Genetic background influences cataractogenesis, but not lens growth deficiency, in Cx50-knockout mice

Investigative Ophthalmology and Visual Science

Volumn 44, Issue 6, 2003, Pages 2669-2674

  Gerido, Dwan A ^b   Sellitto, Caterina ^b   Li, Leping ^b   White, Thomas W ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 46; CONNEXIN 50; CRYSTALLIN; GAP JUNCTION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; DISEASE SEVERITY; DNA MODIFICATION; GENE DELETION; GROWTH RETARDATION; HEREDITY; KNOCKOUT MOUSE; LENS; MICROPHTHALMIA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SOLUBILITY;

ANIMALS; CATARACT; CONNEXINS; CROSSES, GENETIC; CRYSTALLINS; EYE PROTEINS; LENS, CRYSTALLINE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROPHTHALMOS; PHENOTYPE;

EID: 0038147088     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.02-1311     Document Type: Article

References (29)

1. Piatigorsky J. Lens differentiation in vertebrates: a review of cellular and molecular features. Differentiation. 1981;19:134-153.
2. McAvoy JW, Chamberlain CG, de longh RU, Hales AM, Lovicu FJ. Lens development. Eye. 1999;13:425-437.
3. Mathias RT, Rae JL, Baldo GJ. Physiological properties of the normal lens. Physiol Rev. 1997;77:21-50.
4. Harris AL. Emerging issues of connexin channels: biophysics fills the gap. Q Rev Biophys. 2001;34:325-472.
5. Bruzzone R, White TW, Paul DL. Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem. 1996;238:1-27.
6. Willecke K, Eiberger J, Degen J, et al. Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem. 2002;383:725-737.
7. White TW, Bruzzone R. Intercellular communication in the eye: clarifying the need for connexin diversity. Brain Res Rev. 2000;32:130-137.
8. Beyer EC, Kistler J, Paul DL, Goodenough DA. Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J Cell Biol 1989;108:595-605.
9. Musil LS, Beyer EC, Goodenough DA. Expression of the gap junction protein connexin43 in embryonic chick lens: molecular cloning, ultrastructural localization, and post-translational phosphorylation. J Membr Biol. 1990;116:163-175.
10. Kistler J, Kirkland B, Bullivant S. Identification of a 70,000-D protein in lens membrane junctional domains. J Cell Biol. 1985;101:28-35.
11. Paul DL, Ebihara L, Takemoto LJ, Swenson KI, Goodenough DA. Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J Cell Biol. 1991;115:1077-1089.
12. White TW, Bruzzone R, Goodenough DA, Paul DL. Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein Mp70. Mol Biol Cell. 1992;3:711-720.
13. Evans CW, Eastwood S, Rains J, Gruijters WT, Bullivant S, Kistler J. Gap junction formation during development of the mouse lens. Eur J Cell Biol. 1993;60:243-249.
14. Reaume AG, de Sousa PA, Kulkarni S, et al. Cardiac malformation in neonatal mice lacking connexin43. Science. 1995;267:1831-1834.
15. Gao Y, Spray DC. Structural changes in lenses of mice lacking the gap junction protein connexin43. Invest Ophthalmol Vis Sci. 1998;39:1198-1209.
16. White TW, Sellitto C, Paul DL, Goodenough DA. Prenatal lens development in connexin43 and connexin50 double knockout mice. Invest Ophthalmol Vis Sci. 2001;42:2916-2923.
17. Gong X, Li E, Klier G, et al. Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell. 1997;91:833-843.
18. White TW, Goodenough DA, Paul DL. Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts. J Cell Biol. 1998;143:815-825.
19. Rong P, Wang X, Niesman I, et al. Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation. Development. 2002;129:167-174.
20. Piatigorsky TJ. Intracellular ions, protein metabolism, and cataract formation. Curr Top Eye Res. 1980;3:1-39.
21. Baruch A, Greenbaum D, Levy ET, et al. Defining a link between gap junction communication, proteolysis, and cataract formation. J Biol Chem. 2001;276:28999-29006.
22. White TW. Unique and redundant connexin contributions to lens development. Science. 2002;295:319-320.
23. Gong X, Agopian K, Kumar NM, Giluli NB. Genetic factors influence cataract formation in alpha 3 connexin knockout mice. Dev Genet. 1999;24:27-32.
24. Baldo GJ, Gong X, Martinez-Wittinghan FJ, Kumar NM, Gilula NB, Mathias RT. Gap junctional coupling in lenses from alpha(8) connexin knockout mice. J Gen Physiol. 2001;118:447-456.
25. Maeda YY, Funata N, Takahama S, Sugata Y, Yonekawa H. Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Mamm Genome. 2001;12:278-283.
26. Steele EC Jr, Lyon MF, Favor J, Guillot PV, Boyd Y, Church RL. A mutation in the connexin 50 (Cx50) gene is a candidate for the No2 mouse cataract. Curr Eye Res. 1998;17:883-889.
27. Graw J, Loster J, Soewarto D, et al. Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract. Exp Eye Res. 2001;73:867-876.
28. Chang B, Wang X, Hawes NL, et al. A Gja8 (Cx50) point mutation causes an alteration of alpha 3 connexin (Cx46) in semi-dominant cataracts of Lop10 mice. Hum Mol Genet. 2002;11:507-513.
29. Yamashita S, Furumoto K, Nobukiyo A, Kamohara M, Ushijima T, Furukawa T. Mapping of A gene responsible for cataract formation and its modifier in the UPL rat. Invest Ophthalmol Vis Sci. 2002;43:3153-3159.