-
1
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, Hilgaard P, Gane E, Blanc JF, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378-90.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgaard, P.4
Gane, E.5
Blanc, J.F.6
-
2
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomized, double-blind, placebo-controlled trial
-
Cheng AL, Kong YK, Chen Z, Tsao CJ, Qin S, Kim JS, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomized, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10:25-34.
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kong, Y.K.2
Chen, Z.3
Tsao, C.J.4
Qin, S.5
Kim, J.S.6
-
3
-
-
19144366561
-
Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor
-
Mise M, Arii S, Higashituji H, Furutani M, Niwano M, Harada T, et al. Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology. 1996;23:455-64. (Pubitemid 26087158)
-
(1996)
Hepatology
, vol.23
, Issue.3
, pp. 455-464
-
-
Mise, M.1
Arii, S.2
Higashituji, H.3
Furutani, M.4
Niwano, M.5
Harada, T.6
Ishigami, S.-I.7
Toda, Y.8
Nakayama, H.9
Fukumoto, M.10
Fujita, J.11
Imamura, M.12
-
4
-
-
0004623809
-
Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis
-
Park YN, Kim YB, Yang KM, Park C. Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis. Arch Pathol Lab Med. 2000;124:1061-5. (Pubitemid 30602050)
-
(2000)
Archives of Pathology and Laboratory Medicine
, vol.124
, Issue.7
, pp. 1061-1065
-
-
Park, Y.N.1
Kim, Y.-B.2
Yang, K.M.3
Park, C.4
-
5
-
-
33751115483
-
Correlation of four vascular specific growth factors with carcinogenesis and portal vein tumor thrombus formation in human hepatocellular carcinoma
-
Li Q, Xu B, Fu L, Hao XS. Correlation of four vascular specific growth factors with carcinogenesis and portal vein tumor thrombus formation in human hepatocellular carcinoma. J Exp Clin Cancer Res. 2006;25:403-9. (Pubitemid 44763732)
-
(2006)
Journal of Experimental and Clinical Cancer Research
, vol.25
, Issue.3
, pp. 403-409
-
-
Li, Q.1
Xu, B.2
Fu, L.3
Hao, X.S.4
-
6
-
-
19944415267
-
Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma
-
Uematsu S, Higashi T, Nouso K, Kariyama K, Nakamura S, Suzuki M, et al. Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma. J Gastroenterol Hepatol. 2005;20:583-5.
-
(2005)
J Gastroenterol Hepatol
, vol.20
, pp. 583-585
-
-
Uematsu, S.1
Higashi, T.2
Nouso, K.3
Kariyama, K.4
Nakamura, S.5
Suzuki, M.6
-
7
-
-
0031955570
-
Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma
-
Li XM, Tang ZY, Zhou G, Lui YK, Ye SL. Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma. J Exp Clin Cancer. 1998;17:13-7. (Pubitemid 28215959)
-
(1998)
Journal of Experimental and Clinical Cancer Research
, vol.17
, Issue.1
, pp. 13-17
-
-
Li, X.M.1
Tang, Z.Y.2
Zhou, G.3
Lui, Y.K.4
Ye, S.L.5
-
8
-
-
0032526475
-
Parallel hybridization analysis of multiple protein kinase: Identification of gene expression patterns characteristic of human hepatocellular carcinoma
-
Tsou AP, Wu KM, Tsen TY, Chi CW, Chiu JH, Lui WY, et al. Parallel hybridization analysis of multiple protein kinase: identification of gene expression patterns characteristic of human hepatocellular carcinoma. Genomics. 1998;50:331-40.
-
(1998)
Genomics
, vol.50
, pp. 331-340
-
-
Tsou, A.P.1
Wu, K.M.2
Tsen, T.Y.3
Chi, C.W.4
Chiu, J.H.5
Lui, W.Y.6
-
9
-
-
34447326697
-
Platelet-derived growth factor receptor-alpha: A novel therapeutic target in human hepatocellular cancer
-
DOI 10.1158/1535-7163.MCT-06-0720
-
Stock P, Monga D, Tan X, Micsenyi A, Loizos N, Monga SP. Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer. Mol Cancer Ther. 2007;6:1932-41. (Pubitemid 47052483)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.7
, pp. 1932-1941
-
-
Stock, P.1
Monga, D.2
Tan, X.3
Micsenyi, A.4
Loizos, N.5
Monga, S.P.S.6
-
10
-
-
0034906312
-
The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma
-
El-Assal ON, Yamanoi A, Ono T, Kohno H, Nagasue N. The clinicopathological significance of heparanase and basic fibroblast growth factor expression in hepatocellular carcinoma. Clin Cancer Res. 2001;7:1299-305. (Pubitemid 32708684)
-
(2001)
Clinical Cancer Research
, vol.7
, Issue.5
, pp. 1299-1305
-
-
El-Assal, O.N.1
Yamanoi, A.2
Ono, T.3
Kohno, H.4
Nagasue, N.5
-
11
-
-
0032939205
-
Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma
-
Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR. Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest. 1999;103:341-5. (Pubitemid 29069983)
-
(1999)
Journal of Clinical Investigation
, vol.103
, Issue.3
, pp. 341-345
-
-
Tanaka, S.1
Mori, M.2
Sakamoto, Y.3
Makuuchi, M.4
Sugimachi, K.5
Wands, J.R.6
-
12
-
-
0032006647
-
Membrane-type matrix metalloproteinase-1(MT1-MMP) gene is overexpressed in highly invasive hepatocellular carcinomas
-
DOI 10.1016/0168-8278(88)80010-2
-
Harada T, Arii S, Mise M, Imamura T, Higashitsuji H, Furutani M, et al. Membrane-type matrix metalloproteinase-1 (MT1- MMP) gene is overexpressed in highly invasive hepatocellular carcinomas. J Hepatol. 1998;28:231-9. (Pubitemid 28116431)
-
(1998)
Journal of Hepatology
, vol.28
, Issue.2
, pp. 231-239
-
-
Harada, T.1
Arii, S.2
Mise, M.3
Imamura, T.4
Higashitsuji, H.5
Furutani, M.6
Niwano, M.7
Ishigami, S.-I.8
Fukumoto, M.9
Seiki, M.10
Sato, H.11
Imamura, M.12
-
13
-
-
0141447422
-
A study on angiogenesis-related matrix metalloproteinase networks in primary hepatocellular carcinoma
-
Tshii Y, Nakasato Y, Kobayashi S, Yamazaki Y, Aoki T. A study on angiogenesis-related matrix metalloproteinase networks in primary hepatocellular carcinoma. J Exp Clin Cancer Res. 2003;22:461-70. (Pubitemid 37205405)
-
(2003)
Journal of Experimental and Clinical Cancer Research
, vol.22
, Issue.3
, pp. 461-470
-
-
Ishii, Y.1
Nakasato, Y.2
Kobayashi, S.3
Yamazaki, Y.4
Aoki, T.5
-
14
-
-
0037110699
-
Serum endostatin predicts tumor vascularity in hepatocellular carcinoma
-
DOI 10.1002/cncr.10972
-
Dhar DK, Ono T, Yamanoi A, Soda Y, Yamaguchi E, Rahman MA, et al. Serum endostatin predicts tumor vascularity in hepatocellular carcinoma. Cancer. 2002;95:2188-95. (Pubitemid 35253381)
-
(2002)
Cancer
, vol.95
, Issue.10
, pp. 2188-2195
-
-
Dhar, D.K.1
Ono, T.2
Yamanoi, A.3
Soda, Y.4
Yamaguchi, E.5
Rahman, M.A.6
Kohno, H.7
Nagasue, N.8
-
15
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
DOI 10.1200/JCO.2002.10.088
-
Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol. 2002;20:4368-80. (Pubitemid 35266299)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.21
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
16
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
DOI 10.1200/JCO.2005.06.081
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth fator pathway in tumor growth and angiogenesis. J Clin Oncol. 2005;23:1011-27. (Pubitemid 46202320)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.5
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
17
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
DOI 10.1200/JCO.2005.02.2574
-
Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Wilding G, Figlin RA. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol. 2006;24:16-24. (Pubitemid 46630489)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.1
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
Hudes, G.R.4
Wilding, G.5
Figlin, R.A.6
Ginsberg, M.S.7
Kim, S.T.8
Baum, C.M.9
DePrimo, S.E.10
Li, J.Z.11
Bello, C.L.12
Theuer, C.P.13
George, D.J.14
Rini, B.I.15
-
18
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 2009;27:3584-90.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Oudard, S.6
-
19
-
-
33947423448
-
Approval summary: Sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma
-
DOI 10.1158/1078-0432.CCR-06-2328
-
Goodman VL, Rock EP, Dagher R, Ramchandani RP, Abraham S, Gobburu JV, et al. Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma. Clin Cancer Res. 2007;13:1367-73. (Pubitemid 46450424)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.5
, pp. 1367-1373
-
-
Goodman, V.L.1
Rock, E.P.2
Dagher, R.3
Ramchandani, R.P.4
Abraham, S.5
Gobburu, J.V.S.6
Booth, B.P.7
Verbois, S.L.8
Morse, D.E.9
Liang, C.Y.10
Chidambaram, N.11
Jiang, J.X.12
Tang, S.13
Mahjoob, K.14
Justice, R.15
Pazdur, R.16
-
20
-
-
73749087933
-
Phase II study of sorafenib in patients with sunitinib-refractory metastatic renal cell cancer
-
Di Lorenzo G, Cartenì G, Autorino R, Bruni G, Tudini M, Rizzo M, et al. Phase II study of sorafenib in patients with sunitinib-refractory metastatic renal cell cancer. J Clin Oncol. 2009;27:4469-74.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4469-4474
-
-
Di Lorenzo, G.1
Cartenì, G.2
Autorino, R.3
Bruni, G.4
Tudini, M.5
Rizzo, M.6
-
21
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
-
Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol. 2010;28:1061-8.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
Szczylik, C.4
Lee, E.5
Wagstaff, J.6
-
22
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
DOI 10.1056/NEJMoa032691
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335-42. (Pubitemid 38702844)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
Berlin, J.7
Baron, A.8
Griffing, S.9
Holmgren, E.10
Ferrara, N.11
Fyfe, G.12
Rogers, B.13
Ross, R.14
Kabbinavar, F.15
-
23
-
-
34147190880
-
FDA drug approval summary: Bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer
-
DOI 10.1634/theoncologist.12-3-356
-
Cohen MH, Gootenberg J, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer. Oncologist. 2007;12:356-61. (Pubitemid 46556802)
-
(2007)
Oncologist
, vol.12
, Issue.3
, pp. 356-361
-
-
Cohen, M.H.1
Gootenberg, J.2
Keegan, P.3
Pazdur, R.4
-
24
-
-
34447130180
-
FDA drug approval summary: Bevacizumab (Avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer
-
DOI 10.1634/theoncologist.12-6-713
-
Cohen MH, Gootenberg J, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab (Avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer. Oncologist. 2007;12:713-8. (Pubitemid 47036205)
-
(2007)
Oncologist
, vol.12
, Issue.6
, pp. 713-718
-
-
Cohen, M.H.1
Gootenberg, J.2
Keegan, P.3
Pazdur, R.4
-
25
-
-
77952318310
-
Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Archer L, et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol. 2010;28:2137-43.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2137-2143
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
Stadler, W.M.4
Vaena, D.A.5
Archer, L.6
-
26
-
-
75449088610
-
FDA drug approval summary: Bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme
-
Cohen MH, Shen YL, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme. Oncologist. 2009;14:1131-8.
-
(2009)
Oncologist
, vol.14
, pp. 1131-1138
-
-
Cohen, M.H.1
Shen, Y.L.2
Keegan, P.3
Pazdur, R.4
-
27
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman MW, Herrgard S, Treiber DK, Gallant P, Atteridge CE, Campbell BT, et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol. 2008;26:127-32.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
Gallant, P.4
Atteridge, C.E.5
Campbell, B.T.6
-
28
-
-
59149101627
-
Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma and vascular invasion or extrahepatic spread: A subanalysis from the SHARP trial
-
abstract no. 4584
-
Sherman M, Mazzaferro V, Amadori D, Seitz J, Moscovici M, Shan M, et al. Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma and vascular invasion or extrahepatic spread: a subanalysis from the SHARP trial. J Clin Oncol. 2008;26 (Suppl; abstract no. 4584).
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Sherman, M.1
Mazzaferro, V.2
Amadori, D.3
Seitz, J.4
Moscovici, M.5
Shan, M.6
-
29
-
-
58049210869
-
Clinical benefit of sorafenib in hepatitis C patients with hepatocellular carcinoma (HCC): Subgroup analysis of the SHARP trial
-
abstract no. 129
-
Bolondi L, Caspary W, Bennouna J, Thomson B, Van Steenbergen W, Degos F, et al. Clinical benefit of sorafenib in hepatitis C patients with hepatocellular carcinoma (HCC): subgroup analysis of the SHARP trial. In: 2008 Gastrointestinal Cancers Symposium (abstract no. 129).
-
2008 Gastrointestinal Cancers Symposium
-
-
Bolondi, L.1
Caspary, W.2
Bennouna, J.3
Thomson, B.4
Van Steenbergen, W.5
Degos, F.6
-
30
-
-
59149092913
-
Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to ECOG performance status: A subanalysis from the SHARP trial
-
abstract no. 4587
-
Raoul J, Santoro A, Beaugrand M, Marrero JA, Moscovici M, Shan M, et al. Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to ECOG performance status: a subanalysis from the SHARP trial. J Clin Oncol. 2008;26 (Suppl; abstract no. 4587).
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Raoul, J.1
Santoro, A.2
Beaugrand, M.3
Marrero, J.A.4
Moscovici, M.5
Shan, M.6
-
31
-
-
58049199610
-
Efficacy and safety of sorafenib in patients with alcohol-related hepatocellular carcinoma: A subanalysis from the SHARP trial
-
abstract no. 15591
-
Craxi A, Porta C, Sangiovanni A, Seitz J, Moscovici M, Shan M, et al. Efficacy and safety of sorafenib in patients with alcohol-related hepatocellular carcinoma: a subanalysis from the SHARP trial. J Clin Oncol. 2008;26 (Suppl; abstract no. 15591).
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Craxi, A.1
Porta, C.2
Sangiovanni, A.3
Seitz, J.4
Moscovici, M.5
Shan, M.6
-
32
-
-
77955823345
-
Effect of macroscopic vascular invasion (MVI), extrahepatic spread (EHS), and ECOG performance status (ECOG PS) on outcome in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib: Analysis of two phase III, randomized, double-blind trials
-
abstract no. 4580
-
Bruix J, Cheng A, Kang Y, Tsao C, Qin S, Lentini G, et al. Effect of macroscopic vascular invasion (MVI), extrahepatic spread (EHS), and ECOG performance status (ECOG PS) on outcome in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib: analysis of two phase III, randomized, double-blind trials. J Clin Oncol. 2009;27 (Suppl; abstract no. 4580).
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Bruix, J.1
Cheng, A.2
Kang, Y.3
Tsao, C.4
Qin, S.5
Lentini, G.6
-
33
-
-
84897581225
-
Efficacy and safety of sorafenib (Sor) in patients (pts) with advanced hepatocellular carcinoma (HCC): Subgroup analyses of the SHARP trial by baseline (BL) transaminase (ALT/AST)/alphafetoprotein (AFP) and bilirubin (Bil) levels
-
abstract no. 129
-
Raoul J, Sherman M, Nadel A, Lentini G, Moscovici M, Voliotis D, et al. Efficacy and safety of sorafenib (Sor) in patients (pts) with advanced hepatocellular carcinoma (HCC): subgroup analyses of the SHARP trial by baseline (BL) transaminase (ALT/AST)/alphafetoprotein (AFP) and bilirubin (Bil) levels. In: 2010 Gastrointestinal Cancer Symposium (abstract no. 129).
-
2010 Gastrointestinal Cancer Symposium
-
-
Raoul, J.1
Sherman, M.2
Nadel, A.3
Lentini, G.4
Moscovici, M.5
Voliotis, D.6
-
34
-
-
33644852640
-
Effect of the etiology of viral cirrhosis on the survival of patients with hepatocellular carcinoma
-
DOI 10.1111/j.1572-0241.2006.00364.x
-
Cantarini MC, Trevisani F, Morselli-Labate AM, Rapaccini G, Farinati F, Del Poggio P, et al. Effect of the etiology of viral cirrhosis on the survival of patients with hepatocellular carcinoma. Am J Gastroenterol. 2006;101:91-8. (Pubitemid 43381714)
-
(2006)
American Journal of Gastroenterology
, vol.101
, Issue.1
, pp. 91-98
-
-
Cantarini, M.C.1
Trevisani, F.2
Morselli-Labate, A.M.3
Rapaccini, G.4
Farinati, F.5
Poggio, P.D.6
Nolfo, M.A.D.7
Benvegnu, L.8
Zoli, M.9
Borzio, F.10
Bernardi, M.11
-
35
-
-
73049092595
-
Geographic difference in survival outcome for advanced hepatocellular carcinoma: Implications on future clinical trial design
-
Hsu C, Shen YC, Cheng CC, Hu FC, Cheng AL. Geographic difference in survival outcome for advanced hepatocellular carcinoma: Implications on future clinical trial design. Contemp Clin Trials. 2010;31:55-61.
-
(2010)
Contemp Clin Trials
, vol.31
, pp. 55-61
-
-
Hsu, C.1
Shen, Y.C.2
Cheng, C.C.3
Hu, F.C.4
Cheng, A.L.5
-
36
-
-
70349393610
-
Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: A systematic review and meta-analysis of clinical trials
-
Je Y, Schutz FA, Choueiri TK. Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials. Lancet Oncol. 2009;10:967-74.
-
(2009)
Lancet Oncol
, vol.10
, pp. 967-974
-
-
Je, Y.1
Schutz, F.A.2
Choueiri, T.K.3
-
37
-
-
1942421303
-
The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes
-
DOI 10.2174/1389200043489054
-
Elbekai RH, Korashy HM, El-Kadi AO. The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes. Curr Drug Metab. 2004;5:157-67. (Pubitemid 38515245)
-
(2004)
Current Drug Metabolism
, vol.5
, Issue.2
, pp. 157-167
-
-
Elbekai, R.H.1
Korashy, H.M.2
El-Kadi, A.O.S.3
-
38
-
-
33748170694
-
Liver disease selectively modulates cytochrome P450-mediated metabolism
-
DOI 10.1016/j.clpt.2006.05.006, PII S0009923606001986
-
Frye RF, Zgheib NK, Matzke GR, Chaves-Gnecco D, Rabinovitz M, Shaikh OS, et al. Liver disease selectively modulates cytochrome P450-mediated metabolism. Clin Pharmacol Ther. 2006;80:235-45. (Pubitemid 44313901)
-
(2006)
Clinical Pharmacology and Therapeutics
, vol.80
, Issue.3
, pp. 235-245
-
-
Frye, R.F.1
Zgheib, N.K.2
Matzke, G.R.3
Chaves-Gnecco, D.4
Rabinovitz, M.5
Shaikh, O.S.6
Branch, R.A.7
-
39
-
-
33749017926
-
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
-
DOI 10.1200/JCO.2005.01.3441
-
Abou-Alfa GK, Schwartz L, Ricci S, Amadori D, Santoro A, Figer A, et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2006;24:4293-300. (Pubitemid 46630787)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.26
, pp. 4293-4300
-
-
Abou-Alfa, G.K.1
Schwartz, L.2
Ricci, S.3
Amadori, D.4
Santoro, A.5
Figer, A.6
De Greve, J.7
Douillard, J.-Y.8
Lathia, C.9
Schwartz, B.10
Taylor, I.11
Moscovici, M.12
Saltz, L.B.13
-
40
-
-
36949033865
-
Phase I study of sorafenib in Japanese patients with hepatocellular carcinoma
-
DOI 10.1111/j.1349-7006.2007.00648.x
-
Furuse J, Ishii H, Nakachi K, Suzuki E, Shimizu S, Nakajima K. Phase I study of sorafenib in Japanese patients with heatocellular carcinoma. Cancer Sci. 2008;99:159-65. (Pubitemid 350239045)
-
(2008)
Cancer Science
, vol.99
, Issue.1
, pp. 159-165
-
-
Furuse, J.1
Ishii, H.2
Nakachi, K.3
Suzuki, E.4
Shimizu, S.5
Nakajima, K.6
-
41
-
-
64649083367
-
Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301
-
Miller AA, Murry DJ, Owzar K, Hollis DR, Kennedy EB, Abou-Alfa G, et al. Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301. J Clin Oncol. 2009;27:1800-5.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1800-1805
-
-
Miller, A.A.1
Murry, D.J.2
Owzar, K.3
Hollis, D.R.4
Kennedy, E.B.5
Abou-Alfa, G.6
-
42
-
-
61449256583
-
Sorafenib in unresectable hepatocellular carcinoma from mild to advanced stage liver cirrhosis
-
Pinter M, Sieghart W, Graziadei I, Vogel W, Maieron A, Königsberg R, et al. Sorafenib in unresectable hepatocellular carcinoma from mild to advanced stage liver cirrhosis. Oncologist. 2009;14:70-6.
-
(2009)
Oncologist
, vol.14
, pp. 70-76
-
-
Pinter, M.1
Sieghart, W.2
Graziadei, I.3
Vogel, W.4
Maieron, A.5
Königsberg, R.6
-
43
-
-
67651095716
-
Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis
-
Wörns MA, Weinmann A, Pfingst K, Schulte-Sasse C, Messow CM, Schulze-Bergkamen H, et al. Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis. J Clin Gastroenterol. 2009;43:489-95.
-
(2009)
J Clin Gastroenterol
, vol.43
, pp. 489-495
-
-
Wörns, M.A.1
Weinmann, A.2
Pfingst, K.3
Schulte-Sasse, C.4
Messow, C.M.5
Schulze-Bergkamen, H.6
-
44
-
-
78349275393
-
Tolerance and outcome of patients with unresectable hepatocellular carcinoma treated with sorafenib
-
Epub ahead of print
-
Ozenne V, Paradis V, Pernot S, Castelnau V, Cullierme MP, Bouattour M, et al. Tolerance and outcome of patients with unresectable hepatocellular carcinoma treated with sorafenib. Eur J Gastroenterol Hepatol. 2010. [Epub ahead of print].
-
(2010)
Eur J Gastroenterol Hepatol
-
-
Ozenne, V.1
Paradis, V.2
Pernot, S.3
Castelnau, V.4
Cullierme, M.P.5
Bouattour, M.6
-
45
-
-
34548316976
-
Molecular basis for sunitinib efficacy and future clinical development
-
DOI 10.1038/nrd2380, PII NRD2380
-
Faivre S, Demeri G, Sargent W, Raymond E. Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov. 2007;6:734-45. (Pubitemid 47338181)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.9
, pp. 734-745
-
-
Faivre, S.1
Demetri, G.2
Sargent, W.3
Raymond, E.4
-
46
-
-
67651165187
-
Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: An open-label, multicentre, phase II study
-
Faivre S, Raymond E, Boucher E, Douillard J, Lim HY, Kim JS, et al. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study. Lancet Oncol. 2009;10:794-800.
-
(2009)
Lancet Oncol
, vol.10
, pp. 794-800
-
-
Faivre, S.1
Raymond, E.2
Boucher, E.3
Douillard, J.4
Lim, H.Y.5
Kim, J.S.6
-
47
-
-
67649946279
-
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: A phase II study
-
Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, et al. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol. 2009;27:3027-35.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3027-3035
-
-
Zhu, A.X.1
Sahani, D.V.2
Duda, D.G.3
Di Tomaso, E.4
Ancukiewicz, M.5
Catalano, O.A.6
-
48
-
-
77950546450
-
Continuous sunitinib treatment in patients with advanced hepatocellular carcinoma: A Swiss Group for Clinical Cancer Research (SAKK) and Swiss Association for the Study of the Liver (SASL) multicenter phase II trial (SAKK 77/ 06)
-
Koeberle D, Montemurro M, Samaras P, Majno P, Simcock M, Limacher A, et al. Continuous sunitinib treatment in patients with advanced hepatocellular carcinoma: A Swiss Group for Clinical Cancer Research (SAKK) and Swiss Association for the Study of the Liver (SASL) multicenter phase II trial (SAKK 77/ 06). Oncologist. 2010;15:285-92.
-
(2010)
Oncologist
, vol.15
, pp. 285-292
-
-
Koeberle, D.1
Montemurro, M.2
Samaras, P.3
Majno, P.4
Simcock, M.5
Limacher, A.6
-
49
-
-
74549223962
-
An open-label phase II study of first- and second-line treatment with brivanib in patients with hepatocellular carcinoma (HCC)
-
abstract no. 4577
-
Raoul JL, Finn R, Kang YK, Park JW, Harris R, Coric V, et al. An open-label phase II study of first- and second-line treatment with brivanib in patients with hepatocellular carcinoma (HCC). J Clin Oncol. 2009;27 (Suppl; abstract no. 4577).
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Raoul, J.L.1
Finn, R.2
Kang, Y.K.3
Park, J.W.4
Harris, R.5
Coric, V.6
-
50
-
-
67650857880
-
Phase II, open label study of brivanib alaninate in patients (pts) with hepatocellular carcinoma (HCC) who failed prior antiangiogenic therapy
-
abstract no. 200
-
Finn RS, Kang Y, Park J, Harris R, Donica M, Walters I. Phase II, open label study of brivanib alaninate in patients (pts) with hepatocellular carcinoma (HCC) who failed prior antiangiogenic therapy. In: 2009 Gastrointestinal Cancers Symposium. (abstract no. 200).
-
2009 Gastrointestinal Cancers Symposium
-
-
Finn, R.S.1
Kang, Y.2
Park, J.3
Harris, R.4
Donica, M.5
Walters, I.6
-
51
-
-
84860294161
-
Time-to-progression sub-analysis of second-line treatment with brivanib after failure of prior antiangiogenic therapy in patients with unresectable, locally advanced, or metastatic hepatocellular carcinoma
-
abstract
-
Finn RS, Park JW, Kang YK, et al. Time-to-progression sub-analysis of second-line treatment with brivanib after failure of prior antiangiogenic therapy in patients with unresectable, locally advanced, or metastatic hepatocellular carcinoma. In: AASLD Annual Meeting 2009 (abstract).
-
AASLD Annual Meeting 2009
-
-
Finn, R.S.1
Park, J.W.2
Kang, Y.K.3
-
52
-
-
33751348618
-
New feasibility study design with hepatocellular carcinoma: A phase I/II study of TSU-68, an oral angiogenesis inhibitor
-
abstract no. 4145
-
Kanai F, Yoshida H, Teratani T, Sato S, Tateishi R, Obi S, et al. New feasibility study design with hepatocellular carcinoma: A phase I/II study of TSU-68, an oral angiogenesis inhibitor. J Clin Oncol. 2006;24 (Suppl; abstract no. 4145).
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL.
-
-
Kanai, F.1
Yoshida, H.2
Teratani, T.3
Sato, S.4
Tateishi, R.5
Obi, S.6
-
53
-
-
79954437549
-
A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma
-
Epub ahead of print
-
Kanai F, Yoshida H, Tateishi R, Sato S, Kawabe T, Obi S, et al. A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma. Cancer Chemother Pharmacol. 2010. [Epub ahead of print].
-
(2010)
Cancer Chemother Pharmacol
-
-
Kanai, F.1
Yoshida, H.2
Tateishi, R.3
Sato, S.4
Kawabe, T.5
Obi, S.6
-
54
-
-
78650847886
-
Linifanib phase II trial in patients with advanced hepatocellular carcinoma (HCC)
-
abstract no. 4038
-
Toh H, Chen P, Carr BI, Knox JJ, Gill S, Qian J, et al. Linifanib phase II trial in patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol. 2010;28 (Suppl; abstract no. 4038).
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Toh, H.1
Chen, P.2
Carr, B.I.3
Knox, J.J.4
Gill, S.5
Qian, J.6
-
55
-
-
71449116258
-
A phase I study of pazopanib in patients with advanced hepatocellular carcinoma
-
Yau CC, Chen PJ, Curtis CM, Murphy PS, Suttle AB, Arumugham T, et al. A phase I study of pazopanib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2009;27:3561.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3561
-
-
Yau, C.C.1
Chen, P.J.2
Curtis, C.M.3
Murphy, P.S.4
Suttle, A.B.5
Arumugham, T.6
-
56
-
-
46449091500
-
Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
-
Siegel AB, Cohen EI, Ocean A, Lehrer D, Goldenberg A, Knox JJ, et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol. 2008;26:2992-8.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2992-2998
-
-
Siegel, A.B.1
Cohen, E.I.2
Ocean, A.3
Lehrer, D.4
Goldenberg, A.5
Knox, J.J.6
-
57
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hannahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008;8:592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hannahan, D.2
-
58
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
DOI 10.1016/j.ccr.2005.09.005, PII S1535610805002989
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 2005;8:299-309. (Pubitemid 41443415)
-
(2005)
Cancer Cell
, vol.8
, Issue.4
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
59
-
-
33846149645
-
AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients
-
DOI 10.1016/j.ccr.2006.11.021, PII S1535610806003709
-
Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalized tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 2007;11:83-95. (Pubitemid 46075199)
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
Di, T.E.3
Zhang, W.-T.4
Duda, D.G.5
Cohen, K.S.6
Kozak, K.R.7
Cahill, D.P.8
Chen, P.-J.9
Zhu, M.10
Ancukiewicz, M.11
Mrugala, M.M.12
Plotkin, S.13
Drappatz, J.14
Louis, D.N.15
Ivy, P.16
Scadden, D.T.17
Benner, T.18
Loeffler, J.S.19
Wen, P.Y.20
Jain, R.K.21
more..
-
60
-
-
35148820611
-
Molecular and cellular biomarkers for angiogenesis in clinical oncology
-
DOI 10.1016/j.drudis.2007.08.011, PII S1359644607003534
-
Bertolini F, Mancuso P, Shaked Y, Kerbel RS. Molecular and cellular biomarkers for angiogenesis in clinical oncology. Drug Discov Today. 2007;12:806-12. (Pubitemid 47539970)
-
(2007)
Drug Discovery Today
, vol.12
, Issue.19-20
, pp. 806-812
-
-
Bertolini, F.1
Mancuso, P.2
Shaked, Y.3
Kerbel, R.S.4
-
61
-
-
39849102836
-
HIF1a Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion
-
DOI 10.1016/j.ccr.2008.01.034, PII S153561080800041X
-
Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, et al. HIF 1a induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008;13:206-20. (Pubitemid 351318372)
-
(2008)
Cancer Cell
, vol.13
, Issue.3
, pp. 206-220
-
-
Du, R.1
Lu, K.V.2
Petritsch, C.3
Liu, P.4
Ganss, R.5
Passegue, E.6
Song, H.7
VandenBerg, S.8
Johnson, R.S.9
Werb, Z.10
Bergers, G.11
-
62
-
-
26944437515
-
+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
-
DOI 10.1038/ncb1288, PII N1288
-
Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol. 2005;7:870-9. (Pubitemid 41486287)
-
(2005)
Nature Cell Biology
, vol.7
, Issue.9
, pp. 870-879
-
-
Song, S.1
Ewald, A.J.2
Stallcup, W.3
Werb, Z.4
Bergers, G.5
-
63
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
DOI 10.1016/S1535-6108(03)00085-0, PII S1535610803000850
-
Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comogli PM, et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncoene. Cancer Cell. 2003;3:347-61. (Pubitemid 38340304)
-
(2003)
Cancer Cell
, vol.3
, Issue.4
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
Mazzone, M.4
Giordano, S.5
Comoglio, P.M.6
-
64
-
-
0037703383
-
Angiogenesis inhibitors: Motivators of metastasis?
-
DOI 10.1038/nm0703-822
-
Steeg PS. Angiogenesis inhibitors: motivators of metastasis? Nat Med. 2003;9:822-3. (Pubitemid 36889916)
-
(2003)
Nature Medicine
, vol.9
, Issue.7
, pp. 822-823
-
-
Steeg, P.S.1
-
65
-
-
0028216334
-
Thalidomide is an inhibitor of angiogenesis
-
D'Amato RJ, Loughnan MS, Flynn E, Folkman J. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA. 1994;91:4082-5. (Pubitemid 24139577)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.9
, pp. 4082-4085
-
-
D'Amato, R.J.1
Loughnan, M.S.2
Flynn, E.3
Folkman, J.4
-
66
-
-
0031863851
-
Thalidomide inhibits corneal angiogenesis induced by vascular endothelial growth factor
-
DOI 10.1007/s004170050106
-
Kruse FE, Joussen AM, Rohrschneider K, Becker MD, Völcker HE. Thalidomide inhibits corneal angiogenesis induced by vascular endothelial growth factor. Graefes Arch Clin Exp Opthalmol. 1998;236:461-6. (Pubitemid 28269042)
-
(1998)
Graefe's Archive for Clinical and Experimental Ophthalmology
, vol.236
, Issue.6
, pp. 461-466
-
-
Kruse, F.E.1
Joussen, A.M.2
Rohrschneider, K.3
Becker, M.D.4
Volcker, H.E.5
-
67
-
-
2942711726
-
Thalidomid: Current role in the treatment of non-plasma cell malignancies
-
DOI 10.1200/JCO.2004.10.127
-
Kumar S, Witzig TE, Rajkumar SV. Thalidomide: current role in the treatment of non-plasma cell malignancies. J Clin Oncol. 2004;22:2477-88. (Pubitemid 41115407)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.12
, pp. 2477-2488
-
-
Kumar, S.1
Witzig, T.E.2
Rajkumar, S.V.3
-
68
-
-
0344305652
-
Low-dose thalidomide treatment for advanced hepatocellular carcinoma
-
DOI 10.1159/000074477
-
Hsu C, Chen CN, Chen LT, Wu CY, Hsieh FJ, Cheng AL. Low-dose thalidomide treatment for advanced hepatocellular carcinoma. Oncology. 2003;65:242-9. (Pubitemid 37505832)
-
(2003)
Oncology
, vol.65
, Issue.3
, pp. 242-249
-
-
Hsu, C.1
Chen, C.-N.2
Chen, L.-T.3
Wu, C.-Y.4
Yang, P.-M.5
Lai, M.-Y.6
Lee, P.-H.7
Cheng, A.-L.8
-
69
-
-
13444303839
-
Thalidomide in the treatment of patients with hepatocellular carcinoma: A phase II trial
-
DOI 10.1002/cncr.20821
-
Patt YZ, Hassan MM, Lozano RD, Nooka AK, Schnirer II, Zeldis JB, et al. Thalidomide in the treatment of patients with hepatocellular carcinoma: a phase II trial. Cancer. 2005;103:749-55. (Pubitemid 40216403)
-
(2005)
Cancer
, vol.103
, Issue.4
, pp. 749-755
-
-
Patt, Y.Z.1
Hassan, M.M.2
Lozano, R.D.3
Nooka, A.K.4
Schnirer, I.I.5
Zeldis, J.B.6
Abbruzzese, J.L.7
Brown, T.D.8
-
70
-
-
33751544445
-
Efficacy and safety of thalidomide in patients with hepatocellular carcinoma
-
Chiou HE, Wang TE, Wang YY, Liu HW. Efficacy and safety of thalidomide in patients with hepatocellular carcinoma. World J Gastroenterol. 2006;12:6955-6.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 6955-6956
-
-
Chiou, H.E.1
Wang, T.E.2
Wang, Y.Y.3
Liu, H.W.4
-
71
-
-
33847056761
-
Multi-centre phase II trial of thalidomide in the treatment of unresectable hepatocellular carcinoma
-
Chuah B, Lim R, Boyer M, Ong AB, Wong SW, Kong HL, Millward M, et al. Multi-centre phase II trial of thalidomide in the treatment of unresectable hepatocellular carcinoma. Acta Oncol. 2007;46:234-8.
-
(2007)
Acta Oncol
, vol.46
, pp. 234-238
-
-
Chuah, B.1
Lim, R.2
Boyer, M.3
Ong, A.B.4
Wong, S.W.5
Kong, H.L.6
Millward, M.7
-
72
-
-
23844534451
-
Alpha-fetoprotein response predicts survival benefits of thalidomide in advanced hepatocellular carcinoma
-
DOI 10.1111/j.1365-2036.2005.02547.x
-
Chen LT, Liu TW, Chao Y, Shiah HS, Chang JY, Juang SH, et al. Alpha-fetoprotein response predicts survival benefits of thalidomide in advanced hepatocellular carcinoma. Aliment Pharmacol Ther. 2005;22:217-26. (Pubitemid 41153064)
-
(2005)
Alimentary Pharmacology and Therapeutics
, vol.22
, Issue.3
, pp. 217-226
-
-
Chen, L.-T.1
Liu, T.-W.2
Chao, Y.3
Shiah, H.-S.4
Chang, J.-Y.5
Juang, S.-H.6
Chen, S.-C.7
Chuang, T.-R.8
Chin, Y.-H.9
Whang-Peng, J.10
-
73
-
-
37149051789
-
Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma
-
DOI 10.1159/000111709
-
Yau T, Chan P, Wong H, Ng KK, Chok SH, Cheung TT, et al. Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma. Oncology. 2007;72:67-71. (Pubitemid 350256667)
-
(2007)
Oncology
, vol.72
, Issue.SUPPL. 1
, pp. 67-71
-
-
Yau, T.1
Chan, P.2
Wong, H.3
Ng, K.K.4
Chok, S.-H.5
Cheung, T.-T.6
Lam, V.7
Epstein, R.J.8
Fan, S.-T.9
Poon, R.T.P.10
-
74
-
-
2942615257
-
The anti-angiogenic basis of metronomic chemotherapy
-
Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer. 2004;4:423-36. (Pubitemid 38745528)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.6
, pp. 423-436
-
-
Kerbel, R.S.1
Kamen, B.A.2
-
75
-
-
0035214416
-
Metronomic scheduling: The future of chemotherapy?
-
DOI 10.1016/S1470-2045(01)00587-3
-
Gasparini G. Metronomic scheduling: the future of chemotherapy? Lancet Oncol. 2001;2:733-40. (Pubitemid 33134058)
-
(2001)
Lancet Oncology
, vol.2
, Issue.12
, pp. 733-740
-
-
Gasparini, G.1
-
76
-
-
0034048358
-
Less is, more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
-
Hanahan D, Bergers G, Bergsland E. Less is more, regularly: metronomic dosing of cyotoxic drugs can target tumor angiogenesis in mice. J Clin Invest. 2000;105:1045-7. (Pubitemid 30217688)
-
(2000)
Journal of Clinical Investigation
, vol.105
, Issue.8
, pp. 1045-1047
-
-
Hanahan, D.1
Bergers, G.2
Bergsland, E.3
-
77
-
-
0242331613
-
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
-
DOI 10.1073/pnas.2135406100
-
Bocci G, Francia G, Man S, Lawler J, Kerbel RS. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci USA. 2003;100:12917-22. (Pubitemid 37340000)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.22
, pp. 12917-12922
-
-
Bocci, G.1
Francia, G.2
Man, S.3
Lawler, J.4
Kerbel, R.S.5
-
78
-
-
71649094684
-
Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: A phase II study
-
Reardon DA, Desjardins A, Vredenburgh JJ, Gururangan S, Sampson JH, Sathornsumetee S, et al. Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study. Br J Cancer. 2009;101:1986-94.
-
(2009)
Br J Cancer
, vol.101
, pp. 1986-1994
-
-
Reardon, D.A.1
Desjardins, A.2
Vredenburgh, J.J.3
Gururangan, S.4
Sampson, J.H.5
Sathornsumetee, S.6
-
79
-
-
37849035249
-
Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital phase II consortia
-
Garcia AA, Hirte H, Fleming G, Yang D, Tsao-Wei DD, Roman L, et al. Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia. J Clin Oncol. 2008;26:76-82.
-
(2008)
J Clin Oncol
, vol.26
, pp. 76-82
-
-
Garcia, A.A.1
Hirte, H.2
Fleming, G.3
Yang, D.4
Tsao-Wei, D.D.5
Roman, L.6
-
80
-
-
54449099774
-
Metronomic cyclophosphamide and capecitabine combined with bevacizumab in advanced breast cancer
-
Dellapasqua S, Bertolini F, Bagnardi V, Campagnoli E, Scarano E, Torrisi R, et al. Metronomic cyclophosphamide and capecitabine combined with bevacizumab in advanced breast cancer. J Clin Oncol. 2008;26:4899-905.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4899-4905
-
-
Dellapasqua, S.1
Bertolini, F.2
Bagnardi, V.3
Campagnoli, E.4
Scarano, E.5
Torrisi, R.6
-
81
-
-
77953124105
-
Phase II study of combining sorafenbi with metronomic tegafur/uracil for advanced hepatocelular carcinoma
-
doi:10.1016/j.jhep.2010.01.035
-
Hsu CH, Shen YC, Lin ZZ, Chen PJ, Shao YY, Ding YH, et al. Phase II study of combining sorafenbi with metronomic tegafur/uracil for advanced hepatocelular carcinoma. J Hepatol. 2010. doi:10.1016/j.jhep.2010.01.035.
-
(2010)
J Hepatol
-
-
Hsu, C.H.1
Shen, Y.C.2
Lin, Z.Z.3
Chen, P.J.4
Shao, Y.Y.5
Ding, Y.H.6
-
82
-
-
84984578313
-
Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
-
Hsu CH, Yang TS, Hsu C, Toh HC, Epstein RJ, Hsiao LT, et al. Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma. Br J Cancer. 2010;102:981-6.
-
(2010)
Br J Cancer
, vol.102
, pp. 981-986
-
-
Hsu, C.H.1
Yang, T.S.2
Hsu, C.3
Toh, H.C.4
Epstein, R.J.5
Hsiao, L.T.6
-
83
-
-
77957552789
-
Thalidomide plus tegafur/uracil for the treatment of advanced/ metastatic hepatocellular carcinoma (HCC): A phase II single-arm study
-
abstract no. 15598
-
Hsu C, Chang D, Lin Z, Lee K, Hsiao C, Shen Y, et al. Thalidomide plus tegafur/uracil for the treatment of advanced/ metastatic hepatocellular carcinoma (HCC): a phase II single-arm study. J Clin Oncol. 2008;26 (Suppl; abstract no. 15598).
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Hsu, C.1
Chang, D.2
Lin, Z.3
Lee, K.4
Hsiao, C.5
Shen, Y.6
-
84
-
-
33751337166
-
A combination of capecitabine and thalidomide in patients with hepatocellular carcinoma
-
abstract no. 4142
-
Jeong W, Chun HG, Cer D, Sekhri V, Kim-Schluger L, Wolf D. A combination of capecitabine and thalidomide in patients with hepatocellular carcinoma. J Clin Oncol. 2006;24 (Suppl; abstract no. 4142).
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL.
-
-
Jeong, W.1
Chun, H.G.2
Cer, D.3
Sekhri, V.4
Kim-Schluger, L.5
Wolf, D.6
-
85
-
-
32944480899
-
Opportunities for targeted therapies in hepatocellular carcinoma
-
DOI 10.1200/JCO.2004.00.1537
-
Thomas MB, Abbruzzese JL. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol. 2005;23:8093-108. (Pubitemid 46657412)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.31
, pp. 8093-8108
-
-
Thomas, M.B.1
Abbruzzese, J.L.2
-
86
-
-
77349092851
-
Molecular classification and novel targets in hepatocellular carcinoma: Recent advancements
-
Hoshida Y, Toffanin S, Lachenmayer A, Villanueva A, Minguez B, Llovet JM. Molecular classification and novel targets in hepatocellular carcinoma: recent advancements. Semin Liver Dis. 2010;30:35-51.
-
(2010)
Semin Liver Dis
, vol.30
, pp. 35-51
-
-
Hoshida, Y.1
Toffanin, S.2
Lachenmayer, A.3
Villanueva, A.4
Minguez, B.5
Llovet, J.M.6
-
87
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3:721-32. (Pubitemid 37328811)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
88
-
-
17344372847
-
Activation of mitogen-activated protein kinases/extracellular signal- regulated kinases in human hepatocellular carcinoma
-
DOI 10.1002/hep.510270409
-
Ito Y, Sasaki Y, Horimoto M, Wada S, Tanaka Y, Kasahara A, et al. Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology. 1998;27:951-8. (Pubitemid 28160479)
-
(1998)
Hepatology
, vol.27
, Issue.4
, pp. 951-958
-
-
Ito, Y.1
Sasaki, Y.2
Horimoto, M.3
Wada, S.4
Tanaka, Y.5
Kasahara, A.6
Ueki, T.7
Hirano, T.8
Yamamoto, H.9
Fujimoto, J.10
Okamoto, E.11
Hayashi, N.12
Hori, M.13
-
89
-
-
2542473135
-
Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: Its role in tumor progression and apoptosis
-
Huynh H, Nguyen TT, Chow KH, Tan PH, Soo KC, Tran E. Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis. BMC Gastroenterol. 2003;8:3-19.
-
(2003)
BMC Gastroenterol
, vol.8
, pp. 3-19
-
-
Huynh, H.1
Nguyen, T.T.2
Chow, K.H.3
Tan, P.H.4
Soo, K.C.5
Tran, E.6
-
90
-
-
33749319933
-
Loss of Raf Kinase Inhibitor Protein Promotes Cell Proliferation and Migration of Human Hepatoma Cells
-
DOI 10.1053/j.gastro.2006.07.012, PII S001650850601537X
-
Lee HC, Tian B, Sedivy JM, Wands JR, Kim M. Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology. 2006;131:1208-17. (Pubitemid 44498689)
-
(2006)
Gastroenterology
, vol.131
, Issue.4
, pp. 1208-1217
-
-
Lee, H.C.1
Tian, B.2
Sedivy, J.M.3
Wands, J.R.4
Kim, M.5
-
91
-
-
0036058267
-
Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line
-
DOI 10.1006/viro.2001.1227
-
Erhardt A, Hassan M, Heintges T, Häussinger D. Hepatitis C virus core protein induces cell proliferation, activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line. Virology. 2002;292:272-84. (Pubitemid 34920547)
-
(2002)
Virology
, vol.292
, Issue.2
, pp. 272-284
-
-
Erhardt, A.1
Hassan, M.2
Heintges, T.3
Haussinger, D.4
-
92
-
-
7744229935
-
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: Involvement of invasive potential
-
DOI 10.1096/fj.03-1429fje
-
Chung TW, Lee YC, Kim CH. Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J. 2004;18:1123-5. (Pubitemid 39561544)
-
(2004)
FASEB Journal
, vol.18
, Issue.10
, pp. 1123-1125
-
-
Chung, T.-W.1
Lee, Y.-C.2
Kim, C.-H.3
-
93
-
-
0037624602
-
Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma
-
DOI 10.1136/gut.52.5.706
-
Tannapfel A, Sommerer F, Benicke M, Katalinic A, Uhlmann D, Witzigmann H, et al. Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Gut. 2003;52:706-12. (Pubitemid 36528874)
-
(2003)
Gut
, vol.52
, Issue.5
, pp. 706-712
-
-
Tannapfel, A.1
Sommerer, F.2
Benicke, M.3
Katalinic, A.4
Uhlmann, D.5
Witzigmann, H.6
Hauss, J.7
Wittekind, C.8
-
94
-
-
72449204288
-
A phase II study of AZD6244 in advanced or metastatic hepatocellular carcinoma
-
O'Neil BH, Williams-Goff LW, Kauh J, Bekaii-Saab T, Strosberg JR, Lee R, et al. A phase II study of AZD6244 in advanced or metastatic hepatocellular carcinoma. J Clin Oncol. 2009;27:15574.
-
(2009)
J Clin Oncol
, vol.27
, pp. 15574
-
-
O'Neil, B.H.1
Williams-Goff, L.W.2
Kauh, J.3
Bekaii-Saab, T.4
Strosberg, J.R.5
Lee, R.6
-
95
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer. 2004;4:335-48. (Pubitemid 38579480)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.5
, pp. 335-348
-
-
Bjornsti, M.-A.1
Houghton, P.J.2
-
96
-
-
0034079163
-
PTEN/MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas
-
Fujiwara Y, Hoon DS, Yamada T, Umeshita K, Gotoh M, Sakon M, et al. PTEN/MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinoma. Jpn J Cancer Res. 2000;92:287-92. (Pubitemid 30198168)
-
(2000)
Japanese Journal of Cancer Research
, vol.91
, Issue.3
, pp. 287-292
-
-
Fujiwara, Y.1
Hoon, D.S.B.2
Yamada, T.3
Umeshita, K.4
Gotoh, M.5
Sakon, M.6
Nishisho, I.7
Monden, M.8
-
97
-
-
0344407448
-
Expression and prognostic role of tumor suppressor gene PTEN/ MMAC1/TEP1 in hepatocellular carcinoma
-
Hu TH, Huang CC, Lin PR, Lin PR, Liu SY, Chang HW, et al. Expression and prognostic role of tumor suppressor gene PTEN/ MMAC1/TEP1 in hepatocellular carcinoma. Cancer. 2003;97:1929-40.
-
(2003)
Cancer
, vol.97
, pp. 1929-1940
-
-
Hu, T.H.1
Huang, C.C.2
Lin, P.R.3
Lin, P.R.4
Liu, S.Y.5
Chang, H.W.6
-
98
-
-
57349087153
-
Pivotal role of mTOR signaling in hepatocellular carcinoma
-
Villanueva A, Chiang DY, Newell P, Peix J, Thung S, Alsinet C, et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology. 2008;135:1972-83.
-
(2008)
Gastroenterology
, vol.135
, pp. 1972-1983
-
-
Villanueva, A.1
Chiang, D.Y.2
Newell, P.3
Peix, J.4
Thung, S.5
Alsinet, C.6
-
99
-
-
11144236505
-
mTOR and P70 S6 kinase expression in primary liver neoplasms
-
DOI 10.1158/1078-0432.CCR-04-0941
-
Sahin F, Kannangai R, Adegbola O, Wang J, Su G, Torbenson M. mTOR and P70S6 kinase expression in primary liver neoplasms. Clin Cancer Res. 2004;10:8421-5. (Pubitemid 40053405)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.24
, pp. 8421-8425
-
-
Sahin, F.1
Kannangai, R.2
Adegbola, O.3
Wang, J.4
Su, G.5
Torbenson, M.6
-
100
-
-
53049087511
-
Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells
-
Chen KF, Yeh PY, Yeh KH, Lu YS, Huang SY, Cheng AL. Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells. Cancer Res. 2008;68:6698-707.
-
(2008)
Cancer Res
, vol.68
, pp. 6698-6707
-
-
Chen, K.F.1
Yeh, P.Y.2
Yeh, K.H.3
Lu, Y.S.4
Huang, S.Y.5
Cheng, A.L.6
-
101
-
-
66449131460
-
Bortezoomib overcomes tumor necorsis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway
-
Chen KF, Yeh PY, Hsu C, Hsu CH, Lu YS, Hsieh HP, et al. Bortezoomib overcomes tumor necorsis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2009;284:11121-33.
-
(2009)
J Biol Chem
, vol.284
, pp. 11121-11133
-
-
Chen, K.F.1
Yeh, P.Y.2
Hsu, C.3
Hsu, C.H.4
Lu, Y.S.5
Hsieh, H.P.6
-
102
-
-
40149098824
-
Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer
-
DOI 10.1007/s10147-007-0733-3
-
Rizell M, Andersson M, Cahlin C, Hafström L, Olausson M, Lindnér P. Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer. Int J Clin Oncol. 2008;13:66-70. (Pubitemid 351326289)
-
(2008)
International Journal of Clinical Oncology
, vol.13
, Issue.1
, pp. 66-70
-
-
Rizell, M.1
Andersson, M.2
Cahlin, C.3
Hafstrom, L.4
Olausson, M.5
Lindner, P.6
-
103
-
-
77952085946
-
Randomized, phase I, and pharmacokinetic (PK) study of RAD001, an mTOR inhibitor, in patients (pts) with advanced hepatocelluar carcinoma (HCC)
-
abstract no. 4587
-
Chen L, Shiah HS, Chen CY, Lin YJ, Lin PW, Su WC, Chan JY. Randomized, phase I, and pharmacokinetic (PK) study of RAD001, an mTOR inhibitor, in patients (pts) with advanced hepatocelluar carcinoma (HCC). J Clin Oncol 2009;27 (Suppl; abstract no. 4587).
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Chen, L.1
Shiah, H.S.2
Chen, C.Y.3
Lin, Y.J.4
Lin, P.W.5
Su, W.C.6
Chan, J.Y.7
-
104
-
-
33745552897
-
Dysregulation of growth factor signaling in human hepatocellular carcinoma
-
DOI 10.1038/sj.onc.1209556, PII 1209556
-
Breuhahn K, Longerich T, Schirmacher P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene. 2006;25:3787-800. (Pubitemid 43980474)
-
(2006)
Oncogene
, vol.25
, Issue.27
, pp. 3787-3800
-
-
Breuhahn, K.1
Longerich, T.2
Schirmacher, P.3
-
105
-
-
44649116436
-
Growth factors as therapeutic targets in HCC
-
Furuse J. Growth factors as therapeutic targets in HCC. Crit Rev Oncol Hematol. 2008;67:8-15.
-
(2008)
Crit Rev Oncol Hematol
, vol.67
, pp. 8-15
-
-
Furuse, J.1
-
106
-
-
0030874427
-
Epidermal growth factor receptor in human hepatocellular carcinoma
-
Hamazaki K, Yunoki Y, Tagashira H, Mimura T, Mori M, Orita K. Epidermal growth factor receptor in human hepatocellular carcinoma. Cancer Detect Prev. 1997;21:355-60. (Pubitemid 27335556)
-
(1997)
Cancer Detection and Prevention
, vol.21
, Issue.4
, pp. 355-360
-
-
Hamazaki, K.1
Yunoki, Y.2
Tagashira, H.3
Mimura, T.4
Mori, M.5
Orita, K.6
-
107
-
-
0142024103
-
Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours
-
DOI 10.1016/S1590-8658(03)00077-X
-
Altimari A, Fiorentino M, Gabusi E, Gruppioni E, Corti B, D'Errico A, Grigioni WF. Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours. Dig Liver Dis. 2003;35:332-8. (Pubitemid 41110860)
-
(2003)
Digestive and Liver Disease
, vol.35
, Issue.5
, pp. 332-338
-
-
Altimari, A.1
Fiorentino, M.2
Gabusi, E.3
Gruppioni, E.4
Corti, B.5
D'Errico, A.6
Grigioni, W.F.7
-
108
-
-
0037080265
-
HER-2/neu overexpression is rare in hepatocellular carcinoma and not predictive of anti-HER-2/neu regulation of cell growth and chemosensitivity
-
DOI 10.1002/cncr.10180
-
Hsu C, Huang CL, Hsu HC, Lee PH, Wang SJ, Cheng AL. HER- 2/neu overexpression is rare in hepatocellular carcinoma and not predictive of anti-HER-2/neu regulation of cell growth and chemosensitivity. Cancer. 2002;94:415-20. (Pubitemid 34081371)
-
(2002)
Cancer
, vol.94
, Issue.2
, pp. 415-420
-
-
Hsu, C.1
Huang, C.-L.2
Hsu, H.-C.3
Lee, P.-H.4
Wang, S.-J.5
Cheng, A.-L.6
-
109
-
-
19444379632
-
Absence of epidermal growth factor receptor exon 18-21 mutation in hepatocellular carcioma
-
Su MC, Lien HC, Jeng YM. Absence of epidermal growth factor receptor exon 18-21 mutation in hepatocellular carcioma. Cancer Lett. 2005;224:117-21.
-
(2005)
Cancer Lett
, vol.224
, pp. 117-121
-
-
Su, M.C.1
Lien, H.C.2
Jeng, Y.M.3
-
110
-
-
27244447373
-
Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer
-
DOI 10.1200/JCO.2005.14.696
-
Philip PA, Mahoney MR, Allmer C, Thomas J, Pitot HC, Kim G, et al. Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol. 2005;23:6657-63. (Pubitemid 46190260)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.27
, pp. 6657-6663
-
-
Philip, P.A.1
Mahoney, M.R.2
Allmer, C.3
Thomas, J.4
Pitot, H.C.5
Kim, G.6
Donehower, R.C.7
Fitch, T.8
Picus, J.9
Erlichman, C.10
-
111
-
-
34548150925
-
Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
-
DOI 10.1002/cncr.22886
-
Thomas MB, Ghadha R, Glover K, Wang X, Morris J, Brown T, et al. Phase II study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer. 2007;110:1059-67. (Pubitemid 47312872)
-
(2007)
Cancer
, vol.110
, Issue.5
, pp. 1059-1067
-
-
Thomas, M.B.1
Chadha, R.2
Glover, K.3
Wang, X.4
Morris, J.5
Brown, T.6
Rashid, A.7
Dancey, J.8
Abbruzzese, J.L.9
-
112
-
-
33750929534
-
Gefitinib in advanced unresectable hepatocellular carcinoma: Results from the Eastern Cooperative Oncology Group's Study E1203
-
abstract no. 4143
-
O'Dwyer PJ, Gianotonio BJ, Levy DE, Kauh JS, Fitzgerald DB, Benson AB. Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperative Oncology Group's Study E1203. J Clin Oncol. 2006;24 (Suppl; abstract no. 4143).
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL.
-
-
O'Dwyer, P.J.1
Gianotonio, B.J.2
Levy, D.E.3
Kauh, J.S.4
Fitzgerald, D.B.5
Benson, A.B.6
-
113
-
-
70349443677
-
A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas
-
Bekaii-Saab T, Markowitz J, Prescott N, Sadee W, Heerema N, Wei L, et al. A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas. Clin Cancer Res. 2009;15:5895-901.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5895-5901
-
-
Bekaii-Saab, T.1
Markowitz, J.2
Prescott, N.3
Sadee, W.4
Heerema, N.5
Wei, L.6
-
114
-
-
58849086599
-
A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma
-
Gruenwald V, Wilkens L, Gebel M, Wirth T, Greten S, Kubicka MP, et al. A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma. J Clin Oncol. 2006;24:14079.
-
(2006)
J Clin Oncol
, vol.24
, pp. 14079
-
-
Gruenwald, V.1
Wilkens, L.2
Gebel, M.3
Wirth, T.4
Greten, S.5
Kubicka, M.P.6
-
115
-
-
34547102484
-
Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma
-
DOI 10.1002/cncr.22829
-
Zhu AX, Stuart K, Blaszkowsky LS, Muzikansky A, Reitberg DP, Clark JW, et al. Phase 2 study of cetuximab in patients with advanced HCC. Cancer. 2007;110:581-9. (Pubitemid 47106147)
-
(2007)
Cancer
, vol.110
, Issue.3
, pp. 581-589
-
-
Zhu, A.X.1
Stuart, K.2
Blaszkowsky, L.S.3
Muzikansky, A.4
Reitberg, D.P.5
Clark, J.W.6
Enzinger, P.C.7
Bhargava, P.8
Meyerhardt, J.A.9
Horgan, K.10
Fuchs, C.S.11
Ryan, D.P.12
-
117
-
-
33748958139
-
High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma
-
DOI 10.1111/j.1349-7006.2006.00322.x
-
Aishima S, Basaki Y, Oda Y, Kuroda Y, Nishihara Y, Taguchi K, et al. High expression of insulin-like growth factor binding protein-3 is correlated with low portal invasion and better prognosis in human hepatocellular carcinoma. Cancer Sci. 2006;97:1182-90. (Pubitemid 44437362)
-
(2006)
Cancer Science
, vol.97
, Issue.11
, pp. 1182-1190
-
-
Aishima, S.1
Basaki, Y.2
Oda, Y.3
Kuroda, Y.4
Nishihara, Y.5
Taguchi, K.6
Taketomi, A.7
Maehara, Y.8
Hosoi, F.9
Maruyama, Y.10
Fotovati, A.11
Oie, S.12
Ono, M.13
Ueno, T.14
Sata, M.15
Yano, H.16
Kojiro, M.17
Kuwano, M.18
Tsuneyoshi, M.19
-
118
-
-
41849105045
-
Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma
-
DOI 10.3748/wjg.14.1690
-
Breuhahn K, Schirmacher P. Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma. World J Gastroenterol. 2008;14:1690-8. (Pubitemid 351493375)
-
(2008)
World Journal of Gastroenterology
, vol.14
, Issue.11
, pp. 1690-1698
-
-
Breuhahn, K.1
Schirmacher, P.2
-
119
-
-
77949875878
-
IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage
-
Tovar V, Alsinet C, Villanueva A, Hoshida Y, Chiang DY, Sole M, et al. IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage. J Hepatol. 2010;52:550-9.
-
(2010)
J Hepatol
, vol.52
, pp. 550-559
-
-
Tovar, V.1
Alsinet, C.2
Villanueva, A.3
Hoshida, Y.4
Chiang, D.Y.5
Sole, M.6
-
120
-
-
0033065805
-
Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: An immunohistochemical study
-
Okano J, Shiota G, Kawasaki H. Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver disease: an immunohistochemical study. Liver. 1999;19:151-9. (Pubitemid 29139769)
-
(1999)
Liver
, vol.19
, Issue.2
, pp. 151-159
-
-
Okano, J.-I.1
Shiota, G.2
Kawasaki, H.3
-
121
-
-
44349155339
-
Clinical significance of Serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma
-
Osada S, Kanematsu M, Imai H, Goshima S. Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma. Hepatogastroenterology. 2008;55:544-9. (Pubitemid 351741499)
-
(2008)
Hepato-Gastroenterology
, vol.55
, Issue.82-83
, pp. 544-549
-
-
Osada, S.1
Kanematsu, M.2
Imai, H.3
Goshima, S.4
-
122
-
-
4344683925
-
Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells
-
DOI 10.1016/j.jhep.2004.05.018, PII S016882780400306X
-
Chiba T, Yokosuka O, Arai M, Tada M, Fukai K, Imazeli E, et al. Identification of genes up-regulated by histone deaceetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells. J Hepatol. 2004;41:436-45. (Pubitemid 39158753)
-
(2004)
Journal of Hepatology
, vol.41
, Issue.3
, pp. 436-445
-
-
Chiba, T.1
Yokosuka, O.2
Arai, M.3
Tada, M.4
Fukai, K.5
Imazeki, F.6
Kato, M.7
Seki, N.8
Saisho, H.9
-
123
-
-
0037455825
-
Histone deacetylase inhibitor trichostatin a induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells
-
DOI 10.1002/ijc.10699
-
Yamashita Y, Shimada M, Harimoto N, Rikimaru T, Shirabe K, Tanaka S, et al. Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. In J Cancer. 2003;103:572-6. (Pubitemid 36091459)
-
(2003)
International Journal of Cancer
, vol.103
, Issue.5
, pp. 572-576
-
-
Yamashita, Y.-I.1
Shimada, M.2
Harimoto, N.3
Rikimaru, T.4
Shirabe, K.5
Tanaka, S.6
Sugimachi, K.7
-
124
-
-
36348996655
-
Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma
-
DOI 10.1002/hep.21804
-
Lu YS, Kashida Y, Kulp SK, Wang YC, Wnag D, Hung JH, et al. Efficay of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma. Hepatology. 2007;46:1119-30. (Pubitemid 350144776)
-
(2007)
Hepatology
, vol.46
, Issue.4
, pp. 1119-1130
-
-
Lu, Y.-S.1
Kashida, Y.2
Kulp, S.K.3
Wang, Y.-C.4
Wang, D.5
Hung, J.-H.6
Tang, M.7
Lin, Z.-Z.8
Chen, T.-J.9
Cheng, A.-L.10
Chen, C.-S.11
-
125
-
-
67650648501
-
Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma
-
Shirakawa H, Suzuki H, Shimomura M, Kojima M, Gotohda N, Takahashi S, et al. Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma. Cancer Sci. 2009;100:1403-7.
-
(2009)
Cancer Sci
, vol.100
, pp. 1403-1407
-
-
Shirakawa, H.1
Suzuki, H.2
Shimomura, M.3
Kojima, M.4
Gotohda, N.5
Takahashi, S.6
-
126
-
-
84897581120
-
Glypican 3 expression in human nonneoplastic, preneoplastic, and neoplastic tissues: A tissue microarray analysis of 4,387 tissue samples
-
Baumhoer D, Tornillo L, Stadimann S, Roncalli M, Diamantis EK, Terracciano LM. Glypican 3 expression in human nonneoplastic, preneoplastic, and neoplastic tissues: a tissue microarray analysis of 4,387 tissue samples. Am J Clin Pathol. 2008;29:1319-26.
-
(2008)
Am J Clin Pathol
, vol.29
, pp. 1319-1326
-
-
Baumhoer, D.1
Tornillo, L.2
Stadimann, S.3
Roncalli, M.4
Diamantis, E.K.5
Terracciano, L.M.6
-
127
-
-
69949129964
-
Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
-
Newell P, Toffanin S, Villanueva A, Chiang DY, Minguez B, Cabellos L, et al. Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J Hepatol. 2009;51:725-33.
-
(2009)
J Hepatol
, vol.51
, pp. 725-733
-
-
Newell, P.1
Toffanin, S.2
Villanueva, A.3
Chiang, D.Y.4
Minguez, B.5
Cabellos, L.6
-
128
-
-
67649715548
-
Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
-
Huynh H, Ngo VC, Koong HN, Poon D, Choo SP, Thng CH, et al. Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Cell Mol Med. 2009;13:2673-83.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 2673-2683
-
-
Huynh, H.1
Ngo, V.C.2
Koong, H.N.3
Poon, D.4
Choo, S.P.5
Thng, C.H.6
-
129
-
-
69949106121
-
Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: Rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma
-
Desbois-Mouthon C, Baron A, Blivet-Van Eggelpoel MJ, Fartoux L, Venot C, Bladt F, et al. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. Clin Cancer Res. 2009;15:5445-56.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5445-5456
-
-
Desbois-Mouthon, C.1
Baron, A.2
Blivet-Van Eggelpoel, M.J.3
Fartoux, L.4
Venot, C.5
Bladt, F.6
-
130
-
-
33750605628
-
Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib
-
DOI 10.1002/ijc.22221
-
Desbois-Mouthon C, Cacheux W, Blivet-Van Eggelpoel MJ, Barbu V, Fartoux L, Poupon R, et al. Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib. Int J Cancer. 2006;119:2557-66. (Pubitemid 44691308)
-
(2006)
International Journal of Cancer
, vol.119
, Issue.11
, pp. 2557-2566
-
-
Desbois-Mouthon, C.1
Cacheux, W.2
Blivet-Van, E.M.-J.3
Barbu, V.4
Fartoux, L.5
Poupon, R.6
Housset, C.7
Rosmorduc, O.8
-
131
-
-
70349452270
-
Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/ extracellular signaling-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma
-
Ou DL, Shen YC, Liang JD, Liou JY, Yu SL, Fan HH, et al. Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/ extracellular signaling-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma. Clin Cancer Res. 2009;15:5820-8.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5820-5828
-
-
Ou, D.L.1
Shen, Y.C.2
Liang, J.D.3
Liou, J.Y.4
Yu, S.L.5
Fan, H.H.6
-
132
-
-
60849124241
-
Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma
-
Thomas MB, Morris JS, Chadha R, Iwasaki M, Kaur H, Lin E, et al. Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol. 2009;27:843-50.
-
(2009)
J Clin Oncol
, vol.27
, pp. 843-850
-
-
Thomas, M.B.1
Morris, J.S.2
Chadha, R.3
Iwasaki, M.4
Kaur, H.5
Lin, E.6
-
133
-
-
74549175296
-
Biological activity of bevacizumab and erlotinib in patients with advanced hepatocellular carcinoma (HCC)
-
abstract no. 4522
-
Kaseb AL, Iwasaki M, Javle M, Onicescu G, Garrett-Mayer E, Abbruzzese GL, et al. Biological activity of bevacizumab and erlotinib in patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol. 2009;27 (Suppl; abstract no. 4522).
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Kaseb, A.L.1
Iwasaki, M.2
Javle, M.3
Onicescu, G.4
Garrett-Mayer, E.5
Abbruzzese, G.L.6
-
134
-
-
84984556329
-
Phase II study of efficacy of bevacizumab and erlotinib in inoperable previously untreated hepatocellular carcinoma (HCC)
-
abstract no. 264
-
Govindarajan R, Siegel ER, Makhoul I, Williamson SK. Phase II study of efficacy of bevacizumab and erlotinib in inoperable previously untreated hepatocellular carcinoma (HCC). In: 2009 Gastrointestinal Cancers Symposium (abstract no. 264).
-
2009 Gastrointestinal Cancers Symposium
-
-
Govindarajan, R.1
Siegel, E.R.2
Makhoul, I.3
Williamson, S.K.4
-
135
-
-
84897578822
-
A phase II study of bevacizumab (B) and erlotinib (E) in combination for Asian patients (pts) with advanced/metastatic hepatocellular carcinoma (HCC): An interim report
-
abstract no. 4585
-
Hsu C, Kang Y, Yang T, Su W, Sandoval-Tan J, Chiou T, et al. A phase II study of bevacizumab (B) and erlotinib (E) in combination for Asian patients (pts) with advanced/metastatic hepatocellular carcinoma (HCC): an interim report. J Clin Oncol. 2009;27 (Suppl; abstract no. 4585).
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Hsu, C.1
Kang, Y.2
Yang, T.3
Su, W.4
Sandoval-Tan, J.5
Chiou, T.6
-
136
-
-
84897582317
-
Evaluation of vandetanib in patients with inoperable hepatocellular carcinoma (HCC): A randomized, double-blind, parallel group, multicenter, Phase II study
-
abstract no. 6518
-
Hsu C, Yang TS, Huo TI, Hsieh RK, Hwang WS, Hsieh TY, et al. Evaluation of vandetanib in patients with inoperable hepatocellular carcinoma (HCC): a randomized, double-blind, parallel group, multicenter, Phase II study. European Cancer Organization (ECCO) 15/European Society of Medical Oncology (ESMO) 34 Meeting, 2009 (abstract no. 6518).
-
European Cancer Organization (ECCO) 15/European Society of Medical Oncology (ESMO) 34 Meeting, 2009
-
-
Hsu, C.1
Yang, T.S.2
Huo, T.I.3
Hsieh, R.K.4
Hwang, W.S.5
Hsieh, T.Y.6
-
137
-
-
59149085061
-
Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab
-
Yeo W, Chan TC, Leung NW, Lam WY, Mo FK, Chu MT, et al. Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab. J Clin Oncol. 2009;27:605-11.
-
(2009)
J Clin Oncol
, vol.27
, pp. 605-611
-
-
Yeo, W.1
Chan, T.C.2
Leung, N.W.3
Lam, W.Y.4
Mo, F.K.5
Chu, M.T.6
-
138
-
-
77953531899
-
HCV genotype 2 as a risk factor for reactivation in patients with B-cell lymphoma undergoing rituximab combination chemotherapy
-
Epub ahead of print
-
Pitini V, Sturniolo G, Arrigo C, Leonardi S, Pino S, Altavilla G. HCV genotype 2 as a risk factor for reactivation in patients with B-cell lymphoma undergoing rituximab combination chemotherapy. Br J Haematol. 2010. [Epub ahead of print].
-
(2010)
Br J Haematol
-
-
Pitini, V.1
Sturniolo, G.2
Arrigo, C.3
Leonardi, S.4
Pino, S.5
Altavilla, G.6
-
139
-
-
77349124041
-
Current strategy for staging and treatment: The BCLC update and future prospects
-
Forner A, Reig ME, de Lope CR, Bruix J. Current strategy for staging and treatment: the BCLC update and future prospects. Semin Liver Dis. 2010;30:61-74.
-
(2010)
Semin Liver Dis
, vol.30
, pp. 61-74
-
-
Forner, A.1
Reig, M.E.2
De Lope, C.R.3
Bruix, J.4
-
140
-
-
71249126197
-
Management of hepatocellular carcinoma in Asia: Consensus statement from the Asian Oncology Summit 2009
-
Poon D, Anderson BO, Chen LT, Tanaka K, Lau WY, Van Cutsem E, et al. Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncol. 2009;10:1111-8.
-
(2009)
Lancet Oncol
, vol.10
, pp. 1111-1118
-
-
Poon, D.1
Anderson, B.O.2
Chen, L.T.3
Tanaka, K.4
Lau, W.Y.5
Van Cutsem, E.6
-
141
-
-
58849159660
-
Evidence-based clinical practice guidelines for hepatocellular carcinoma in Japan: The J-HCC guidelines
-
Kokudo N, Makuuchi M. Evidence-based clinical practice guidelines for hepatocellular carcinoma in Japan: the J-HCC guidelines. J Gastroenterol. 2009;44:119-21.
-
(2009)
J Gastroenterol
, vol.44
, pp. 119-121
-
-
Kokudo, N.1
Makuuchi, M.2
-
142
-
-
37149003891
-
Management of hepatocellular carcinoma in Japan: Consensus-based clinical practice manual proposed by the Japan Society of Hepatology
-
DOI 10.1159/000111702
-
Kudo M, Okanoue T. Management of hepatocellular carcinoma in Japan: consensus-based clinical practice manual proposed by the Japan Society of Hepatology. Oncology. 2007;72:2-15. (Pubitemid 350256660)
-
(2007)
Oncology
, vol.72
, Issue.SUPPL. 1
, pp. 2-15
-
-
Kudo, M.1
Okanoue, T.2
-
143
-
-
1242307281
-
Hepatectomy for hepatocellular carcinoma: Patient selection and postoperative outcome
-
Poon RT, Fan ST. Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome. Liver Transpl. 2004;10:S39-45. (Pubitemid 38240099)
-
(2004)
Liver Transplantation
, vol.10
, Issue.2 SUPPL. 1
-
-
Poon, R.T.-P.1
Fan, S.-T.2
-
144
-
-
79955617020
-
Prognostic values of baseline circulating endothelial progenitor level for advanced heaptocellular carcinoma (HCC) patients under anti-angiogenic therapy
-
abstract
-
Shao YY, Lin ZZ, Chen TJ, Hsu C, Shen YC, Hsu CH, Cheng AL. Prognostic values of baseline circulating endothelial progenitor level for advanced heaptocellular carcinoma (HCC) patients under anti-angiogenic therapy. J Clin Oncol. 2010;28 (abstract).
-
(2010)
J Clin Oncol
, pp. 28
-
-
Shao, Y.Y.1
Lin, Z.Z.2
Chen, T.J.3
Hsu, C.4
Shen, Y.C.5
Hsu, C.H.6
Cheng, A.L.7
-
145
-
-
84897583210
-
Circulating endothelial cells (CEC) and angiogenic proteins monitoring in patients (pts) with advanced hepatocellular carcinoma (HCC) treated with bevacizumab
-
abstract no. 4597
-
Booiege V, Baey C, Dromain C, Ducreux M, Malka D, Pignon J, et al. Circulating endothelial cells (CEC) and angiogenic proteins monitoring in patients (pts) with advanced hepatocellular carcinoma (HCC) treated with bevacizumab. J Clin Oncol. 2009;27 (Suppl; abstract no. 4597).
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Booiege, V.1
Baey, C.2
Dromain, C.3
Ducreux, M.4
Malka, D.5
Pignon, J.6
-
146
-
-
46949084994
-
Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: Tools or decorations?
-
DOI 10.1038/ncponc1150, PII NCPONC1150
-
Sessa C, Guibal A, Del Conte G, Ruegg C. Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations? Nat Rev Pract Oncol. 2008;5:378-91. (Pubitemid 351958963)
-
(2008)
Nature Clinical Practice Oncology
, vol.5
, Issue.7
, pp. 378-391
-
-
Sessa, C.1
Guibal, A.2
Del, C.G.3
Ruegg, C.4
-
147
-
-
74249092481
-
Biomarkers of angiogenesis and their role in the development of VEGF inhibitors
-
Murukesh N, Dive C, Jayson GC. Biomarkers of angiogenesis and their role in the development of VEGF inhibitors. Br J Cancer. 2010;102:8-18.
-
(2010)
Br J Cancer
, vol.102
, pp. 8-18
-
-
Murukesh, N.1
Dive, C.2
Jayson, G.C.3
-
148
-
-
33846478656
-
DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
-
DOI 10.1038/sj.bjc.6603515, PII 6603515
-
O'Connor JPB, Jackson A, Parker GJM, et al. DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. Br J Cancer. 2007;96:189-95. (Pubitemid 46160619)
-
(2007)
British Journal of Cancer
, vol.96
, Issue.2
, pp. 189-195
-
-
O'Connor, J.P.B.1
Jackson, A.2
Parker, G.J.M.3
Jayson, G.C.4
-
149
-
-
19944394201
-
The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: Issues and recommendations
-
DOI 10.1038/sj.bjc.6602550
-
Leach MO, Brindle KM, Evelhock JL, Griffiths JR, Horsman MR, Jackson A, et al. The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations. Br J Cancer. 2005;92:1599-610. (Pubitemid 40756468)
-
(2005)
British Journal of Cancer
, vol.92
, Issue.9
, pp. 1599-1610
-
-
Leach, M.O.1
Brindle, K.M.2
Evelhoch, J.L.3
Griffiths, J.R.4
Horsman, M.R.5
Jackson, A.6
Jayson, G.C.7
Judson, I.R.8
Knopp, M.V.9
Maxwell, R.J.10
McIntyre, D.11
Padhani, A.R.12
Price, P.13
Rathbone, R.14
Rustin, G.J.15
Tofts, P.S.16
Tozer, G.M.17
Vennart, W.18
Waterton, J.C.19
Williams, S.R.20
Workman, P.21
more..
-
150
-
-
67650380136
-
Biomarkers of response and resistance to antiangiogenic therapy
-
Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JX, et al. Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol. 2009;6:327-38.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 327-338
-
-
Jain, R.K.1
Duda, D.G.2
Willett, C.G.3
Sahani, D.V.4
Zhu, A.X.5
Loeffler, J.X.6
-
151
-
-
84897583120
-
Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict treatment outcomes for advanced hepatocellular carcinoma (HCC) patients who received sorafenib plus tegafur/uracil therapy
-
abstract no. 116
-
Shen YC, Hsu CY, Yu CW, Hsu C, Hsu CH, Cheng AL, et al. Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict treatment outcomes for advanced hepatocellular carcinoma (HCC) patients who received sorafenib plus tegafur/uracil therapy. J Hepatol. 2010;52 (Suppl 1):S52 (abstract no. 116).
-
(2010)
J Hepatol
, vol.52
, Issue.SUPPL. 1
-
-
Shen, Y.C.1
Hsu, C.Y.2
Yu, C.W.3
Hsu, C.4
Hsu, C.H.5
Cheng, A.L.6
-
152
-
-
8144222903
-
Influence of slide aging on results of translational research studies using immunohistochemistry
-
DOI 10.1038/modpathol.3800208
-
Mirlacher M, Kasper M, Storz M, Knecht Y, Dürmüller U, Simon R, et al. Influence of slide aging on results of translational research studies using immunohistochemistry. Mod Pathol. 2004;17:1414-20. (Pubitemid 39472998)
-
(2004)
Modern Pathology
, vol.17
, Issue.11
, pp. 1414-1420
-
-
Mirlacher, M.1
Kasper, M.2
Storz, M.3
Knecht, Y.4
Durmuller, U.5
Simon, R.6
Mihatsch, M.J.7
Sauter, G.8
-
153
-
-
84897581866
-
Discordance of the immunohistochemical expression of phosphor-Akt and phosphor-ERK between paired biopsy and hepatectomy specimens of hepatocellular carcinoma
-
Abstract no. 3759
-
Shao YY, Chen CL, Huang CC, Tu HC, Lin ZZ, Hsu CH, et al. Discordance of the immunohistochemical expression of phosphor-Akt and phosphor-ERK between paired biopsy and hepatectomy specimens of hepatocellular carcinoma. In: AACR annual meeting 2010 (Abstract no. 3759).
-
AACR Annual Meeting 2010
-
-
Shao, Y.Y.1
Chen, C.L.2
Huang, C.C.3
Tu, H.C.4
Lin, Z.Z.5
Hsu, C.H.6
-
154
-
-
4544273428
-
Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
-
DOI 10.1002/hep.20375
-
Lee JS, Chu IS, Heo J, Calvisi DF, Sun Z, Roskams T, et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology. 2004;40:667-76. (Pubitemid 39265589)
-
(2004)
Hepatology
, vol.40
, Issue.3
, pp. 667-676
-
-
Lee, J.-S.1
Chu, I.-S.2
Heo, J.3
Calvisi, D.F.4
Sun, Z.5
Roskams, T.6
Durnez, A.7
Demetris, A.J.8
Thorgeirsson, S.S.9
-
155
-
-
0035985214
-
Gene expression patterns in human liver cancers
-
DOI 10.1091/mbc.02-02-0023.
-
Chen X, Cheung ST, So S, Fan ST, Barry C, Higgins J, et al. Gene expression patterns in human liver cancers. Mol Biol Cell. 2002;13:1929-39. (Pubitemid 34651483)
-
(2002)
Molecular Biology of the Cell
, vol.13
, Issue.6
, pp. 1929-1939
-
-
Chen, X.1
Cheung, S.T.2
So, S.3
Fan, S.T.4
Barry, C.5
Higgins, J.6
Lai, K.-M.7
Ji, J.8
Dudoit, S.9
Ng, I.O.L.10
Van De, R.M.11
Botstein, D.12
Brown, P.O.13
-
156
-
-
0037443891
-
Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection
-
DOI 10.1016/S0140-6736(03)12775-4
-
Izuka N, Oka M, Yamada-Okabe H, Nishida M, Maeda Y, Mori N, et al. Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection. Lancet. 2003;361:923-9. (Pubitemid 36332108)
-
(2003)
Lancet
, vol.361
, Issue.9361
, pp. 923-929
-
-
Iizuka, N.1
Oka, M.2
Yamada-Okabe, H.3
Nishida, M.4
Maeda, Y.5
Mori, N.6
Takao, T.7
Tamesa, T.8
Tangoku, A.9
Tabuchi, H.10
Hamada, K.11
Nakayama, H.12
Ishitsuka, H.13
Miyamoto, T.14
Hirabayashi, A.15
Uchimura, S.16
Hamamoto, Y.17
-
157
-
-
4344652974
-
Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth factor II overexpression
-
DOI 10.1158/0008-5472.CAN-04-0292
-
Breuhahan K, Vreden S, Haddad R, Beckebaum S, Stippel D, Flemming P, et al. Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth factor II overexpression. Cancer Res. 2004;64:6058-64. (Pubitemid 39129404)
-
(2004)
Cancer Research
, vol.64
, Issue.17
, pp. 6058-6064
-
-
Breuhahn, K.1
Vreden, S.2
Haddad, R.3
Beckebaum, S.4
Stippel, D.5
Flemming, P.6
Nussbaum, T.7
Caselmann, W.H.8
Haab, B.B.9
Schirmacher, P.10
-
158
-
-
0037391756
-
Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
-
DOI 10.1038/nm843
-
Ye QH, Qin LX, Forgues M, He P, Kim JW, Peng AC, et al. Predicting hepatitis B virus-positive metastatic hepatocellulr carcinomas using gene expression profiling and supervised machine learning. Nat Med. 2003;9:416-23. (Pubitemid 36460075)
-
(2003)
Nature Medicine
, vol.9
, Issue.4
, pp. 416-423
-
-
Ye, Q.-H.1
Qin, L.-X.2
Forgues, M.3
He, P.4
Kim, J.W.5
Peng, A.C.6
Simon, R.7
Li, Y.8
Robles, A.I.9
Chen, Y.10
Ma, Z.-C.11
Wu, Z.-Q.12
Ye, S.-L.13
Liu, Y.-K.14
Tang, Z.-Y.15
Wang, X.W.16
-
159
-
-
5644258323
-
Distinct chromosomal bias of gene expression signatures in the progression of hepatocellular carcinoma
-
DOI 10.1158/0008-5472.CAN-04-1275
-
Midorkawa Y, Tsutsumi S, Nishimura K, Kamimura N, Kano M, Sakamoto H, et al. Distinct chromosomal bias of gene expression signatures in the progression of hepatocellular carcinoma. Cancer Res. 2004;64:7263-70. (Pubitemid 39372063)
-
(2004)
Cancer Research
, vol.64
, Issue.20
, pp. 7263-7270
-
-
Midorikawa, Y.1
Tsutsumi, S.2
Nishimura, K.3
Kamimura, N.4
Kano, M.5
Sakamoto, H.6
Makuuchi, M.7
Aburatani, H.8
-
160
-
-
33846463379
-
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
-
DOI 10.1002/hep.21467
-
Boyault S, Rickman DS, de Reynies A, Balabaud C, Rebouissou S, Jeannot E, et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology. 2007;45:42-52. (Pubitemid 46144363)
-
(2007)
Hepatology
, vol.45
, Issue.1
, pp. 42-52
-
-
Boyault, S.1
Rickman, D.S.2
De Reynies, A.3
Balabaud, C.4
Rebouissou, S.5
Jeannot, E.6
Herault, A.7
Saric, J.8
Belghiti, J.9
Franco, D.10
Bioulac-Sage, P.11
Laurent-Puig, P.12
Zucman-Rossi, J.13
-
161
-
-
53049086329
-
Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
-
Chiang DY, Villanueva A, Hoshida Y, Peix J, Newell P, Minguez B, et al. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res. 2008;68:6779-88.
-
(2008)
Cancer Res
, vol.68
, pp. 6779-6788
-
-
Chiang, D.Y.1
Villanueva, A.2
Hoshida, Y.3
Peix, J.4
Newell, P.5
Minguez, B.6
-
162
-
-
33744502855
-
Cancer biomarkers - An invitation to the table
-
DOI 10.1126/science.1125948
-
Dalton WS, Friend SH. Cancer biomarkers - an invitation to the table. Science. 2006;312:1165-8. (Pubitemid 43801132)
-
(2006)
Science
, vol.312
, Issue.5777
, pp. 1165-1168
-
-
Dalton, W.S.1
Friend, S.H.2
-
163
-
-
0036841485
-
Changes in differential gene expression because of warm ischemia time of radical prostatectomy specimens
-
Dash A, Maine IP, Varambally S, Shen R, Chinnaiyan AM, Rubin MA. Changes in differential gene expression because of warm ischemia time of radical prostatectomy specimens. Am J Pathol. 2002;161:1743-8. (Pubitemid 35265532)
-
(2002)
American Journal of Pathology
, vol.161
, Issue.5
, pp. 1743-1748
-
-
Dash, A.1
Maine, I.P.2
Varambally, S.3
Shen, R.4
Chinnaiyan, A.M.5
Rubin, M.A.6
-
164
-
-
70350650795
-
Gene expression in Barrett's esophagus: Laser capture versus whole tissue
-
El-Serag HB, Nurgalieva ZZ, Mistretta TA, Finegold MJ, Souza R, Hilsenbeck S, et al. Gene expression in Barrett's esophagus: laser capture versus whole tissue. Scand J Gastroenterol. 2009;44:787-95.
-
(2009)
Scand J Gastroenterol
, vol.44
, pp. 787-795
-
-
El-Serag, H.B.1
Nurgalieva, Z.Z.2
Mistretta, T.A.3
Finegold, M.J.4
Souza, R.5
Hilsenbeck, S.6
-
165
-
-
64649094395
-
Impact of sample acquisition and linear amplification on gene expression profiling of lung adenocarcinoma: Laser capure micro-dissection cell-sampling versus bulk tissue-sampling
-
Klee EW, Erdogan S, Tillmans L, Kosari F, Sun Z, Wigle DA. Impact of sample acquisition and linear amplification on gene expression profiling of lung adenocarcinoma: laser capure micro-dissection cell-sampling versus bulk tissue-sampling. BMC Med Genom. 2009;9:2-13.
-
(2009)
BMC Med Genom
, vol.9
, pp. 2-13
-
-
Klee, E.W.1
Erdogan, S.2
Tillmans, L.3
Kosari, F.4
Sun, Z.5
Wigle, D.A.6
-
166
-
-
71549121346
-
Impact of biospecimens handling on biomarker research in breast cancer
-
De Cecco L, Musella V, Veneroni S, Cappelletti V, Bongarzone I, Callari M, et al. Impact of biospecimens handling on biomarker research in breast cancer. BMC Cancer. 2009;9:409-10.
-
(2009)
BMC Cancer
, vol.9
, pp. 409-410
-
-
De Cecco, L.1
Musella, V.2
Veneroni, S.3
Cappelletti, V.4
Bongarzone, I.5
Callari, M.6
-
167
-
-
70349739285
-
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
-
Hoshida Y, Nijman SMB, Kobayashi M, Chan JA, Brunet JP, Chiang DY, et al. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res. 2009;69:7385-92.
-
(2009)
Cancer Res
, vol.69
, pp. 7385-7392
-
-
Hoshida, Y.1
Nijman, S.M.B.2
Kobayashi, M.3
Chan, J.A.4
Brunet, J.P.5
Chiang, D.Y.6
-
168
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
DOI 10.1056/NEJM200104053441402
-
Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001;344:1038-42. (Pubitemid 32267973)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
Resta, D.J.4
Reese, S.F.5
Ford, J.M.6
Capdeville, R.7
Talpaz, M.8
-
169
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
DOI 10.1056/NEJM200104053441401
-
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031-7. (Pubitemid 32267972)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
170
-
-
0036817874
-
Targeting the molecular pathophysiology of gastrointestinal stromal tumors with imatinib mechanisms, successes, and challenges to rational drug development
-
DOI 10.1016/S0889-8588(02)00052-7, PII S0889858802000527
-
Demetri GD. Targeting the molecular pathophysiology of gastrointestinal stromal tumors with imatinib. Mechanisms, successes, and challenges to rational drug development. Hematol Oncol Clin North Am. 2002;16:1115-24. (Pubitemid 35462917)
-
(2002)
Hematology/Oncology Clinics of North America
, vol.16
, Issue.5
, pp. 1115-1124
-
-
Demetri, G.D.1
-
171
-
-
33744788136
-
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies
-
DOI 10.1016/j.ccr.2006.04.022, PII S1535610806001462
-
Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell. 2006;9:485-95. (Pubitemid 43832191)
-
(2006)
Cancer Cell
, vol.9
, Issue.6
, pp. 485-495
-
-
Ji, H.1
Li, D.2
Chen, L.3
Shimamura, T.4
Kobayashi, S.5
McNamara, K.6
Mahmood, U.7
Mitchell, A.8
Sun, Y.9
Al-Hashem, R.10
Chirieac, L.R.11
Padera, R.12
Bronson, R.T.13
Kim, W.14
Janne, P.A.15
Shapiro, G.I.16
Tenen, D.17
Johnson, B.E.18
Weissleder, R.19
Sharpless, N.E.20
Wong, K.-K.21
more..
-
172
-
-
33751295869
-
Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy
-
DOI 10.1158/1078-0432.CCR-06-1732
-
Meric-Bernstam F, Hung MC. Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy. Clin Cancer Res. 2006;12:6326-30. (Pubitemid 44799700)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.21
, pp. 6326-6330
-
-
Meric-Bernstam, F.1
Hung, M.-C.2
|