Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice

Journal of Immunology

Volumn 183, Issue 7, 2009, Pages 4292-4301

  Weber, Claudia ^a   Krueger, Andreas ^a   Münk, Anika ^a   Bode, Constantin ^a   Van Veldhoven, Paul P ^b   Gräler, Markus H ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE; UNCLASSIFIED DRUG; LYASE; SPHINGOSINE 1 PHOSPHATE LYASE (ALDOLASE); SPHINGOSINE 1-PHOSPHATE LYASE (ALDOLASE);

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIRTH; CELL MATURATION; CONTROLLED STUDY; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; POSTNATAL DEVELOPMENT; PRE T LYMPHOCYTE; PRIORITY JOURNAL; THYMOCYTE; ANIMAL; ATROPHY; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL MOTION; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; IMMUNOLOGY; LYMPHOCYTOPENIA; LYMPHOPOIESIS; MOUSE MUTANT; NEWBORN; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; STEM CELL; THYMUS;

ALDEHYDE-LYASES; ANIMALS; ANIMALS, NEWBORN; ATROPHY; CELL DIFFERENTIATION; CELL MOVEMENT; CERAMIDES; LYMPHOPENIA; LYMPHOPOIESIS; MICE; MICE, KNOCKOUT; MICE, NUDE; STEM CELLS; THYMUS GLAND;

EID: 70449700288     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901724     Document Type: Article

References (48)

1. Perry, S. S., H. Wang, L. J. Pierce, A. M. Yang, S. Tsai, and G. J. Spangrude. 2004. L-selectin defines a bone marrow analog to the thymic early T-lineage progenitor. Blood 103: 2990-2996.
2. Igarashi, H., S. C. Gregory, T. Yokota, N. Sakaguchi, and P. W. Kincade. 2002. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity 17: 117-130. (Pubitemid 35245955)
3. + stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 15: 659-669.
4. + common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages. Blood 111: 5562-5570.
5. Krueger, A., and H. von Boehmer. 2007. Identification of a T lineage-committed progenitor in adult blood. Immunity 26: 105-116. (Pubitemid 46109345)
6. Wu, L., R. Scollay, M. Egerton, M. Pearse, G. J. Spangrude, and K. Shortman. 1991. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349: 71-74. (Pubitemid 21912017)
7. Moore, T. A., and A. Zlotnik. 1995. T-cell lineage commitment and cytokine responses of thymic progenitors. Blood 86: 1850-1860.
8. Allman, D., A. Sambandam, S. Kim, J. P. Miller, A. Pagan, D. Well, A. Meraz, and A. Bhandoola. 2003. Thymopoiesis independent of common lymphoid progenitors. Nat. Immunol. 4: 168-174. (Pubitemid 36193019)
9. Rossi, F. M., S. Y. Corbel, J. S. Merzaban, D. A. Carlow, K. Gossens, J. Duenas, L. So, L. Yi, and H. J. Ziltener. 2005. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat. Immunol. 6: 626-634.
10. Uehara, S., A. Grinberg, J. M. Farber, and P. E. Love. 2002. A role for CCR9 in T lymphocyte development and migration. J. Immunol. 168: 2811-2819. (Pubitemid 34211660)
11. Matloubian, M., C. G. Lo, G. Cinamon, M. J. Lesneski, Y. Xu, V. Brinkmann, M. L. Allende, R. L. Proia, and J. G. Cyster. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360. (Pubitemid 38133663)
12. Allende, M. L., J. L. Dreier, S. Mandala, and R. L. Proia. 2004. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J. Biol. Chem. 279: 15396-15401.
13. Lo, C. G., Y. Xu, R. L. Proia, and J. G. Cyster. 2005. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J. Exp. Med. 201: 291-301.
14. Schwab, S. R., J. P. Pereira, M. Matloubian, Y. Xu, Y. Huang, and J. G. Cyster. 2005. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309: 1735-1739.
15. Pappu, R., S. R. Schwab, I. Cornelissen, J. P. Pereira, J. B. Regard, Y. Xu, E. Camerer, Y. W. Zheng, Y. Huang, J. G. Cyster, and S. R. Coughlin. 2007. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316: 295-298. (Pubitemid 46633109)
16. Hänel, P., P. Andréani, and M. H. Gräler. 2007. Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB J. 21: 1202-1209. (Pubitemid 46495709)
17. Cuvillier, O., G. Pirianov, B. Kleuser, P. G. Vanek, O. A. Coso, S. Gutkind, and S. Spiegel. 1996. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381: 800-803. (Pubitemid 26243122)
18. Neumeyer, J., C. Hallas, O. Merkel, S. Winoto-Morbach, M. Jakob, L. Thon, D. Adam, W. Schneider-Brachert, and S. Schutze. 2006. TNF-receptor I defective in internalization allows for cell death through activation of neutral sphingomyelinase. Exp. Cell Res. 312: 2142-2153.
19. Thon, L., H. Mohlig, S. Mathieu, A. Lange, E. Bulanova, S. Winoto-Morbach, S. Schutze, S. Bulfone-Paus, and D. Adam. 2005. Ceramide mediates caspasein-dependent programmed cell death. FASEB J. 19: 1945-1956.
20. Sanna, M. G., J. Liao, E. Jo, C. Alfonso, M. Y. Ahn, M. S. Peterson, B. Webb, S. Lefebvre, J. Chun, N. Gray, and H. Rosen. 2004. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J. Biol. Chem. 279: 13839-13848.
21. Wei, S. H., H. Rosen, M. P. Matheu, M. G. Sanna, S. K. Wang, E. Jo, C. H. Wong, I. Parker, and M. D. Cahalan. 2005. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol. 6: 1228-1235.
22. Sanna, M. G., S. K. Wang, P. J. Gonzalez-Cabrera, A. Don, D. Marsolais, M. P. Matheu, S. H. Wei, I. Parker, E. Jo, W. C. Cheng, et al. 2006. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat. Chem. Biol. 2: 434-441.
23. Brown, P., K. Frazier, D. Augeri, D. W. Walke, C. Pappas, B. Brooks, M. Donoviel, and T. Oravecz. 2008. LX2931: a potential small molecule treatment for autoimmune disorders. In 2008 Annual Meeting of the American College of Rheumatology. Arthritis Rheum. 58(9 Suppl.): 351.
24. Van Veldhoven, P. P. 2005. Abstracts from the 46th International Conference on the Bioscience of Lipids, Ajaccio, Corsica, September 20-24, 2005. Chem. Phys. Lipids 136: 164-165.
25. Zambrowicz, B. P., G. A. Friedrich, E. C. Buxton, S. L. Lilleberg, C. Person, and A. T. Sands. 1998. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature 392: 608-611.
26. Andréani, P., and M. H. Gräler. 2006. Comparative quantification of sphingolipids and analogs in biological samples by high-performance liquid chromatography after chloroform extraction. Anal. Biochem. 358: 239-246.
27. Benz, C., V. C. Martins, F. Radtke, and C. C. Bleul. 2008. The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development. J. Exp. Med. 205: 1187-1199.
28. Schwarz, B. A., and A. Bhandoola. 2004. Circulating hematopoietic progenitors with T lineage potential. Nat. Immunol. 5: 953-960.
29. Chen, Y., B. Dabovic, C. Colarossi, F. R. Santori, M. Lilic, S. Vukmanovic, and D. B. Rifkin. 2003. Growth retardation as well as spleen and thymus involution in latent TGF-β binding protein (Ltbp)-3 null mice. J. Cell Physiol. 196: 319-325.
30. Koch, U., E. Fiorini, R. Benedito, V. Besseyrias, K. Schuster-Gossler, M. Pierres, N. R. Manley, A. Duarte, H. R. Macdonald, and F. Radtke. 2008. Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205: 2515-2523.
31. Fiorini, E., I. Ferrero, E. Merck, S. Favre, M. Pierres, S. A. Luther, and H. R. MacDonald. 2008. Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells. J. Immunol. 181: 8199-8203.
32. Peschon, J. J., P. J. Morrissey, K. H. Grabstein, F. J. Ramsdell, E. Maraskovsky, B. C. Gliniak, L. S. Park, S. F. Ziegler, D. E. Williams, C. B. Ware, et al. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180: 1955-1960.
33. Schmahl, J., C. S. Raymond, and P. Soriano. 2007. PDGF signaling specificity is mediated through multiple immediate early genes. Nat. Genet. 39: 52-60.
34. Vogel, P., M. S. Donoviel, R. Read, G. M. Hansen, J. Hazlewood, S. J. Anderson, W. Sun, J. Swaffield, and T. Oravecz. 2009. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS ONE 4: e4112.
35. Santana, P., L. A. Pena, A. Haimovitz-Friedman, S. Martin, D. Green, M. McLoughlin, C. Cordon-Cardo, E. H. Schuchman, Z. Fuks, and R. Kolesnick. 1996. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86: 189-199.
36. + endothelial cells in splenic marginal sinus organization. J. Exp. Med. 200: 1491-1501.
37. Liu, Y., R. Wada, T. Yamashita, Y. Mi, C. X. Deng, J. P. Hobson, H. M. Rosenfeldt, V. E. Nava, S. S. Chae, M. J. Lee, et al. 2000. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J. Clin. Invest. 106: 951-961.
38. Ishii, I., X. Ye, B. Friedman, S. Kawamura, J. J. Contos, M. A. Kingsbury, A. H. Yang, G. Zhang, J. H. Brown, and J. Chun. 2002. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J. Biol. Chem. 277: 25152-25159.
39. Sensken, S. C., C. Bode, and M. H. Gräler. 2008. Accumulation of FTY720 in lymphoid tissues contributes to prolonged efficacy. J. Pharmacol. Exp. Ther. 328: 963-969.
40. Mandala, S., R. Hajdu, J. Bergstrom, E. Quackenbush, J. Xie, J. Milligan, R. Thornton, G. J. Shei, D. Card, C. Keohane, et al. 2002. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296: 346-349.
41. Coburn, S. P., and J. D. Mahuren. 1976. In vivo metabolism of 4′-deoxypyridoxine in rat and man. J. Biol. Chem. 251: 1646-1652.
42. Watts, J. D., M. Gu, A. J. Polverino, S. D. Patterson, and R. Aebersold. 1997. Fas-induced apoptosis of T cells occurs independently of ceramide generation. Proc. Natl. Acad. Sci. USA 94: 7292-7296.
43. Gulbins, E., R. Bissonnette, A. Mahboubi, S. Martin, W. Nishioka, T. Brunner, G. Baier, G. Baier-Bitterlich, C. Byrd, F. Lang, et al. 1995. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity 2: 341-351.
44. Sebzda, E., S. Mariathasan, T. Ohteki, R. Jones, M. F. Bachmann, and P. S. Ohashi. 1999. Selection of the T cell repertoire. Annu. Rev. Immunol. 17: 829-874.
45. Cifone, M. G., G. Migliorati, R. Parroni, C. Marchetti, D. Millimaggi, A. Santoni, and C. Riccardi. 1999. Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases. Blood 93: 2282-2296.
46. Ashwell, J. D., F. W. Lu, and M. S. Vacchio. 2000. Glucocorticoids in T cell development and function. Annu. Rev. Immunol. 18: 309-345.
47. Kitatani, K., J. Idkowiak-Baldys, and Y. A. Hannun. 2008. The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal. 20: 1010-1018.
48. Gossens, K., S. Naus, S. Y. Corbel, S. Lin, F. M. Rossi, J. Kast, and H. J. Ziltener. 2009. Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25. J. Exp. Med. 206: 761-778.