Imaging of peripheral-type benzodiazepine receptor in tumor: in vitro binding and in vivo biodistribution of N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

Nuclear Medicine and Biology

Volumn 36, Issue 7, 2009, Pages 801-809

  Yamasaki, Tomoteru ^a   Kumata, Katsushi ^a   Yanamoto, Kazuhiko ^a   Hatori, Akiko ^a   Takei, Makoto ^b   Nakamura, Yukio ^b   Koike, Sachiko ^a   Ando, Koichi ^a   Suzuki, Kazutoshi ^a   Zhang, Ming Rong ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b Department of Engineering and Environment   (Japan)

Author keywords

11C DAC; NFSa; PBR; PET; Tumor imaging

Indexed keywords

BENZODIAZEPINE RECEPTOR; CARBON 11; LIGAND; METHYL IODIDE; N BENZYL N METHYL 2 (7 METHYL 8 OXO 2 PHENYL 7,8 DIHYDRO 9H PURIN 9 YL)ACETAMIDE C 11; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; FIBROSARCOMA; GLIOMA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; TUMOR CELL LINE;

ACETAMIDES; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; IMMUNOHISTOCHEMISTRY; ISOQUINOLINES; MALE; MICE; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PURINES; RADIOCHEMISTRY; RATS; RECEPTORS, GABA; RECEPTORS, GABA-A; TISSUE DISTRIBUTION;

EID: 69249217781     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2009.05.002     Document Type: Article

References (35)

1. Diederichs C.G., Staib G., Glatting G., Beger H.G., and Reske S.N. FDG PET: elevated plasma glucose reduces both uptake and detection rate of pancreatic malignancies. J Nucl Med 39 (1998) 1030-1033
2. Braestrup C., Albrechtsen R., and Squires R.F. High densities of benzodiazepine receptors in human cortical areas. Nature 269 (1977) 702-704
3. Papadopoulos V., Baraldi M., Guilarte T.R., Knudsen T.B., Lacapère L.L., Lindemann P., et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Pharmacol Sci 27 (2006) 402-409
4. -affinity binding of Peripheral benzodiazepine receptor ligands to brain tumors in rat and man. Cancer 65 (1990) 93-97
5. Cornu P., Benavides J., Scatton B., Hauw J.J., and Philippon J. Increase in omega 3 (Peripheral-type benzodiazepine) binding site densities in different types of human brain tumors. A quantitative autoradiography study. Acta Neurochir 19 (1992) 146-152
6. Miettinen H., Kononen J., Haapasalo H., Helén P., Sallinen P., Harjunausta T., et al. Expression of peripheral-type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: relationship to cell proliferation. Cancer Res 5 (1995) 2691-2695
7. Hardwick M., Fertikh D., Culty M., Li H., Vidic B., and Papadopulos V. Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol. Cancer Res 59 (1999) 831-842
8. Galiègue S., Casellas P., Kramar A., Tinel N., and Lafontaine J.S. Immunohistochemical assessment of the peripheral benzodiazepine receptor in breast cancer and its relationship with survival. Clin Cancer Res 10 (2004) 2058-2064
9. Katz Y., Eitan A., and Gavish M. Increase in peripheral benzodiazepine binding sites in colonic adenocarcinoma. Oncology 47 (1990) 139-142
10. Deane N.G., Manning H.C., Foutch A.C., Washington M.K., Aronow B.A., Bornhop D.J., et al. Targeted imaging of colonic tumors in smad3/mice discriminates cancer and inflammation. Mol Cancer Res 5 (2007) 341-349
11. Venturini I., Zeneroli M.L., Corsi L., Avallone R., Farina F., Alho H., et al. Up-regulation of peripheral benzodiazepine receptor system in hepatocellular carcinoma. Life Sci 63 (1998) 1269-1280
12. Costa B., Salvetti A., Rosssi L., Spinetti F., Lena A., Chelli B., et al. Peripheral benzodiazepine receptor: characterization in human T-lymphoma jurkat cells. Mol Pharmacol 69 (2006) 37-44
13. 3H]PK-11195 binding in mouse fibrosarcoma. Nucl Med Biol 33 (2006) 797-800
14. Santidrian A.F., Cosialls A.M., Coll-Mulet L., Iglesoas-Serret D., de Frias M., Gonzáles-Gironès D.M., et al. The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia cells. Haematologica 92 (2007) 1631-1638
15. Furre I.E., Shahzidi S., Luksiene Z., Møller M.T., Borqen E., Morgan J., et al. Targeting PBR by hexaminolevulinate-mediated photodynamic therapy induces apoptosis through translocation of apoptosis-inducing factor in human leukemia cells. Cancer Res 65 (2005) 11051-11060
16. Walter R.B., Pirga J.L., Cronk M.R., Mayer S., Appelbaum F.R., and Banker D.E. PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism. Blood 106 (2005) 3584-3593
17. Pappata S., Cornu P., Samson Y., Prenant C., Benavides J., Scatton B., et al. PET study of carbon-11-PK11195 binding to peripheral type benzodiazepine sites in glioblastoma: a case report. J Nucl Med 32 (1991) 1608-1610
18. Kita A., Kohayakawa H., Kinoshita T., Ochi Y., Nakamichi K., Kurumiya S., et al. Antianxienty and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Bri J Phamacol 142 (2004) 1059-1072
19. Amitani M., Zhang M.R., Noguchi J., Kumata K., Ito T., Takai N., et al. Blood flow dependence of the intratumoral distribution of peripheral benzodiazepine receptor binding in intact mouse fibrosarcoma. Nucl Med Biol 33 (2006) 971-975
20. Zhang M.R., Kumata K., Maeda J., Yanamoto K., Hatori A., Okada M., et al. 11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain. J Nucl Med 48 (2007) 1853-1861
21. Manning H.C., Smith S.M., Sexton M., Haviland S., Bai M., Cederquist K., et al. A peripheral benzodiazepine receptor targeted agent for in vitro imaging and screening. Bioconjug Chem 17 (2006) 735-740
22. Kozikowski A.P., Kotoula M., Ma D., Boujrad N., Tückmantel W., and Papadopoulos V. Synthesis and biology of a 7-nitro-2,1,3-benaoxadiazol-4-yl derivative of 2-phenylindole-3-acetamide: a fluorescent probe for the peripheral-type benzodiazepine receptor. J Med Chem 40 (1997) 2435-2439
23. Murata A, Masumoto K, Kondo K, Furukawa K, Oka M. inventors; Dainippon Sumitomo Pharma Co., Ltd., assignee. February 20, 2001. 2-Aryl-8-oxodihydropurine derivatives. Japanese patent JP 2001-48882A.
24. Ando K., Koike S., and Sato S. Nonlinear survival curves for cells of solid tumors after large doses of fast neutrons and γ rays. Radiat Res 131 (1992) 157-161
25. Ji B., Maeda J., Sawada M., Ono M., Okauchi T., Inaji M., et al. Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. J Neurosci 28 (2008) 12255-12267
26. Keyes J.W. SUV: standard uptake or silly useless value?. J Nucl Med 36 (1995) 1836-1839
27. 11C-PK11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography. Annal Nucl Med 3 (1989) 63-71
28. Tsujii H., Morita S., Miyamoto T., Mizoe J., Mukai M., Nakano T., et al. Preliminary results of phase I/II carbon-ion therapy at the national institute of radiation sciences. J Brachythera Int 13 (1997) 1-8
29. Ando K., Koike S., Ohira C., Chen Y.J., Nojima K., Ando S., et al. Accelerated reoxygenation of a murine fibrosarcoma after carbon-ion radiation. Int J Radiat Biol 75 (1999) 505-512
30. Koike S., Ando K., Oohira C., Fukawa T., Lee R., Takai N., et al. Relative biological effectiveness of 290 MeV/u carbon ions for the growth delay of a radioresistant murine fibrosarcoma. J Radiat Res 43 (2002) 247-255
31. Ando K., Koike S., Uzawa A., Takai N., Fukawa T., Furusawa Y., et al. Biological gain of carbon-ion radiation for the early response of tumor growth delay and against early response of skin reaction in mice. J Radiat Res 46 (2005) 51-57
32. Gavish M., Bachman I., and Shoukrun R. Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev 51 (1999) 629-650
33. Anholt R.R., De Souza E.B., Oster-Granite M.L., and Synder S.H. Peripheral-type benzodiazepine receptors: autoradiographic localization in whole-body sections of neonatal rats. J Pharmacol Exp Ther 233 (1985) 517-526
34. 11C]DAA1106: radiosynthesis and in vivo binding to peripheral benzodiazepine receptors in mouse brain. Nucl Med Biol 30 (2003) 513-519
35. 11C]methionine positron emission tomography and survival in patients with bone and soft tissue sarcomas treated by carbon ion radiotherapy. Clin Cancer Res 10 (2004) 1764-1772