CHIP-dependent p53 regulation occurs specifically during cellular senescence

Free Radical Biology and Medicine

Volumn 50, Issue 1, 2011, Pages 157-165

  Sisoula, Christina ^a   Trachana, Varvara ^a   Patterson, Cam ^b   Gonos, Efstathios S ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Aging; CHIP ligase; Degradation; Free radicals; p53; Replicative senescence; Ubiquitin proteasome system

Indexed keywords

CHAPERONE; PROTEIN CHIP; PROTEIN MDM2; PROTEIN P53; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; DOWN REGULATION; FIBROBLAST; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SENESCENCE; UBIQUITINATION; UPREGULATION;

ANIMALS; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; FIBROBLASTS; HUMANS; MICE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-MDM2; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

MUS;

EID: 78650682540     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.10.701     Document Type: Article

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