Connexins in lens development and cataractogenesis

Journal of Membrane Biology

Volumn 218, Issue 1-3, 2007, Pages 9-12

  Gong, Xiaohua ^a   Cheng, Catherine ^a   Xia, Chun Hong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cataractogenesis; Connexin; Lens

Indexed keywords

CONNEXIN 46; CONNEXIN 8; GAP JUNCTION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL ELONGATION; CELL JUNCTION; CELL MATURATION; CHANNEL GATING; CONTROLLED STUDY; EMBRYO; EYE DEVELOPMENT; INTROSPECTION; LENS; LENS FIBER; MOUSE; NONHUMAN;

CATARACT; CONNEXINS; GAP JUNCTIONS; HUMANS; LENS, CRYSTALLINE;

EID: 36249012485     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-007-9033-0     Document Type: Article

References (27)

1. Addison PK, Berry V, Holden KR, Espinal D, Rivera B, Su H, Srivastava AK, Bhattacharya SS (2006) A novel mutation in the connexin 46 gene (GJA3) causes autosomal dominant zonular pulverulent cataract in a Hispanic family. Mol Vis 12:791-795
2. Baldo GJ, Gong X, Martinez-Wittinghan FJ, Kumar NM, Gilula NB, Mathias RT (2001) Gap junctional coupling in lenses from alpha(8) connexin knockout mice. J Gen Physiol 118:447-456
3. Baruch A, Greenbaum D, Levy ET, Nielsen PA, Gilula NB, Kumar NM, Bogyo M (2001) Defining a link between gap junction communication, proteolysis, and cataract formation. J Biol Chem 276:28999-29006
4. Bassnett S (2004) Lens fiber differentiation. In: Lovicu FJ, Robinson ML (eds), Development of the Ocular Lens. Cambridge: Cambridge University Press, pp 214-244
5. Beyer EC, Kistler J, Paul DL, Goodenough DA (1989) Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J Cell Biol 108:595-605
6. Chang B, Wang X, Hawes NL, Ojakian R, Davisson MT, Lo WK, Gong X (2002) A Gja8 (Cx50) point mutation causes an alteration of alpha 3 connexin (Cx46) in semi-dominant cataracts of Lop10 mice. Hum Mol Genet 11:507-513
7. Fleishman SJ, Unger VM, Yeager M, Ben-Tal N (2004) A Calpha model for the transmembrane alpha helices of gap junction intercellular channels. Mol Cell 15:879-888
8. Gao J, Sun X, Martinez-Wittinghan FJ, Gong X, White TW, Mathias RT (2004) Connections between connexins, calcium, and cataracts in the lens. J Gen Physiol 124:289-300
9. Gong X, Baldo GJ, Kumar NM, Gilula NB, Mathias RT (1998) Gap junctional coupling in lenses lacking alpha3 connexin. Proc Natl Acad Sci USA 95:15303-15308
10. Gong X, Li E, Klier G, Huang Q, Wu Y, Lei H, Kumar NM, Horwitz J, Gilula NB (1997) Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell 91:833-843
11. Goodenough DA (1992) The crystalline lens. A system networked by gap junctional intercellular communication. Semin Cell Biol 3:49-58
12. Hansen L, Yao W, Eiberg H, Funding M, Riise R, Kjaer KW, Hejtmancik JF, Rosenberg T (2006) The congenital "ant-egg" cataract phenotype is caused by a missense mutation in connexin46. Mol Vis 12:1033-1039
13. Kumar NM, Gilula NB (1996) The gap junction communication channel. Cell 84:381-388
14. Martinez-Wittinghan FJ, Sellitto C, White TW, Mathias RT, Paul D, Goodenough DA (2004) Lens gap junctional coupling is modulated by connexin identity and the locus of gene expression. Invest Ophthalmol Vis Sci 45:3629-3637
15. Mathias RT, Rae JL, Baldo GJ (1997) Physiological properties of the normal lens. Physiol Rev 77:21-50
16. Piatigorsky J (1981) Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation 19:134-153
17. Rong P, Wang X, Niesman I, Wu Y, Benedetti LE, Dunia I, Levy E, Gong X (2002) Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation. Development 129:167-174
18. Sellitto C, Li L, White TW (2004) Connexin50 is essential for normal postnatal lens cell proliferation. Invest Ophthalmol Vis Sci 45:3196-3202
19. Unger VM, Kumar NM, Gilula NB, Yeager M (1999) Three-dimensional structure of a recombinant gap junction membrane channel. Science 283:1176-1180
20. Vanita V, Hennies HC, Singh D, Nurnberg P, Sperling K, Singh JR (2006) A novel mutation in GJA8 associated with autosomal dominant congenital cataract in a family of Indian origin. Mol Vis 12:1217-1222
21. White TW (2002) Unique and redundant connexin contributions to lens development. Science 295:319-320
22. White TW, Bruzzone R, Wolfram S, Paul DL, Goodenough DA (1994) Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins. J Cell Biol 125:879-892
23. White TW, Goodenough DA, Paul DL (1998) Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts. J Cell Biol 143:815-825
24. Xia CH, Cheng C, Huang Q, Cheung D, Li L, Dunia I, Benedetti LE, Horwitz J, Gong X (2006a) Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells. Exp Eye Res 83:688-696
25. Xia CH, Cheung D, DeRosa AM, Chang B, Lo WK, White TW, Gong X (2006b) Knockin a3 (Cx46) connexin prevents severe cataracts caused by an a8 (Cx50)-G22R mutation. J Cell Sci (in press)
26. Xia CH, Liu H, Cheung D, Cheng C, Wang E, Du X, Beutler B, Lo WK, Gong X (2006c) Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. Development 133:2033-2040
27. Yeager M, Nicholson BJ (2000) Structure and biochemistry of gap junction. Adv Mol Cell Biol 30:31-98