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Volumn 45, Issue 8, 2010, Pages 794-807

Molecular targeted therapy for advanced hepatocellular carcinoma: Current status and future perspectives

Author keywords

Anti angiogenic therapy; Hepatocellular carcinoma; Molecular targeted therapy; Sorafenib

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BENZENESULFONIC ACID DERIVATIVE; PYRIDINE DERIVATIVE; SORAFENIB; VASCULOTROPIN A;

EID: 78650835158     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-010-0270-0     Document Type: Review
Times cited : (62)

References (172)
  • 2
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomized, double-blind, placebo-controlled trial
    • Cheng AL, Kong YK, Chen Z, Tsao CJ, Qin S, Kim JS, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomized, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10:25-34.
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kong, Y.K.2    Chen, Z.3    Tsao, C.J.4    Qin, S.5    Kim, J.S.6
  • 4
    • 0004623809 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis
    • Park YN, Kim YB, Yang KM, Park C. Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis. Arch Pathol Lab Med. 2000;124:1061-5. (Pubitemid 30602050)
    • (2000) Archives of Pathology and Laboratory Medicine , vol.124 , Issue.7 , pp. 1061-1065
    • Park, Y.N.1    Kim, Y.-B.2    Yang, K.M.3    Park, C.4
  • 5
    • 33751115483 scopus 로고    scopus 로고
    • Correlation of four vascular specific growth factors with carcinogenesis and portal vein tumor thrombus formation in human hepatocellular carcinoma
    • Li Q, Xu B, Fu L, Hao XS. Correlation of four vascular specific growth factors with carcinogenesis and portal vein tumor thrombus formation in human hepatocellular carcinoma. J Exp Clin Cancer Res. 2006;25:403-9. (Pubitemid 44763732)
    • (2006) Journal of Experimental and Clinical Cancer Research , vol.25 , Issue.3 , pp. 403-409
    • Li, Q.1    Xu, B.2    Fu, L.3    Hao, X.S.4
  • 6
    • 19944415267 scopus 로고    scopus 로고
    • Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma
    • Uematsu S, Higashi T, Nouso K, Kariyama K, Nakamura S, Suzuki M, et al. Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma. J Gastroenterol Hepatol. 2005;20:583-5.
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 583-585
    • Uematsu, S.1    Higashi, T.2    Nouso, K.3    Kariyama, K.4    Nakamura, S.5    Suzuki, M.6
  • 7
    • 0031955570 scopus 로고    scopus 로고
    • Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma
    • Li XM, Tang ZY, Zhou G, Lui YK, Ye SL. Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma. J Exp Clin Cancer. 1998;17:13-7. (Pubitemid 28215959)
    • (1998) Journal of Experimental and Clinical Cancer Research , vol.17 , Issue.1 , pp. 13-17
    • Li, X.M.1    Tang, Z.Y.2    Zhou, G.3    Lui, Y.K.4    Ye, S.L.5
  • 8
    • 0032526475 scopus 로고    scopus 로고
    • Parallel hybridization analysis of multiple protein kinase: Identification of gene expression patterns characteristic of human hepatocellular carcinoma
    • Tsou AP, Wu KM, Tsen TY, Chi CW, Chiu JH, Lui WY, et al. Parallel hybridization analysis of multiple protein kinase: identification of gene expression patterns characteristic of human hepatocellular carcinoma. Genomics. 1998;50:331-40.
    • (1998) Genomics , vol.50 , pp. 331-340
    • Tsou, A.P.1    Wu, K.M.2    Tsen, T.Y.3    Chi, C.W.4    Chiu, J.H.5    Lui, W.Y.6
  • 9
    • 34447326697 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor-alpha: A novel therapeutic target in human hepatocellular cancer
    • DOI 10.1158/1535-7163.MCT-06-0720
    • Stock P, Monga D, Tan X, Micsenyi A, Loizos N, Monga SP. Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer. Mol Cancer Ther. 2007;6:1932-41. (Pubitemid 47052483)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.7 , pp. 1932-1941
    • Stock, P.1    Monga, D.2    Tan, X.3    Micsenyi, A.4    Loizos, N.5    Monga, S.P.S.6
  • 10
    • 0034906312 scopus 로고    scopus 로고
    • The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma
    • El-Assal ON, Yamanoi A, Ono T, Kohno H, Nagasue N. The clinicopathological significance of heparanase and basic fibroblast growth factor expression in hepatocellular carcinoma. Clin Cancer Res. 2001;7:1299-305. (Pubitemid 32708684)
    • (2001) Clinical Cancer Research , vol.7 , Issue.5 , pp. 1299-1305
    • El-Assal, O.N.1    Yamanoi, A.2    Ono, T.3    Kohno, H.4    Nagasue, N.5
  • 15
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • DOI 10.1200/JCO.2002.10.088
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol. 2002;20:4368-80. (Pubitemid 35266299)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.21 , pp. 4368-4380
    • Dvorak, H.F.1
  • 16
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • DOI 10.1200/JCO.2005.06.081
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth fator pathway in tumor growth and angiogenesis. J Clin Oncol. 2005;23:1011-27. (Pubitemid 46202320)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 18
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 2009;27:3584-90.
    • (2009) J Clin Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5    Oudard, S.6
  • 20
    • 73749087933 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with sunitinib-refractory metastatic renal cell cancer
    • Di Lorenzo G, Cartenì G, Autorino R, Bruni G, Tudini M, Rizzo M, et al. Phase II study of sorafenib in patients with sunitinib-refractory metastatic renal cell cancer. J Clin Oncol. 2009;27:4469-74.
    • (2009) J Clin Oncol , vol.27 , pp. 4469-4474
    • Di Lorenzo, G.1    Cartenì, G.2    Autorino, R.3    Bruni, G.4    Tudini, M.5    Rizzo, M.6
  • 21
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol. 2010;28:1061-8.
    • (2010) J Clin Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3    Szczylik, C.4    Lee, E.5    Wagstaff, J.6
  • 23
    • 34147190880 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer
    • DOI 10.1634/theoncologist.12-3-356
    • Cohen MH, Gootenberg J, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer. Oncologist. 2007;12:356-61. (Pubitemid 46556802)
    • (2007) Oncologist , vol.12 , Issue.3 , pp. 356-361
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 24
    • 34447130180 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab (Avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer
    • DOI 10.1634/theoncologist.12-6-713
    • Cohen MH, Gootenberg J, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab (Avastin) plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer. Oncologist. 2007;12:713-8. (Pubitemid 47036205)
    • (2007) Oncologist , vol.12 , Issue.6 , pp. 713-718
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 25
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Archer L, et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol. 2010;28:2137-43.
    • (2010) J Clin Oncol , vol.28 , pp. 2137-2143
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3    Stadler, W.M.4    Vaena, D.A.5    Archer, L.6
  • 26
    • 75449088610 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme
    • Cohen MH, Shen YL, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme. Oncologist. 2009;14:1131-8.
    • (2009) Oncologist , vol.14 , pp. 1131-1138
    • Cohen, M.H.1    Shen, Y.L.2    Keegan, P.3    Pazdur, R.4
  • 28
    • 59149101627 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma and vascular invasion or extrahepatic spread: A subanalysis from the SHARP trial
    • abstract no. 4584
    • Sherman M, Mazzaferro V, Amadori D, Seitz J, Moscovici M, Shan M, et al. Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma and vascular invasion or extrahepatic spread: a subanalysis from the SHARP trial. J Clin Oncol. 2008;26 (Suppl; abstract no. 4584).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Sherman, M.1    Mazzaferro, V.2    Amadori, D.3    Seitz, J.4    Moscovici, M.5    Shan, M.6
  • 30
    • 59149092913 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to ECOG performance status: A subanalysis from the SHARP trial
    • abstract no. 4587
    • Raoul J, Santoro A, Beaugrand M, Marrero JA, Moscovici M, Shan M, et al. Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to ECOG performance status: a subanalysis from the SHARP trial. J Clin Oncol. 2008;26 (Suppl; abstract no. 4587).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Raoul, J.1    Santoro, A.2    Beaugrand, M.3    Marrero, J.A.4    Moscovici, M.5    Shan, M.6
  • 31
    • 58049199610 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients with alcohol-related hepatocellular carcinoma: A subanalysis from the SHARP trial
    • abstract no. 15591
    • Craxi A, Porta C, Sangiovanni A, Seitz J, Moscovici M, Shan M, et al. Efficacy and safety of sorafenib in patients with alcohol-related hepatocellular carcinoma: a subanalysis from the SHARP trial. J Clin Oncol. 2008;26 (Suppl; abstract no. 15591).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Craxi, A.1    Porta, C.2    Sangiovanni, A.3    Seitz, J.4    Moscovici, M.5    Shan, M.6
  • 32
    • 77955823345 scopus 로고    scopus 로고
    • Effect of macroscopic vascular invasion (MVI), extrahepatic spread (EHS), and ECOG performance status (ECOG PS) on outcome in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib: Analysis of two phase III, randomized, double-blind trials
    • abstract no. 4580
    • Bruix J, Cheng A, Kang Y, Tsao C, Qin S, Lentini G, et al. Effect of macroscopic vascular invasion (MVI), extrahepatic spread (EHS), and ECOG performance status (ECOG PS) on outcome in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib: analysis of two phase III, randomized, double-blind trials. J Clin Oncol. 2009;27 (Suppl; abstract no. 4580).
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Bruix, J.1    Cheng, A.2    Kang, Y.3    Tsao, C.4    Qin, S.5    Lentini, G.6
  • 33
    • 84897581225 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib (Sor) in patients (pts) with advanced hepatocellular carcinoma (HCC): Subgroup analyses of the SHARP trial by baseline (BL) transaminase (ALT/AST)/alphafetoprotein (AFP) and bilirubin (Bil) levels
    • abstract no. 129
    • Raoul J, Sherman M, Nadel A, Lentini G, Moscovici M, Voliotis D, et al. Efficacy and safety of sorafenib (Sor) in patients (pts) with advanced hepatocellular carcinoma (HCC): subgroup analyses of the SHARP trial by baseline (BL) transaminase (ALT/AST)/alphafetoprotein (AFP) and bilirubin (Bil) levels. In: 2010 Gastrointestinal Cancer Symposium (abstract no. 129).
    • 2010 Gastrointestinal Cancer Symposium
    • Raoul, J.1    Sherman, M.2    Nadel, A.3    Lentini, G.4    Moscovici, M.5    Voliotis, D.6
  • 35
    • 73049092595 scopus 로고    scopus 로고
    • Geographic difference in survival outcome for advanced hepatocellular carcinoma: Implications on future clinical trial design
    • Hsu C, Shen YC, Cheng CC, Hu FC, Cheng AL. Geographic difference in survival outcome for advanced hepatocellular carcinoma: Implications on future clinical trial design. Contemp Clin Trials. 2010;31:55-61.
    • (2010) Contemp Clin Trials , vol.31 , pp. 55-61
    • Hsu, C.1    Shen, Y.C.2    Cheng, C.C.3    Hu, F.C.4    Cheng, A.L.5
  • 36
    • 70349393610 scopus 로고    scopus 로고
    • Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: A systematic review and meta-analysis of clinical trials
    • Je Y, Schutz FA, Choueiri TK. Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials. Lancet Oncol. 2009;10:967-74.
    • (2009) Lancet Oncol , vol.10 , pp. 967-974
    • Je, Y.1    Schutz, F.A.2    Choueiri, T.K.3
  • 37
    • 1942421303 scopus 로고    scopus 로고
    • The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes
    • DOI 10.2174/1389200043489054
    • Elbekai RH, Korashy HM, El-Kadi AO. The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes. Curr Drug Metab. 2004;5:157-67. (Pubitemid 38515245)
    • (2004) Current Drug Metabolism , vol.5 , Issue.2 , pp. 157-167
    • Elbekai, R.H.1    Korashy, H.M.2    El-Kadi, A.O.S.3
  • 40
    • 36949033865 scopus 로고    scopus 로고
    • Phase I study of sorafenib in Japanese patients with hepatocellular carcinoma
    • DOI 10.1111/j.1349-7006.2007.00648.x
    • Furuse J, Ishii H, Nakachi K, Suzuki E, Shimizu S, Nakajima K. Phase I study of sorafenib in Japanese patients with heatocellular carcinoma. Cancer Sci. 2008;99:159-65. (Pubitemid 350239045)
    • (2008) Cancer Science , vol.99 , Issue.1 , pp. 159-165
    • Furuse, J.1    Ishii, H.2    Nakachi, K.3    Suzuki, E.4    Shimizu, S.5    Nakajima, K.6
  • 41
    • 64649083367 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301
    • Miller AA, Murry DJ, Owzar K, Hollis DR, Kennedy EB, Abou-Alfa G, et al. Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301. J Clin Oncol. 2009;27:1800-5.
    • (2009) J Clin Oncol , vol.27 , pp. 1800-1805
    • Miller, A.A.1    Murry, D.J.2    Owzar, K.3    Hollis, D.R.4    Kennedy, E.B.5    Abou-Alfa, G.6
  • 42
    • 61449256583 scopus 로고    scopus 로고
    • Sorafenib in unresectable hepatocellular carcinoma from mild to advanced stage liver cirrhosis
    • Pinter M, Sieghart W, Graziadei I, Vogel W, Maieron A, Königsberg R, et al. Sorafenib in unresectable hepatocellular carcinoma from mild to advanced stage liver cirrhosis. Oncologist. 2009;14:70-6.
    • (2009) Oncologist , vol.14 , pp. 70-76
    • Pinter, M.1    Sieghart, W.2    Graziadei, I.3    Vogel, W.4    Maieron, A.5    Königsberg, R.6
  • 43
    • 67651095716 scopus 로고    scopus 로고
    • Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis
    • Wörns MA, Weinmann A, Pfingst K, Schulte-Sasse C, Messow CM, Schulze-Bergkamen H, et al. Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis. J Clin Gastroenterol. 2009;43:489-95.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 489-495
    • Wörns, M.A.1    Weinmann, A.2    Pfingst, K.3    Schulte-Sasse, C.4    Messow, C.M.5    Schulze-Bergkamen, H.6
  • 45
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • DOI 10.1038/nrd2380, PII NRD2380
    • Faivre S, Demeri G, Sargent W, Raymond E. Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov. 2007;6:734-45. (Pubitemid 47338181)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.9 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 46
    • 67651165187 scopus 로고    scopus 로고
    • Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: An open-label, multicentre, phase II study
    • Faivre S, Raymond E, Boucher E, Douillard J, Lim HY, Kim JS, et al. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study. Lancet Oncol. 2009;10:794-800.
    • (2009) Lancet Oncol , vol.10 , pp. 794-800
    • Faivre, S.1    Raymond, E.2    Boucher, E.3    Douillard, J.4    Lim, H.Y.5    Kim, J.S.6
  • 47
    • 67649946279 scopus 로고    scopus 로고
    • Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: A phase II study
    • Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, et al. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol. 2009;27:3027-35.
    • (2009) J Clin Oncol , vol.27 , pp. 3027-3035
    • Zhu, A.X.1    Sahani, D.V.2    Duda, D.G.3    Di Tomaso, E.4    Ancukiewicz, M.5    Catalano, O.A.6
  • 48
    • 77950546450 scopus 로고    scopus 로고
    • Continuous sunitinib treatment in patients with advanced hepatocellular carcinoma: A Swiss Group for Clinical Cancer Research (SAKK) and Swiss Association for the Study of the Liver (SASL) multicenter phase II trial (SAKK 77/ 06)
    • Koeberle D, Montemurro M, Samaras P, Majno P, Simcock M, Limacher A, et al. Continuous sunitinib treatment in patients with advanced hepatocellular carcinoma: A Swiss Group for Clinical Cancer Research (SAKK) and Swiss Association for the Study of the Liver (SASL) multicenter phase II trial (SAKK 77/ 06). Oncologist. 2010;15:285-92.
    • (2010) Oncologist , vol.15 , pp. 285-292
    • Koeberle, D.1    Montemurro, M.2    Samaras, P.3    Majno, P.4    Simcock, M.5    Limacher, A.6
  • 49
    • 74549223962 scopus 로고    scopus 로고
    • An open-label phase II study of first- and second-line treatment with brivanib in patients with hepatocellular carcinoma (HCC)
    • abstract no. 4577
    • Raoul JL, Finn R, Kang YK, Park JW, Harris R, Coric V, et al. An open-label phase II study of first- and second-line treatment with brivanib in patients with hepatocellular carcinoma (HCC). J Clin Oncol. 2009;27 (Suppl; abstract no. 4577).
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Raoul, J.L.1    Finn, R.2    Kang, Y.K.3    Park, J.W.4    Harris, R.5    Coric, V.6
  • 50
    • 67650857880 scopus 로고    scopus 로고
    • Phase II, open label study of brivanib alaninate in patients (pts) with hepatocellular carcinoma (HCC) who failed prior antiangiogenic therapy
    • abstract no. 200
    • Finn RS, Kang Y, Park J, Harris R, Donica M, Walters I. Phase II, open label study of brivanib alaninate in patients (pts) with hepatocellular carcinoma (HCC) who failed prior antiangiogenic therapy. In: 2009 Gastrointestinal Cancers Symposium. (abstract no. 200).
    • 2009 Gastrointestinal Cancers Symposium
    • Finn, R.S.1    Kang, Y.2    Park, J.3    Harris, R.4    Donica, M.5    Walters, I.6
  • 51
    • 84860294161 scopus 로고    scopus 로고
    • Time-to-progression sub-analysis of second-line treatment with brivanib after failure of prior antiangiogenic therapy in patients with unresectable, locally advanced, or metastatic hepatocellular carcinoma
    • abstract
    • Finn RS, Park JW, Kang YK, et al. Time-to-progression sub-analysis of second-line treatment with brivanib after failure of prior antiangiogenic therapy in patients with unresectable, locally advanced, or metastatic hepatocellular carcinoma. In: AASLD Annual Meeting 2009 (abstract).
    • AASLD Annual Meeting 2009
    • Finn, R.S.1    Park, J.W.2    Kang, Y.K.3
  • 52
    • 33751348618 scopus 로고    scopus 로고
    • New feasibility study design with hepatocellular carcinoma: A phase I/II study of TSU-68, an oral angiogenesis inhibitor
    • abstract no. 4145
    • Kanai F, Yoshida H, Teratani T, Sato S, Tateishi R, Obi S, et al. New feasibility study design with hepatocellular carcinoma: A phase I/II study of TSU-68, an oral angiogenesis inhibitor. J Clin Oncol. 2006;24 (Suppl; abstract no. 4145).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Kanai, F.1    Yoshida, H.2    Teratani, T.3    Sato, S.4    Tateishi, R.5    Obi, S.6
  • 53
    • 79954437549 scopus 로고    scopus 로고
    • A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma
    • Epub ahead of print
    • Kanai F, Yoshida H, Tateishi R, Sato S, Kawabe T, Obi S, et al. A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma. Cancer Chemother Pharmacol. 2010. [Epub ahead of print].
    • (2010) Cancer Chemother Pharmacol
    • Kanai, F.1    Yoshida, H.2    Tateishi, R.3    Sato, S.4    Kawabe, T.5    Obi, S.6
  • 54
    • 78650847886 scopus 로고    scopus 로고
    • Linifanib phase II trial in patients with advanced hepatocellular carcinoma (HCC)
    • abstract no. 4038
    • Toh H, Chen P, Carr BI, Knox JJ, Gill S, Qian J, et al. Linifanib phase II trial in patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol. 2010;28 (Suppl; abstract no. 4038).
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Toh, H.1    Chen, P.2    Carr, B.I.3    Knox, J.J.4    Gill, S.5    Qian, J.6
  • 56
    • 46449091500 scopus 로고    scopus 로고
    • Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
    • Siegel AB, Cohen EI, Ocean A, Lehrer D, Goldenberg A, Knox JJ, et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol. 2008;26:2992-8.
    • (2008) J Clin Oncol , vol.26 , pp. 2992-2998
    • Siegel, A.B.1    Cohen, E.I.2    Ocean, A.3    Lehrer, D.4    Goldenberg, A.5    Knox, J.J.6
  • 57
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hannahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008;8:592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hannahan, D.2
  • 58
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • DOI 10.1016/j.ccr.2005.09.005, PII S1535610805002989
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 2005;8:299-309. (Pubitemid 41443415)
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 60
    • 35148820611 scopus 로고    scopus 로고
    • Molecular and cellular biomarkers for angiogenesis in clinical oncology
    • DOI 10.1016/j.drudis.2007.08.011, PII S1359644607003534
    • Bertolini F, Mancuso P, Shaked Y, Kerbel RS. Molecular and cellular biomarkers for angiogenesis in clinical oncology. Drug Discov Today. 2007;12:806-12. (Pubitemid 47539970)
    • (2007) Drug Discovery Today , vol.12 , Issue.19-20 , pp. 806-812
    • Bertolini, F.1    Mancuso, P.2    Shaked, Y.3    Kerbel, R.S.4
  • 62
    • 26944437515 scopus 로고    scopus 로고
    • + perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
    • DOI 10.1038/ncb1288, PII N1288
    • Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol. 2005;7:870-9. (Pubitemid 41486287)
    • (2005) Nature Cell Biology , vol.7 , Issue.9 , pp. 870-879
    • Song, S.1    Ewald, A.J.2    Stallcup, W.3    Werb, Z.4    Bergers, G.5
  • 63
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • DOI 10.1016/S1535-6108(03)00085-0, PII S1535610803000850
    • Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comogli PM, et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncoene. Cancer Cell. 2003;3:347-61. (Pubitemid 38340304)
    • (2003) Cancer Cell , vol.3 , Issue.4 , pp. 347-361
    • Pennacchietti, S.1    Michieli, P.2    Galluzzo, M.3    Mazzone, M.4    Giordano, S.5    Comoglio, P.M.6
  • 64
    • 0037703383 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: Motivators of metastasis?
    • DOI 10.1038/nm0703-822
    • Steeg PS. Angiogenesis inhibitors: motivators of metastasis? Nat Med. 2003;9:822-3. (Pubitemid 36889916)
    • (2003) Nature Medicine , vol.9 , Issue.7 , pp. 822-823
    • Steeg, P.S.1
  • 67
    • 2942711726 scopus 로고    scopus 로고
    • Thalidomid: Current role in the treatment of non-plasma cell malignancies
    • DOI 10.1200/JCO.2004.10.127
    • Kumar S, Witzig TE, Rajkumar SV. Thalidomide: current role in the treatment of non-plasma cell malignancies. J Clin Oncol. 2004;22:2477-88. (Pubitemid 41115407)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.12 , pp. 2477-2488
    • Kumar, S.1    Witzig, T.E.2    Rajkumar, S.V.3
  • 70
    • 33751544445 scopus 로고    scopus 로고
    • Efficacy and safety of thalidomide in patients with hepatocellular carcinoma
    • Chiou HE, Wang TE, Wang YY, Liu HW. Efficacy and safety of thalidomide in patients with hepatocellular carcinoma. World J Gastroenterol. 2006;12:6955-6.
    • (2006) World J Gastroenterol , vol.12 , pp. 6955-6956
    • Chiou, H.E.1    Wang, T.E.2    Wang, Y.Y.3    Liu, H.W.4
  • 71
    • 33847056761 scopus 로고    scopus 로고
    • Multi-centre phase II trial of thalidomide in the treatment of unresectable hepatocellular carcinoma
    • Chuah B, Lim R, Boyer M, Ong AB, Wong SW, Kong HL, Millward M, et al. Multi-centre phase II trial of thalidomide in the treatment of unresectable hepatocellular carcinoma. Acta Oncol. 2007;46:234-8.
    • (2007) Acta Oncol , vol.46 , pp. 234-238
    • Chuah, B.1    Lim, R.2    Boyer, M.3    Ong, A.B.4    Wong, S.W.5    Kong, H.L.6    Millward, M.7
  • 73
    • 37149051789 scopus 로고    scopus 로고
    • Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma
    • DOI 10.1159/000111709
    • Yau T, Chan P, Wong H, Ng KK, Chok SH, Cheung TT, et al. Efficacy and tolerability of low-dose thalidomide as first-line systemic treatment of patients with advanced hepatocellular carcinoma. Oncology. 2007;72:67-71. (Pubitemid 350256667)
    • (2007) Oncology , vol.72 , Issue.SUPPL. 1 , pp. 67-71
    • Yau, T.1    Chan, P.2    Wong, H.3    Ng, K.K.4    Chok, S.-H.5    Cheung, T.-T.6    Lam, V.7    Epstein, R.J.8    Fan, S.-T.9    Poon, R.T.P.10
  • 74
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer. 2004;4:423-36. (Pubitemid 38745528)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.6 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 75
    • 0035214416 scopus 로고    scopus 로고
    • Metronomic scheduling: The future of chemotherapy?
    • DOI 10.1016/S1470-2045(01)00587-3
    • Gasparini G. Metronomic scheduling: the future of chemotherapy? Lancet Oncol. 2001;2:733-40. (Pubitemid 33134058)
    • (2001) Lancet Oncology , vol.2 , Issue.12 , pp. 733-740
    • Gasparini, G.1
  • 76
    • 0034048358 scopus 로고    scopus 로고
    • Less is, more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
    • Hanahan D, Bergers G, Bergsland E. Less is more, regularly: metronomic dosing of cyotoxic drugs can target tumor angiogenesis in mice. J Clin Invest. 2000;105:1045-7. (Pubitemid 30217688)
    • (2000) Journal of Clinical Investigation , vol.105 , Issue.8 , pp. 1045-1047
    • Hanahan, D.1    Bergers, G.2    Bergsland, E.3
  • 78
    • 71649094684 scopus 로고    scopus 로고
    • Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: A phase II study
    • Reardon DA, Desjardins A, Vredenburgh JJ, Gururangan S, Sampson JH, Sathornsumetee S, et al. Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study. Br J Cancer. 2009;101:1986-94.
    • (2009) Br J Cancer , vol.101 , pp. 1986-1994
    • Reardon, D.A.1    Desjardins, A.2    Vredenburgh, J.J.3    Gururangan, S.4    Sampson, J.H.5    Sathornsumetee, S.6
  • 79
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital phase II consortia
    • Garcia AA, Hirte H, Fleming G, Yang D, Tsao-Wei DD, Roman L, et al. Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia. J Clin Oncol. 2008;26:76-82.
    • (2008) J Clin Oncol , vol.26 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3    Yang, D.4    Tsao-Wei, D.D.5    Roman, L.6
  • 80
    • 54449099774 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide and capecitabine combined with bevacizumab in advanced breast cancer
    • Dellapasqua S, Bertolini F, Bagnardi V, Campagnoli E, Scarano E, Torrisi R, et al. Metronomic cyclophosphamide and capecitabine combined with bevacizumab in advanced breast cancer. J Clin Oncol. 2008;26:4899-905.
    • (2008) J Clin Oncol , vol.26 , pp. 4899-4905
    • Dellapasqua, S.1    Bertolini, F.2    Bagnardi, V.3    Campagnoli, E.4    Scarano, E.5    Torrisi, R.6
  • 81
    • 77953124105 scopus 로고    scopus 로고
    • Phase II study of combining sorafenbi with metronomic tegafur/uracil for advanced hepatocelular carcinoma
    • doi:10.1016/j.jhep.2010.01.035
    • Hsu CH, Shen YC, Lin ZZ, Chen PJ, Shao YY, Ding YH, et al. Phase II study of combining sorafenbi with metronomic tegafur/uracil for advanced hepatocelular carcinoma. J Hepatol. 2010. doi:10.1016/j.jhep.2010.01.035.
    • (2010) J Hepatol
    • Hsu, C.H.1    Shen, Y.C.2    Lin, Z.Z.3    Chen, P.J.4    Shao, Y.Y.5    Ding, Y.H.6
  • 82
    • 84984578313 scopus 로고    scopus 로고
    • Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
    • Hsu CH, Yang TS, Hsu C, Toh HC, Epstein RJ, Hsiao LT, et al. Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma. Br J Cancer. 2010;102:981-6.
    • (2010) Br J Cancer , vol.102 , pp. 981-986
    • Hsu, C.H.1    Yang, T.S.2    Hsu, C.3    Toh, H.C.4    Epstein, R.J.5    Hsiao, L.T.6
  • 83
    • 77957552789 scopus 로고    scopus 로고
    • Thalidomide plus tegafur/uracil for the treatment of advanced/ metastatic hepatocellular carcinoma (HCC): A phase II single-arm study
    • abstract no. 15598
    • Hsu C, Chang D, Lin Z, Lee K, Hsiao C, Shen Y, et al. Thalidomide plus tegafur/uracil for the treatment of advanced/ metastatic hepatocellular carcinoma (HCC): a phase II single-arm study. J Clin Oncol. 2008;26 (Suppl; abstract no. 15598).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Hsu, C.1    Chang, D.2    Lin, Z.3    Lee, K.4    Hsiao, C.5    Shen, Y.6
  • 84
    • 33751337166 scopus 로고    scopus 로고
    • A combination of capecitabine and thalidomide in patients with hepatocellular carcinoma
    • abstract no. 4142
    • Jeong W, Chun HG, Cer D, Sekhri V, Kim-Schluger L, Wolf D. A combination of capecitabine and thalidomide in patients with hepatocellular carcinoma. J Clin Oncol. 2006;24 (Suppl; abstract no. 4142).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Jeong, W.1    Chun, H.G.2    Cer, D.3    Sekhri, V.4    Kim-Schluger, L.5    Wolf, D.6
  • 85
    • 32944480899 scopus 로고    scopus 로고
    • Opportunities for targeted therapies in hepatocellular carcinoma
    • DOI 10.1200/JCO.2004.00.1537
    • Thomas MB, Abbruzzese JL. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol. 2005;23:8093-108. (Pubitemid 46657412)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.31 , pp. 8093-8108
    • Thomas, M.B.1    Abbruzzese, J.L.2
  • 87
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3:721-32. (Pubitemid 37328811)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 89
    • 2542473135 scopus 로고    scopus 로고
    • Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: Its role in tumor progression and apoptosis
    • Huynh H, Nguyen TT, Chow KH, Tan PH, Soo KC, Tran E. Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis. BMC Gastroenterol. 2003;8:3-19.
    • (2003) BMC Gastroenterol , vol.8 , pp. 3-19
    • Huynh, H.1    Nguyen, T.T.2    Chow, K.H.3    Tan, P.H.4    Soo, K.C.5    Tran, E.6
  • 90
    • 33749319933 scopus 로고    scopus 로고
    • Loss of Raf Kinase Inhibitor Protein Promotes Cell Proliferation and Migration of Human Hepatoma Cells
    • DOI 10.1053/j.gastro.2006.07.012, PII S001650850601537X
    • Lee HC, Tian B, Sedivy JM, Wands JR, Kim M. Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology. 2006;131:1208-17. (Pubitemid 44498689)
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 1208-1217
    • Lee, H.C.1    Tian, B.2    Sedivy, J.M.3    Wands, J.R.4    Kim, M.5
  • 91
    • 0036058267 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line
    • DOI 10.1006/viro.2001.1227
    • Erhardt A, Hassan M, Heintges T, Häussinger D. Hepatitis C virus core protein induces cell proliferation, activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line. Virology. 2002;292:272-84. (Pubitemid 34920547)
    • (2002) Virology , vol.292 , Issue.2 , pp. 272-284
    • Erhardt, A.1    Hassan, M.2    Heintges, T.3    Haussinger, D.4
  • 92
    • 7744229935 scopus 로고    scopus 로고
    • Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: Involvement of invasive potential
    • DOI 10.1096/fj.03-1429fje
    • Chung TW, Lee YC, Kim CH. Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J. 2004;18:1123-5. (Pubitemid 39561544)
    • (2004) FASEB Journal , vol.18 , Issue.10 , pp. 1123-1125
    • Chung, T.-W.1    Lee, Y.-C.2    Kim, C.-H.3
  • 95
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer. 2004;4:335-48. (Pubitemid 38579480)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.5 , pp. 335-348
    • Bjornsti, M.-A.1    Houghton, P.J.2
  • 97
    • 0344407448 scopus 로고    scopus 로고
    • Expression and prognostic role of tumor suppressor gene PTEN/ MMAC1/TEP1 in hepatocellular carcinoma
    • Hu TH, Huang CC, Lin PR, Lin PR, Liu SY, Chang HW, et al. Expression and prognostic role of tumor suppressor gene PTEN/ MMAC1/TEP1 in hepatocellular carcinoma. Cancer. 2003;97:1929-40.
    • (2003) Cancer , vol.97 , pp. 1929-1940
    • Hu, T.H.1    Huang, C.C.2    Lin, P.R.3    Lin, P.R.4    Liu, S.Y.5    Chang, H.W.6
  • 100
    • 53049087511 scopus 로고    scopus 로고
    • Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells
    • Chen KF, Yeh PY, Yeh KH, Lu YS, Huang SY, Cheng AL. Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells. Cancer Res. 2008;68:6698-707.
    • (2008) Cancer Res , vol.68 , pp. 6698-6707
    • Chen, K.F.1    Yeh, P.Y.2    Yeh, K.H.3    Lu, Y.S.4    Huang, S.Y.5    Cheng, A.L.6
  • 101
    • 66449131460 scopus 로고    scopus 로고
    • Bortezoomib overcomes tumor necorsis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway
    • Chen KF, Yeh PY, Hsu C, Hsu CH, Lu YS, Hsieh HP, et al. Bortezoomib overcomes tumor necorsis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2009;284:11121-33.
    • (2009) J Biol Chem , vol.284 , pp. 11121-11133
    • Chen, K.F.1    Yeh, P.Y.2    Hsu, C.3    Hsu, C.H.4    Lu, Y.S.5    Hsieh, H.P.6
  • 103
    • 77952085946 scopus 로고    scopus 로고
    • Randomized, phase I, and pharmacokinetic (PK) study of RAD001, an mTOR inhibitor, in patients (pts) with advanced hepatocelluar carcinoma (HCC)
    • abstract no. 4587
    • Chen L, Shiah HS, Chen CY, Lin YJ, Lin PW, Su WC, Chan JY. Randomized, phase I, and pharmacokinetic (PK) study of RAD001, an mTOR inhibitor, in patients (pts) with advanced hepatocelluar carcinoma (HCC). J Clin Oncol 2009;27 (Suppl; abstract no. 4587).
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Chen, L.1    Shiah, H.S.2    Chen, C.Y.3    Lin, Y.J.4    Lin, P.W.5    Su, W.C.6    Chan, J.Y.7
  • 104
    • 33745552897 scopus 로고    scopus 로고
    • Dysregulation of growth factor signaling in human hepatocellular carcinoma
    • DOI 10.1038/sj.onc.1209556, PII 1209556
    • Breuhahn K, Longerich T, Schirmacher P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene. 2006;25:3787-800. (Pubitemid 43980474)
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3787-3800
    • Breuhahn, K.1    Longerich, T.2    Schirmacher, P.3
  • 105
    • 44649116436 scopus 로고    scopus 로고
    • Growth factors as therapeutic targets in HCC
    • Furuse J. Growth factors as therapeutic targets in HCC. Crit Rev Oncol Hematol. 2008;67:8-15.
    • (2008) Crit Rev Oncol Hematol , vol.67 , pp. 8-15
    • Furuse, J.1
  • 108
    • 0037080265 scopus 로고    scopus 로고
    • HER-2/neu overexpression is rare in hepatocellular carcinoma and not predictive of anti-HER-2/neu regulation of cell growth and chemosensitivity
    • DOI 10.1002/cncr.10180
    • Hsu C, Huang CL, Hsu HC, Lee PH, Wang SJ, Cheng AL. HER- 2/neu overexpression is rare in hepatocellular carcinoma and not predictive of anti-HER-2/neu regulation of cell growth and chemosensitivity. Cancer. 2002;94:415-20. (Pubitemid 34081371)
    • (2002) Cancer , vol.94 , Issue.2 , pp. 415-420
    • Hsu, C.1    Huang, C.-L.2    Hsu, H.-C.3    Lee, P.-H.4    Wang, S.-J.5    Cheng, A.-L.6
  • 109
    • 19444379632 scopus 로고    scopus 로고
    • Absence of epidermal growth factor receptor exon 18-21 mutation in hepatocellular carcioma
    • Su MC, Lien HC, Jeng YM. Absence of epidermal growth factor receptor exon 18-21 mutation in hepatocellular carcioma. Cancer Lett. 2005;224:117-21.
    • (2005) Cancer Lett , vol.224 , pp. 117-121
    • Su, M.C.1    Lien, H.C.2    Jeng, Y.M.3
  • 112
    • 33750929534 scopus 로고    scopus 로고
    • Gefitinib in advanced unresectable hepatocellular carcinoma: Results from the Eastern Cooperative Oncology Group's Study E1203
    • abstract no. 4143
    • O'Dwyer PJ, Gianotonio BJ, Levy DE, Kauh JS, Fitzgerald DB, Benson AB. Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperative Oncology Group's Study E1203. J Clin Oncol. 2006;24 (Suppl; abstract no. 4143).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • O'Dwyer, P.J.1    Gianotonio, B.J.2    Levy, D.E.3    Kauh, J.S.4    Fitzgerald, D.B.5    Benson, A.B.6
  • 113
    • 70349443677 scopus 로고    scopus 로고
    • A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas
    • Bekaii-Saab T, Markowitz J, Prescott N, Sadee W, Heerema N, Wei L, et al. A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas. Clin Cancer Res. 2009;15:5895-901.
    • (2009) Clin Cancer Res , vol.15 , pp. 5895-5901
    • Bekaii-Saab, T.1    Markowitz, J.2    Prescott, N.3    Sadee, W.4    Heerema, N.5    Wei, L.6
  • 114
    • 58849086599 scopus 로고    scopus 로고
    • A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma
    • Gruenwald V, Wilkens L, Gebel M, Wirth T, Greten S, Kubicka MP, et al. A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma. J Clin Oncol. 2006;24:14079.
    • (2006) J Clin Oncol , vol.24 , pp. 14079
    • Gruenwald, V.1    Wilkens, L.2    Gebel, M.3    Wirth, T.4    Greten, S.5    Kubicka, M.P.6
  • 118
    • 41849105045 scopus 로고    scopus 로고
    • Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma
    • DOI 10.3748/wjg.14.1690
    • Breuhahn K, Schirmacher P. Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma. World J Gastroenterol. 2008;14:1690-8. (Pubitemid 351493375)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.11 , pp. 1690-1698
    • Breuhahn, K.1    Schirmacher, P.2
  • 119
    • 77949875878 scopus 로고    scopus 로고
    • IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage
    • Tovar V, Alsinet C, Villanueva A, Hoshida Y, Chiang DY, Sole M, et al. IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage. J Hepatol. 2010;52:550-9.
    • (2010) J Hepatol , vol.52 , pp. 550-559
    • Tovar, V.1    Alsinet, C.2    Villanueva, A.3    Hoshida, Y.4    Chiang, D.Y.5    Sole, M.6
  • 120
    • 0033065805 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: An immunohistochemical study
    • Okano J, Shiota G, Kawasaki H. Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver disease: an immunohistochemical study. Liver. 1999;19:151-9. (Pubitemid 29139769)
    • (1999) Liver , vol.19 , Issue.2 , pp. 151-159
    • Okano, J.-I.1    Shiota, G.2    Kawasaki, H.3
  • 121
    • 44349155339 scopus 로고    scopus 로고
    • Clinical significance of Serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma
    • Osada S, Kanematsu M, Imai H, Goshima S. Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma. Hepatogastroenterology. 2008;55:544-9. (Pubitemid 351741499)
    • (2008) Hepato-Gastroenterology , vol.55 , Issue.82-83 , pp. 544-549
    • Osada, S.1    Kanematsu, M.2    Imai, H.3    Goshima, S.4
  • 122
    • 4344683925 scopus 로고    scopus 로고
    • Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells
    • DOI 10.1016/j.jhep.2004.05.018, PII S016882780400306X
    • Chiba T, Yokosuka O, Arai M, Tada M, Fukai K, Imazeli E, et al. Identification of genes up-regulated by histone deaceetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells. J Hepatol. 2004;41:436-45. (Pubitemid 39158753)
    • (2004) Journal of Hepatology , vol.41 , Issue.3 , pp. 436-445
    • Chiba, T.1    Yokosuka, O.2    Arai, M.3    Tada, M.4    Fukai, K.5    Imazeki, F.6    Kato, M.7    Seki, N.8    Saisho, H.9
  • 123
    • 0037455825 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor trichostatin a induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells
    • DOI 10.1002/ijc.10699
    • Yamashita Y, Shimada M, Harimoto N, Rikimaru T, Shirabe K, Tanaka S, et al. Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. In J Cancer. 2003;103:572-6. (Pubitemid 36091459)
    • (2003) International Journal of Cancer , vol.103 , Issue.5 , pp. 572-576
    • Yamashita, Y.-I.1    Shimada, M.2    Harimoto, N.3    Rikimaru, T.4    Shirabe, K.5    Tanaka, S.6    Sugimachi, K.7
  • 125
    • 67650648501 scopus 로고    scopus 로고
    • Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma
    • Shirakawa H, Suzuki H, Shimomura M, Kojima M, Gotohda N, Takahashi S, et al. Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma. Cancer Sci. 2009;100:1403-7.
    • (2009) Cancer Sci , vol.100 , pp. 1403-1407
    • Shirakawa, H.1    Suzuki, H.2    Shimomura, M.3    Kojima, M.4    Gotohda, N.5    Takahashi, S.6
  • 126
    • 84897581120 scopus 로고    scopus 로고
    • Glypican 3 expression in human nonneoplastic, preneoplastic, and neoplastic tissues: A tissue microarray analysis of 4,387 tissue samples
    • Baumhoer D, Tornillo L, Stadimann S, Roncalli M, Diamantis EK, Terracciano LM. Glypican 3 expression in human nonneoplastic, preneoplastic, and neoplastic tissues: a tissue microarray analysis of 4,387 tissue samples. Am J Clin Pathol. 2008;29:1319-26.
    • (2008) Am J Clin Pathol , vol.29 , pp. 1319-1326
    • Baumhoer, D.1    Tornillo, L.2    Stadimann, S.3    Roncalli, M.4    Diamantis, E.K.5    Terracciano, L.M.6
  • 127
    • 69949129964 scopus 로고    scopus 로고
    • Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
    • Newell P, Toffanin S, Villanueva A, Chiang DY, Minguez B, Cabellos L, et al. Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J Hepatol. 2009;51:725-33.
    • (2009) J Hepatol , vol.51 , pp. 725-733
    • Newell, P.1    Toffanin, S.2    Villanueva, A.3    Chiang, D.Y.4    Minguez, B.5    Cabellos, L.6
  • 128
    • 67649715548 scopus 로고    scopus 로고
    • Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
    • Huynh H, Ngo VC, Koong HN, Poon D, Choo SP, Thng CH, et al. Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Cell Mol Med. 2009;13:2673-83.
    • (2009) J Cell Mol Med , vol.13 , pp. 2673-2683
    • Huynh, H.1    Ngo, V.C.2    Koong, H.N.3    Poon, D.4    Choo, S.P.5    Thng, C.H.6
  • 129
    • 69949106121 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: Rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma
    • Desbois-Mouthon C, Baron A, Blivet-Van Eggelpoel MJ, Fartoux L, Venot C, Bladt F, et al. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. Clin Cancer Res. 2009;15:5445-56.
    • (2009) Clin Cancer Res , vol.15 , pp. 5445-5456
    • Desbois-Mouthon, C.1    Baron, A.2    Blivet-Van Eggelpoel, M.J.3    Fartoux, L.4    Venot, C.5    Bladt, F.6
  • 131
    • 70349452270 scopus 로고    scopus 로고
    • Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/ extracellular signaling-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma
    • Ou DL, Shen YC, Liang JD, Liou JY, Yu SL, Fan HH, et al. Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/ extracellular signaling-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma. Clin Cancer Res. 2009;15:5820-8.
    • (2009) Clin Cancer Res , vol.15 , pp. 5820-5828
    • Ou, D.L.1    Shen, Y.C.2    Liang, J.D.3    Liou, J.Y.4    Yu, S.L.5    Fan, H.H.6
  • 132
    • 60849124241 scopus 로고    scopus 로고
    • Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma
    • Thomas MB, Morris JS, Chadha R, Iwasaki M, Kaur H, Lin E, et al. Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol. 2009;27:843-50.
    • (2009) J Clin Oncol , vol.27 , pp. 843-850
    • Thomas, M.B.1    Morris, J.S.2    Chadha, R.3    Iwasaki, M.4    Kaur, H.5    Lin, E.6
  • 133
    • 74549175296 scopus 로고    scopus 로고
    • Biological activity of bevacizumab and erlotinib in patients with advanced hepatocellular carcinoma (HCC)
    • abstract no. 4522
    • Kaseb AL, Iwasaki M, Javle M, Onicescu G, Garrett-Mayer E, Abbruzzese GL, et al. Biological activity of bevacizumab and erlotinib in patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol. 2009;27 (Suppl; abstract no. 4522).
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Kaseb, A.L.1    Iwasaki, M.2    Javle, M.3    Onicescu, G.4    Garrett-Mayer, E.5    Abbruzzese, G.L.6
  • 134
    • 84984556329 scopus 로고    scopus 로고
    • Phase II study of efficacy of bevacizumab and erlotinib in inoperable previously untreated hepatocellular carcinoma (HCC)
    • abstract no. 264
    • Govindarajan R, Siegel ER, Makhoul I, Williamson SK. Phase II study of efficacy of bevacizumab and erlotinib in inoperable previously untreated hepatocellular carcinoma (HCC). In: 2009 Gastrointestinal Cancers Symposium (abstract no. 264).
    • 2009 Gastrointestinal Cancers Symposium
    • Govindarajan, R.1    Siegel, E.R.2    Makhoul, I.3    Williamson, S.K.4
  • 135
    • 84897578822 scopus 로고    scopus 로고
    • A phase II study of bevacizumab (B) and erlotinib (E) in combination for Asian patients (pts) with advanced/metastatic hepatocellular carcinoma (HCC): An interim report
    • abstract no. 4585
    • Hsu C, Kang Y, Yang T, Su W, Sandoval-Tan J, Chiou T, et al. A phase II study of bevacizumab (B) and erlotinib (E) in combination for Asian patients (pts) with advanced/metastatic hepatocellular carcinoma (HCC): an interim report. J Clin Oncol. 2009;27 (Suppl; abstract no. 4585).
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Hsu, C.1    Kang, Y.2    Yang, T.3    Su, W.4    Sandoval-Tan, J.5    Chiou, T.6
  • 137
    • 59149085061 scopus 로고    scopus 로고
    • Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab
    • Yeo W, Chan TC, Leung NW, Lam WY, Mo FK, Chu MT, et al. Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab. J Clin Oncol. 2009;27:605-11.
    • (2009) J Clin Oncol , vol.27 , pp. 605-611
    • Yeo, W.1    Chan, T.C.2    Leung, N.W.3    Lam, W.Y.4    Mo, F.K.5    Chu, M.T.6
  • 138
    • 77953531899 scopus 로고    scopus 로고
    • HCV genotype 2 as a risk factor for reactivation in patients with B-cell lymphoma undergoing rituximab combination chemotherapy
    • Epub ahead of print
    • Pitini V, Sturniolo G, Arrigo C, Leonardi S, Pino S, Altavilla G. HCV genotype 2 as a risk factor for reactivation in patients with B-cell lymphoma undergoing rituximab combination chemotherapy. Br J Haematol. 2010. [Epub ahead of print].
    • (2010) Br J Haematol
    • Pitini, V.1    Sturniolo, G.2    Arrigo, C.3    Leonardi, S.4    Pino, S.5    Altavilla, G.6
  • 139
    • 77349124041 scopus 로고    scopus 로고
    • Current strategy for staging and treatment: The BCLC update and future prospects
    • Forner A, Reig ME, de Lope CR, Bruix J. Current strategy for staging and treatment: the BCLC update and future prospects. Semin Liver Dis. 2010;30:61-74.
    • (2010) Semin Liver Dis , vol.30 , pp. 61-74
    • Forner, A.1    Reig, M.E.2    De Lope, C.R.3    Bruix, J.4
  • 140
    • 71249126197 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma in Asia: Consensus statement from the Asian Oncology Summit 2009
    • Poon D, Anderson BO, Chen LT, Tanaka K, Lau WY, Van Cutsem E, et al. Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncol. 2009;10:1111-8.
    • (2009) Lancet Oncol , vol.10 , pp. 1111-1118
    • Poon, D.1    Anderson, B.O.2    Chen, L.T.3    Tanaka, K.4    Lau, W.Y.5    Van Cutsem, E.6
  • 141
    • 58849159660 scopus 로고    scopus 로고
    • Evidence-based clinical practice guidelines for hepatocellular carcinoma in Japan: The J-HCC guidelines
    • Kokudo N, Makuuchi M. Evidence-based clinical practice guidelines for hepatocellular carcinoma in Japan: the J-HCC guidelines. J Gastroenterol. 2009;44:119-21.
    • (2009) J Gastroenterol , vol.44 , pp. 119-121
    • Kokudo, N.1    Makuuchi, M.2
  • 142
    • 37149003891 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma in Japan: Consensus-based clinical practice manual proposed by the Japan Society of Hepatology
    • DOI 10.1159/000111702
    • Kudo M, Okanoue T. Management of hepatocellular carcinoma in Japan: consensus-based clinical practice manual proposed by the Japan Society of Hepatology. Oncology. 2007;72:2-15. (Pubitemid 350256660)
    • (2007) Oncology , vol.72 , Issue.SUPPL. 1 , pp. 2-15
    • Kudo, M.1    Okanoue, T.2
  • 143
    • 1242307281 scopus 로고    scopus 로고
    • Hepatectomy for hepatocellular carcinoma: Patient selection and postoperative outcome
    • Poon RT, Fan ST. Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome. Liver Transpl. 2004;10:S39-45. (Pubitemid 38240099)
    • (2004) Liver Transplantation , vol.10 , Issue.2 SUPPL. 1
    • Poon, R.T.-P.1    Fan, S.-T.2
  • 144
    • 79955617020 scopus 로고    scopus 로고
    • Prognostic values of baseline circulating endothelial progenitor level for advanced heaptocellular carcinoma (HCC) patients under anti-angiogenic therapy
    • abstract
    • Shao YY, Lin ZZ, Chen TJ, Hsu C, Shen YC, Hsu CH, Cheng AL. Prognostic values of baseline circulating endothelial progenitor level for advanced heaptocellular carcinoma (HCC) patients under anti-angiogenic therapy. J Clin Oncol. 2010;28 (abstract).
    • (2010) J Clin Oncol , pp. 28
    • Shao, Y.Y.1    Lin, Z.Z.2    Chen, T.J.3    Hsu, C.4    Shen, Y.C.5    Hsu, C.H.6    Cheng, A.L.7
  • 145
    • 84897583210 scopus 로고    scopus 로고
    • Circulating endothelial cells (CEC) and angiogenic proteins monitoring in patients (pts) with advanced hepatocellular carcinoma (HCC) treated with bevacizumab
    • abstract no. 4597
    • Booiege V, Baey C, Dromain C, Ducreux M, Malka D, Pignon J, et al. Circulating endothelial cells (CEC) and angiogenic proteins monitoring in patients (pts) with advanced hepatocellular carcinoma (HCC) treated with bevacizumab. J Clin Oncol. 2009;27 (Suppl; abstract no. 4597).
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Booiege, V.1    Baey, C.2    Dromain, C.3    Ducreux, M.4    Malka, D.5    Pignon, J.6
  • 146
    • 46949084994 scopus 로고    scopus 로고
    • Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: Tools or decorations?
    • DOI 10.1038/ncponc1150, PII NCPONC1150
    • Sessa C, Guibal A, Del Conte G, Ruegg C. Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations? Nat Rev Pract Oncol. 2008;5:378-91. (Pubitemid 351958963)
    • (2008) Nature Clinical Practice Oncology , vol.5 , Issue.7 , pp. 378-391
    • Sessa, C.1    Guibal, A.2    Del, C.G.3    Ruegg, C.4
  • 147
    • 74249092481 scopus 로고    scopus 로고
    • Biomarkers of angiogenesis and their role in the development of VEGF inhibitors
    • Murukesh N, Dive C, Jayson GC. Biomarkers of angiogenesis and their role in the development of VEGF inhibitors. Br J Cancer. 2010;102:8-18.
    • (2010) Br J Cancer , vol.102 , pp. 8-18
    • Murukesh, N.1    Dive, C.2    Jayson, G.C.3
  • 148
    • 33846478656 scopus 로고    scopus 로고
    • DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
    • DOI 10.1038/sj.bjc.6603515, PII 6603515
    • O'Connor JPB, Jackson A, Parker GJM, et al. DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. Br J Cancer. 2007;96:189-95. (Pubitemid 46160619)
    • (2007) British Journal of Cancer , vol.96 , Issue.2 , pp. 189-195
    • O'Connor, J.P.B.1    Jackson, A.2    Parker, G.J.M.3    Jayson, G.C.4
  • 151
    • 84897583120 scopus 로고    scopus 로고
    • Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict treatment outcomes for advanced hepatocellular carcinoma (HCC) patients who received sorafenib plus tegafur/uracil therapy
    • abstract no. 116
    • Shen YC, Hsu CY, Yu CW, Hsu C, Hsu CH, Cheng AL, et al. Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict treatment outcomes for advanced hepatocellular carcinoma (HCC) patients who received sorafenib plus tegafur/uracil therapy. J Hepatol. 2010;52 (Suppl 1):S52 (abstract no. 116).
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Shen, Y.C.1    Hsu, C.Y.2    Yu, C.W.3    Hsu, C.4    Hsu, C.H.5    Cheng, A.L.6
  • 153
    • 84897581866 scopus 로고    scopus 로고
    • Discordance of the immunohistochemical expression of phosphor-Akt and phosphor-ERK between paired biopsy and hepatectomy specimens of hepatocellular carcinoma
    • Abstract no. 3759
    • Shao YY, Chen CL, Huang CC, Tu HC, Lin ZZ, Hsu CH, et al. Discordance of the immunohistochemical expression of phosphor-Akt and phosphor-ERK between paired biopsy and hepatectomy specimens of hepatocellular carcinoma. In: AACR annual meeting 2010 (Abstract no. 3759).
    • AACR Annual Meeting 2010
    • Shao, Y.Y.1    Chen, C.L.2    Huang, C.C.3    Tu, H.C.4    Lin, Z.Z.5    Hsu, C.H.6
  • 161
    • 53049086329 scopus 로고    scopus 로고
    • Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
    • Chiang DY, Villanueva A, Hoshida Y, Peix J, Newell P, Minguez B, et al. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res. 2008;68:6779-88.
    • (2008) Cancer Res , vol.68 , pp. 6779-6788
    • Chiang, D.Y.1    Villanueva, A.2    Hoshida, Y.3    Peix, J.4    Newell, P.5    Minguez, B.6
  • 162
    • 33744502855 scopus 로고    scopus 로고
    • Cancer biomarkers - An invitation to the table
    • DOI 10.1126/science.1125948
    • Dalton WS, Friend SH. Cancer biomarkers - an invitation to the table. Science. 2006;312:1165-8. (Pubitemid 43801132)
    • (2006) Science , vol.312 , Issue.5777 , pp. 1165-1168
    • Dalton, W.S.1    Friend, S.H.2
  • 163
  • 165
    • 64649094395 scopus 로고    scopus 로고
    • Impact of sample acquisition and linear amplification on gene expression profiling of lung adenocarcinoma: Laser capure micro-dissection cell-sampling versus bulk tissue-sampling
    • Klee EW, Erdogan S, Tillmans L, Kosari F, Sun Z, Wigle DA. Impact of sample acquisition and linear amplification on gene expression profiling of lung adenocarcinoma: laser capure micro-dissection cell-sampling versus bulk tissue-sampling. BMC Med Genom. 2009;9:2-13.
    • (2009) BMC Med Genom , vol.9 , pp. 2-13
    • Klee, E.W.1    Erdogan, S.2    Tillmans, L.3    Kosari, F.4    Sun, Z.5    Wigle, D.A.6
  • 167
    • 70349739285 scopus 로고    scopus 로고
    • Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
    • Hoshida Y, Nijman SMB, Kobayashi M, Chan JA, Brunet JP, Chiang DY, et al. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res. 2009;69:7385-92.
    • (2009) Cancer Res , vol.69 , pp. 7385-7392
    • Hoshida, Y.1    Nijman, S.M.B.2    Kobayashi, M.3    Chan, J.A.4    Brunet, J.P.5    Chiang, D.Y.6
  • 168
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • DOI 10.1056/NEJM200104053441402
    • Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001;344:1038-42. (Pubitemid 32267973)
    • (2001) New England Journal of Medicine , vol.344 , Issue.14 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3    Resta, D.J.4    Reese, S.F.5    Ford, J.M.6    Capdeville, R.7    Talpaz, M.8
  • 170
    • 0036817874 scopus 로고    scopus 로고
    • Targeting the molecular pathophysiology of gastrointestinal stromal tumors with imatinib mechanisms, successes, and challenges to rational drug development
    • DOI 10.1016/S0889-8588(02)00052-7, PII S0889858802000527
    • Demetri GD. Targeting the molecular pathophysiology of gastrointestinal stromal tumors with imatinib. Mechanisms, successes, and challenges to rational drug development. Hematol Oncol Clin North Am. 2002;16:1115-24. (Pubitemid 35462917)
    • (2002) Hematology/Oncology Clinics of North America , vol.16 , Issue.5 , pp. 1115-1124
    • Demetri, G.D.1
  • 172
    • 33751295869 scopus 로고    scopus 로고
    • Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy
    • DOI 10.1158/1078-0432.CCR-06-1732
    • Meric-Bernstam F, Hung MC. Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy. Clin Cancer Res. 2006;12:6326-30. (Pubitemid 44799700)
    • (2006) Clinical Cancer Research , vol.12 , Issue.21 , pp. 6326-6330
    • Meric-Bernstam, F.1    Hung, M.-C.2


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