-
1
-
-
52449089987
-
Thirty years of Alzheimer's disease genetics: The implications of systematic meta-analyses
-
Bertram L, Tanzi RE (2008) Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci 9, 768-778.
-
(2008)
Nat Rev Neurosci
, vol.9
, pp. 768-778
-
-
Bertram, L.1
Tanzi, R.E.2
-
2
-
-
13944276825
-
Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
-
Tanzi RE, Bertram L (2005) Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120, 545-555.
-
(2005)
Cell
, vol.120
, pp. 545-555
-
-
Tanzi, R.E.1
Bertram, L.2
-
3
-
-
0023109592
-
Amyloid beta protein gene: CDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
-
Tanzi RE, Gusella JF, Watkins PC, Brans GA, St George-Hyslop P, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL (1987) Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235, 880-884.
-
(1987)
Science
, vol.235
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
Brans, G.A.4
St George-Hyslop, P.5
Van Keuren, M.L.6
Patterson, D.7
Pagan, S.8
Kurnit, D.M.9
Neve, R.L.10
-
4
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298, 789-791.
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
5
-
-
18244389436
-
The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease
-
Gandy S (2005) The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. J Clin Invest 115, 1121-1129.
-
(2005)
J Clin Invest
, vol.115
, pp. 1121-1129
-
-
Gandy, S.1
-
6
-
-
77949730091
-
Therapeutic targeting of the alpha-secretase pathway to treat Alzheimer's disease
-
Saunders AJ
-
Zhang C, Saunders AJ (2007) Therapeutic targeting of the alpha-secretase pathway to treat Alzheimer's disease. Discov Med 7, 113-117.
-
(2007)
Discov Med
, vol.7
, pp. 113-117
-
-
Zhang, C.1
-
7
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
8
-
-
0033595706
-
Beta-secretase cleavage ofAlzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinki, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
9
-
-
0038664363
-
Reconstitution of gamma-secretase activity
-
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C (2003) Reconstitution of gamma-secretase activity. Nat Cell Biol 5, 486-488.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
10
-
-
0036548070
-
Gamma-Secretase, Notch, Abeta and Alzheimer's disease: Where do the prese-nilins fit in?
-
Sisodia SS, St George-Hyslop PH (2002) gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the prese-nilins fit in? Nat Rev Neurosci 3, 281-290.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 281-290
-
-
Sisodia, S.S.1
St George-Hyslop, P.H.2
-
11
-
-
33947529531
-
RNA interference silencing ofthe adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation
-
Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE (2007) RNA interference silencing ofthe adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem 282, 4318-4325.
-
(2007)
J Biol Chem
, vol.282
, pp. 4318-4325
-
-
Xie, Z.1
Dong, Y.2
Maeda, U.3
Xia, W.4
Tanzi, R.E.5
-
12
-
-
17644409092
-
RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing
-
Xie Z, Romano DM, Tanzi RE (2005) RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing. J Biol Chem 280, 15413-15421.
-
(2005)
J Biol Chem
, vol.280
, pp. 15413-15421
-
-
Xie, Z.1
Romano, D.M.2
Tanzi, R.E.3
-
13
-
-
77950557873
-
Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein
-
Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. J Biol Chem 285, 8515-8526.
-
J Biol Chem
, vol.285
, pp. 8515-8526
-
-
Zhang, C.1
Browne, A.2
Child, D.3
Divito, J.R.4
Stevenson, J.A.5
Tanzi, R.E.6
-
14
-
-
77956498654
-
Curcumin decreases amyloid beta-peptide levels by attenuating the maturation of amyloid-beta precursor protein
-
Zhang C, Browne A, Child D, Tanzi RE (2010) Curcumin decreases amyloid beta-peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem 285, 28472-28480.
-
(2010)
J Biol Chem
, vol.285
, pp. 28472-28480
-
-
Zhang, C.1
Browne, A.2
Child, D.3
Tanzi, R.E.4
-
15
-
-
34948867875
-
HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endo-plasmic reticulum-associated degradation
-
Huttunen HJ, Guenette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM (2007) HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endo-plasmic reticulum-associated degradation. J Biol Chem 282, 28285-28295.
-
(2007)
J Biol Chem
, vol.282
, pp. 28285-28295
-
-
Huttunen, H.J.1
Guenette, S.Y.2
Peach, C.3
Greco, C.4
Xia, W.5
Kim, D.Y.6
Barren, C.7
Tanzi, R.E.8
Kovacs, D.M.9
-
16
-
-
36048978614
-
An AICD-based Functional Screen to Identify APP Metabolism Regulators
-
Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ (2007) An AICD-based Functional Screen to Identify APP Metabolism Regulators. Mol Neurodegener 2, 15.
-
(2007)
Mol Neurodegener
, vol.2
, pp. 15
-
-
Zhang, C.1
Khandelwal, P.J.2
Chakraborty, R.3
Cuellar, T.L.4
Sarangi, S.5
Patel, S.A.6
Cosentino, C.P.7
O'Connor, M.8
Lee, J.C.9
Tanzi, R.E.10
Saunders, A.J.11
-
17
-
-
33845942219
-
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion
-
Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE (2006) Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem 281, 32240-32253.
-
(2006)
J Biol Chem
, vol.281
, pp. 32240-32253
-
-
Hiltunen, M.1
Lu, A.2
Thomas, A.V.3
Romano, D.M.4
Kim, M.5
Jones, P.B.6
Xie, Z.7
Kounnas, M.Z.8
Wagner, S.L.9
Berezovska, O.10
Hyman, B.T.11
Tesco, G.12
Bertram, L.13
Tanzi, R.E.14
-
18
-
-
77949728358
-
Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage
-
Zhang C, Browne A, Kim DY, Tanzi RE (2010) Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage. Curr Alzheimer Res 7, 21-26.
-
(2010)
Curr Alzheimer Res
, vol.7
, pp. 21-26
-
-
Zhang, C.1
Browne, A.2
Kim, D.Y.3
Tanzi, R.E.4
-
19
-
-
33750002577
-
Statins inhibit the dimerization of beta-secretase via both isoprenoid-and cholesterol-mediated mechanisms
-
Parsons RB, Price GC, Farrant JK, Subramaniam D, Adeagbo-Sheikh J, Austen BM (2006) Statins inhibit the dimerization of beta-secretase via both isoprenoid-and cholesterol-mediated mechanisms. Biochem J 399, 205-214.
-
(2006)
Biochem J
, vol.399
, pp. 205-214
-
-
Parsons, R.B.1
Price, G.C.2
Farrant, J.K.3
Subramaniam, D.4
Adeagbo-Sheikh, J.5
Austen, B.M.6
-
20
-
-
16944365745
-
Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins
-
Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ (1997) Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem 272, 7977-7982.
-
(1997)
J Biol Chem
, vol.272
, pp. 7977-7982
-
-
Xia, W.1
Zhang, J.2
Kholodenko, D.3
Citron, M.4
Podlisny, M.B.5
Teplow, D.B.6
Haass, C.7
Seubert, P.8
Koo, E.H.9
Selkoe, D.J.10
-
21
-
-
0032524865
-
Subcellular distribution and turnover of presenilins in transfected cells
-
Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH (1998) Subcellular distribution and turnover of presenilins in transfected cells. J Biol Chem 273, 12436-12442.
-
(1998)
J Biol Chem
, vol.273
, pp. 12436-12442
-
-
Zhang, J.1
Kang, D.E.2
Xia, W.3
Okochi, M.4
Mori, H.5
Selkoe, D.J.6
Koo, E.H.7
-
22
-
-
0028866435
-
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
-
Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ (1995) The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med 1, 1291-1296.
-
(1995)
Nat Med
, vol.1
, pp. 1291-1296
-
-
Haass, C.1
Lemere, C.A.2
Capell, A.3
Citron, M.4
Seubert, P.5
Schenk, D.6
Lannfelt, L.7
Selkoe, D.J.8
-
23
-
-
0033401526
-
Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts
-
Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, Schutte M, Gordon R, Holstein GR, Martinelli G, MehtaP, Friedrich VL, Jr., Robakis NK (1999) Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol Cell 4, 893-902.
-
(1999)
Mol Cell
, vol.4
, pp. 893-902
-
-
Georgakopoulos, A.1
Marambaud, P.2
Efthimiopoulos, S.3
Shioi, J.4
Cui, W.5
Li, H.C.6
Schutte, M.7
Gordon, R.8
Holstein, G.R.9
Martinelli, G.10
Mehta, P.11
Friedrich Jr., V.L.12
Robakis, N.K.13
-
24
-
-
59049101595
-
P120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide
-
Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis NK (2009) p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide. J Biol Chem 284, 1954-1961.
-
(2009)
J Biol Chem
, vol.284
, pp. 1954-1961
-
-
Kouchi, Z.1
Barthet, G.2
Serban, G.3
Georgakopoulos, A.4
Shioi, J.5
Robakis, N.K.6
-
25
-
-
27744531603
-
Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability
-
Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK (2005) Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability. J Biol Chem 280, 36007-36012.
-
(2005)
J Biol Chem
, vol.280
, pp. 36007-36012
-
-
Serban, G.1
Kouchi, Z.2
Baki, L.3
Georgakopoulos, A.4
Litterst, C.M.5
Shioi, J.6
Robakis, N.K.7
-
26
-
-
18344380083
-
Apresenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
-
Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK (2002) Apresenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBOJ 21, 1948-1956.
-
(2002)
EMBOJ
, vol.21
, pp. 1948-1956
-
-
Marambaud, P.1
Shioi, J.2
Serban, G.3
Georgakopoulos, A.4
Sarner, S.5
Nagy, V.6
Baki, L.7
Wen, P.8
Efthimiopoulos, S.9
Shao, Z.10
Wisniewski, T.11
Robakis, N.K.12
-
27
-
-
0030760544
-
Cell confluence regulates tyrosine phos-phorylation of adherens junction components in endothelial cells
-
Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (1997) Cell confluence regulates tyrosine phos-phorylation of adherens junction components in endothelial cells. J Cell Sci 110 (Pt 17), 2065-2077.
-
(1997)
J Cell Sci
, vol.110
, Issue.PART 17
, pp. 2065-2077
-
-
Lampugnani, M.G.1
Corada, M.2
Andriopoulou, P.3
Esser, S.4
Risau, W.5
Dejana, E.6
-
28
-
-
0033895709
-
Wnt signaling and cancer
-
Polakis P (2000) Wnt signaling and cancer. Genes Dev 14, 1837-1851.
-
(2000)
Genes Dev
, vol.14
, pp. 1837-1851
-
-
Polakis, P.1
-
29
-
-
33845350346
-
The ups and downs of Wnt signaling in prevalent neurological disorders
-
De Ferrari GV, Moon RT (2006) The ups and downs of Wnt signaling in prevalent neurological disorders. Oncogene 25, 7545-7553.
-
(2006)
Oncogene
, vol.25
, pp. 7545-7553
-
-
De Ferrari, G.V.1
Moon, R.T.2
-
30
-
-
44049089139
-
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling
-
Magdesian MH, Carvalho MM, Mendes FA, Saraiva LM, Juliano MA, Juliano L, Garcia-Abreu J, Ferreira ST (2008) Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem 283, 9359-9368.
-
(2008)
J Biol Chem
, vol.283
, pp. 9359-9368
-
-
Magdesian, M.H.1
Carvalho, M.M.2
Mendes, F.A.3
Saraiva, L.M.4
Juliano, M.A.5
Juliano, L.6
Garcia-Abreu, J.7
Ferreira, S.T.8
|