Radiosynthesis of 7-chloro-N,N-dimethyl-5-[11C]methyl-4-oxo-3- phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, [11C] SSR180575, a novel radioligand for imaging the TSPO (peripheral benzodiazepine receptor) with PET

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 53, Issue 13, 2010, Pages 767-773

  Thominiaux, Cyrille ^a   Damont, Annelaure ^a   Kuhnast, Bertrand ^a   Demphel, Stéphane ^a   Le Helleix, Stéphane ^a   Boisnard, Sabine ^b   Rivron, Luc ^b   Chauveau, Fabien ^a,c,e,f   Boutin, Hervé ^a,c,g   Van Camp, Nadia ^a,c   Boisgard, Raphaél ^a,c   Roy, Sébastien ^b   Allen, John ^b   Rooney, Thomas ^b   Benavides, Jesus ^b   Hantraye, Philippe ^d   Tavitian, Bertrand ^a   Dollé, Frédéric ^a  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^b SANOFI   (France)

^c INSERM   (France)

^d DIF   (France)

^e CNRS   (France)

^f UNIVERSITÉ DE LYON   (France)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

carbon 11; methylation; PBR; SSR180575; TSPO 18 Da

Indexed keywords

ALKYLATION; CARBON; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEAD COMPOUNDS; POLYCYCLIC AROMATIC HYDROCARBONS; POTASH;

BENZODIAZEPINES; CARBON-11; PBR; PRODUCTION BATCHES; RADIOCHEMICAL YIELD; RADIOLIGANDS; RADIOSYNTHESIS; SSR180575; TRIMETHYL; TSPO 18 DA;

PURIFICATION;

7 CHLORO N,N,5 TRIMETHYL 4 OXO 3 PHENYL 3,5 DIHYDRO 4H PYRIDAZINO[4,5 B]INDOLE 1 ACETAMIDE C 11; BENZODIAZEPINE RECEPTOR; N,N DIMETHYLACETAMIDE; RADIOISOTOPE; RADIOLIGAND; RADIOPHARMACEUTICAL AGENT; SSR 180575; UNCLASSIFIED DRUG; ZORBAX;

ARTICLE; CYCLOTRON; DRUG STRUCTURE; DRUG SYNTHESIS; HEATING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; METHYLATION; NERVOUS SYSTEM INFLAMMATION; POSITRON; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RADIOCHEMISTRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 78650647537     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1794     Document Type: Article

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