pH gating of lens fibre connexins

Pflugers Archiv European Journal of Physiology

Volumn 443, Issue 5-6, 2002, Pages 843-851

  Eckert, Reiner ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

Cx46; Cx49; Gap junction; Ocular lens, pH gating; Truncation mutant

Indexed keywords

GAP JUNCTION PROTEIN;

ACIDIFICATION; ARTICLE; CATARACT; CELL ADHESION; CELL PH; CHANNEL GATING; CONTROLLED STUDY; DIABETIC RETINOPATHY; GAP JUNCTION; HELA CELL; HUMAN; HUMAN CELL; LENS FIBER; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ACIDS; CATARACT; CELL COMMUNICATION; CONNEXINS; GAP JUNCTIONS; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; LENS, CRYSTALLINE; MUTAGENESIS; PATCH-CLAMP TECHNIQUES; TRANSFECTION;

EID: 0036126655     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-001-0760-2     Document Type: Article

References (30)

1. Inactivation of the sodium channel II. Gating current experiments
2. Spatial variations in membrane properties in the intact rat lens
3. Direct measurement of pH in the rat lens by ion-sensitive microelectrodes
4. Diffusion of lactate and its role in determining intracellular pH in the lens of the eye
5. Liquefaction of cortical tissue in diabetic and galactosemic rat lenses defined by confocal laser scanning microscopy
6. 2-sensitive and voltagesensitive
7. Quantitative determination of gap junctional permeability in the lens cortex
8. Gating of gap junction channels and hemichannels in the lens: A role in cataract?
9. Role of histidine 95 on pH gating of the cardiac gap junction protein connexin43
10. pH regulation of connexin43 - Molecular analysis of the gating particle
11. Method for manipulation of cytosolic pH in cells clamped in the whole cell or perforated-patch configurations
12. A particle-receptor model for the insulin-induced closure of connexin43 channels
13. Functional rescue of defective mutant connexons by pairing with wild-type connexons
14. Protein processing in lens intercellular junctions: Cleavage of MP70 to MP38
15. Connexins in the lens: Are they to blame in diabetic cataractogenesis?
16. Processing of the gap junction protein connexin50 in the ocular lens is accomplished by calpain
17. Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage
18. A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: The carboxyl tail length
19. Cell to cell communication and pH in the frog lens
20. Physiological properties of the normal lens
21. Intramolecular interactions mediate pH regulation of connexin43 channels
22. i
23. Single-channel currents of an intercellular junction
24. Stoichiometry of transjunctional voltage-gating polarity reversal by a negative charge substitution in the amino terminus of a Connexin32 chimera
25. Reversal of the gating polarity of gap junctions by negative charge substitutions in the N-terminus of connexin 32
26. Physiological and pharmacological regulation of gap junction channels
27. Hetero-domain interactions as a mechanism for the regulation of connexin channels
28. Rapid and direct effects of pH on connexins revealed by the connexin46 hemichannel preparation
29. Chimeric evidence for a role of the connexin cytoplasmic loop in gap junction channel gating
30. Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts