메뉴 건너뛰기




Volumn 10, Issue 9, 2010, Pages 851-863

Gap junctions or hemichannel-dependent and independent roles of connexins in cataractogenesis and lens development

Author keywords

Cataract formation; Connexin; Cx46; Cx50; Gap junctions; Gene knockout; Hemichannel; Lens development; Mutation

Indexed keywords

CONNEXIN 46; CONNEXIN 50; GAP JUNCTION PROTEIN; UNCLASSIFIED DRUG;

EID: 78651289158     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652410793937750     Document Type: Article
Times cited : (54)

References (154)
  • 1
    • 0030013202 scopus 로고    scopus 로고
    • Connexins, connexons, and intercellular communication
    • Goodenough DA, Goliger JA, Paul DL. Connexins, connexons, and intercellular communication. Annu Rev Biochem 1996; 65: 475-502.
    • (1996) Annu Rev Biochem , vol.65 , pp. 475-502
    • Goodenough, D.A.1    Goliger, J.A.2    Paul, D.L.3
  • 2
    • 0035985057 scopus 로고    scopus 로고
    • Structural andfunctional diversity of connexin genes in the mouse andhuman genome
    • Willecke K, Eiberger J, Degen J, et al. Structural andfunctional diversity of connexin genes in the mouse andhuman genome. Biol Chem 2002; 383: 725-37.
    • (2002) Biol Chem , vol.383 , pp. 725-737
    • Willecke, K.1    Eiberger, J.2    Degen, J.3
  • 3
    • 0030028301 scopus 로고    scopus 로고
    • The gap junction communicationchannel
    • Kumar N, Gilula NB. The gap junction communicationchannel. Cell 1996; 84: 381-8.
    • (1996) Cell , vol.84 , pp. 381-388
    • Kumar, N.1    Gilula, N.B.2
  • 4
    • 35548930792 scopus 로고    scopus 로고
    • Gap junction channel structure in theearly 21st century: Facts and fantasies
    • Yeager M, Harris A. Gap junction channel structure in theearly 21st century: facts and fantasies. Cur Opin Cell Biol 2007; 19: 521-8.
    • (2007) Cur Opin Cell Biol , vol.19 , pp. 521-528
    • Yeager, M.1    Harris, A.2
  • 5
    • 0028089678 scopus 로고
    • Attempts to define functionaldomains of gap junction proteins with synthetic peptides
    • Dahl G, Nonner W, Werner R. Attempts to define functionaldomains of gap junction proteins with synthetic peptides. Biophys J 1994; 67: 1816-22.
    • (1994) Biophys J , vol.67 , pp. 1816-1822
    • Dahl, G.1    Nonner, W.2    Werner, R.3
  • 6
    • 0028214204 scopus 로고
    • Selective interactions among the multiple connexinproteins expressed in the vertebrate lens: The secondextracellular domain is a determinant of compatibilitybetween connexins
    • White TW, Bruzzone R, Wolfram S, Paul DL, Goodenough DA. Selective interactions among the multiple connexinproteins expressed in the vertebrate lens: the secondextracellular domain is a determinant of compatibilitybetween connexins. J Cell Biol 1994; 125: 879-92.
    • (1994) J Cell Biol , vol.125 , pp. 879-892
    • White, T.W.1    Bruzzone, R.2    Wolfram, S.3    Paul, D.L.4    Goodenough, D.A.5
  • 7
    • 0036872332 scopus 로고    scopus 로고
    • Interaction ofconnexins with protein partners in the control of channelturnover and gating
    • Thomas MA, Huang S, Cokoja A, et al. Interaction ofconnexins with protein partners in the control of channelturnover and gating. Biol Cell 2002; 94: 445-56.
    • (2002) Biol Cell , vol.94 , pp. 445-456
    • Thomas, M.A.1    Huang, S.2    Cokoja, A.3
  • 8
    • 34249082403 scopus 로고    scopus 로고
    • Connexin channel permeabillity to cytoplasmicmolecules
    • Harris AL. Connexin channel permeabillity to cytoplasmicmolecules. Prog Biophys Mol Biol 2007; 94: 120-43.
    • (2007) Prog Biophys Mol Biol , vol.94 , pp. 120-143
    • Harris, A.L.1
  • 9
    • 0037382614 scopus 로고    scopus 로고
    • Beyond the gap: Functions ofunpaired connexon channels
    • Goodenough DA, Paul DL. Beyond the gap: Functions ofunpaired connexon channels. Nat Rev Mol Cell Biol 2003; u: 285-94.
    • (2003) Nat Rev Mol Cell Biol , vol.U , pp. 285-294
    • Goodenough, D.A.1    Paul, D.L.2
  • 10
    • 0347126492 scopus 로고    scopus 로고
    • Open pore blockof connexin26 and connexin32 hemichannels by neutral, acidic and basic glycoconjugates
    • Locke D, Wang LXBCG, Lee YC, Harris AL. Open pore blockof connexin26 and connexin32 hemichannels by neutral, acidic and basic glycoconjugates. Cell Commun Adhes 2003; 10: 239-44.
    • (2003) Cell Commun Adhes , vol.10 , pp. 239-244
    • Locke, D.1    Wang, L.X.B.C.G.2    Lee, Y.C.3    Harris, A.L.4
  • 11
    • 0032171494 scopus 로고    scopus 로고
    • Visualization and functional blockingof gap junction hemichannel (connexons) with antibodiesagainst external loop domains in astrocytes
    • Hofer A, Dermietzel R. Visualization and functional blockingof gap junction hemichannel (connexons) with antibodiesagainst external loop domains in astrocytes. Glia 1998; 24: 141-54.
    • (1998) Glia , vol.24 , pp. 141-154
    • Hofer, A.1    Dermietzel, R.2
  • 12
    • 0037405358 scopus 로고    scopus 로고
    • Differential connexin expression, gap junction intercellular coupling, and hemichannelformation in NT2/D1 human neural progenitors and terminallydifferentiated hNT neurons
    • Boucher S, Bennett SAL. Differential connexin expression, gap junction intercellular coupling, and hemichannelformation in NT2/D1 human neural progenitors and terminallydifferentiated hNT neurons. J Neuro Res 2003; dd: 393-404.
    • (2003) J Neuro Res , vol.DD , pp. 393-404
    • Boucher, S.1    Bennett, S.A.L.2
  • 16
    • 0034918779 scopus 로고    scopus 로고
    • Dual mechanism of intercellularcommunication in HOBIT osteoblastic cells: A role for gapjunctionalhemichannels
    • Romanello M, D'Andrea P. Dual mechanism of intercellularcommunication in HOBIT osteoblastic cells: A role for gapjunctionalhemichannels. J Bone Miner Res 2001; hh: 1465-76.
    • (2001) J Bone Miner Res , vol.HH , pp. 1465-1476
    • Romanello, M.1    D'Andrea, P.2
  • 17
    • 0037040922 scopus 로고    scopus 로고
    • Transduction of cellsurvival signals by connexin-43 hemichannels
    • Plotkin LI, Manolagas SC, Bellido T. Transduction of cellsurvival signals by connexin-43 hemichannels. J Biol Chem 2002; 277: 8648-57.
    • (2002) J Biol Chem , vol.277 , pp. 8648-8657
    • Plotkin, L.I.1    Manolagas, S.C.2    Bellido, T.3
  • 18
    • 0037155841 scopus 로고    scopus 로고
    • Intercellularcalcium signaling in astrocytes via ATP release throughconnexin hemichannels
    • Stout CE, Costantin JL, Naus CCG, Charles AC. Intercellularcalcium signaling in astrocytes via ATP release throughconnexin hemichannels. J Biol Chem 2002; 277: 10482-8.
    • (2002) J Biol Chem , vol.277 , pp. 10482-10488
    • Stout, C.E.1    Costantin, J.L.2    Naus, C.C.G.3    Charles, A.C.4
  • 19
    • 0036510537 scopus 로고    scopus 로고
    • Intercellular calcium signalingoccurs between human osteoblasts and osteoclasts andrequires activation of osteoclast P2X7 receptors
    • Jorgensen NR, Henriksen Z, Sørensen OH, Eriksen EF, Civitelli R, Steinberg TH. Intercellular calcium signalingoccurs between human osteoblasts and osteoclasts andrequires activation of osteoclast P2X7 receptors. J Biol Chem 2002; 277: 7574-80.
    • (2002) J Biol Chem , vol.277 , pp. 7574-7580
    • Jorgensen, N.R.1    Henriksen, Z.2    Sørensen, O.H.3    Eriksen, E.F.4    Civitelli, R.5    Steinberg, T.H.6
  • 20
    • 0037112390 scopus 로고    scopus 로고
    • ATP release from human airwayepithelial cells studied using a capillary cell culture system
    • Guyot A, Hanrahan JW. ATP release from human airwayepithelial cells studied using a capillary cell culture system. JPhysiol 2002; 545: 199-206.
    • (2002) JPhysiol , vol.545 , pp. 199-206
    • Guyot, A.1    Hanrahan, J.W.2
  • 25
    • 0033989502 scopus 로고    scopus 로고
    • Regulation of lens rCx46-formed hemichannels by activationof protein kinase C, external Ca(2+) and protons
    • Jedamzik B, Marten I, Negezahayo A, Ernst A, Kolb HA. Regulation of lens rCx46-formed hemichannels by activationof protein kinase C, external Ca(2+) and protons. J Membr Biol 2000; 173: 39-46.
    • (2000) J Membr Biol , vol.173 , pp. 39-46
    • Jedamzik, B.1    Marten, I.2    Negezahayo, A.3    Ernst, A.4    Kolb, H.A.5
  • 26
    • 0034611012 scopus 로고    scopus 로고
    • Physiological role of gapjunctionalhemichannels: Extracellular calcium-dependentisomotic volume regulation
    • Quist AP, Rhee SK, Lin H, Lal R. Physiological role of gapjunctionalhemichannels: extracellular calcium-dependentisomotic volume regulation. J Cell Biol 2000; 148: 1063-74.
    • (2000) J Cell Biol , vol.148 , pp. 1063-1074
    • Quist, A.P.1    Rhee, S.K.2    Lin, H.3    Lal, R.4
  • 27
    • 0345865183 scopus 로고    scopus 로고
    • 2 byostocytes in response to mechanical strain
    • 2 byostocytes in response to mechanical strain. Cell Commun Adhes 2003; 10: 259-64.
    • (2003) Cell Commun Adhes , vol.10 , pp. 259-264
    • Jiang, J.X.1    Cherian, P.P.2
  • 28
    • 21844442343 scopus 로고    scopus 로고
    • Mechanical strainopens connexin 43 hemichannels in osteocytes: A novelmechanism for the release of prostaglandin
    • Cherian PP, Siller-Jackson AJ, Gu S, et al. Mechanical strainopens connexin 43 hemichannels in osteocytes: a novelmechanism for the release of prostaglandin. Mol Biol Cell 2005; 16: 3100-6.
    • (2005) Mol Biol Cell , vol.16 , pp. 3100-3106
    • Cherian, P.P.1    Siller-Jackson, A.J.2    Gu, S.3
  • 30
    • 33645002735 scopus 로고    scopus 로고
    • Life cycle of connexins in health and disease
    • Laird DW. Life cycle of connexins in health and disease. Biochem J 2006; 394: 527-43.
    • (2006) Biochem J , vol.394 , pp. 527-543
    • Laird, D.W.1
  • 31
    • 36249012485 scopus 로고    scopus 로고
    • Connexins in lens developmentand cataractogenesis
    • Gong X, Cheng C, Xia C. Connexins in lens developmentand cataractogenesis. J Membr Biol 2007; 218: 9-12.
    • (2007) J Membr Biol , vol.218 , pp. 9-12
    • Gong, X.1    Cheng, C.2    Xia, C.3
  • 32
    • 0032780886 scopus 로고    scopus 로고
    • Connexin 50 mutation ina family with congenital "zonular nuclear" pulverulent cataractof Pakistani origin
    • Berry V, Mackay D, Khaliq S, et al. Connexin 50 mutation ina family with congenital "zonular nuclear" pulverulent cataractof Pakistani origin. Hum Genet 1999; 105: 168-70.
    • (1999) Hum Genet , vol.105 , pp. 168-170
    • Berry, V.1    Mackay, D.2    Khaliq, S.3
  • 33
    • 0031014473 scopus 로고    scopus 로고
    • Physiological properties ofthe normal lens
    • Mathias RT, Rae JL, Baldo GJ. Physiological properties ofthe normal lens. Physiol Rev 1997; 77: 21-50.
    • (1997) Physiol Rev , vol.77 , pp. 21-50
    • Mathias, R.T.1    Rae, J.L.2    Baldo, G.J.3
  • 34
    • 0026815368 scopus 로고
    • The crystalline lens: A system networkedby gap junctional intercellular communication
    • In: Gilula NB, editor, London: Sauders Scientific Pub./Academic Press
    • Goodenough DA. The crystalline lens: a system networkedby gap junctional intercellular communication. In: Gilula NB, editor. Seminars in Cell Biology. London: Sauders Scientific Pub./Academic Press, 1992: pp. 49-58.
    • (1992) Seminars in Cell Biology , pp. 49-58
    • Goodenough, D.A.1
  • 35
    • 0022213397 scopus 로고
    • Cell-to-cell fusion of lens fiber cells in situ: Correlative light, scanning electron microscopic, and freeze-fracture studies
    • Kuszak JR, Macsai MS, Bloom KJ, Rae JL, Weinstein RS. Cell-to-cell fusion of lens fiber cells in situ: correlative light, scanning electron microscopic, and freeze-fracture studies. JUltrastruct Res 1985; 93: 144-160.
    • (1985) JUltrastruct Res , vol.93 , pp. 144-160
    • Kuszak, J.R.1    Macsai, M.S.2    Bloom, K.J.3    Rae, J.L.4    Weinstein, R.S.5
  • 36
    • 0022644198 scopus 로고
    • Evidence for two physiologicallydistinct gap junctions expressed by the chick lens epithelialcell
    • Miller TM, Goodenough DA. Evidence for two physiologicallydistinct gap junctions expressed by the chick lens epithelialcell. J Cell Biol 1986; 102: 194-9.
    • (1986) J Cell Biol , vol.102 , pp. 194-199
    • Miller, T.M.1    Goodenough, D.A.2
  • 37
    • 0028348508 scopus 로고
    • Intercellular communication between epithelial and fiber cellsof the eye lens
    • Bassnett S, Kuszak JR, Reinisch L, Brown HG, Beebe DC. Intercellular communication between epithelial and fiber cellsof the eye lens. J Cell Sci 1994; 107: 799-811.
    • (1994) J Cell Sci , vol.107 , pp. 799-811
    • Bassnett, S.1    Kuszak, J.R.2    Reinisch, L.3    Brown, H.G.4    Beebe, D.C.5
  • 38
    • 0028970667 scopus 로고
    • An ultrastructural analysisof the epithelial-fiber interface (EFI) in primate lenses
    • Kuszak JR, Novak LA, Brown HG. An ultrastructural analysisof the epithelial-fiber interface (EFI) in primate lenses. Exp Eye Res 1995; 61: 579-97.
    • (1995) Exp Eye Res , vol.61 , pp. 579-597
    • Kuszak, J.R.1    Novak, L.A.2    Brown, H.G.3
  • 39
    • 0023551497 scopus 로고
    • Connexin43: A proteinfrom rat heart homologous to a gap junction protein fromliver
    • Beyer EC, Paul DL, Goodenough DA. Connexin43: a proteinfrom rat heart homologous to a gap junction protein fromliver. J Cell Biol 1987; 105: 2621-9.
    • (1987) J Cell Biol , vol.105 , pp. 2621-2629
    • Beyer, E.C.1    Paul, D.L.2    Goodenough, D.A.3
  • 40
    • 0026352039 scopus 로고
    • Connexin46, a novel lens gap junction protein, inducesvoltage-gated currents in nonjunctional plasma membrane ofXenopus oocytes
    • Paul DL, Ebihara L, Takemoto LJ, Swenson KI, Goodenough DA. Connexin46, a novel lens gap junction protein, inducesvoltage-gated currents in nonjunctional plasma membrane ofXenopus oocytes. J Cell Biol 1991; 115: 1077-89.
    • (1991) J Cell Biol , vol.115 , pp. 1077-1089
    • Paul, D.L.1    Ebihara, L.2    Takemoto, L.J.3    Swenson, K.I.4    Goodenough, D.A.5
  • 41
    • 0027070644 scopus 로고
    • Mouse Cx50, a functional member of the connexin family of gapjunction proteins, is the lens fiber protein MP70
    • White TW, Bruzzone R, Goodenough DA, Paul DL. Mouse Cx50, a functional member of the connexin family of gapjunction proteins, is the lens fiber protein MP70. Mol Biol Cell 1992; 3: 711-20.
    • (1992) Mol Biol Cell , vol.3 , pp. 711-720
    • White, T.W.1    Bruzzone, R.2    Goodenough, D.A.3    Paul, D.L.4
  • 42
    • 0033854573 scopus 로고    scopus 로고
    • Molecular cloning of ovine connexin44and temporal expression of gap junction proteins in a lenscell culture
    • Yang D-I, Louis CF. Molecular cloning of ovine connexin44and temporal expression of gap junction proteins in a lenscell culture. Invest Ophthalmol Vis Sci 2000; 41: 2658-64.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 2658-2664
    • Yang, D.-I.1    Louis, C.F.2
  • 43
    • 0021868690 scopus 로고
    • Identification of a 70,000-Dprotein in lens membrane junctional domains
    • Kistler J, Kirkland B, Bullivant S. Identification of a 70,000-Dprotein in lens membrane junctional domains. J Cell Biol 1985; 101: 28-35.
    • (1985) J Cell Biol , vol.101 , pp. 28-35
    • Kistler, J.1    Kirkland, B.2    Bullivant, S.3
  • 45
    • 0028267415 scopus 로고
    • Molecularcloning and functional characterization of chick lens fiberconnexin45.6
    • Jiang JX, White TW, Goodenough DA, Paul DL. Molecularcloning and functional characterization of chick lens fiberconnexin45.6. Mol Biol Cell 1994; 5: 363-73.
    • (1994) Mol Biol Cell , vol.5 , pp. 363-373
    • Jiang, J.X.1    White, T.W.2    Goodenough, D.A.3    Paul, D.L.4
  • 46
    • 0030052934 scopus 로고    scopus 로고
    • Heteromeric connexons in lensgap junction channels
    • Jiang JX, Goodenough DA. Heteromeric connexons in lensgap junction channels. Proc Natl Acad Sci USA 1996; 93: 1287-91.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1287-1291
    • Jiang, J.X.1    Goodenough, D.A.2
  • 48
    • 0032952351 scopus 로고    scopus 로고
    • Coexpressionof lens fiber connexins modifies hemi-gapjunctionalchannel behavior
    • Ebihara L, Xu X, Oberti C, Beyer EC, Berthoud VM. Coexpressionof lens fiber connexins modifies hemi-gapjunctionalchannel behavior. Biophys J 1999; 76: 198-206.
    • (1999) Biophys J , vol.76 , pp. 198-206
    • Ebihara, L.1    Xu, X.2    Oberti, C.3    Beyer, E.C.4    Berthoud, V.M.5
  • 49
    • 0033808250 scopus 로고    scopus 로고
    • Properties of gapjunction channels formed by Cx46 alone and in combinationwith Cx50
    • Hopperstad MG, Sprinivas M, Spray DC. Properties of gapjunction channels formed by Cx46 alone and in combinationwith Cx50. Biophys J 2000; 79: 1954-66.
    • (2000) Biophys J , vol.79 , pp. 1954-1966
    • Hopperstad, M.G.1    Sprinivas, M.2    Spray, D.C.3
  • 50
    • 0032913131 scopus 로고    scopus 로고
    • Gating of cx46 gap junction hemichannelsby calcium and voltage
    • Pfahnl A, Dahl G. Gating of cx46 gap junction hemichannelsby calcium and voltage. Eur J Physiol 1999; 437: 345-53.
    • (1999) Eur J Physiol , vol.437 , pp. 345-353
    • Pfahnl, A.1    Dahl, G.2
  • 52
    • 33746080847 scopus 로고    scopus 로고
    • The gating effect of calmodulinand calcium on the connexin50 hemichannel
    • Zhang X, Zou T, Liu Y, Qi Y. The gating effect of calmodulinand calcium on the connexin50 hemichannel. Biol Chem 2006; 387: 595-601.
    • (2006) Biol Chem , vol.387 , pp. 595-601
    • Zhang, X.1    Zou, T.2    Liu, Y.3    Qi, Y.4
  • 53
    • 0036218448 scopus 로고    scopus 로고
    • Hemichannel and junctional properties ofconnexin 50
    • Beahm DL, Hall JE. Hemichannel and junctional properties ofconnexin 50. Biophys J 2002; 82: 2016-31.
    • (2002) Biophys J , vol.82 , pp. 2016-2031
    • Beahm, D.L.1    Hall, J.E.2
  • 54
    • 0033936136 scopus 로고    scopus 로고
    • Electrical properties of gap junctionhemichannels identified in transfected cells
    • Valiunas V, Weingart R. Electrical properties of gap junctionhemichannels identified in transfected cells. Pflugers Arch 2000; 440: 366-79.
    • (2000) Pflugers Arch , vol.440 , pp. 366-379
    • Valiunas, V.1    Weingart, R.2
  • 55
    • 1142274309 scopus 로고    scopus 로고
    • Opening hemichannels in nonjunctionalmembrane stimulates gap junction formation
    • Beahm D, Hall J. Opening hemichannels in nonjunctionalmembrane stimulates gap junction formation. Biophys J 2004; 86: 781-96.
    • (2004) Biophys J , vol.86 , pp. 781-796
    • Beahm, D.1    Hall, J.2
  • 56
    • 33748464388 scopus 로고    scopus 로고
    • Structural determinants for thedifferences in voltage gating of chicken Cx56 and Cx45.6gap-junctional hemichannels
    • Tong JJ, Ebihara L. Structural determinants for thedifferences in voltage gating of chicken Cx56 and Cx45.6gap-junctional hemichannels. Biophys J 2006; 91: 2142-54.
    • (2006) Biophys J , vol.91 , pp. 2142-2154
    • Tong, J.J.1    Ebihara, L.2
  • 58
    • 0032903938 scopus 로고    scopus 로고
    • Functional and morphological correlates of connexin50exprssed in Xenopus laevis oocytes
    • Zampighi GA, Loo DDF, Kreman M, Eskandari S, Wright EM. Functional and morphological correlates of connexin50exprssed in Xenopus laevis oocytes. J Gen Physiol 1999; 113: 507-23.
    • (1999) J Gen Physiol , vol.113 , pp. 507-523
    • Zampighi, G.A.1    Loo, D.D.F.2    Kreman, M.3    Eskandari, S.4    Wright, E.M.5
  • 59
    • 0346496124 scopus 로고    scopus 로고
    • Distribution of connexin50 channels andhemichannels in lens fibers: A structural approach
    • Zampighi GA. Distribution of connexin50 channels andhemichannels in lens fibers: a structural approach. Cell Commun Adhes 2003; 10: 265-70.
    • (2003) Cell Commun Adhes , vol.10 , pp. 265-270
    • Zampighi, G.A.1
  • 61
    • 0020429970 scopus 로고
    • Localization of steady-statecurrents in the lens
    • Robinson KR, Patterson JW. Localization of steady-statecurrents in the lens. Curr Eye Res 1983; 2: 843-7.
    • (1983) Curr Eye Res , vol.2 , pp. 843-847
    • Robinson, K.R.1    Patterson, J.W.2
  • 62
    • 0035354578 scopus 로고    scopus 로고
    • Molecular solutions tomammalian lens transparency
    • Donaldson P, Kistler J, Mathias RT. Molecular solutions tomammalian lens transparency. News Physiol 2001; 16: 118-23.
    • (2001) News Physiol , vol.16 , pp. 118-123
    • Donaldson, P.1    Kistler, J.2    Mathias, R.T.3
  • 63
    • 33750203700 scopus 로고    scopus 로고
    • Cystallins and hereditary cataracts: Molecularmechanisms and potential for therapy
    • Andley UP. Cystallins and hereditary cataracts: molecularmechanisms and potential for therapy. Expert Rev Mol Med 2006; 8: 1-19.
    • (2006) Expert Rev Mol Med , vol.8 , pp. 1-19
    • Andley, U.P.1
  • 64
    • 0031959735 scopus 로고    scopus 로고
    • A missense mutation in the humanconnexin50 gene (GJA8) underlies autosomal dominant"zonular pulverulent" cataract, on chromosome 1q
    • Shiels A, Mackay D, Ionides A, Berry V, Moore A, Bhattacharya S. A missense mutation in the humanconnexin50 gene (GJA8) underlies autosomal dominant"zonular pulverulent" cataract, on chromosome 1q. Am JHum Genet 1998; 62: 526-32.
    • (1998) Am JHum Genet , vol.62 , pp. 526-532
    • Shiels, A.1    Mackay, D.2    Ionides, A.3    Berry, V.4    Moore, A.5    Bhattacharya, S.6
  • 65
    • 0141498594 scopus 로고    scopus 로고
    • Connexin46 mutations inautosomal dominant congenital cataract
    • Mackay D, Ionides A, Kibar Z, et al. Connexin46 mutations inautosomal dominant congenital cataract. Am J Human Gene 1999; 64: 1357-64.
    • (1999) Am J Human Gene , vol.64 , pp. 1357-1364
    • Mackay, D.1    Ionides, A.2    Kibar, Z.3
  • 66
    • 0034019915 scopus 로고    scopus 로고
    • Further evidence ofautosomal dominant congenital zonular pulverulent cataractslinked to 13q11 (CZP3) and a novel mutation in connexin 46(GJA3)
    • Rees MI, Watts P, Fenton I, et al. Further evidence ofautosomal dominant congenital zonular pulverulent cataractslinked to 13q11 (CZP3) and a novel mutation in connexin 46(GJA3). Hum Genet 2000; 106: 206-09.
    • (2000) Hum Genet , vol.106 , pp. 206-209
    • Rees, M.I.1    Watts, P.2    Fenton, I.3
  • 67
    • 0347093424 scopus 로고    scopus 로고
    • A novel mutation in GJA3(connexin 46) for autosomal dominant congenital nuclearpulverulent cataract
    • Jiang H, Jin Y, Zhang W, et al. A novel mutation in GJA3(connexin 46) for autosomal dominant congenital nuclearpulverulent cataract. Mol Vis 2003; 9: 579-83.
    • (2003) Mol Vis , vol.9 , pp. 579-583
    • Jiang, H.1    Jin, Y.2    Zhang, W.3
  • 68
    • 3543148924 scopus 로고    scopus 로고
    • A novelmissense mutation in the gene for gap-junction protein mm3(GJA3) associated with autosomal dominant "nuclearpunctate" cataracts linked to chromosome 13q
    • Bennett TM, Mackay DS, Knopf HLS, Shiels A. A novelmissense mutation in the gene for gap-junction protein mm3(GJA3) associated with autosomal dominant "nuclearpunctate" cataracts linked to chromosome 13q. Mol Vis 2004; 10: 376-82.
    • (2004) Mol Vis , vol.10 , pp. 376-382
    • Bennett, T.M.1    Mackay, D.S.2    Knopf, H.L.S.3    Shiels, A.4
  • 69
    • 16544392566 scopus 로고    scopus 로고
    • A novel connexin46 (GJA3)mutation in autosomal dominant congenital nuclearpulverulent cataract
    • Li Y, Wang J, Dong B, Man H. A novel connexin46 (GJA3)mutation in autosomal dominant congenital nuclearpulverulent cataract. Mol Vis 2004; 10: 668-71.
    • (2004) Mol Vis , vol.10 , pp. 668-671
    • Li, Y.1    Wang, J.2    Dong, B.3    Man, H.4
  • 70
    • 16544394632 scopus 로고    scopus 로고
    • A novel mutation inthe connexin 46 gene causes autosomal dominant congenitalcataract with incomplete penetrance
    • Erratum in: J Med Genet 2005; 42: 288
    • Burdon KP, Wirth MG, Mackey DA, et al. A novel mutation inthe connexin 46 gene causes autosomal dominant congenitalcataract with incomplete penetrance. J Med Genet 2004; 41:e106. Erratum in: J Med Genet 2005; 42: 288.
    • (2004) J Med Genet , vol.41
    • Burdon, K.P.1    Wirth, M.G.2    Mackey, D.A.3
  • 71
    • 27644437222 scopus 로고    scopus 로고
    • Novel mutations inGJA3 associated with autosomal dominant congenitalcataract in the Indian population
    • Devi RR, Reena C, Vijayalakshmi P. Novel mutations inGJA3 associated with autosomal dominant congenitalcataract in the Indian population. Mol Vis 2005; 11: 846-52.
    • (2005) Mol Vis , vol.11 , pp. 846-852
    • Devi, R.R.1    Reena, C.2    Vijayalakshmi, P.3
  • 72
    • 29744463376 scopus 로고    scopus 로고
    • Two novelmutations of connexin gens in Chinese families withautosomal dominant congenital nuclear cataract
    • Erratum in, Br J Ophthalmol 2005; 89: 1535-7
    • Ma ZW, Zheng JQ, Ji Ji XR, ang X, uan XY et al. Two novelmutations of connexin gens in Chinese families withautosomal dominant congenital nuclear cataract. Erratum in:Br J Ophthalmol 2006, 90: 125. Br J Ophthalmol 2005; 89: 1535-7.
    • (2006) Br J Ophthalmol , vol.90 , pp. 125
    • Ma, Z.W.1    Zheng, J.Q.2    Jiji, X.R.3    Ang, X.4    Uan, X.Y.5
  • 73
    • 39549088084 scopus 로고    scopus 로고
    • A novelmutation in GJA8 assicated with jellyfish-like cataract in afamily of Indian origin
    • Vanita V, Singh JR, Singh D, Varon R, Sperling K. A novelmutation in GJA8 assicated with jellyfish-like cataract in afamily of Indian origin. Mol Vis 2008; 14: 323-6.
    • (2008) Mol Vis , vol.14 , pp. 323-326
    • Vanita, V.1    Singh, J.R.2    Singh, D.3    Varon, R.4    Sperling, K.5
  • 74
    • 33748281736 scopus 로고    scopus 로고
    • The congenital "ant-egg" cataract phenotype is causedby a missense mutation in connexin46
    • Hansen L, Yao W, Eiberg H, Funding M, Riise R, Kjaer KWet al. The congenital "ant-egg" cataract phenotype is causedby a missense mutation in connexin46. Mol Vis 2006; 12: 1033-9.
    • (2006) Mol Vis , vol.12 , pp. 1033-1039
    • Hansen, L.1    Yao, W.2    Eiberg, H.3    Funding, M.4    Riise, R.5    Kjaer, K.W.6
  • 75
    • 33746364495 scopus 로고    scopus 로고
    • A novel mutation inthe connexin 46 gene (GJA3) causes autosomal dominantzonular pulverulent cataract in a Hispanic family
    • Addison PK, Berry V, Holden KR, et al. A novel mutation inthe connexin 46 gene (GJA3) causes autosomal dominantzonular pulverulent cataract in a Hispanic family. Mol Vis 2006; 12: 791-5.
    • (2006) Mol Vis , vol.12 , pp. 791-795
    • Addison, P.K.1    Berry, V.2    Holden, K.R.3
  • 76
    • 34250003488 scopus 로고    scopus 로고
    • A novel "pearl box"cataract associated with a mutation in the connexin 46(GJA3) gene
    • Guleria K, Vanita v, Singh D, Singh J. A novel "pearl box"cataract associated with a mutation in the connexin 46(GJA3) gene. Mol Vis 2007; 13: 797-803.
    • (2007) Mol Vis , vol.13 , pp. 797-803
    • Guleria, K.1    Vanita, V.2    Singh, D.3    Singh, J.4
  • 77
    • 34548860092 scopus 로고    scopus 로고
    • A novel mutation in the connexin 46 (GJA3) gene associatedwith autosomal dominant congenital cataract in an Indianfamily
    • Guleria K, Sperling K, Singh D, Varon R, Singh JR, Vanita v. A novel mutation in the connexin 46 (GJA3) gene associatedwith autosomal dominant congenital cataract in an Indianfamily. Mol Vis 2007; 13: 1657-65.
    • (2007) Mol Vis , vol.13 , pp. 1657-1665
    • Guleria, K.1    Sperling, K.2    Singh, D.3    Varon, R.4    Singh, J.R.5    Vanita, V.6
  • 78
    • 0035697326 scopus 로고    scopus 로고
    • Mutation in the connexin 50 gene (GJA8) in a Russian familywith zonular pulverulent cataract
    • Polyakov AV, Shagina IA, Khlebnikova OV, Evgrafov OV. Mutation in the connexin 50 gene (GJA8) in a Russian familywith zonular pulverulent cataract. Clin Genet 2001; 60: 476-8.
    • (2001) Clin Genet , vol.60 , pp. 476-478
    • Polyakov, A.V.1    Shagina, I.A.2    Khlebnikova, O.V.3    Evgrafov, O.V.4
  • 79
    • 1542648244 scopus 로고    scopus 로고
    • A novel GJA8mutation in an Iranian family with progressive autosomaldominant congenital nuclear cataract
    • Willoughby CE, Arab S, Gandhi R, et al. A novel GJA8mutation in an Iranian family with progressive autosomaldominant congenital nuclear cataract. J Med Genet 2003; 40:e124.
    • (2003) J Med Genet , vol.40
    • Willoughby, C.E.1    Arab, S.2    Gandhi, R.3
  • 80
    • 33750410962 scopus 로고    scopus 로고
    • A novel mutation in GJA8 associated withautosomal dominant congenital cataract in a family of Indianorigin
    • Vanita v, Hennies HC, Singh D, Nurnberg P, Sperling K, Singh JR. A novel mutation in GJA8 associated withautosomal dominant congenital cataract in a family of Indianorigin. Mol Vis 2006; 12: 1217-22.
    • (2006) Mol Vis , vol.12 , pp. 1217-1222
    • Vanita, V.1    Hennies, H.C.2    Singh, D.3    Nurnberg, P.4    Sperling, K.5    Singh, J.R.6
  • 81
    • 33847131692 scopus 로고    scopus 로고
    • A novel GJA8 mutation is associatedwith autosomal dominant lamellar pulverulent cataract:Further evidence for gap junction dysfunction in humancataract
    • Arora A, Minogue PJ, Liu X, Reddy MA, Ainsworth JR, Bhattacharya SS et al. A novel GJA8 mutation is associatedwith autosomal dominant lamellar pulverulent cataract:further evidence for gap junction dysfunction in humancataract. J Med Genet 2006; 43: e2.
    • (2006) J Med Genet , vol.43
    • Arora, A.1    Minogue, P.J.2    Liu, X.3    Reddy, M.A.4    Ainsworth, J.R.5    Bhattacharya, S.S.6
  • 82
    • 33645115350 scopus 로고    scopus 로고
    • Novel mutations in GJA8associated with autosomal dominant congenital cataract andmicrocornea
    • Devi RR, Vijayalakshmi P. Novel mutations in GJA8associated with autosomal dominant congenital cataract andmicrocornea. Mol Vis 2006; 12: 190-5.
    • (2006) Mol Vis , vol.12 , pp. 190-195
    • Devi, R.R.1    Vijayalakshmi, P.2
  • 83
    • 35148832522 scopus 로고    scopus 로고
    • Genetic heterogeneity inmicrocornea-cataract: Five novel mutations in CRYAA, CRYGD, and GJA8
    • Hansen L, Yao W, Eiberg H, et al. Genetic heterogeneity inmicrocornea-cataract: five novel mutations in CRYAA, CRYGD, and GJA8. Invest Opththalmol Vis Sci 2007; 48: 3937-44.
    • (2007) Invest Opththalmol Vis Sci , vol.48 , pp. 3937-3944
    • Hansen, L.1    Yao, W.2    Eiberg, H.3
  • 84
    • 34548826683 scopus 로고    scopus 로고
    • Mutation of the gap junction protein alpha 8(GJA8) gene causes autosomal recessive cataract
    • Ponnam SP, Ramesha K, Tejwani S, Ramamurthy B., Kannabiran C. Mutation of the gap junction protein alpha 8(GJA8) gene causes autosomal recessive cataract. J Med Genet 2007; 44: e85.
    • (2007) J Med Genet , vol.44
    • Ponnam, S.P.1    Ramesha, K.2    Tejwani, S.3    Ramamurthy, B.4    Kannabiran, C.5
  • 86
    • 40649092855 scopus 로고    scopus 로고
    • Anovel connexin 50 (GJA8) mutation in a Chinese family witha dominant congenital pulverulent nuclear cataract
    • Yan M, Xiong C, Ye SQ, Chen Y, Ke M, Zheng F et al. Anovel connexin 50 (GJA8) mutation in a Chinese family witha dominant congenital pulverulent nuclear cataract. Mole Vis 2008; 14(418): 424.
    • (2008) Mole Vis , vol.14 , Issue.418 , pp. 424
    • Yan, M.1    Xiong, C.2    Ye, S.Q.3    Chen, Y.4    Ke, M.5    Zheng, F.6
  • 87
    • 27344433456 scopus 로고    scopus 로고
    • Two novel mutations ofconnexin gens in Chinese families with autosomal dominantcongenital nuclear cataract
    • Ma Z, Zheng J, Yang F, et al. Two novel mutations ofconnexin gens in Chinese families with autosomal dominantcongenital nuclear cataract. Br J Ophthalmol 2005; 89: 1535-7.
    • (2005) Br J Ophthalmol , vol.89 , pp. 1535-1537
    • Ma, Z.1    Zheng, J.2    Yang, F.3
  • 88
    • 43949140835 scopus 로고    scopus 로고
    • A novel GJA8 mutationcausing a recessive triangular cataract
    • Schmidt W, Klopp N, Xllig T, Graw J. A novel GJA8 mutationcausing a recessive triangular cataract. Mol Vis 2008; 14: 851-6.
    • (2008) Mol Vis , vol.14 , pp. 851-856
    • Schmidt, W.1    Klopp, N.2    Xllig, T.3    Graw, J.4
  • 90
    • 0035701565 scopus 로고    scopus 로고
    • Characterization of amutation in the lens-specific MP70 encoding gene of themouse leading to a dominant cataract
    • Graw J, Löster J, Soewarto D, et al. Characterization of amutation in the lens-specific MP70 encoding gene of themouse leading to a dominant cataract. Exp Eye Res 2001; 73: 867-76.
    • (2001) Exp Eye Res , vol.73 , pp. 867-876
    • Graw, J.1    Löster, J.2    Soewarto, D.3
  • 91
    • 0036501610 scopus 로고    scopus 로고
    • A Gja8 (Cx50) pointmutation causes an alteration of alpha3 connexin (Cx46) insemi-dominant cataracts of Lop10 mice
    • Chang B, Wang X, Hawes NL, et al. A Gja8 (Cx50) pointmutation causes an alteration of alpha3 connexin (Cx46) insemi-dominant cataracts of Lop10 mice. Hum Mol Gene 2002; 11: 507-13.
    • (2002) Hum Mol Gene , vol.11 , pp. 507-513
    • Chang, B.1    Wang, X.2    Hawes, N.L.3
  • 92
    • 33745208795 scopus 로고    scopus 로고
    • Knock-in of alpha 3connexin prevents severe cataracts caused by an alpha8point mutation
    • Xia CH, Cheung D, De Rosa AM, et al. Knock-in of alpha 3connexin prevents severe cataracts caused by an alpha8point mutation. J Cell Sci 2006; 119: 2138-44.
    • (2006) J Cell Sci , vol.119 , pp. 2138-2144
    • Xia, C.H.1    Cheung, D.2    De Rosa, A.M.3
  • 94
    • 28544440716 scopus 로고    scopus 로고
    • New genetic model rat for congential cataracts due to aconnexin 46 (Gja3) mutation
    • Yoshida M, Harada Y, Kaidzu S, Ohira A, Masuda J, Nabika T. New genetic model rat for congential cataracts due to aconnexin 46 (Gja3) mutation. Pathol Int 2005; 55: 732-7.
    • (2005) Pathol Int , vol.55 , pp. 732-737
    • Yoshida, M.1    Harada, Y.2    Kaidzu, S.3    Ohira, A.4    Masuda, J.5    Nabika, T.6
  • 95
    • 43749120056 scopus 로고    scopus 로고
    • Microphthalmia andcataract in rat with a novel point mutation in connexin 50-L7Q
    • Liska F, Chyliková B, Martinek J, Kren V. Microphthalmia andcataract in rat with a novel point mutation in connexin 50-L7Q. Mol Vis 2008; 14: 823-8.
    • (2008) Mol Vis , vol.14 , pp. 823-828
    • Liska, F.1    Chyliková, B.2    Martinek, J.3    Kren, V.4
  • 96
    • 29144441379 scopus 로고    scopus 로고
    • Connexin 46 and connexin 50 in selenitecataract
    • Fleschner CR. Connexin 46 and connexin 50 in selenitecataract. Ophthal Res 2006; 38: 24-8.
    • (2006) Ophthal Res , vol.38 , pp. 24-28
    • Fleschner, C.R.1
  • 97
    • 45549100531 scopus 로고    scopus 로고
    • Mutation in a novel connexinlikegene (Gjf1) in the mouse affects early lens developmentand causes a variable small-eye phenotype
    • Puk O, Löster J, Dalke C, et al. Mutation in a novel connexinlikegene (Gjf1) in the mouse affects early lens developmentand causes a variable small-eye phenotype. Invest Opthalmol Vis Sci 2008; 49: 1525-32.
    • (2008) Invest Opthalmol Vis Sci , vol.49 , pp. 1525-1532
    • Puk, O.1    Löster, J.2    Dalke, C.3
  • 98
    • 0033834495 scopus 로고    scopus 로고
    • Connexin46 mutations linkedto congenital cataract show loss of gap junction channelfunction
    • Pal JD, Liu X, Mackay D, et al. Connexin46 mutations linkedto congenital cataract show loss of gap junction channelfunction. Am J Physiol (Cell Physiol) 2000; 279: C596-602.
    • (2000) Am J Physiol (Cell Physiol) , vol.279
    • Pal, J.D.1    Liu, X.2    Mackay, D.3
  • 99
    • 28844450617 scopus 로고    scopus 로고
    • Anaberrant sequence in a connexin46 mutant underliescongenital cataracts
    • Minogue PJ, Liu X, Ebihara L, Beyer EC, Berthoud VM. Anaberrant sequence in a connexin46 mutant underliescongenital cataracts. J Biol Chem 2005; 280: 40788-95.
    • (2005) J Biol Chem , vol.280 , pp. 40788-40795
    • Minogue, P.J.1    Liu, X.2    Ebihara, L.3    Beyer, E.C.4    Berthoud, V.M.5
  • 100
    • 0345517256 scopus 로고    scopus 로고
    • Characterization of a mouse Cx50 mutationassociated with the No2 mouse cataract
    • Xu X, Ebihara L. Characterization of a mouse Cx50 mutationassociated with the No2 mouse cataract. Invest Ophthalmol Vis Sci 1999; 40: 1844-50.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1844-1850
    • Xu, X.1    Ebihara, L.2
  • 102
    • 0037809509 scopus 로고    scopus 로고
    • Loss of function andimpaired degradation of a cataract-associated mutantconnexin50
    • Berthoud VM, Minogue PJ, Guo J, et al. Loss of function andimpaired degradation of a cataract-associated mutantconnexin50. Eur J Cell Biol 2003; 82(5): 209-21.
    • (2003) Eur J Cell Biol , vol.82 , Issue.5 , pp. 209-221
    • Berthoud, V.M.1    Minogue, P.J.2    Guo, J.3
  • 103
    • 0027295398 scopus 로고
    • Properties of a nonjunctional currentexpressed from a rat connexin46 cDNA in Xenopus oocytes
    • Ebihara L, Steiner E. Properties of a nonjunctional currentexpressed from a rat connexin46 cDNA in Xenopus oocytes. J Gen Physiol 1993; 102: 59-74.
    • (1993) J Gen Physiol , vol.102 , pp. 59-74
    • Ebihara, L.1    Steiner, E.2
  • 104
    • 0037214571 scopus 로고    scopus 로고
    • Effect of external magnesium andcalcium on human connexin 46 hemichannels
    • Ebihara L, Liu X, Pal JD. Effect of external magnesium andcalcium on human connexin 46 hemichannels. Biophys J 2003; 84: 277-86.
    • (2003) Biophys J , vol.84 , pp. 277-286
    • Ebihara, L.1    Liu, X.2    Pal, J.D.3
  • 105
    • 0031283282 scopus 로고    scopus 로고
    • Disruption of connexin geneleads to proteolysis and cataractogenesis in mice
    • Gong X, Li E, Klier G, et al. Disruption of connexin geneleads to proteolysis and cataractogenesis in mice. Cell 1997; 91: 833-43.
    • (1997) Cell , vol.91 , pp. 833-843
    • Gong, X.1    Li, E.2    Klier, G.3
  • 107
    • 44649126696 scopus 로고    scopus 로고
    • Gapjunction communication influences intercellular proteindistribution in the lens
    • Cheng C, Xia CH, Li L, White TW, Niimi J, Gong X. Gapjunction communication influences intercellular proteindistribution in the lens. Exp Eye Res 2008; 86: 966-74.
    • (2008) Exp Eye Res , vol.86 , pp. 966-974
    • Cheng, C.1    Xia, C.H.2    Li, L.3    White, T.W.4    Niimi, J.5    Gong, X.6
  • 108
    • 0035800832 scopus 로고    scopus 로고
    • Defining a linkbetween gap junction communication, proteolysis, andcataract formation
    • Baruch A, Greenbaum D, Levy ET, et al. Defining a linkbetween gap junction communication, proteolysis, andcataract formation. J Biol Chem 2001; 276: 28999-29006.
    • (2001) J Biol Chem , vol.276 , pp. 28999-29006
    • Baruch, A.1    Greenbaum, D.2    Levy, E.T.3
  • 109
    • 34347253592 scopus 로고    scopus 로고
    • Age-related cataracts in. αCx46-knockout mice are dependent on a calpain 3 isoform
    • Tang Y, Liu X, Zoltoski R, et al. Age-related cataracts in. αCx46-knockout mice are dependent on a calpain 3 isoform. Invest Ophthal Vis Sci 2007; 48: 2685-94.
    • (2007) Invest Ophthal Vis Sci , vol.48 , pp. 2685-2694
    • Tang, Y.1    Liu, X.2    Zoltoski, R.3
  • 111
    • 0032476578 scopus 로고    scopus 로고
    • Targeted ablation ofconnexin50 in mice results in microphthalmia and zonularpulverulent cataracts
    • White TW, Goodenough DA, Paul DL. Targeted ablation ofconnexin50 in mice results in microphthalmia and zonularpulverulent cataracts. J Cell Biol 1998; 143: 815-25.
    • (1998) J Cell Biol , vol.143 , pp. 815-825
    • White, T.W.1    Goodenough, D.A.2    Paul, D.L.3
  • 112
    • 0036023359 scopus 로고    scopus 로고
    • Disruption of Gja8 (((8connexin) in mice leads to microphthalmia associated withretardation of lens growth and lens fiber maturation
    • Rong P, Wang X, Niesman I, et al. Disruption of Gja8 (((8connexin) in mice leads to microphthalmia associated withretardation of lens growth and lens fiber maturation. Development 2002; 129: 167-74.
    • (2002) Development , vol.129 , pp. 167-174
    • Rong, P.1    Wang, X.2    Niesman, I.3
  • 114
    • 0028965024 scopus 로고
    • Changes in connexinexpression and distribution during chick lens development
    • Jiang JX, White TW, Goodenough DA. Changes in connexinexpression and distribution during chick lens development. Dev Biol 1995; 168: 649-61.
    • (1995) Dev Biol , vol.168 , pp. 649-661
    • Jiang, J.X.1    White, T.W.2    Goodenough, D.A.3
  • 115
    • 0038147088 scopus 로고    scopus 로고
    • Genetic backgroundinfluences cataractogenesis, but not lens growth deficiency, in Cx50-knockout mice
    • Gerido D, Sellitto C, Li L, White TW. Genetic backgroundinfluences cataractogenesis, but not lens growth deficiency, in Cx50-knockout mice. Invest Ophthal Vis Sci 2003; 44: 2669-74.
    • (2003) Invest Ophthal Vis Sci , vol.44 , pp. 2669-2674
    • Gerido, D.1    Sellitto, C.2    Li, L.3    White, T.W.4
  • 119
    • 33745114667 scopus 로고    scopus 로고
    • Diverse gap junctionsmodulate distinct mechanisms for fiber cell formation duringlens development and cataractogenesis
    • Xia C-H, Liu H, Cheung D, et al. Diverse gap junctionsmodulate distinct mechanisms for fiber cell formation duringlens development and cataractogenesis. Dev Dis 2006; 133: 2033-40.
    • (2006) Dev Dis , vol.133 , pp. 2033-2040
    • Xia, C.-H.1    Liu, H.2    Cheung, D.3
  • 120
    • 38349054558 scopus 로고    scopus 로고
    • The cataractinducingS50P mutation in Cx50 dominantly alters thechannel gating of wild-type lens connexins
    • De Rosa AM, Xia C-H, Gong X, White TW. The cataractinducingS50P mutation in Cx50 dominantly alters thechannel gating of wild-type lens connexins. J Cell Sci 2007; 120: 4107-16.
    • (2007) J Cell Sci , vol.120 , pp. 4107-4116
    • De Rosa, A.M.1    Xia, C.-H.2    Gong, X.3    White, T.W.4
  • 121
    • 0028907907 scopus 로고
    • Cardiacmalformation in neonatal mice lacking connexin43
    • Reaume AG, De Sousa PA, Kulkarni S, et al. Cardiacmalformation in neonatal mice lacking connexin43. Science 1995; 267: 1831-4.
    • (1995) Science , vol.267 , pp. 1831-1834
    • Reaume, A.G.1    De Sousa, P.A.2    Kulkarni, S.3
  • 122
    • 0031833887 scopus 로고    scopus 로고
    • Structural changes in lenses of micelacking the gap junction protein connexin43
    • Gao Y, Spray DC. Structural changes in lenses of micelacking the gap junction protein connexin43. Invest Ophthalmol Vis Sci 1998; 37: 1198-209.
    • (1998) Invest Ophthalmol Vis Sci , vol.37 , pp. 1198-1209
    • Gao, Y.1    Spray, D.C.2
  • 124
    • 14844323116 scopus 로고    scopus 로고
    • Growth factor regulation of lensdevelopment
    • Lovicu FJ, McAvoy JW. Growth factor regulation of lensdevelopment. Dev Biol 2005; 280: 1-14.
    • (2005) Dev Biol , vol.280 , pp. 1-14
    • Lovicu, F.J.1    McAvoy, J.W.2
  • 125
    • 11144304548 scopus 로고    scopus 로고
    • Lens differentiation and crystallinregulation: A chick model
    • Reza HM, Yasuda K. Lens differentiation and crystallinregulation: a chick model. Int J Dev Biol 2004; 48: 805-17.
    • (2004) Int J Dev Biol , vol.48 , pp. 805-817
    • Reza, H.M.1    Yasuda, K.2
  • 127
    • 0019434721 scopus 로고
    • Translational regulation of deltacrystallinsynthesis during lens development in the chickenembryo
    • Beebe DC, Piatigorsky J. Translational regulation of deltacrystallinsynthesis during lens development in the chickenembryo. Dev Biol 1981; 84: 96-101.
    • (1981) Dev Biol , vol.84 , pp. 96-101
    • Beebe, D.C.1    Piatigorsky, J.2
  • 128
    • 25444431821 scopus 로고    scopus 로고
    • Identification of global expression differences betweenhuman lens epithelial and cortical cells reveals specificgenes and their associated pathways important forspecialized lens cell function
    • Hawse JR, De Amicis-Tress C, Cowell TL, Kantorow M. Identification of global expression differences betweenhuman lens epithelial and cortical cells reveals specificgenes and their associated pathways important forspecialized lens cell function. Mol Vis 2005; 11: 274-83.
    • (2005) Mol Vis , vol.11 , pp. 274-283
    • Hawse, J.R.1    De Amicis-Tress, C.2    Cowell, T.L.3    Kantorow, M.4
  • 130
    • 0029730560 scopus 로고    scopus 로고
    • Cellular and molecular features of lensdifferentiation: A review of recent advances
    • Wride MA. Cellular and molecular features of lensdifferentiation: a review of recent advances. Differentiation 1996; 61: 77-93.
    • (1996) Differentiation , vol.61 , pp. 77-93
    • Wride, M.A.1
  • 131
    • 0037059499 scopus 로고    scopus 로고
    • Unique and redundant connexin contributions tolens development
    • White TW. Unique and redundant connexin contributions tolens development. Science 2002; 295: 319-20.
    • (2002) Science , vol.295 , pp. 319-320
    • White, T.W.1
  • 132
    • 0242500295 scopus 로고    scopus 로고
    • Stimulation of lens celldifferentiation by gap junction protein connexin 45.6
    • Gu S, Yu XS, Yin X, Jiang JX. Stimulation of lens celldifferentiation by gap junction protein connexin 45.6. Invest Ophthalmol Vis Sci 2003; 44: 2103-11.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 2103-2111
    • Gu, S.1    Yu, X.S.2    Yin, X.3    Jiang, J.X.4
  • 133
    • 4344647629 scopus 로고    scopus 로고
    • Connexin50 is essential for normalpostnatal lens cell proliferation
    • Sellitto C, Li L, White TW. Connexin50 is essential for normalpostnatal lens cell proliferation. Invest Ophthal Vis Sci 2004; 45: 3196-202.
    • (2004) Invest Ophthal Vis Sci , vol.45 , pp. 3196-3202
    • Sellitto, C.1    Li, L.2    White, T.W.3
  • 134
    • 38549125531 scopus 로고    scopus 로고
    • Optimal lensepithelial cell proliferation is dependent on the connexinisoform providing gap junctional coupling
    • White TW, Gao Y, Li L, Sellitto C, Srinivas M. Optimal lensepithelial cell proliferation is dependent on the connexinisoform providing gap junctional coupling. Invest Ophthalmol Vis Sci 2007; 48: 5630-7.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 5630-5637
    • White, T.W.1    Gao, Y.2    Li, L.3    Sellitto, C.4    Srinivas, M.5
  • 135
    • 33746085618 scopus 로고    scopus 로고
    • Structual andimmunocytochemical alterations in eye lens fiber cells fromCx46 and Cx50 knockout mice
    • Dunia I, Cibert C, Gong X, et al. Structual andimmunocytochemical alterations in eye lens fiber cells fromCx46 and Cx50 knockout mice. Eur J Cell Biol 2006; 85: 729-52.
    • (2006) Eur J Cell Biol , vol.85 , pp. 729-752
    • Dunia, I.1    Cibert, C.2    Gong, X.3
  • 136
    • 1642365478 scopus 로고    scopus 로고
    • Interaction of major intrinsic protein(aquaporin-0) with fiber connexins in lens development
    • Yu XS, Jiang JX. Interaction of major intrinsic protein(aquaporin-0) with fiber connexins in lens development. JCell Sci 2004; 117: 871-80.
    • (2004) JCell Sci , vol.117 , pp. 871-880
    • Yu, X.S.1    Jiang, J.X.2
  • 137
    • 20444505236 scopus 로고    scopus 로고
    • Developmental regulationof the direct interaction between the intracellular loop ofconnexin 45.6 and the C-terminus of major intrinsic protein(aquaporin-0)
    • Yu XS, Yin X, Lafer EM, Jiang JX. Developmental regulationof the direct interaction between the intracellular loop ofconnexin 45.6 and the C-terminus of major intrinsic protein(aquaporin-0). J Biol Chem 2005; 280: 22081-90.
    • (2005) J Biol Chem , vol.280 , pp. 22081-22090
    • Yu, X.S.1    Yin, X.2    Lafer, E.M.3    Jiang, J.X.4
  • 138
    • 36249010758 scopus 로고    scopus 로고
    • Promotion of lensepithelial-fiber differentiation by the C-terminus of connexin45.6 a role independent of gap junction communication
    • Banks EA, Yu XS, Shi Q, Jiang JX. Promotion of lensepithelial-fiber differentiation by the C-terminus of connexin45.6 a role independent of gap junction communication. JCell Sci 2007; 120: 3602-12.
    • (2007) JCell Sci , vol.120 , pp. 3602-3612
    • Banks, E.A.1    Yu, X.S.2    Shi, Q.3    Jiang, J.X.4
  • 139
    • 0032396517 scopus 로고    scopus 로고
    • Normal differentiation of cultured lenscells after inhibition of gap junction-mediated intercellularcommunication
    • Le A-CN, Musil LS. Normal differentiation of cultured lenscells after inhibition of gap junction-mediated intercellularcommunication. Dev Biol 1998; 204: 80-96.
    • (1998) Dev Biol , vol.204 , pp. 80-96
    • Le, A.-C.N.1    Musil, L.S.2
  • 140
    • 20444420130 scopus 로고    scopus 로고
    • Gap junction-and hemichannel-independentactions of connexins
    • Jiang JX, Gu S. Gap junction-and hemichannel-independentactions of connexins. Biochim Biophys Acta 2005; 1711: 208-14.
    • (2005) Biochim Biophys Acta , vol.1711 , pp. 208-214
    • Jiang, J.X.1    Gu, S.2
  • 141
    • 0036126655 scopus 로고    scopus 로고
    • pH gating of lens fiber connexins
    • Eckert R. pH gating of lens fiber connexins. Pflügers Arch-Eur J Physiol 2002; 443: 843-51.
    • (2002) Pflügers Arch-Eur J Physiol , vol.443 , pp. 843-851
    • Eckert, R.1
  • 142
    • 0036872373 scopus 로고    scopus 로고
    • Connexins, gap junctionalintercellular communication and kinases
    • Cruciani V, Mikalsen S. Connexins, gap junctionalintercellular communication and kinases. Biol Cell 2002; 94: 433-43.
    • (2002) Biol Cell , vol.94 , pp. 433-443
    • Cruciani, V.1    Mikalsen, S.2
  • 143
    • 0036872993 scopus 로고    scopus 로고
    • Modulation of junctionalcommunication by phosphorylation: Protein phosphatases, the missing link in the chain
    • Herve JC, Sarrouilhe D. Modulation of junctionalcommunication by phosphorylation: protein phosphatases, the missing link in the chain. Biol Cell 2002; 94: 423-32.
    • (2002) Biol Cell , vol.94 , pp. 423-432
    • Herve, J.C.1    Sarrouilhe, D.2
  • 144
    • 0034629297 scopus 로고    scopus 로고
    • Casein kinase IIphosphorylates lens connexin 45.6 and is involved in itsdegradation
    • Yin X, Jedrzejewski PT, Jiang JX. Casein kinase IIphosphorylates lens connexin 45.6 and is involved in itsdegradation. J Biol Chem 2000; 275: 6850-6.
    • (2000) J Biol Chem , vol.275 , pp. 6850-6856
    • Yin, X.1    Jedrzejewski, P.T.2    Jiang, J.X.3
  • 145
    • 48449100846 scopus 로고    scopus 로고
    • Lens fiber connexin turnover andcaspase-3-mediated cleavage are regulated alternately byphosphorylation
    • Yin X, Liu J, Jiang JX. Lens fiber connexin turnover andcaspase-3-mediated cleavage are regulated alternately byphosphorylation. Cell Communica Adhes 2008; 15: 1-11.
    • (2008) Cell Communica Adhes , vol.15 , pp. 1-11
    • Yin, X.1    Liu, J.2    Jiang, J.X.3
  • 146
    • 0031709970 scopus 로고    scopus 로고
    • Assembly of connexins and MP26 in lens fiberplasma membranes studied by SDS-fractureimmunolabeling
    • Dunia I, Recouvreur M, Nicolas P, Kumar N, Bloemendahl H, Benedetti EL. Assembly of connexins and MP26 in lens fiberplasma membranes studied by SDS-fractureimmunolabeling. J Cell Sci 1998; 111: 09-2120.
    • (1998) J Cell Sci , vol.111 , pp. 09-2120
    • Dunia, I.1    Recouvreur, M.2    Nicolas, P.3    Kumar, N.4    Bloemendahl, H.5    Benedetti, E.L.6
  • 150
    • 0024308379 scopus 로고
    • A non-connexon protein (MIP) is involved ineye lens gap-junction formation
    • Gruijters WT. A non-connexon protein (MIP) is involved ineye lens gap-junction formation. J Cell Sci 1989; 93: 509-13.
    • (1989) J Cell Sci , vol.93 , pp. 509-513
    • Gruijters, W.T.1
  • 151
    • 0026786352 scopus 로고
    • The distribution ofthe fiber cell intrinsic membrane proteins MP20 and connexin46 in the bovine lens
    • Tenbroek E, Arneson M, Jarvis L, Louis C. The distribution ofthe fiber cell intrinsic membrane proteins MP20 and connexin46 in the bovine lens. J Cell Sci 1992; 103: 245-57.
    • (1992) J Cell Sci , vol.103 , pp. 245-257
    • Tenbroek, E.1    Arneson, M.2    Jarvis, L.3    Louis, C.4
  • 152
    • 0037036374 scopus 로고    scopus 로고
    • Role of Cterminaldomain and transmembrane helices 5 and 6 infunction and quaternary structure of major intrinsic proteins:Analysis of aquaporin/glycerol facilitator chimeric proteins
    • Duchesne L, Pellerin I, Delamarche C, et al. Role of Cterminaldomain and transmembrane helices 5 and 6 infunction and quaternary structure of major intrinsic proteins:analysis of aquaporin/glycerol facilitator chimeric proteins. JBiol Chem 2002; 277: 598-604.
    • (2002) JBiol Chem , vol.277 , pp. 598-604
    • Duchesne, L.1    Pellerin, I.2    Delamarche, C.3
  • 153
    • 33745170655 scopus 로고    scopus 로고
    • Absence of α3 (Cx46) and α8 (Cx50) connexins leads to cataracts by affecting lensinner fiber cells
    • Xia CH, Cheng C, Huang Q, et al. Absence of α3 (Cx46) and α8 (Cx50) connexins leads to cataracts by affecting lensinner fiber cells. Exp Eye Res 2006; 83: 688-96.
    • (2006) Exp Eye Res , vol.83 , pp. 688-696
    • Xia, C.H.1    Cheng, C.2    Huang, Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.