Methyl CpG-binding proteins and transcriptional repression

BioEssays

Volumn 23, Issue 12, 2001, Pages 1131-1137

  Wade, Paul A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MAMMALIA;

DNA BINDING PROTEIN; DNA BINDING PROTEINS; MBD1 PROTEIN; MBD2 PROTEIN; MBD3 PROTEIN; MECP2 PROTEIN; REPRESSOR PROTEIN;

ANIMAL; CPG ISLAND; DNA METHYLATION; GENETICS; HUMAN; REVIEW;

ANIMAL; CPG ISLANDS; DNA METHYLATION; DNA-BINDING PROTEINS; HUMAN; REPRESSOR PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035542974     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.10008     Document Type: Review

References (41)

1. Initial sequencing and analysis of the human genome
2. Methylation-induced repression-belts, braces, and chromatin
3. The sequence of the human genome
4. The DNA methyltransferases of mammals
5. DNA methylation in health and disease
6. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA
7. Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2
8. Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA
9. DNA methylation specifies chromosomal localization of MeCP2
10. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
11. Mutation analysis of the MECP2 gene in British and Italian Rett syndrome females
12. The solution structure of the domain from MeCP2 that binds to methylated DNA
13. DNA recognition by the methyl-CpG binding domain of MeCP2
14. Chicken MAR-binding protein ARBP is homologous to rat methyl-CpG- binding protein MeCP2
15. The methyl-CpG binding transcriptional repressor MeCP2 stably associates with nucleosomal DNA
16. Methyl-CpG-binding protein MeCP2 represses Sp1-activated transcription of the human leukosialin gene when the promoter is methylated
17. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
18. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
19. Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2
20. MeCP2 driven transcriptional repression in vitro: Selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery
21. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
22. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
23. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl- CpG-binding protein 2
24. A component of the transcriptional represser MeCP1 shares a motif with DNA methyltransferase and HRX proteins
25. Identification and characterization of a family of mammalian methyl-CpG binding proteins
26. Methylation-mediated transcriptional silencing in euchromatin by methyl- CpG binding protein MBD1 isoforms
27. Active repression of methylated genes by the chromosomal protein MBD1
28. Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1
29. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
30. Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1
31. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
32. A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase
33. NuRD and SIN3 histone deacetylase complexes in development
34. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development
35. The minimal repression domain of MBD2b overlaps with the methyl-CpG- binding domain and binds directly to sin3A
36. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
37. Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs
38. The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
39. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities
40. DNA methylation, chromatin inheritance, and cancer
41. Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia