Repeated administration of phencyclidine, amphetamine and MK-801 selectively impairs spatial learning in mice: A possible model of psychotomimetic drug-induced cognitive deficits

Behavioural Pharmacology

Volumn 14, Issue 7, 2003, Pages 533-544

  Mandillo, S ^a   Rinaldi, A ^a   Oliverio, A ^a   Mele, A ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Dopamine; Mouse; NMDA; Non spatial novelty; Psychostimulants; Schizophrenia; Spatial novelty

Indexed keywords

AMPHETAMINE; DIZOCILPINE; PHENCYCLIDINE; PSYCHEDELIC AGENT; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE MODEL; DRUG SELECTIVITY; EXPLORATORY BEHAVIOR; HABITUATION; LEARNING DISORDER; LOCOMOTION; MALE; MOUSE; NONHUMAN; OBJECT RELATION; OPEN FIELD BEHAVIOR; TASK PERFORMANCE;

AGE FACTORS; ANIMALS; AROUSAL; CENTRAL NERVOUS SYSTEM STIMULANTS; DEXTROAMPHETAMINE; DISCRIMINATION LEARNING; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXPLORATORY BEHAVIOR; INJECTIONS, INTRAPERITONEAL; MALE; MEMORY, SHORT-TERM; MENTAL RECALL; MICE; MOTOR ACTIVITY; ORIENTATION; PHENCYCLIDINE; RECEPTORS, N-METHYL-D-ASPARTATE; SOCIAL ENVIRONMENT;

EID: 1442299144     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-200311000-00006     Document Type: Article

References (47)

1. Adriani W, Sargolini F, Coccurello R, Oliverio A, Mele A (2000). Role of dopaminergic system in reactivity to spatial and non-spatial changes in mice. Psychopharmacology 150:67-76.
2. Andreasen NC (2000). Schizophrenia: the fundamental questions. Brain Res Brain Res Rev 31:106-112.
3. Andreasen NC, O'Leary DS, Cizadlo T, Arndt S, Rezai K, Ponto LL, et al. (1996). Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc Natl Acad Sci USA 93:9985-9990.
4. Angrist BM, Gershon S (1970). The phenomenology of experimentally induced amphetamine psychosis - preliminary observations. Biol Psychiatry 2: 95-107.
5. Carlsson A, Waters N, Waters S, Carlsson ML (2000). Network interactions in schizophrenia - therapeutic implications. Brain Res Brain Res Rev 31: 342-349.
6. Coccurello R, Adriani W, Oliverio A, Mele A (2000). Role of nucleus accumbens dopaminergic system in reactivity to spatial and non-spatial changes in mice. Psychopharmacology 152:189-199.
7. Deutsch SI, Hitri A (1993). A measurement of an explosive behavior in the mouse, induced by MK-801, a PCP analogue. Clin Neuropharmacol 16:251-257.
8. Ellenbroek BA, Cools AR (2000). Animal models for the negative symptoms of schizophrenia. Behav Pharmacol 11:223-233.
9. Ellison G (1995). The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias. Brain Res Brain Res Rev 20:250-267.
10. Fleming K, Goldberg TE, Binks S, Randolph C, Gold JM, Weinberger DR (1997). Visuospatial working memory in patients with schizophrenia. Biol Psychiatry 41:43-49.
11. Gold JM, Harvey PD (1993). Cognitive deficits in schizophrenia. Psychiatr Clin North Am 16:95-312.
12. Handelmann GE, Contreras PC, O'Donohue TL (1987). Selective memory impairment by phencyclidine in rats. Eur J Pharmacol 140:69-73.
13. Healy DJ, Meador-Woodruff JH (1996). Differential regulation, by MK-801, of dopamine receptor gene expression in rat nigrostriatal and mesocorticolimbic systems. Brain Res 708:38-44.
14. Heimer L (2000). The basal forebrain in the context of schizophrenia. Brain Res Brain Res Rev 31:205-235.
15. Javitt DC, Zukin SR (1991). Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148:1301-1308.
16. Jentsch JD, Roth RH (1999). The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 20:201-225.
17. Koek W, Woods JH, Winger GD (1988). MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys. J Pharmacol Exp Ther 245:969-974.
18. Kokkinidis L, Anisman H (1981). Amphetamine psychosis and schizophrenia: a dual model. Neurosci Biobehav Rev 5:449-461.
19. Lannes B, Bernard V, Bloch B, Micheletti G (1995). Chronic treatment with dizocilpine maleate increases the number of striatal neurons expressing the D2 receptor gene. Neuroscience 65:431-438.
20. Lieberman JA, Sheitman BB, Kinon BJ (1997). Neurochemical sensitization in the pathophysiology of schizophrenia: deficits and dysfunction in neuronal regulation and plasticity. Neuropsychopharmacology 17:205-229.
21. McLamb RL, Williams LR, Nanry KP, Wilson WA, Tilson HA (1990). MK-801 impedes the acquisition of a spatial memory task in rats. Pharmacol Biochem Behav 37:41-45.
22. Nabeshima T, Kitaichi K, Noda Y (1996). Functional changes in neuronal systems induced by phencyclidine administration. Ann N Y Acad Sci 801:29-38.
23. Nestler EJ, Aghajanian GK (1997). Molecular and cellular basis of addiction. Science 278:58-63.
24. Noda Y, Yamada K, Furukawa H, Nabeshima T (1995). Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine: a new model of schizophrenia. Br J Pharmacol 116: 2531-2537.
25. Noda Y, Kamei H, Mamiya T, Furukawa H, Nabeshima T (2000). Repeated phencyclidine treatment induces negative symptom-like behavior in forced swimming test in mice: imbalance of prefrontal serotonergic and dopaminergic functions. Neuropsychopharmacology 23:375-387.
26. O'Keefe J, Nadel L (1978.) The Hippocampus as a Cognitive Map. New York: Oxford University Press.
27. Park S, Holzman PS (1992). Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry 49:975-982.
28. Perry W, Light GA, Davis H, Braff DL (2000). Schizophrenia patients demonstrate a dissociation on declarative and non-declarative memory test. Schizophr Res 46:167-174.
29. Robbins TW (1998). Homology in behavioural pharmacology: an approach to animal models of human cognition. Behav Pharmacol 9:509-519.
30. Robinson TE, Becker JB (1986). Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res Brain Res Rev 11: 157-198.
31. Robinson TE, Berridge KC (1993). The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247-291.
32. Rothman RB, Reid AA, Monn JA, Jacobson AE, Riece KC (1989). The psychotomimetic drug phencyclidine labels two high affinity binding sites in guinea pig brain: evidence for N-methyl-D-aspartate-coupled and dopamine reuptake carrier-associated phencyclidine binding sites. Mol Pharmacol 36:887-896.
33. Roullet P, Mele A, Ammassari-Teule M (1996). Involvement of glutamatergic and dopaminergic systems in the reactivity of mice to spatial and nonspatial change. Psychopharmacology 126:55-61.
34. Sams-Dodd F (1998). A test for the predictive validity of animal models of schizophrenia based on phencyclidine and D-amphetamine. Neuropsychopharmacology 18:293-304.
35. Sanger D, Young A, Willner P (2000). The behavioural pharmacology of schizophrenia. Behav Pharmacol 11:181-183.
36. Sargolini F, Roullet P, Oliverio A, Mele A (1999). Selective roles of glutamatergic afferents to the nucleus accumbens in the modulation of reactivity to spatial and non-spatial novelty in mice. Neuroscience 93:855-867.
37. Save E, Poucet B, Foreman N, Buhot MC (1992). Object exploration and reactions to spatial change and nonspatial changes in hooded rats following damage to parietal cortex or dorsal hippocampus. Behav Neurosci 106: 447-456.
38. Schroeder U, Schroeder H, Schwegler H, Sabel B (2000). Neuroleptics ameliorate phencyclidine-induced impairments of short-term memory. Br J Pharmacol 130:33-40.
39. Smith-Roe SL, Sadaghian K, Kelley AE (1999). Spatial learning and performance in the radial arm maze is impaired after N-methyl-D-aspartate (NMDA) receptor blockade in striatal subregions. Behav Neurosci 113: 703-717.
40. Stefani MR, Moghaddam B (2002). Effects of repeated treatment with amphetamine or phencyclidine on working memory in the rat. Behav Brain Res 134:267-274.
41. Steinpreis RE (1996). The behavioral and neurochemical effects of phencyclidine in humans and animals: some implications for modeling psychosis. Behav Brain Res 74:45-55.
42. Stewart J, Badiani A (1993). Tolerance sensitization to the behavioral effects of drugs. Behav Pharmacol 4:289-312.
43. Vanderschuren LJMJ, Kalivas PW (2000). Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology 151:99-120.
44. Verma A, Moghaddam B (1996). NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine. J Neurosci 16:373-379.
45. Ward L, Mason SE, Abraham WC (1990). Effects of the NMDA antagonists PCP and MK-801 on radial arm maze performance in rats. Pharmacol Biochem Behav 35:785-790.
46. White FJ (1996). Synaptic regulation of mesocorticolimbic dopamine neurons. Annu Rev Neurosci 19:405-436.
47. Wolf ME (1998). The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol 54:679-720.