c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

Genes and Development

Volumn 13, Issue 18, 1999, Pages 2400-2411

  Plattner, Rina ^a   Kadlec, Lisa ^a,b   Demali, Kris A ^c,d   Kazlauskas, Andrius ^d   Pendergast, Ann Marie ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

c Abl; Cytoskeleton; Receptor tyrosine kinases; Src

Indexed keywords

GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL STRUCTURE; CONTROLLED STUDY; CYTOPLASM; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

3T3 CELLS; ACTINS; ANIMALS; CELL LINE; CYTOSKELETON; ENZYME ACTIVATION; FIBROBLASTS; GROWTH SUBSTANCES; HUMANS; MICE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS C-ABL; RATS; SRC-FAMILY KINASES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0033568349     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.18.2400     Document Type: Article

References (60)

1. Andoniou, C.E., C.B.F. Thien, and W.Y. Langdon. 1994. Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J. 13: 4515-4523.
2. Broome, M.A. and T. Hunter. 1996. Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling. J. Biol. Chem. 271: 16798-16806.
3. Cobb, B.S., M.D. Schaller, T.H. Leu, and J.T. Parsons. 1994. Stable association of pp60 src and pp59 fyn with the focal adhesion-associated protein tyrosine kinase, pp125 FAK. Mol. Cell Biol. 14: 147-155.
4. Dai, Z. and A.M. Pendergast. 1995. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes & Dev. 9: 2569-2582.
5. Dai, Z., R.C. Quackenbush, K.D. Courtney, M. Grove, D. Cortez, G.W. Reuther, and A.M. Pendergast. 1998. Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of the Abi family of proteins by a Ras-independent mechanism. Genes & Dev. 12: 1415-1424.
6. DeMali, K.A. and A. Kazlauskas. 1998. Activation of Src family members is not required for the platelet-derived growth factor B receptor to initiate mitogenesis. Mol. Cell Biol. 18: 2014-2022.
7. Dombrosky-Ferlan, P.M. and S.J. Corey. 1997. Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase. Oncogene 14: 2019-2024.
8. Elkins, T., K. Zinn, L. McAllister, and F.M. Hoffmann. 1990. Genetic analysis of a Drosophila neural cell adhesion molecule: Interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell 60: 565-575.
9. Eriksson, A., A. Siegbahn, B. Westermark, C.H. Heldin, and L. Claesson-Welsh. 1992. PDGF-α and β-receptors activate unique and common signal transduction pathways. EMBO J. 11: 543-550.
10. Fincham, V.J. and M.C. Frame. 1998. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. 17: 81-92.
11. Fincham, V.J., M. Unlu, V.G. Brunton, J.D. Pitts, J.A. Wyke, and M.C. Frame. 1996. Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins, J. Cell Biol. 135: 1551-1564.
12. Gertler, F.B., R.L. Benet, M.J. Clark, and F.M. Hoffman. 1989. Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell 58: 103-113.
13. Gertler, F.B., K.K. Hill, M.J. Clark, and F.M. Hoffman. 1993. Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero a regulator of axonal outgrowth, and disabled a novel tyrosine kinase substrate. Genes & Dev. 7: 441-453.
14. Giniger, E. 1998. A role for Abl in Notch signaling. Neuron 20: 667-681.
15. Gotoh, A., K. Miyazawa, K. Ohyashiki, T. Tauchi, H.S. Boswell, H.E. Broxmeyer, and K. Toyama. 1995. Tyrosine phosphorylation and activation of focal adhesion kinase (p125 FAK) by BCR-ABL oncoprotein. Exp. Hematol. 23: 1153-1159.
16. Hackel, P.O., E. Zwick, N. Prenzel, and A. Ullrich. 1999. Epidermal growth factor receptors: Critical mediators of multiple receptor pathways. Curr. Opin. Cell Biol. 11: 184-189.
17. Heldin, C.H. 1997. Simultaneous induction of stimulatory and inhibitory signals by PDGF. FEBS Lett. 410: 17-21.
18. Hill, K.K., V. Bedian, J.L. Juang, and F.M. Hoffmann. 1995. Genetic interactions between the Drosophila Abelson (Abl) tyrosine kinase and failed axon connections (Fax), a novel protein in axon bundles. Genetics 141: 595-606.
19. Hooshmand-Rad, R., L. Claesson-Welsh, S. Wennstrom, K. Yokote, A. Siegbahn, and C.H. Heldin. 1997. Involvement of phosphotidylinositide 3′-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis. Exp. Cell Res. 234: 434-441.
20. Hubbard, S.R. 1997. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J. 16: 5572-5581.
21. Kadlec, L. and A.M. Pendergast. 1997. The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation. Proc. Natl. Acad. Sci. 94: 12390-12395.
22. Koleske, A.J., A.M. Gifford, M.L. Scott, M. Nee, R.T. Bronson, K.A. Miczek, and D. Baltimore. 1998. Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron 21: 1259-1272.
23. Kypta, R.M., Y. Goldberg, E.T. Ulug, and S.A. Courtneidge. 1990. Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell 62: 481-492.
24. Lewis, J.M., R. Baskaran, S. Taagepera, M.A. Schwartz, and J.Y.J. Wang. 1996. Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport. Proc. Natl. Acad. Sci. 93: 15174-15179.
25. Liu, Z.G., R. Baskaran, E.T. Lea-Chou, L.D. Wood, Y. Chen, M. Karin, and J.Y.J. Wang. 1996. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature 384: 273-276.
26. Loureiro, J. and M. Peifer. 1998. Roles of Armadillo, a Drosophila catenin during central nervous system development. Curr. Biol. 8: 622-632.
27. Mellstrom, K., C.H. Heldin, and B. Westermark. 1988. Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor. Exp. Cell Res. 177: 347-359.
28. Melo, J.V. 1996. The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood 88: 2375-2384.
29. Moro, L., M. Venturino, C. Bozzo, L. Silengo, F. Altruda, L. Beguinot, G. Tarone, and P. Defilippi. 1998. Integrins induce activation of the EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival. EMBO J. 17: 6622-6632.
30. Muller, A.J., A.M. Pendergast, K. Parmar, M.H. Havlik, N. Rosenberg, and O.N. Witte. 1993. En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. Proc. Natl. Acad. Sci. 90: 3457-3461.
31. Nehme, A., R. Baskaran, S. Aebi, D. Fink, S. Nebel, B. Cenni, J.Y.J. Wang, S.B. Howel, and R.D. Christen. 1997. Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and-deficient cells exposed to cisplatin. Cancer Res. 57: 3253-3257.
32. Osherov, N. and A. Levitzki. 1994. Epidermal-growth-factor-dependent activation of the Src-family kinases. Eur. J. Biochem. 225: 1047-1053.
33. Pear, W.S., J.P. Miller, L. Xu, J.C. Pui, B. Soffer, R.C. Quackenbush, A.M. Pendergast, R. Bronson, J.C. Aster, M.L. Scott, and D. Baltimore. 1998. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving p210 bcr/abl-transduced bone marrow. Blood 92: 3780-3792.
34. Pendergast, A.M. 1996. Nuclear tyrosine kinases: From Abl to WEE1. Curr. Opin. Cell Biol. 8: 174-181.
35. Pendergast, A.M., A.J. Muller, M.H. Havlik, R. Clark, F. McCormick, and O.N. Witte. 1991. Evidence for regulation of the human Abl tyrosine kinase by a cellular inhibitor. Proc. Natl. Acad. Sci. 88: 5927-5931.
36. Renshaw, M.W., E. Lea-Chou, and J.Y.J. Wang. 1996. Rac is required for v-Abl tyrosine kinase to activate mitogenesis. Curr. Biol. 6: 76-83.
37. Ridley, A.J., H.F. Paterson, C.L. Johnston, D. Diekmann, and A. Hall. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70: 401-410.
38. Salgia, R., J.-L. Li, S.H. Lo, B. Brunkhorst, G.S. Kansas, E.S. Sobhany, Y. Sun, E. Pisick, M. Hallek, T. Ernst, R. Tantravahi, L.B. Chen, and J.D. Griffin. 1995. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by p210 BCR-ABL. J. Biol. Chem. 270: 5039-5047.
39. Salgia, R., J.-L. Li, D.S. Ewaniuk, W. Pear, E. Pisick, S.A. Burky, T. Ernst, M. Sattler, L.B. Chen, and J.D. Griffin. 1997. BCR/ ABL induces multiple abnormalities of cytoskeletal function. J. Clin. Invest. 100: 46-57.
40. Sawyers, C.L., J. McLaughlin, A. Goga, M. Havlik, and O. Witte. 1994. The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell 77: 121-131.
41. Schneller, M., K. Vuori, and E. Ruoslahti. 1997. αvβ3 integrin associates with activated insulin and PDGFβ receptors and potentiates the biological activity of PDGF. EMBO J. 16: 5600-5607.
42. Skorski, T., M. Nieborowska-Skorska, P. Wlodarski, M. Wasik, M. Trotta, P. Kanakaraj, P. Salomoni, M. Antonyak, R. Martinez, M. Majewski, A. Wong, B. Perussia, and B. Calabretta. 1998. The SH3 domain contributes to BCR/ABL-dependent leukemogenesis in vivo: Role in adhesion, invasion and homing. Blood 91: 406-418.
43. Suetsugu, S., H. Miki, and T. Takenawa. 1998. The essential role of profilin in the assembly of actin for microspike formation. EMBO J. 17: 6516-6526.
44. Taagepera, S., D. McDonald, J.E. Loeb, L.L. Whitaker, A.K. McElroy, J.Y.J. Wang, and T.J. Hope. 1998. Nuclear-cytoplasmic shuttling of c-Abl tyrosine kinase. Proc. Natl. Acad. Sci. 95: 7457-7462.
45. Theriot, J.A. and T.J. Mitchison. 1993. The three faces of profilin. Cell 75: 835-838.
46. Tice, D.A., J.S. Biscardi, A.L. Nickles, and S.J. Parsons. 1999. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc. Natl. Acad. Sci. 96: 1415-1420.
47. Twamley-Stein, G.M., R. Pepperkok, W. Ansorge, and S.A. Courtneidge. 1993. The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells. Proc. Natl. Acad. Sci. 90: 7696-7700.
48. Van Etten, R.A., P.K. Jackson, D. Baltimore, M.C. Sanders, P.T. Matsudaira, and P.A. Janmey. 1994. The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains and bundling activity. J. Cell Biol. 124: 325-340.
49. Veithen, A., P. Cupers, P. Baudhuin, and P.J. Courtoy. 1996. v-Src induces constitutive macropinocytosis in rat fibroblasts. J. Cell Sci. 109: 2005-2012.
50. Wang, F., V.M. Weaver, O.W. Petersen, C.A. Larabell, S. Dedhar, P. Briand, R. Lupu, and M.J. Bissell. 1998. Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three dimensional basement membrane breast cultures: A different perspective in epithelial biology. Proc. Natl. Acad. Sci. 95: 14821-14826.
51. Wang, J.Y.J. 1993. Abl tyrosine kinase in signal transduction and cell cycle regulation. Curr. Opin. Genet. Dev. 3: 35-43.
52. _. 1998. Cellular responses to DNA damage. Curr. Opin. Cell Biol. 10: 240-247.
53. Wang, X., R. Sato, M.S. Brown, X. Xua, and J.L. Goldstein. 1994. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77: 53-62.
54. Wen, S.T., P.K. Jackson, and R.A. Van Etten. 1996. The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J. 15: 1583-1595.
55. Weng, Z., J.A. Taylor, C.E. Turner, J.S. Brugge, and C. Seidel-Dugan. 1993. Detection of Src homology 3-binding proteins including paxillin, in normal and v-Src transformed Balb/c 3T3 cells. J. Biol. Chem. 268: 14956-14963.
56. Wennstrom, S., A. Siegbahn, K. Yokote, A. Arvidsson, C. Heldin, S. Mori, and L, Welsh. 1994. Membrane ruffling and chemotaxis transduced by the PDGF-β receptor require the binding site for phosphotidylinositol 3′ kinase. Oncogene 9: 651-660.
57. Westermark, B., A. Siegbahn, C.H. Heldin, and L. Claesson-Welsh. 1990. B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase. Proc. Natl. Acad. Sci. 87: 128-132.
58. Wills, Z., L. Marr, K. Zinn, C.S. Goodman, and D. VanVactor. 1999. Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo. Neuron 22: 291-299.
59. Wilson, L.K., D.K. Luttrell, J.T. Parsons, and S.J. Parsons. 1989. pp60 c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src. Mol. Cell Biol. 9: 1536-1544.
60. Yuan, Z.M., Y. Huang, Y. Whang, C. Sawyers, R. Weichelbaum, S. Kharbanda, and D. Kufe. 1996. Role of c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature 382: 272-274.