Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway

Journal of Biological Chemistry

Volumn 284, Issue 17, 2009, Pages 11121-11133

  Chen, Kuen Feng ^a   Yeh, Pei Yen ^a   Hsu, Chiun ^a   Hsu, Chih Hung ^a   Lu, Yen Shen ^b   Hsieh, Hsing Pang ^a   Chen, Pei Jer ^a   Cheng, Ann Lii ^a,b,c  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c NONE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; GLYCOPROTEINS; LIGANDS; MACROPHAGES; NUCLEIC ACIDS; RNA; TUMORS;

ANTI-TUMOR AGENTS; APOPTOSIS; BORTEZOMIB; DOWN-REGULATION; ECTOPIC EXPRESSIONS; HEPATOCELLULAR CARCINOMA; HEPATOCELLULAR CARCINOMA CELL; HUH-7 CELLS; HUMAN MALIGNANCIES; INDUCED APOPTOSIS; LY294002; MOLECULAR CHANGES; OKADAIC ACID; PHOSPHATIDYLINOSITOL; PROTEASOME INHIBITORS; PROTEIN PHOSPHATASE 2A; SMALL INTERFERENCE RNA; TIME-DEPENDENT; TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGANDS;

CELL MEMBRANES;

BORTEZOMIB; CASPASE 3; CASPASE 8; CASPASE 9; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEIN KINASE B; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; 2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; MORPHOLINE DERIVATIVE; PYRAZINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG RESISTANCE; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; RNA INTERFERENCE; UPREGULATION; BIOSYNTHESIS; DOSE RESPONSE; DRUG ANTAGONISM; LIVER TUMOR; METABOLISM; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BORONIC ACIDS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; LIVER NEOPLASMS; MORPHOLINES; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZINES; RNA, SMALL INTERFERING; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 66449131460     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806268200     Document Type: Article

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