Methylation of amide and thiol functions with [11C]methyl triflate, as exemplified by [11C]NMSP, [11C]flumazenil and [11C]methionine

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 41, Issue 9, 1998, Pages 831-841

  Någren, Kjell ^a   Halldin, Christer ^b  

^a TURKU PET CENTRE   (Finland)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

11C methionine; 11C NMSP; 11C lMethyl triffate; ltC flumazenil

Indexed keywords

ALKYLATION; AMIDES; AMINO ACIDS; SODIUM HYDROXIDE;

METHIONINE; METHYL IODIDE; METHYL TRIFLATES; PET RADIOLIGAND; RADIOCHEMICAL YIELD; THIOL FUNCTIONS; [11C]LMETHYL TRIFFATE; [11C]METHIONINE; [11C]NMSP; [LTC]FLUMAZENIL;

METHYLATION;

3 METHYLSPIPERONE; CARBON 11; FLUMAZENIL; METHIONINE; RO 15 5528; TRIFLUOROMETHANESULFONIC ACID METHYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG BINDING; DRUG PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LIGAND BINDING; METHYLATION; POSITRON EMISSION TOMOGRAPHY; STRUCTURE ACTIVITY RELATION; TEMPERATURE SENSITIVITY;

EID: 0031658664     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(1998090)41:9<831::AID-JLCR129>3.0.CO;2-E     Document Type: Article

References (18)

1. Långström B. and Lundqvist H. - Int. J. Appl. Radiat. Isot. 27, 357, (1976)
2. Marazano C., Maziere M., Berger G. and Comar D. - Int. J. Appl. Radiat. Isot. 28, 49, (1977)
3. Jewett D. M. - Appl. Radiat. Isot. 43, 1383, (1992)
4. Någren K., Müller L., Halldin C., Swahn C.-G. and Lehikonen P. - Nucl. Med. Biol. 22, 235, (1995)
5. Någren K., Halldin C., Müller L., Swahn C.-G. and Lehikonen P. - Nucl. Med. Biol. 22, 965, (1995)
6. Chakraborty P. K., Gildersleeve D. L., Jewett D. M., Toorongian S. A., Kilbourn M. R., Schwaiger M. and Wieland D. M. - Nucl. Med. Biol. 20, 939, (1993)
7. Bender D., Holschbach M. and Stöcklin G. - Nucl. Med. Biol. 21, 921, (1994)
8. Jewett, D.M. and Chakraborty, P.K. - J. Labelled Cmpd. Radiopharm. 35, 97, (1994)
9. Holschbach M. Schüller M., Bender D., Roden W. and Stöcklin G. - J. Nucl. Med, 34, 68P, (1993), abstract
10. Lundkvist C., Sandell J., Någren K., Pike V.W. and Halldin C. - J. Labelled Cmpd. Radiopharm. (in press, 1998)
11. Dannals R.F., Ravert H.T., Wilson A.A. and Wagner H.N. Jr. - Appl. Radiat. Isot. 37, 433, (1986)
12. Nyberg S., Farde L. and Halldin C. - Neuropsychopharmacol. 16, 1, (1997)
13. Maziere M., Hantraye P., Prenant C., Sastre J. and Comar, D. - Int. J. Appl. Radiat. Isot. 35, 973, (1984)
14. Halldin C., Stone-Elander S., Thorell J.-O., Persson A. and Sedvall G. - Appl. Radiat. Isot. 22, 993, (1988)
15. Comar D., Cartron J.-C., Maziere M. and Marazano C. - Eur. J. Nucl. Med. 1, 11, (1976)
16. Långström B., Antoni G., Gullberg P., Halldin C., Malmborg P., Någren K, Rimland A. and Svärd H. - J. Nucl. Med. 28, 1037 (1987)
17. Någren, K. - In: PET studies on amino acid metabolism and protein synthesis, B.M. Mazoyer, W.D. Heiss & D. Comar (eds), Kluwer Academic Publishers, Dordrecht, p. 81, (1993)
18. Ishiwata K., Ido T. and Vaalburg W. - Appl. Radiat. Isot. 39, 311, (1988)