A viral mechanism for inhibition of the cellular phosphatase calcineurin

Science

Volumn 281, Issue 5376, 1998, Pages 562-565

  Miskin, James E ^a   Abrams, Charles C ^a   Goatley, Lynnette C ^a   Dixon, Linda K ^a  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CELL ENZYME; COMPLEMENTARY DNA; CYCLOPHILIN A; CYCLOSPORIN A; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; PHOSPHATASE; TRANSCRIPTION FACTOR; VIRUS PROTEIN;

AFRICAN SWINE FEVER VIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; IMMUNOMODULATION; NONHUMAN; PRIORITY JOURNAL; VERO CELL; VIRUS CELL INTERACTION; VIRUS INFECTION;

AFRICAN SWINE FEVER VIRUS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCINEURIN; CELL NUCLEUS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CYCLOSPORINE; DNA-BINDING PROTEINS; GENES, REPORTER; MACROPHAGES, ALVEOLAR; MOLECULAR SEQUENCE DATA; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; RECOMBINANT PROTEINS; SWINE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VERO CELLS; VIRAL PROTEINS;

AFRICAN SWINE FEVER VIRUS; ANIMALIA; CLASSICAL SWINE FEVER VIRUS; SUS SCROFA;

EID: 0032563244     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.281.5376.562     Document Type: Article

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26. We thank S. J. Elledge for two-hybrid reagents; R. Hay for PT7-SV5-IκB; G. R. Crabtree for the NFAT-luc reporter plasmid; E. McKenzie, I. O'Beirne, and A. Lennard for mNFAT-luc and AP-1-luc; and Sandoz Pharmaceutical for CsA. Supported by the Biotechnology and Biological Sciences Research Council and Ministry of Agriculture Fisheries and Food.