Open pore block of connexin26 and connexin32 hemichannels by neutral, acidic and basic glycoconjugates

Cell Communication and Adhesion

Volumn 10, Issue 4-6, 2003, Pages 239-244

  Locke, Darren ^a   Wang, Lai Xi ^b   Bevans, Carville G ^c   Lee, Yuan C ^d   Harris, Andrew L ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b INSTITUTE OF HUMAN VIROLOGY   (United States)

^c MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Anthranilic acid; Channel; Connexin; Glycoconjugate; Maltosaccharide; Open pore block

Indexed keywords

AMINOPYRIDINE; ANTHRANILIC ACID DERIVATIVE; CONNEXIN 26; CONNEXIN 32; CONNEXIN 43; DISACCHARIDE; GLYCOCONJUGATE; OLIGOSACCHARIDE; TRISACCHARIDE;

ARTICLE; CELL COMMUNICATION; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; CHEMICAL STRUCTURE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; INTRACELLULAR TRANSPORT; MEMBRANE CHANNEL; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

EID: 0347126492     PISSN: 15419061     EISSN: None     Source Type: Journal    
DOI: 10.1080/cac.10.4-6.239.244     Document Type: Article

References (33)

1. Bevans CG, Kordel M, Rhee SK, Harris AL (1998). Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules. Journal of Biological Chemistry 273: 2808-2816.
2. Bock K, Meldal M, Refn S (1991). Controlled reduction of acarbose: Conformational analysis of acarbose and the resulting saturated products. Carbohydrate Research 221: 1-16.
3. Brayer GD, Sidhu G, Maurus R, Rydberg EH, Braun C, Wang Y, Nguyen NT, Overall CM, Withers SG (2000). Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry 39: 4778-4791.
4. Bukauskas FF, Elfgang C, Willecke K, Weingart R (1995). Heterotypic gap junction channels (connexin26-connexin32) violate the paradigm of unitary conductance. Pflugers Archiv 429: 870-872.
5. Catterall WA (1988). Structure and function of voltage-sensitive ion channels. Science 242: 50-61.
6. Dumas F, Koebnik R, Winterhalter M, Van Gelder P (2000). Sugar transport through maltoporin of Escherichia coli. Role of polar tracks. Journal of Biological Chemistry 275: 19747-19751.
7. Elfgang C, Eckert R, Lichtenberg-Frate H, Butterweck A, Traub O, Klein RA, Hulser DF, Willecke K (1995). Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. Journal of Cell Biology 129: 805-817.
8. Goldberg GS, Lampe PD, Nicholson BJ (1999). Selective transfer of endogenous metabolites through gap junctions composed of different connexins. Nature Cell Biology 1: 457-459.
9. Goldberg GS, Lampe PD, Sheedy D, Stewart CC, Nicholson BJ, Naus CC (1998). Direct isolation and analysis of endogenous transjunctional ADP from Cx43 transfected C6 glioma cells. Experimental Cell Research 239: 82-92.
10. Goldberg GS, Moreno AP, Lampe PD (2002). Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP. Journal of Biological Chemistry 277: 36725-36730.
11. Goldstein SA, Pheasant DJ, Miller C (1994). The charybdotoxin receptor of a Shaker K+ channel: Peptide and channel residues mediating molecular recognition. Neuron 12: 1377-1388.
12. Gross A, MacKinnon R (1996). Agitoxin footprinting the Shaker potassium channel pore. Neuron 16: 399-406.
13. Harris AL, Bevans CG (2001). Exploring hemichannel permeability in vitro. Methods in Molecular Biology 154: 357-377.
14. Harris AL, Walter A, Zimmerberg J (1989). Transport-specific isolation of large channels reconstituted into lipid vesicles. Journal of Membrane Biology 109: 243-250.
15. Hase S, Ibuki T, Ikenaka T (1984). Reexamination of the pyridylamination used for fluorescence labeling of oligosaccharides and its application to glycoproteins. Journal of Biochemistry (Tokyo) 95: 197-203.
16. Immel S, Lichtenthaler FW (2000). The hydrophobic topographies of amylose and its blue iodine complex. Starch 52: 1-8.
17. Kam Y, Kim DY, Koo SK, Joe CO (1998). Transfer of second messengers through gap junction connexin 43 channels reconstituted in liposomes. Biochima Biophysa Acta 1372: 384-388.
18. Locke D, Perusinghe N, Newman T, Jayatilake H, Evans WH, Monaghan P (2000). Developmental expression and assembly of connexins into homomeric and heteromeric gap junction hemichannels in the mouse mammary gland. Journal of Cellular Physiology 183: 228-237.
19. Nicholson BJ, Weber PA, Cao F, Chang H, Lampe P, Goldberg G (2000). The molecular basis of selective permeability of connexins is complex and includes both size and charge. Brazilian Journal of Medical & Biological Research 33: 369-378.
20. Niessen H, Harz H, Bedner P, Kramer K, Willecke K (2000). Selective permeability of different connexin channels to the second messenger inositol 1,4,5-trisphosphate. Journal of Cell Science 113: 1365-1372.
21. Oh S, Ri Y, Bennett MV, Trexler EB, Verselis VK, Bargiello TA (1997). Changes in permeability caused by connexin 32 mutations underlie X-linked Charcot-Marie-Tooth disease. Neuron 19: 927-938.
22. Oh S, Rubin JB, Bennett MV, Verselis VK, Bargiello TA (1999). Molecular determinants of electrical rectification of single channel conductance in gap junctions formed by connexins 26 and 32. Journal of General Physiology 114: 339-364.
23. Plum A, Hallas G, Magin T, Dombrowski F, Hagendorff A, Schumacher B, Wolpert C, Kim J, Lamers WH, Evert M, Meda P, Traub O, Willecke K (2000). Unique and shared functions of different connexins in mice. Current Biology 10: 1083-1091.
24. Qu Y, Dahl G (2002). Function of the voltage gate of gap junction channels: Selective exclusion of molecules. Proceedings of the National Academy of Sciences of the United States of America 99: 697-702.
25. Rhee SK, Bevans CG, Harris AL (1996). Channel-forming activity of immunoaffinity-purified connexin32 in single phospholipid membranes. Biochemistry 35: 9212-9223.
26. Song L, Hobaugh MR, Shustak C, Cheley S, Bayley H, Gouaux JE (1996). Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science 274: 1859-1866.
27. Suchyna TM, Nitsche JM, Chilton M, Harris AL, Veenstra RD, Nicholson BJ (1999). Different ionic selectivities for connexins 26 and 32 produce rectifying gap junction channels. Biophysical Journal 77: 2968-2987.
28. Van Gelder P, Dumas F, Bartoldus I, Saint N, Prilipov A, Winterhalter M, Wang Y, Philippsen A, Rosenbusch JP, Schirmer T (2002). Sugar transport through maltoporin of Escherichia coli: Role of the greasy slide. Journal of Bacteriology 184: 2994-2999.
29. Veenstra RD (1996). Size and selectivity of gap junction channels formed from different connexins. Journal of Bioenergetics & Biomembranes 28: 327-337.
30. Veenstra RD, Wang HZ, Beblo DA, Chilton MG, Harris AL, Beyer EC, Brink PR (1995). Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circulation Research 77: 1156-1165.
31. White TW (2002). Unique and redundant connexin contributions to lens development. Science 295: 319-320.
32. Yellen G, Jurman ME, Abramson T, MacKinnon R (1991). Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science 251: 939-942.
33. Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland Jr DE (2003). Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 300: 976-980.