Connexins are mechanosensitive

American Journal of Physiology - Cell Physiology

Volumn 287, Issue 5 56-5, 2004, Pages

  Bao, Li ^a   Sachs, Frederick ^b   Dahl, Gerhard ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Lens; Mechanical stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; GAP JUNCTION PROTEIN; ION CHANNEL; MESSENGER RNA;

ANIMAL CELL; ARTICLE; GAP JUNCTION; MECHANICAL STRESS; NONHUMAN; OOCYTE; PATCH CLAMP; PRIORITY JOURNAL; VITELLINE MEMBRANE; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; CONNEXINS; MECHANOTRANSDUCTION, CELLULAR; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; STRESS, MECHANICAL; XENOPUS;

ANIMALIA; XENOPUS LAEVIS;

EID: 6044235527     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00220.2004     Document Type: Article

References (54)

1. Bal-Price A, Moneer Z, and Brown GC. Nitric oxide induces rapid, calcium-dependent release of vesicular glutamate and ATP from cultured rat astrocytes. Glia 40: 312-323, 2002.
2. Beahm DL and Hall JE. Hemichannel and junctional properties of connexin 50. Biophys J 82: 2016-2031, 2002.
3. Bodas E, Aleu J, Pujol G, Martin-Satue M, Marsal J, and Solsona C. ATP crossing the cell plasma membrane generates an ionic current in Xenopus oocytes. J Biol Chem 275: 20268-20273, 2000.
4. Boitano S, Dirksen ER, and Evans WH. Sequence-specific antibodies to connexins block intercellular calcium signaling through gap junctions. Cell Calcium 23: 1-9, 1998.
5. + fluxes in intact cells. FASEB J 15: 10-12, 2001.
6. 3. J Cell Sci 109: 1765-1773, 1996.
7. Charles AC, Naus CC, Zhu D, Kidder GM, Dirksen ER, and Sanderson MJ. Intercellular calcium signaling via gap junctions in glioma cells. J Cell Biol 118: 195-201, 1992.
8. Cotrina ML, Lin JH, Alves-Rodrigues A, Liu S, Li J, Azmi-Ghadimi H, Kang J, Naus CC, and Nedergaard M. Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci USA 95: 15735-15740, 1998.
9. Dahl G. The Xenopus oocyte cell-cell channel assay for functional analysis of gap junction proteins. In: Cell-Cell Interactions. A Practical Approach, edited by Stevenson B, Gallin W, and Paul D. Oxford: IRL, 1992, p. 143-165.
10. Ebihara L. Xenopus connexin38 forms hemi-gap-junctional channels in the nonjunctional plasma membrane of Xenopus oocytes. Biophys J 71: 742-748, 1996.
11. Ebihara L and Steiner E. Properties of a nonjunctional current expressed from a rat connexin46 cDNA in Xenopus oocytes. J Gen Physiol 102: 59-74, 1993.
12. Eckert R, Donaldson P, Goldie K, and Kistler J. A distinct membrane current in rat lens fiber cells isolated under calcium-free conditions. Invest Ophthalmol Vis Sci 39: 1280-1285, 1998.
13. Ferguson DR, Kennedy I, and Burton TJ. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes-a possible sensory mechanism? J Physiol 505: 503-511, 1997.
14. Frame MK and De Feijter AW. Propagation of mechanically induced intercellular calcium waves via gap junctions and ATP receptors in rat liver epithelial cells. Exp Cell Res 230: 197-207, 1997.
15. Franco A Jr and Lansman JB. Calcium entry through stretch-inactivated ion channels in mdx myotubes. Nature 344: 670-673, 1990.
16. Grygorczyk R and Hanrahan JW. CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli. Am J Physiol Cell Physiol 272: C1058-C1066, 1997.
17. + channel. Biophys J 80: 2678-2693, 2001.
18. Guharay F and Sachs F. Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. J Physiol 352: 685-701, 1984.
19. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391: 85-100, 1981.
20. Hamill OP and McBride DW Jr. Rapid adaptation of single mechanosensitive channels in Xenopus oocytes. Proc Natl Acad Sci USA 89: 7462-7466, 1992.
21. Hassinger TD, Guthrie PB, Atkinson PB, Bennett MV, and Kater SB. An extracellular signaling component in propagation of astrocytic calcium waves. Proc Natl Acad Sci USA 93: 13268-13273, 1996.
22. Hu X and Dahl G. Exchange of conductance and gating properties between gap junction hemichannels. FEBS Lett 451: 113-117, 1999.
23. Kronengold J, Trexler EB, Bukauskas FF, Bargiello TA, and Verselis VK. Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels. J Gen Physiol 122: 389-405, 2003.
24. Leybaert L, Braet K, Vandamme W, Cabooter L, Martin PE, and Evans WH. Connexin channels, connexin mimetic peptides and ATP release. Cell Commun Adhes 10: 251-257, 2003.
25. Li H, Liu TF, Lazrak A, Peracchia C, Goldberg GS, Lampe PD, and Johnson RG. Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells. J Cell Biol 134: 1019-1030, 1996.
26. Maroto R and Hamill OP. Brefeldin A block of integrin-dependent mechanosensitive ATP release from Xenopus oocytes reveals a novel mechanism of mechanotransduction. J Biol Chem 276: 23867-23872, 2001.
27. Mathias RT, Rae JL, and Baldo GJ. Physiological properties of the normal lens. Physiol Rev 77: 21-50, 1997.
28. Methfessel C, Witzemann V, Takahashi T, Mishina M, Numa S, and Sakmann B. Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflügers Arch 407: 577-588, 1986.
29. Morris CE and Sigurdson WJ. Stretch-inactivated ion channels coexist with stretch-activated ion channels. Science 243: 807-809, 1989.
30. + channels in adult rat atrial myocytes. Prog Biophys Mol Biol 82: 121-135, 2003.
31. Paul DL, Ebihara L, Takemoto LJ, Swenson KI, and Goodenough DA. Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J Cell Biol 115: 1077-1089, 1991.
32. Pfahnl A and Dahl G. Localization of a voltage gate in connexin46 gap junction hemichannels. Biophys J 15: 2323-2331, 1998.
33. Qu Y and Dahl G. Function of the voltage gate of gap junction channels: selective exclusion of molecules. Proc Natl Acad Sci USA 99: 697-702, 2002.
34. Sachs F, Morris CE, and Hamill O. Does a stretch-inactivated cation channel integrate osmotic and peptidergic signals? Nat Neurosci 3: 847-848, 2000.
35. Saez JC, Connor JA, Spray DC, and Bennett MV. Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions. Proc Natl Acad Sci USA 86: 2708-2712, 1989.
36. 2+ in epithelial cells. Cell Regul 1: 585-596, 1990.
37. Scemes E, Suadicani SO, and Spray DC. Intercellular communication in spinal cord astrocytes: fine tuning between gap junctions and P2 nucleotide receptors in calcium wave propagation. J Neurosci 20: 1435-1445, 2000.
38. Schlosser SF, Burgstahler AD, and Nathanson MH. Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides. Proc Natl Acad Sci USA 93: 9948-9953, 1996.
39. Schutt W and Sackin H. A new technique for evaluating volume sensitivity of ion channels. Pflügers Arch 433: 368-375, 1997.
40. Sigurdson W, Ruknudin A, and Sachs F. Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: role of stretch-activated ion channels. Am J Physiol Heart Circ Physiol 262: H1110-H1115, 1992.
41. Stout CE, Costantin JL, Naus CC, and Charles AC. Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. J Biol Chem 277: 10482-10488, 2002.
42. Suadicani SO, De Pina-Benabou MH, Urban-Maldonado M, Spray DC, and Scemes E. Acute downregulation of Cx43 alters P2Y receptor expression levels in mouse spinal cord astrocytes. Glia 42: 160-171, 2003.
43. Suchyna T and Sachs F. Dynamic regulation of mechanosensitive channels; capacitance used to monitor patch tension in real time. Phys Biol 1: 1-18, 2004.
44. Toyofuku T, Yabuki M, Otsu K, Kuzuya T, Hori M, and Tada M. Intercellular calcium signaling via gap junction in connexin-43-transfected cells. J Biol Chem 273: 1519-1528, 1998. [Corrigenda. J Biol Chem 273: Aug 28, 1998, p. 22856.]
45. Toyofuku T, Yabuki M, Otsu K, Kuzuya T, Hori M, and Tada M. Intercellular calcium signaling via gap junction in connexin-43-transfected cells. J Biol Chem 273: 1519-1528, 1998. [Corrigenda. J Biol Chem 273: Aug 28, 1998, p. 22856.]
46. Trexler EB, Bennett MV, Bargiello TA, and Verselis VK. Voltage gating and permeation in a gap junction hemichannel. Proc Natl Acad Sci USA 93: 5836-5841, 1996.
47. Trexler EB, Bukauskas FF, Bennett MV, Bargiello TA, and Verselis VK. Rapid and direct effects of pH on connexins revealed by the connexin46 hemichannel preparation. J Gen Physiol 113: 721-742, 1999.
48. 2+ influx into human endothelial cells via P2X4 purinoceptors. Circ Res 81: 385-391, 2000.
49. Yang XC and Sachs F. Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science 243: 1068-1071, 1989.
50. 2+ signaling in osteoclasts. Cell Signal 6: 905-914, 1994.
51. Zampighi GA, Loo DD, Kreman M, Eskandari S, and Wright EM. Functional and morphological correlates of connexin50 expressed in Xenopus laevis oocytes. J Gen Physiol 113: 507-524, 1999.
52. Zelles T, Boros I, and Varga G. Membrane stretch and salivary glands-facts and theories. Arch Oral Biol 44, Suppl 1: S67-S71, 1999.
53. Zhang Y and Hamill OP. Calcium-, voltage- and osmotic stress-sensitive currents in Xenopus oocytes and their relationship to single mechanically gated channels. J Physiol 523: 83-99, 2000.
54. Zhang Y and Hamill OP. On the discrepancy between whole-cell and membrane patch mechanosensitivity in Xenopus oocytes. J Physiol 523: 101-115, 2000.