. 6735-6743.2004 (Pubitemid 38781510)
70. J. W. Ludlow J. Shon J. M. Pipas D. M. Livingston J. A. Decaprio 1990 The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T Cell 60 387 396 1:CAS:528:DyaK3cXhsFKjtr0%3D 2154332 10.1016/0092-8674(90)90590-B (Pubitemid 20060868)
71. A. Mai L. Altucci 2009 Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead Int. J. Biochem. Cell. Biol. 41 199 213 1:CAS:528:DC%2BD1cXhsVWnu7zI 18790076 10.1016/j.biocel.2008.08.020
72. D. M. Margolis 2010 Mechanisms of HIV latency: an emerging picture of complexity Curr. HIV/AIDS Rep. 7 37 43 20425056 10.1007/s11904-009-0033-9
73. M. Merimi P. Klener M. Szynal Y. Cleuter C. Bagnis P. Kerkhofs A. Burny P. Martiat A. Van den Broeke 2007 Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy: observations in Bovine Leukemia Virus-infected sheep Retrovirology 4 1 9 10.1186/1742-4690-4-51 1:CAS:528:DC%2BD2sXpslehtbg%3D
74. S. Minucci P. G. Pelicci 2006 Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer Nat. Rev. Cancer 6 38 51 1:CAS:528:DC%2BD28Xht1GgsA%3D%3D 16397526 10.1038/nrc1779 (Pubitemid 43054973)
75. J. Miskin C. Abrams L. Goatley L. Dixon 1998 A viral mechanism for inhibition of the cellular phosphatase calcineurin Science 281 562 565 1:CAS:528:DyaK1cXkvFCqs7s%3D 9677199 10.1126/science.281.5376.562 (Pubitemid 28357371)
76. E. Moran 1993 DNA tumour virus transforming proteins and the cell cycle Curr. Opin. Genet. Dev. 3 63 70 1:CAS:528:DyaK3sXitV2kt7s%3D 8453277 10.1016/S0959-437X(05)80342-9
77. D. Nachmani N. Stern-Ginossar R. Sarid O. Mandelboim 2009 Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells Cell Host Microbe. 5 376 385 1:CAS:528:DC%2BD1MXls1Sqtrk%3D 19380116 10.1016/j.chom.2009.03.003
78. H. Ogawa K. Ishiguro S. Gaubatz D. M. Livingston Y. Nakatani 2002 A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells Science 296 1132 1136 1:CAS:528:DC%2BD38XjslamtLY%3D 12004135 10.1126/science.1069861 (Pubitemid 34517133)
79. s3 protein kinase is sufficient to block apoptosis induced by overexpression of a variety of Bcl-2 family members Virology 319 212 224 1:CAS:528:DC%2BD2cXhsFWks7o%3D 14980482 10.1016/j.virol.2003.10.019 (Pubitemid 38251263)
80. J. Oh N. Fraser 2008 Temporal association of the herpes simplex virus genome with histone proteins during a lytic infection J. Virol. 82 3530 3537 1:CAS:528:DC%2BD1cXjvFensbs%3D 18160436 10.1128/JVI.00586-07 (Pubitemid 351429928)
81. I. Ohki N. Shimotake N. Fujita M. Nakao M. Shirakawa 1999 Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1 EMBO. J. 18 6653 6661 1:CAS:528: DC%2BD3cXhslOqsQ%3D%3D 10581239 10.1093/emboj/18.23.6653
82. R. Pearson Y. K. Kim J. Hokello K. Lassen J. Friedman M. Tyagi J. Karn 2008 Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency J. Virol. 82 12291 12303 1:CAS:528:DC%2BD1cXhsVymsL%2FF 18829756 10.1128/JVI.01383-08
83. M. K. Pflum J. K. Tong W. S. Lane S. L. Schreiber 2001 Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation J. Biol. Chem. 276 47733 47741 1:CAS:528:DC%2BD3MXpt1GlsLg%3D 11602581 10.1074/jbc.M105590200
84. A. P. Poon Y. Liang B. Roizman 2003 Herpes simplex virus 1 gene expression is accelerated by inhibitors of histone deacetylases in rabbit skin cells infected with a mutant carrying a cDNA copy of the infected-cell protein no 0 J. Virol. 77 12671 12678 1:CAS:528:DC%2BD3sXptFOjs70%3D 14610189 10.1128/JVI.77.23.12671-12678.2003 (Pubitemid 37430662)
85. s3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression Proc. Natl. Acad. Sci. USA 103 9993 9998 1:CAS:528:DC%2BD28XmvVajurw%3D 16785443 10.1073/pnas.0604142103 (Pubitemid 43993611)
86. D. L. Poulin A. L. Kung J. A. Decaprio 2004 p53 targets Simian Virus 40 large T antigen for acetylation by CBP J. Virol. 78 8245 8253 1:CAS:528:DC%2BD2cXmtFCjsLk%3D 15254196 10.1128/JVI.78.15.8245-8253.2004 (Pubitemid 38944308)
87. L. Qiu H. Fan W. Jin B. Zhao Y. Wang Y. Ju 2010 miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV Biochem. Biophys. Res. Commun. 398 771 777 1:CAS:528:DC%2BC3cXpvFKgurg%3D 20633528 10.1016/j.bbrc.2010.07.021
88. S. A. Radkov R. Touitou A. Brehm M. Rowe M. West T. Kouzarides M. J. Allday 1999 Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription J. Virol. 73 5688 5697 1:CAS:528: DyaK1MXjvFyksb0%3D 10364319
89. S. Rea F. Eisenhaber D. O'Carroll B. D. Strahl Z. W. Sun M. Schmid S. Opravil K. Mechtler, et al. 2000 Regulation of chromatin structure by site-specific histone H3 methyltransferases Nature (London) 406 593 599 1:CAS:528:DC%2BD3cXmtFegs7s%3D 10.1038/35020506 (Pubitemid 30641039)
90. V. M. Richon J. P. O'Brien 2002 Histone deacetylase inhibitors: a new class of potential therapeutic agents for cancer treatment Clin. Cancer Res. 8 662 664 11895892
91. B. Rincon-Orozco G. Halec S. Rosenberger D. Muschik I. Nindl A. Bachmann T. M. Ritter B. Dondog, et al. 2009 Epigenetic silencing of interferon-kappa in human papillomavirus type 16-positive cells Cancer Res. 69 8718 8725 1:CAS:528:DC%2BD1MXhtl2rtr7M 19887612 10.1158/0008-5472.CAN-09-0550
92. A. Rodriguez S. Griffiths-Jones J. Ashurst A. Bradley 2004 Identification of mammalian microRNA host genes and transcription units Genome Res. 14 1902 1910 1:CAS:528:DC%2BD2cXotl2hu7w%3D 15364901 10.1101/gr.2722704 (Pubitemid 39386503)
93. T. C. Roloff H. H. Ropers U. A. Nuber 2003 Comparative study of methyl-CpG-binding domain proteins BMC Genomics 4 1 12529184 10.1186/1471-2164-4-1 (Pubitemid 39546608)
94. B. Romani S. Engelbrecht R. Glashoff 2010 Functions of Tat: the versatile protein of human immunodeficiency virus type 1 J. Gen. Virol. 91 1 12 1:CAS:528:DC%2BC3cXmtVyjtw%3D%3D 19812265 10.1099/vir.0.016303-0
95. A. Roopra R. Qazi B. Schoenike T. Daley J. Morrison 2004 Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes Mol. Cell. 14 727 738 1:CAS:528:DC%2BD2cXlslemtr4%3D 15200951 10.1016/j.molcel.2004.05.026 (Pubitemid 38780847)
96. F. Rosl A. Arab B. Klevenz 1993 The effect of DNA methylation on gene regulation of human papillomaviruses J. Gen. Virol. 74 791 801 8388016 10.1099/0022-1317-74-5-791
97. J. Routy 2005 Valproic acid: a potential role in treating latent HIV infection Lancet 366 523 524 16099272 10.1016/S0140-6736(05)67074-2 (Pubitemid 41140313)
98. S. C. Sampath I. Marazzi K. L. Yap S. C. Sampath A. N. Krutchinsky I. Mecklenbräuker A. Viale E. Rudensky, et al. 2007 Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly Mol. Cell. 27 596 608 1:CAS:528:DC%2BD2sXhtVSmtL3J 17707231 10.1016/j.molcel.2007.06.026 (Pubitemid 47238630)
99. A. Schaap J. F. Fortin M. Sommer L. Zerboni S. Stamatis C. C. Ku G. P. Nolan A. M. Arvin 2005 T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infection J. Virol. 79 12921 12933 1:CAS:528:DC%2BD2MXhtFWisbrP 16188994 10.1128/JVI.79.20.12921-12933.2005 (Pubitemid 41433211)
100. A. Schuetz J. Min A. Allali-Hassani M. Schapira M. Shuen P. Loppnau R. Mazitschek N. P. Kwiatkowski, et al. 2008 Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity J. Biol. Chem. 283 11355 11363 1:CAS:528:DC%2BD1cXkvVSgtrw%3D 18285338 10.1074/jbc.M707362200
101. H. M. Sheppard S. I. Corneilli C. Espiritu A. Gatti X. Liu 1999 New insights into the mechanism of inhibition of p53 by simian virus 40 large T antigen Mol. Cell. Biol. 19 2746 2753 1:CAS:528:DyaK1MXit1amtL0%3D 10082540
102. Y. Shim G. Yoon H. Choi Y. Chung E. Yu 2003 p16 Hypermethylation in the early stage of hepatitis B virusassociated hepatocarcinogenesis Cancer Lett. 190 213 219 1:CAS:528:DC%2BD3sXmsV2mtw%3D%3D 12565176 10.1016/S0304-3835(02)00613-4 (Pubitemid 36136020)
103. J. D. Siliciano J. Kajdas D. Finzi T. C. Quinn K. Chadwick J. B. Margolick C. Kovacs S. J. Gange, et al. 2003 Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells Nat. Med. 9 727 728 1:CAS:528:DC%2BD3sXktFOnu7k%3D 12754504 10.1038/nm880 (Pubitemid 36749221)
104. G. L. Smith J. A. Symons A. Khanna A. Vanderplasschen A. Alcamí 1997 Vaccinia virus immune evasion Immunol. Rev. 159 137 54 1:CAS:528: DyaK2sXnvFKrtbs%3D 9416508 10.1111/j.1600-065X.1997.tb01012.x
105. M. Spriggs 1996 One step ahead of the game: viral immunomodulatory molecules Annu. Rev Immunol. 14 101 130 1:CAS:528:DyaK28XitlCgt7c%3D 8717509 10.1146/annurev.immunol.14.1.101 (Pubitemid 26130179)
106. D. Stevenson K. L. Colman A. J. Davison 1994 Characterization of the putative protein kinases specified by varicella-zoster virus genes 47 and 66 J. Gen. Virol. 75 317 326 1:CAS:528:DyaK2cXkt12lsbo%3D 8113753 10.1099/0022-1317- 75-2-317
107. C. Sullivan A. Grundhoff S. Tevethia J. Pipas D. Ganem 2005 SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells Nature (London) 435 682 686 1:CAS:528:DC%2BD2MXks1Ogtb8%3D 10.1038/nature03576 (Pubitemid 40825513)
108. C. Sullivan C. Sung C. Pack A. Grundhoff A. Lukacher T. Benjamin D. Ganem 2009 Murine Polyomavirus encodes a microRNA that cleaves early RNA transcripts but is not essential for experimental infection Virology 387 157 167 1:CAS:528:DC%2BD1MXkt1Sjsr4%3D 19272626 10.1016/j.virol.2009.02.017
109. M. Tachibana K. Sugimoto T. Fukushima Y. Shinkai 2001 Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3 J. Biol. Chem. 276 25309 25317 1:CAS:528:DC%2BD3MXlt1ans7s%3D 11316813 10.1074/jbc.M101914200
110. S. Timmermann H. Lehrmann A. Polesskaya A. Harel-Bellan 2001 Histone acetylation and disease Cell Mol Life Sci. 58 728 736 1:CAS:528: DC%2BD3MXlt1ait7s%3D 11437234 10.1007/PL00000896
111. D. Tortorella B. Gewurz M. Furman D. Schust H. Ploegh 2000 Viral subversion of the immune system Annu. Rev Immunol. 18 861 926 1:CAS:528:DC%2BD3cXjs1Gmt78%3D 10837078 10.1146/annurev.immunol.18.1.861 (Pubitemid 30365400)
112. J. Umbach M. Kramer I. Jurak H. Karnowski D. Coen B. Cullen 2008 MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs Nature (London) 454 780 783 1:CAS:528:DC%2BD1cXps1Snt74%3D
113. A. Valenzuela-Fernández J. R. Cabrero J. M. Serrador F. Sánchez-Madrid 2008 HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions Trends Cell Biol. 18 291 297 18472263 10.1016/j.tcb.2008.04.003 1:CAS:528:DC%2BD1cXmvVymu7g%3D
114. E. Valls 2003 The SV40 T antigen modulates CBP histone acetyltransferase activity Nucleic Acids Res. 31 3114 3122 1:CAS:528:DC%2BD3sXks1Wqt7g%3D 12799439 10.1093/nar/gkg418 (Pubitemid 37441771)
115. E. Valls N. Blanco-García N. Aquizu D. Piedra C. Estarás X. de la Cruz M. A. Martínez-Balbás 2007 Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation Nucleic Acids Res. 35 1958 1968 1:CAS:528:DC%2BD2sXlsV2ru7w%3D 17341466 10.1093/nar/gkl1113 (Pubitemid 47061662)
116. C. Van Lint 2000 Role of chromatin in HIV-1 transcriptional regulation Adv Pharmacol. 48 121 160 10987090 10.1016/S1054-3589(00)48005-1
117. P. A. Wade 2001 Methyl CpG-binding proteins and transcriptional repression Bioessays 23 1131 1137 1:CAS:528:DC%2BD38XksFOluw%3D%3D 11746232 10.1002/bies.10008 (Pubitemid 34021016)
118. J. M. Walboomers M. V. Jacobs M. M. Manos F. X. Bosch J. A. Kummer K. V. Shah P. J. Snijders J. Peto, et al. 1999 Human papillomavirus is a necessary cause of invasive cervical cancer worldwide J. Pathol. 189 12 19 1:STN:280:DyaK1Mzot1CjsQ%3D%3D 10451482 10.1002/(SICI)1096-9896(199909)189: 1<12::AID-PATH431>3.0.CO;2-F (Pubitemid 29406813)
119. D. R. Walkinshaw X. J. Yang 2008 Histone deacetylase inhibitors as novel anticancer therapeutics Curr. Oncol. 15 237 243 1:STN:280:DC%2BD1cjjvFOmuw%3D%3D 19008999
120. M. S. Walters A. Erazo P. R. Kinchington S. Silverstein 2009 Histone deacetylases 1 and 2 are phosphorylated at novel sites during varicella-zoster virus infection J. Virol. 83 11502 11513 1:CAS:528:DC%2BC3cXksFKqsbs%3D 19740981 10.1128/JVI.01318-09
121. L. Wang E. F. de Zoeten M. I. Greene W. W. Hancock 2009 Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells Nat. Rev. Drug. Discov. 8 969 981 1:CAS:528:DC%2BD1MXhtlSqsLfP 19855427
122. B. Werness A. Levine P. Howley 1990 Association of human papillomavirus types 16 and 18 E6 proteins with p53 Science 248 76 79 1:CAS:528: DyaK3cXktF2ltL0%3D 2157286 10.1126/science.2157286
123. E. Wong D. Jenne M. Zimmer S. Porter C. Gilks 1999 Changes in chromatin organization at the neutrophil elastase locus associated with myeloid cell differentiation Blood 94 3730 3736 1:CAS:528:DyaK1MXnslyktLw%3D 10572086
124. P. Yaciuk M. C. Carter J. M. Pipas E. Moran 1991 Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products Mol. Cell. Biol. 11 2116 2124 1:CAS:528:DyaK3MXitVSrtbg%3D 1848672
125. S. Younes B. Yassine-Diab A. R. Dumont M. Boulassel Z. Grossman J. Routy R. Sekaly 2003 HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity J. Exp. Med. 198 1909 1922 1:CAS:528:DC%2BD3sXpvFaktbo%3D 14676302 10.1084/jem.20031598 (Pubitemid 38032123)
126. Q. Zhang H. Yao N. Vo R. H. Goodman 2000 Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP Proc. Natl. Acad. Sci. USA 97 14323 14328 1:CAS:528:DC%2BD3MXitVCltA%3D%3D 11114158 10.1073/pnas.011283598 (Pubitemid 32016574)
127. L. Zocchi P. Sassone-Corsi 2010 Joining the dots: from chromatin remodeling to neuronal plasticity Curr. Opin. Neurobiol. 20 432 440 1:CAS:528:DC%2BC3cXhtFyiu7%2FL 20471240 10.1016/j.conb.2010.04.005