Synthesis and receptor binding studies of halogenated N,N-dialkylel-(2-phenyl-1H-indol-3-yl)glyoxylamides to visualize peripheral benzodiazepine receptors with SPECT or PET

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 22, 2006, Pages 7582-7591

  Bennacef, Idriss ^a   Haile, Colin N ^a   Schmidt, Anne ^d   Koren, Andrei O ^c   Seibyl, John P ^a   Staley, Julie K ^a   Bois, Frederic ^a   Baldwin, Ronald M ^b   Tamagnan, Gilles ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c INSTITUTE FOR NEURODEGENERATIVE DISORDERS   (United States)

^d PFIZER INC   (United States)

Author keywords

Arylindolyloxocarboxamides; PBR; Peripheral benzodiazepine receptor; PET; SPECT

Indexed keywords

2 [2 (3 IODOPHENYL) 1H INDOL 3 YL] N,N BIS(2 METHOXYETHYL) 2 OXOACETAMIDE; 2 [2 (4 IODOPHENYL) 1H INDOL 3 YL] N,N BIS(2 METHOXYETHYL) 2 OXOACETAMIDE; AMIDE; BENZODIAZEPINE RECEPTOR; N BENZYL 2 [2 (4 IODOPHENYL) 1H INDOL 3 YL] 2 OXOACETAMIDE; N BENZYL 2 [2 (6 FLUOROPYRIDIN 3 YL) 1H INDOL 3 YL] 2 OXOACETAMIDE; N,N DIBUTYL 2 [2 (2 IODOPHENYL) 1H INDOL 3 YL] 2 OXOACETAMIDE; N,N DIBUTYL 2 [2 (3 IODOPHENYL) 1H INDOL 3 YL] 2 OXOACETAMIDE; N,N DIBUTYL 2 [2 (4 IODOPHENYL) 1H INDOL 3 YL] 2 OXOACETAMIDE; N,N DIBUTYL 2 [2 (6 FLUOROPYRIDIN 3 YL) 1H INDOL 3 YL] 2 OXOACETAMIDE; N,N DIBUTYL 2 [2 (6 IODOPYRIDIN 2 YL) 1H INDOL 3 YL) 2 OXOACETAMIDE; N,N DIETHYL 2 [2 (2 IODOPHENYL) 1H INDOL 3 YL] 2 OXOACETAMIDE; N,N DIETHYL 2 [2 (3 IODOPHENYL) 1H INDOL 3 YL] 2 OXOACETAMIDE; N,N DIETHYL 2 [2 (4 IODOPHENYL) 1H INDOL 3 YL] 2 OXOACETAMIDE; N,N DIHEXYL 2 [2 (4 IODOPHENYL) 1H INDOL 3 YL] 2 OXOACETAMIDE; N,N HEXYL 2 [2 (6 FLUOROPYRIDIN 3 YL) 1H INDOL 3YL] 2 OXOACETAMIDE; RADIOLIGAND; UNCLASSIFIED DRUG;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; FLUORINATION; HALOGENATION; IN VITRO STUDY; IODINATION; LIPOPHILICITY; POSITRON EMISSION TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ALKYLATION; AMIDES; ANIMALS; CEREBRAL CORTEX; GUINEA PIGS; HALOGENS; INDOLES; KIDNEY; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 33749268183     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.001     Document Type: Article

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