메뉴 건너뛰기




Volumn 193, Issue 1-2, 2010, Pages 98-113

The cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cells

Author keywords

Breast cancer; C Abl; Epithelial mesenchymal transition; Metastasis; Signal transduction; Transforming growth factor

Indexed keywords

ABELSON KINASE; CAPECITABINE; EPHRIN B2; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GELATINASE A; IMATINIB; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; RECOMBINANT SOMATOMEDIN C; SCATTER FACTOR; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA;

EID: 78650517027     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000320163     Document Type: Article
Times cited : (23)

References (102)
  • 1
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis
    • Agami, R., G. Blandino, M. Oren, Y. Shaul (1999) Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature 399:809-813.
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1    Blandino, G.2    Oren, M.3    Shaul, Y.4
  • 2
    • 72749120841 scopus 로고    scopus 로고
    • Activated Abl kinase inhibits oncogenic TGF-β signaling and tumorigenesis in mammary tumors
    • Allington, T. M., A. J. Galliher-Beckley, W. P. Schiemann (2009) Activated Abl kinase inhibits oncogenic TGF-β signaling and tumorigenesis in mammary tumors. FASEB J 23:4231-4243.
    • (2009) FASEB J. , vol.23 , pp. 4231-4243
    • Allington, T.M.1    Galliher-Beckley, A.J.2    Schiemann, W.P.3
  • 3
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for TGF-β-mediated epithelial to mesenchymal transition and cell migration
    • Bakin, A. V., A. K. Tomlinson, N. A. Bhowmick, H. L. Moses, C. L. Arteaga (2000) Phosphatidylinositol 3-kinase function is required for TGF-β-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275:36803-36810.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 6
    • 1642359815 scopus 로고    scopus 로고
    • Role of TGF-β in breast carcinogenesis
    • Benson, J. R. (2004) Role of TGF-β in breast carcinogenesis. Lancet Oncol 5:229-239.
    • (2004) Lancet Oncol. , vol.5 , pp. 229-239
    • Benson, J.R.1
  • 8
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • Bhowmick, N. A., E. G. Neilson, H. L. Moses (2004b) Stromal fibroblasts in cancer initiation and progression. Nature 432:332-337.
    • (2004) Nature , vol.432 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 10
    • 33745515023 scopus 로고    scopus 로고
    • Tumour microenvironment: TGF-β: The molecular Jekyll and Hyde of cancer
    • Bierie, B., H. L. Moses (2006) Tumour microenvironment: TGF-β: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer 6:506-520.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 506-520
    • Bierie, B.1    Moses, H.L.2
  • 11
    • 33847770211 scopus 로고    scopus 로고
    • TGF-β signaling in breast cancer
    • Buck, M. B., C. Knabbe (2006) TGF-β signaling in breast cancer. Ann NY Acad Sci 1089:119-126.
    • (2006) Ann. NY Acad. Sci. , vol.1089 , pp. 119-126
    • Buck, M.B.1    Knabbe, C.2
  • 13
    • 2942564711 scopus 로고    scopus 로고
    • Tumor necrosis factor-α-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation
    • Chau, B. N., T. T. Chen, Y. Y. Wan, J. DeGregori, JY. Wang (2004) Tumor necrosis factor-α-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Mol Cell Biol 24:4438-4447.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 4438-4447
    • Chau, B.N.1    Chen, T.T.2    Wan, Y.Y.3    DeGregori, J.4    Wang, J.Y.5
  • 15
    • 23744452875 scopus 로고    scopus 로고
    • Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP-and HGF-mediated signaling networks
    • Cheng, N., N. A. Bhowmick, A. Chytil, A. E. Gorksa, K. A. Brown, R. Muraoka, CL. Arteaga, E. G. Neilson, S. W. Hayward, H. L. Moses (2005) Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP-and HGF-mediated signaling networks. Oncogene 24:5053-5068.
    • (2005) Oncogene , vol.24 , pp. 5053-5068
    • Cheng, N.1    Bhowmick, N.A.2    Chytil, A.3    Gorksa, A.E.4    Brown, K.A.5    Muraoka, R.6    Arteaga, C.L.7    Neilson, E.G.8    Hayward, S.W.9    Moses, H.L.10
  • 18
    • 15244339164 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis
    • Daniels, C. E., M. C. Wilkes, M. Edens, T. J. Kottom, S. J. Murphy, A. H. Limper, E. B. Leof (2004) Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis. J Clin Invest 114:1308-1316.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1308-1316
    • Daniels, C.E.1    Wilkes, M.C.2    Edens, M.3    Kottom, T.J.4    Murphy, S.J.5    Limper, A.H.6    Leof, E.B.7
  • 19
    • 33745081606 scopus 로고    scopus 로고
    • Circumventing resistance to kinase-inhibitor therapy
    • Druker, B. J. (2006) Circumventing resistance to kinase-inhibitor therapy. N Engl J Med 354:2594-2596.
    • (2006) N Engl. J. Med. , vol.354 , pp. 2594-2596
    • Druker, B.J.1
  • 20
    • 0035856481 scopus 로고    scopus 로고
    • Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway
    • Echarri, A., A. M. Pendergast (2001) Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway. Curr Biol 11:1759-1765.
    • (2001) Curr. Biol. , vol.11 , pp. 1759-1765
    • Echarri, A.1    Pendergast, A.M.2
  • 21
    • 58849126879 scopus 로고    scopus 로고
    • Three-dimensional context regulation of metastasis
    • Erler, J. T., V. M. Weaver (2009) Three-dimensional context regulation of metastasis. Clin Exp Metastasis 26:35-49.
    • (2009) Clin. Exp. Metastasis , vol.26 , pp. 35-49
    • Erler, J.T.1    Weaver, V.M.2
  • 22
    • 0035963315 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor
    • Frasca, F., P. Vigneri, V. Vella, R. Vigneri, JY. Wang (2001) Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor. Oncogene 20:3845-3856.
    • (2001) Oncogene , vol.20 , pp. 3845-3856
    • Frasca, F.1    Vigneri, P.2    Vella, V.3    Vigneri, R.4    Wang, J.Y.5
  • 23
    • 33747086130 scopus 로고    scopus 로고
    • 3 integrin and Src facilitate TGF-β mediated induction of epithelial-mesenchymal transition in mammary epithelial cells
    • 3 integrin and Src facilitate TGF-β mediated induction of epithelial-mesenchymal transition in mammary epithelial cells. Breast Cancer Res 8: R42.
    • (2006) Breast Cancer Res. , vol.8
    • Galliher, A.J.1    Schiemann, W.P.2
  • 24
    • 34248584887 scopus 로고    scopus 로고
    • Src phosphorylates Tyr284 in TGF-β type II receptor and regulates TGF-β stimulation of p38 MAPK during breast cancer cell proliferation and invasion
    • Galliher, A. J., W. P. Schiemann (2007) Src phosphorylates Tyr284 in TGF-β type II receptor and regulates TGF-β stimulation of p38 MAPK during breast cancer cell proliferation and invasion. Cancer Res 67:3752-3758.
    • (2007) Cancer Res. , vol.67 , pp. 3752-3758
    • Galliher, A.J.1    Schiemann, W.P.2
  • 25
    • 40549115658 scopus 로고    scopus 로고
    • Grb2 binding to Tyr284 in TβR-II is essential for mammary tumor growth and metastasis stimulated by TGF-β
    • Galliher-Beckley, A. J., W. P. Schiemann (2008) Grb2 binding to Tyr284 in TβR-II is essential for mammary tumor growth and metastasis stimulated by TGF-β. Carcinogenesis 29:244-251.
    • (2008) Carcinogenesis , vol.29 , pp. 244-251
    • Galliher-Beckley, A.J.1    Schiemann, W.P.2
  • 26
    • 42549140156 scopus 로고    scopus 로고
    • A phase II trial of imatinib mesylate in patients with metastatic pancreatic cancer
    • Gharibo, M., L. Patrick-Miller, L. Zheng, L. Guensch, P. Juvidian, E. Poplin (2008) A phase II trial of imatinib mesylate in patients with metastatic pancreatic cancer. Pancreas 36:341-345.
    • (2008) Pancreas , vol.36 , pp. 341-345
    • Gharibo, M.1    Patrick-Miller, L.2    Zheng, L.3    Guensch, L.4    Juvidian, P.5    Poplin, E.6
  • 27
    • 0035913192 scopus 로고    scopus 로고
    • Role for c-Abl and p73 in the radiation response of male germ cells
    • Hamer, G., I. S. Gademan, H. B. Kal, D. G. de Rooij (2001) Role for c-Abl and p73 in the radiation response of male germ cells. Oncogene 20:4298-4304.
    • (2001) Oncogene , vol.20 , pp. 4298-4304
    • Hamer, G.1    Gademan, I.S.2    Kal, H.B.3    De Rooij, D.G.4
  • 28
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D., R. A. Weinberg (2000) The hallmarks of cancer. Cell 100:57-70.
    • (2000) Cell. , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 29
    • 63749105896 scopus 로고    scopus 로고
    • Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelialmesenchymal transition
    • Heldin, C. H., M. Landstrom, A. Moustakas (2009) Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelialmesenchymal transition. Curr Opin Cell Biol 21:166-176.
    • (2009) Curr. Opin. Cell. Biol. , vol.21 , pp. 166-176
    • Heldin, C.H.1    Landstrom, M.2    Moustakas, A.3
  • 32
    • 34547667231 scopus 로고    scopus 로고
    • Treatment for chronic myelogenous leukemia: The long road to imatinib
    • Hunter, T. (2007) Treatment for chronic myelogenous leukemia: the long road to imatinib. J Clin Invest 117:2036-2043.
    • (2007) J. Clin. Invest. , vol.117 , pp. 2036-2043
    • Hunter, T.1
  • 34
    • 0038505214 scopus 로고    scopus 로고
    • Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion
    • Kain, K. H., S. Gooch, R. L. Klemke (2003) Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene 22:6071-6080.
    • (2003) Oncogene , vol.22 , pp. 6071-6080
    • Kain, K.H.1    Gooch, S.2    Klemke, R.L.3
  • 35
    • 0035844250 scopus 로고    scopus 로고
    • Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes
    • Kain, K. H., R. L. Klemke (2001) Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes. J Biol Chem 276:16185-16192.
    • (2001) J. Biol. Chem. , vol.276 , pp. 16185-16192
    • Kain, K.H.1    Klemke, R.L.2
  • 36
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri, R., R. A. Weinberg (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420-1428.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 37
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF-β-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • Lamouille, S., R. Derynck (2007) Cell size and invasion in TGF-β-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol 178:437-451.
    • (2007) J. Cell. Biol. , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 38
    • 78650510746 scopus 로고    scopus 로고
    • Emergence of the phosphoinositide 3-kinase-akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial- mesenchymal transition
    • Lamouille, S., R. Derynck (2011) Emergence of the phosphoinositide 3-kinase-akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition. Cells Tissues Organs 193:8-22.
    • (2011) Cells Tissues Organs , vol.193 , pp. 8-22
    • Lamouille, S.1    Derynck, R.2
  • 39
    • 57349137178 scopus 로고    scopus 로고
    • Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-β in mammary epithelial cells via a MMP-dependent mechanism
    • Lee, Y. H., A. R. Albig, M. Regner, B. J. Schiemann, W. P. Schiemann (2008) Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-β in mammary epithelial cells via a MMP-dependent mechanism. Carcinogenesis 29:2243-2251.
    • (2008) Carcinogenesis , vol.29 , pp. 2243-2251
    • Lee, Y.H.1    Albig, A.R.2    Regner, M.3    Schiemann, B.J.4    Schiemann, W.P.5
  • 41
    • 52049121297 scopus 로고    scopus 로고
    • DNA mismatch repair-dependent activation of c-Abl/p73α/GADD45alpha- mediated apoptosis
    • Li, L. S., J. C Morales, A. Hwang, M. W. Wagner, D. A. Boothman (2008) DNA mismatch repair-dependent activation of c-Abl/p73α/GADD45alpha- mediated apoptosis. J Biol Chem 283:21394-21403.
    • (2008) J. Biol. Chem. , vol.283 , pp. 21394-21403
    • Li, L.S.1    Morales, J.C.2    Hwang, A.3    Wagner, M.W.4    Boothman, D.A.5
  • 43
    • 33748576904 scopus 로고    scopus 로고
    • A phase II trial of imatinib mesylate in patients with biochemical relapse of prostate cancer after definitive local therapy
    • Lin, A. M., B. I. Rini, V. Weinberg, K. Fong, C. J. Ryan, J. E. Rosenberg, L. Fong, E. J. Small (2006) A phase II trial of imatinib mesylate in patients with biochemical relapse of prostate cancer after definitive local therapy. BJU Int 98:763-769.
    • (2006) BJU Int. , vol.98 , pp. 763-769
    • Lin, A.M.1    Rini, B.I.2    Weinberg, V.3    Fong, K.4    Ryan, C.J.5    Rosenberg, J.E.6    Fong, L.7    Small, E.J.8
  • 44
    • 47949106116 scopus 로고    scopus 로고
    • Activated c-Abl tyrosine kinase in malignant solid tumors
    • Lin, J., R. Arlinghaus (2008) Activated c-Abl tyrosine kinase in malignant solid tumors. Oncogene 27:4385-4391.
    • (2008) Oncogene , vol.27 , pp. 4385-4391
    • Lin, J.1    Arlinghaus, R.2
  • 45
    • 35548969446 scopus 로고    scopus 로고
    • Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: Inhibition of c-Abl by the tumor suppressor gene product Fus1
    • Lin, J., T. Sun, L. Ji, W. Deng, J. Roth, J. Minna, R. Arlinghaus (2007b) Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1. Oncogene 26:6989-6996.
    • (2007) Oncogene , vol.26 , pp. 6989-6996
    • Lin, J.1    Sun, T.2    Ji, L.3    Deng, W.4    Roth, J.5    Minna, J.6    Arlinghaus, R.7
  • 47
    • 47549090432 scopus 로고    scopus 로고
    • TGF-β in cancer
    • Massague, J. (2008) TGF-β in Cancer. Cell 134:215-230.
    • (2008) Cell. , vol.134 , pp. 215-230
    • Massague, J.1
  • 48
    • 78650511931 scopus 로고    scopus 로고
    • Smaddening complexity: The role of Smad3 in epithelial-myofibroblast transition
    • Masszi, A., A. Kapus (2011) Smaddening complexity: The role of Smad3 in epithelial-myofibroblast transition. Cells Tissues Organs 193:41-52.
    • (2011) Cells Tissues Organs , vol.193 , pp. 41-52
    • Masszi, A.1    Kapus, A.2
  • 49
    • 0034951384 scopus 로고    scopus 로고
    • STI571: Targeting BCR-ABL as therapy for CML
    • Mauro, M. J., B. J. Druker (2001) STI571: targeting BCR-ABL as therapy for CML. Oncologist 6:233-238.
    • (2001) Oncologist , vol.6 , pp. 233-238
    • Mauro, M.J.1    Druker, B.J.2
  • 53
    • 56049089380 scopus 로고    scopus 로고
    • Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-β through a PGE2-dependent mechanisms
    • Neil, J. R., K. M. Johnson, R. A. Nemenoff, W. P. Schiemann (2008) Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-β through a PGE2-dependent mechanisms. Carcinogenesis 29:2227-2235.
    • (2008) Carcinogenesis , vol.29 , pp. 2227-2235
    • Neil, J.R.1    Johnson, K.M.2    Nemenoff, R.A.3    Schiemann, W.P.4
  • 54
    • 40449092814 scopus 로고    scopus 로고
    • Altered TAB1: IkB kinase interaction promotes TGF-β-mediated NF-kB activation during breast cancer progression
    • Neil, J. R., W. P. Schiemann (2008) Altered TAB1: IkB kinase interaction promotes TGF-β-mediated NF-kB activation during breast cancer progression. Cancer Res 68:1462-1470.
    • (2008) Cancer Res. , vol.68 , pp. 1462-1470
    • Neil, J.R.1    Schiemann, W.P.2
  • 55
    • 69249126664 scopus 로고    scopus 로고
    • X-linked inhibitor of apoptosis protein and its E3 ligase activity promote TGF-β-mediated NF-kB activation during breast cancer progression
    • Neil, J. R., M. Tian, W. P. Schiemann (2009) X-linked inhibitor of apoptosis protein and its E3 ligase activity promote TGF-β-mediated NF-kB activation during breast cancer progression. J Biol Chem 284:21209-21217.
    • (2009) J. Biol. Chem. , vol.284 , pp. 21209-21217
    • Neil, J.R.1    Tian, M.2    Schiemann, W.P.3
  • 56
    • 33746646032 scopus 로고    scopus 로고
    • The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway
    • Noren, N. K., G. Foos, C. A. Hauser, E. B. Pasquale (2006) The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol 8:815-825.
    • (2006) Nat. Cell. Biol. , vol.8 , pp. 815-825
    • Noren, N.K.1    Foos, G.2    Hauser, C.A.3    Pasquale, E.B.4
  • 57
    • 0029662049 scopus 로고    scopus 로고
    • 1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • 1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 10:2462-2477
    • (1996) Genes Dev. , vol.10 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3    Schwarz, H.4    Beug, H.5    Reichmann, E.6
  • 58
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGF-β receptors controls epithelial cell plasticity
    • Ozdamar, B., R. Bose, M. Barrios-Rodiles, H. R. Wang, Y. Zhang, J. L. Wrana (2005) Regulation of the polarity protein Par6 by TGF-β receptors controls epithelial cell plasticity. Science 307:1603-1609.
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 59
    • 33845334175 scopus 로고    scopus 로고
    • Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
    • Pardali, K., A. Moustakas (2007) Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta 1775:21-62.
    • (2007) Biochim Biophys. Acta , vol.1775 , pp. 21-62
    • Pardali, K.1    Moustakas, A.2
  • 60
    • 0029924347 scopus 로고    scopus 로고
    • Nuclear tyrosine kinases: From Abl to WEE1
    • Pendergast, A. M. (1996) Nuclear tyrosine kinases: from Abl to WEE1. Curr Opin Cell Biol 8:174-181.
    • (1996) Curr. Opin. Cell. Biol. , vol.8 , pp. 174-181
    • Pendergast, A.M.1
  • 61
    • 0036391801 scopus 로고    scopus 로고
    • The Abl family kinases: Mechanisms of regulation and signaling
    • Pendergast, A. M. (2002) The Abl family kinases: mechanisms of regulation and signaling. Adv Cancer Res 85:51-100.
    • (2002) Adv. Cancer Res. , vol.85 , pp. 51-100
    • Pendergast, A.M.1
  • 63
    • 0033568349 scopus 로고    scopus 로고
    • C-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF
    • Plattner, R., L. Kadlec, K. A. DeMali, A. Kazlauskas, A. M. Pendergast (1999) c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev 13:2400-2411.
    • (1999) Genes Dev. , vol.13 , pp. 2400-2411
    • Plattner, R.1    Kadlec, L.2    DeMali, K.A.3    Kazlauskas, A.4    Pendergast, A.M.5
  • 64
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak, K., R. A. Weinberg (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9:265-273.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 65
    • 34248571400 scopus 로고    scopus 로고
    • Targeted TGF-β chemotherapies: Friend or foe in treating human malignancies?
    • Schiemann, W. P. (2007) Targeted TGF-β chemotherapies: friend or foe in treating human malignancies? Expert Rev Anticancer Ther 7:609-611.
    • (2007) Expert Rev. Anticancer Ther. , vol.7 , pp. 609-611
    • Schiemann, W.P.1
  • 66
    • 0034064630 scopus 로고    scopus 로고
    • C-Abl: Activation and nuclear targets
    • Shaul, Y. (2000) c-Abl: activation and nuclear targets. Cell Death Differ 7:10-16.
    • (2000) Cell. Death Differ , vol.7 , pp. 10-16
    • Shaul, Y.1
  • 68
    • 36148956209 scopus 로고    scopus 로고
    • The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells
    • Sirvent, A., A. Boureux, V. Simon, C. Leroy, S. Roche (2007) The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells. Oncogene 26:7313-7323.
    • (2007) Oncogene , vol.26 , pp. 7313-7323
    • Sirvent, A.1    Boureux, A.2    Simon, V.3    Leroy, C.4    Roche, S.5
  • 69
    • 33644840524 scopus 로고    scopus 로고
    • The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by TGF-β
    • Sokol, J. P., J. R. Neil, B. J. Schiemann, W. P. Schiemann (2005) The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by TGF-β. Breast Cancer Res 7: R844-R853.
    • (2005) Breast Cancer Res. , vol.7
    • Sokol, J.P.1    Neil, J.R.2    Schiemann, B.J.3    Schiemann, W.P.4
  • 73
    • 33745251071 scopus 로고    scopus 로고
    • Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells
    • Srinivasan, D., R. Plattner (2006) Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells. Cancer Res 66:5648-5655.
    • (2006) Cancer Res. , vol.66 , pp. 5648-5655
    • Srinivasan, D.1    Plattner, R.2
  • 74
    • 39149121810 scopus 로고    scopus 로고
    • Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival
    • Srinivasan, D., J. T. Sims, R. Plattner (2008) Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival. Oncogene 27:1095-1105.
    • (2008) Oncogene , vol.27 , pp. 1095-1105
    • Srinivasan, D.1    Sims, J.T.2    Plattner, R.3
  • 75
    • 38449106371 scopus 로고    scopus 로고
    • Regulation of cellular transformation by oncogenic and normal Abl kinases
    • Suzuki, J., T. Shishido (2007) Regulation of cellular transformation by oncogenic and normal Abl kinases. J Biochem 141:453-458.
    • (2007) J. Biochem. , vol.141 , pp. 453-458
    • Suzuki, J.1    Shishido, T.2
  • 78
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery, J. P. (2003) Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15:740-746.
    • (2003) Curr. Opin. Cell. Biol. , vol.15 , pp. 740-746
    • Thiery, J.P.1
  • 79
    • 77951649508 scopus 로고    scopus 로고
    • PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-β signaling during mammary tumorigenesis
    • Tian, M., W. P. Schiemann (2009a) PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-β signaling during mammary tumorigenesis. FASEB J 24:1105-1116.
    • (2009) FASEB J. , vol.24 , pp. 1105-1116
    • Tian, M.1    Schiemann, W.P.2
  • 80
    • 66349135076 scopus 로고    scopus 로고
    • The TGF-β paradox in human cancer: An update
    • Tian, M., W. P. Schiemann (2009b) The TGF-β paradox in human cancer: an update. Future Oncol 5:259-271.
    • (2009) Future Oncol. , vol.5 , pp. 259-271
    • Tian, M.1    Schiemann, W.P.2
  • 81
    • 0042337427 scopus 로고    scopus 로고
    • Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl
    • Truong, T., G. Sun, M. Doorly, J. Y. Wang, M. A. Schwartz (2003) Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Proc Natl Acad Sci USA 100:10281-10286.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10281-10286
    • Truong, T.1    Sun, G.2    Doorly, M.3    Wang, J.Y.4    Schwartz, M.A.5
  • 82
    • 16344378397 scopus 로고    scopus 로고
    • TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelialmesenchymal cell transition
    • Valcourt, U, M. Kowanetz, H. Niimi, C. H. Heldin, A. Moustakas (2005) TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelialmesenchymal cell transition. Mol Biol Cell 16:1987-2002.
    • (2005) Mol. Biol. Cell. , vol.16 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.H.4    Moustakas, A.5
  • 83
    • 0035122485 scopus 로고    scopus 로고
    • Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase
    • Vigneri, P., J. Y. Wang (2001) Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase. Nat Med 7:228-234.
    • (2001) Nat. Med. , vol.7 , pp. 228-234
    • Vigneri, P.1    Wang, J.Y.2
  • 85
    • 33746635215 scopus 로고    scopus 로고
    • Eph tumour suppression: The dark side of Gleevec
    • Wang, J. Y. (2006) Eph tumour suppression: the dark side of Gleevec. Nat Cell Biol 8:785-786.
    • (2006) Nat. Cell. Biol. , vol.8 , pp. 785-786
    • Wang, J.Y.1
  • 86
    • 0021265841 scopus 로고
    • The mouse c-Abl locus: Molecular cloning and characterization
    • Wang, J. Y., F. Ledley, S. Goff, R. Lee, Y. Groner, D. Baltimore (1984) The mouse c-Abl locus: molecular cloning and characterization. Cell 36:349-356.
    • (1984) Cell. , vol.36 , pp. 349-356
    • Wang, J.Y.1    Ledley, F.2    Goff, S.3    Lee, R.4    Groner, Y.5    Baltimore, D.6
  • 87
    • 11244292291 scopus 로고    scopus 로고
    • Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo
    • Wang, S., M. C. Wilkes, E. B. Leof, R. Hirschberg (2005) Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo. FASEB J 19:1-11.
    • (2005) FASEB J. , vol.19 , pp. 1-11
    • Wang, S.1    Wilkes, M.C.2    Leof, E.B.3    Hirschberg, R.4
  • 88
    • 0029879676 scopus 로고    scopus 로고
    • The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products
    • Wen, S. T., P. K. Jackson, R. A. Van Etten (1996) The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J 15:1583-1595.
    • (1996) EMBO J. , vol.15 , pp. 1583-1595
    • Wen, S.T.1    Jackson, P.K.2    Van Etten, R.A.3
  • 89
    • 75649088874 scopus 로고    scopus 로고
    • Mechanisms of the epithelial-mesenchymal transition by TGF-β
    • Wendt, M. K., T. M. Allington, W. P. Schiemann (2009a) Mechanisms of the epithelial-mesenchymal transition by TGF-β. Future Oncol 5:1145-1168.
    • (2009) Future Oncol. , vol.5 , pp. 1145-1168
    • Wendt, M.K.1    Allington, T.M.2    Schiemann, W.P.3
  • 90
    • 71749100944 scopus 로고    scopus 로고
    • Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-β signaling and metastasis
    • Wendt, M. K., W. P. Schiemann (2009) Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-β signaling and metastasis. Breast Cancer Res 11: R68.
    • (2009) Breast Cancer Res. , vol.11
    • Wendt, M.K.1    Schiemann, W.P.2
  • 91
    • 71749099201 scopus 로고    scopus 로고
    • P130Cas is required for mammary tumor growth and TGF-β-mediated metastasis through regulation of Smad2/3 activity
    • Wendt, M. K., J. A. Smith, W. P. Schiemann (2009b) p130Cas is required for mammary tumor growth and TGF-β-mediated metastasis through regulation of Smad2/3 activity. J Biol Chem 284:34145-34156.
    • (2009) J. Biol. Chem. , vol.284 , pp. 34145-34156
    • Wendt, M.K.1    Smith, J.A.2    Schiemann, W.P.3
  • 92
    • 33748760321 scopus 로고    scopus 로고
    • TGF-β activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures
    • Wilkes, M. C., E. B. Leof (2006) TGF-β activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures. J Biol Chem 281:27846-27854.
    • (2006) J. Biol. Chem. , vol.281 , pp. 27846-27854
    • Wilkes, M.C.1    Leof, E.B.2
  • 93
    • 0035920195 scopus 로고    scopus 로고
    • Inhibition of c-Abl tyrosine kinase activity by filamentous actin
    • Woodring, P. J., T. Hunter, J. Y. Wang (2001) Inhibition of c-Abl tyrosine kinase activity by filamentous actin. J Biol Chem 276:27104-27110.
    • (2001) J. Biol. Chem. , vol.276 , pp. 27104-27110
    • Woodring, P.J.1    Hunter, T.2    Wang, J.Y.3
  • 94
    • 0037018155 scopus 로고    scopus 로고
    • Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension
    • Woodring, P. J., E. D. Litwack, D. D. O'Leary, GR. Lucero, J. Y. Wang, T. Hunter (2002) Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol 156:879-892.
    • (2002) J. Cell. Biol. , vol.156 , pp. 879-892
    • Woodring, P.J.1    Litwack, E.D.2    O'Leary, D.D.3    Lucero, G.R.4    Wang, J.Y.5    Hunter, T.6
  • 97
    • 59449090107 scopus 로고    scopus 로고
    • TGF-β-induced epithelial to mesenchymal transition
    • Xu, J., S. Lamouille, R. Derynck (2009) TGF-β-induced epithelial to mesenchymal transition. Cell Res 19:156-172.
    • (2009) Cell. Res. , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 100
    • 40549133440 scopus 로고    scopus 로고
    • Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases
    • Zandy, N. L., A. M. Pendergast (2008) Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases. Cell Cycle 7:444-448.
    • (2008) Cell. Cycle , vol.7 , pp. 444-448
    • Zandy, N.L.1    Pendergast, A.M.2
  • 101
    • 36749011318 scopus 로고    scopus 로고
    • Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases
    • Zandy, N. L., M. Playford, A. M. Pendergast (2007) Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases. Proc Natl Acad Sci USA 104:17686-17691.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 17686-17691
    • Zandy, N.L.1    Playford, M.2    Pendergast, A.M.3
  • 102
    • 2142818004 scopus 로고    scopus 로고
    • Death by Abl: A matter of location
    • Zhu, J., J. Y. Wang (2004) Death by Abl: a matter of location. Curr Top Dev Biol 59:165-192.
    • (2004) Curr. Top Dev. Biol. , vol.59 , pp. 165-192
    • Zhu, J.1    Wang, J.Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.